A new study highlights the difficult decisions healthcare providers face when treating HIV-positive patients with seizures, where medication options are limited. Seizures are a common symptom in advanced stage HIV, affecting up to 11% of those undiagnosed and untreated.
Researchers at the University of Rochester Medical Center have identified a potential new treatment approach for lysosomal storage disorders, which cause disruptions in cellular functioning. The study found that repurposed drugs can overcome toxic build-up in affected cells, improving survival rates and quality of life.
Researchers discovered that radiotherapy can be less effective due to inflammation and immune response modulation. Combining immunotherapy with radiotherapy may enhance treatment benefits.
Researchers challenged a popular autism hypothesis by studying brain responses to repeated visual and tactile stimuli. The findings showed that brain responses were as stable as those of healthy controls, contradicting the idea that unreliable brain activity causes autism symptoms.
A University of Rochester Medical Center study reveals that e-cigarettes can cause damage to gums and teeth, similar to conventional cigarettes. The study found that flavoring chemicals play a role in damaging cells in the mouth, and nicotine contributes to gum disease.
Researchers have identified a repurposed drug that can 'wake up' damaged peripheral nerves, speeding up repair and functional recovery after injury. Daily treatment with 4-aminopyridine accelerates myelin damage repair and improves nerve function.
Researchers have discovered that infant nose cells possess remarkably similar RNS patterns to those found in the lungs, enabling non-invasive diagnostic methods and potential therapeutics for pediatric lung diseases. This breakthrough could improve diagnosis and treatment of respiratory syncytial virus (RSV) and other infant lung disea...
Huntington's disease, a hereditary neurodegenerative disorder, is characterized by the loss of medium spiny neurons and motor control problems. A new award will support research to develop a stem cell-based therapy that swaps sick brain cells for healthy ones.
Researchers pinpoint a unique metabolic reprogramming in cancer cells that enables their ability to biosynthesize and replicate, and may provide new treatment opportunities. By blocking specific enzymes involved in this process, tumor growth can be slowed or stopped in preclinical tests.
Researchers discovered a nuclear protein, EYA1, that contributes to neuroblastoma's aggression. The protein migrates to the nucleus in more aggressive forms of the disease, and its structure can be altered by inhibiting an enzyme called PRMT1.
Researchers aim to develop a diagnostic test for glymphatic system impairment after traumatic brain injury, which can lead to cognitive difficulties. The study seeks to identify treatments that could help repair the system, with potential applications in military personnel and servicemen.
Researchers have identified a rare mutation in the Non-Structural 1 protein that renders the flu virus defenseless against the immune system. This discovery could lead to the development of more effective live flu vaccines.
A study published in JAMA Oncology found that training oncologists and their patients to have high-quality discussions improves communication and leads to more clinically meaningful conversations. Despite the focused efforts, shared understanding about prognosis was lacking among patients.
Researchers will develop new therapies to protect brain and organs from secondary damage after traumatic events. A promising class of anti-inflammatory and cytoprotective drugs called tetracyclines show promise in preventing such damage.
A new study from the University of Rochester Medical Center highlights cultural differences in refugee developmental screening, including language barriers and differing beliefs about disability. Researchers found that establishing trust and using in-person interpreters improved engagement and milestone identification.
Researchers discovered that microvessels in the brain play a key role in reacting to spikes in demand and accelerating blood flow to respond to neuronal activity. The findings could help explain cognitive decline in Alzheimer's disease.
Researchers discovered a genetic link between Long QT Syndrome (LQTS) and an increased risk for seizures. LQTS patients who experienced seizures were three times more likely to have experienced seizures in the past, and had worse cardiac symptoms.
Researchers identified an inner ear deficiency in children with Autism that affects speech recognition. The non-invasive test measures otoacoustic emissions to detect cochlear impairment, correlating it with ASD symptom severity.
A study found that nearly all cancer patients overestimate their chances of survival compared to their doctors' estimates. The researchers emphasize the importance of accurate communication between physicians and patients in making informed treatment decisions.
A review article argues that telehealth will transform healthcare delivery, providing access to care at a lower cost. The authors identify three trends reshaping telehealth: making care more accessible, expanding its application beyond acute conditions, and migrating from hospitals to home and mobile devices.
A Phase 3 clinical trial found deutetrabenazine significantly decreased chorea in HD patients, with improvements also seen in quality of life measures. The drug was well-tolerated and effective in treating chorea associated with Huntington disease.
By transplanting healthy human glia cells into mice with Huntington's disease, researchers were able to reduce symptoms and slow disease progression. The transplanted cells restored normal neuronal activity and rescued nerve cells at risk of death.
Researchers at the University of Rochester Medical Center found that exercise can significantly reduce neuropathic symptoms in cancer patients undergoing chemotherapy. The study, which involved over 300 participants, showed that a six-week walking routine with gentle resistance-band training reduced pain and sensitivity to cold. Exerci...
A new study from the University of Rochester Medical Center suggests that student-athletes who experience concussions often struggle academically, even after returning to school. The research found significant academic problems among students with concussions compared to those with other sports-related injuries.
A new study suggests that conventional repeated radiation treatments for brain tumors may kill important support cells and cause more damage than single dose radiation therapy. This can lead to cognitive problems in patients after treatment.
Researchers found that individuals with schizophrenia have impaired ability to process visual and touch stimuli, leading to distorted perception of reality. The study's findings suggest a new way to identify the disease at an early stage, potentially allowing for earlier intervention.
Researchers found that altering the balance of ions in the fluid surrounding brain cells can stimulate or dampen nerve cell activity and cause brain cells to shrink while we sleep. This process facilitates waste removal and may lead to new ways to regulate the sleep-wake cycle.
Researchers have developed a new method for gene transfer using an array of carbon nanotubes, overcoming limitations of existing technologies. The device successfully delivers DNA into tens of thousands of cells simultaneously with minimal toxicity and no restrictions on genetic payload.
Researchers discovered that all four parts of the IP3 receptor must be activated for calcium to increase and initiate fluid secretion. This finding has broad implications for understanding human secretory disorders like Sjögren's syndrome, which causes dry mouth and affects quality of life.
A phase 1b clinical trial shows that an experimental therapy can control pancreatic cancer tumors well enough to make patients eligible for surgery. The treatment, PF-04136309, was found to be safe and effective when combined with chemotherapy.
A new study reveals that immune cells called microglia play a crucial role in rewiring brain connections, a process essential for neuroplasticity and learning. By 'pruning' unwanted connections, microglia enable the formation of new pathways between neurons.
Researchers studied 23 active cocaine users and found they exhibited an impaired ability to adjust their behavior and were less fulfilled once they achieved their desired reward. This disconnect between craving for a drug and regulating behavior may be key to breaking the cycle of addiction.
Researchers at the University of Rochester Medical Center have identified a population of stem cells capable of repairing skull formation and craniofacial bone repair in mice. This discovery contributes to an emerging field involving tissue engineering that uses stem cells to replace damaged bones in humans.
Researchers identify microglia cells as primary cause of cognitive problems in MS patients, disrupting communication between nerve cells. The findings suggest that the disease's impact on cognition is more complex than previously thought, with potential new targets for treatment.
The study found that microglia, the brain's immune system, rapidly repair damage to the blood-brain barrier after breaches. This process could be impaired by certain cardiovascular drugs intended to prevent stroke-related damage.
Doctors can address suffering more effectively by recognizing it through questioning and listening to patients. This approach complements the familiar 'diagnosing and treating,' helping patients reconnect with what's important and meaningful in their lives.
A new study from the University of Rochester found that early life exposures to toxic chemicals like PCBs and DDE reduce infants' responses to vaccines. The research, which analyzed blood samples from over 500 mother-infant pairs in eastern Slovakia, shows that even small changes can lead to long-term immune system dysfunction.
A recent study published in the New England Journal of Medicine found that ibrutinib, a targeted drug, was superior to chlorambucil in treating chronic lymphocytic leukemia (CLL) patients. The study showed improved progression-free survival, overall response rate, and overall survival rates for patients taking ibrutinib.
A new study has pinpointed the symptoms of rare myotonic dystrophy type 2 (DM2) that are most important to patients. The research, published in Neurology, found that fatigue and pain were key concerns for DM2 patients.
A new study suggests that the brain's immune system can be harnessed to clear amyloid plaques, a hallmark of Alzheimer's disease. Microglia, native brain cells, play a key role in this process, and manipulating their activation may accelerate plaque removal.
A new experimental treatment regimen combining a drug delivery system and URMC-099 has been shown to effectively combat HIV, reducing the need for daily medication. The nanoformulated protease inhibitor and URMC-099 prolonged therapeutic effects by increasing drug concentration in immune cells.
A new study reveals that patients with lumbar spinal stenosis prefer pain relief to improved mobility, defying medical community assumptions. Researchers surveyed 269 patients and found that 79% chose pain reduction over increased physical function.
Studies suggest that the insular cortex, damaged during a stroke, can lead to increased likelihood of quitting smoking and reduced withdrawal symptoms. Smokers who experienced strokes in this area were almost twice as likely to quit smoking compared to those with strokes in other parts of the brain.
A new study reveals how immune cells, such as neutrophils and T cells, coordinate their efforts to fight infections. By understanding this teamwork, scientists hope to develop new ways to control and improve the body's response to illnesses like multiple sclerosis and lupus.
A pilot study in Parkinson's disease suggests that remote recruitment and conduct of research visits is feasible and well-received by participants. The study leverages direct-to-consumer genetic testing and telemedicine to diagnose and treat diseases, potentially increasing participation in clinical research and accelerating diagnosis.
A new study will examine the relationship between family stress, parenting behaviors, and early childhood cavities in children aged 1-3 years. The two-year study aims to identify factors that contribute to the development of Early Childhood Caries and improve prevention strategies.
A new study found that nursing homes with higher concentrations of racial and ethnic minority residents have improved care, with increases in Medicaid payments associated with reduced clinical care deficiencies. Despite disparities remaining, the progress suggests a narrowing gap in quality of care over time.
Researchers at the University of Rochester Medical Center have identified a subgroup of follicular lymphoma patients who experience early disease recurrence despite modern treatments. These patients may require personalized therapy approaches, such as targeted sequencing or gene-expression profiling, to improve their outcomes.
Research during the Beijing Olympics found a correlation between reduced air pollution and higher birth weights among pregnant women. The study suggests that pollution may interfere with fetal growth, particularly in late pregnancy.
Researchers at the University of Rochester Medical Center found that allowing kids to pick their own summer reading materials significantly reduces literacy loss, particularly among low-income students. More than 75% of students who selected some or all of their books maintained or improved their reading levels.