A new study of 38,537 persons suggests that the rare APOE-ε2 variant is associated with prolonged survival, contrasting with the more widely studied APOE-ε4 variant. The findings could lead to novel preventive and treatment options for healthy aging and longevity.
Researchers at UT Health San Antonio found that higher doses of spironolactone can prevent dialysis in selected heart failure patients who are not responding to conventional diuretics. The study showed significant improvement in urine output and breathing, suggesting potential for avoiding dialysis
Researchers will investigate loss of DNA repair mechanisms and secondary mutations leading to cancer. The goal is to develop improved cancer treatment regimens and predict drug efficacy.
Researchers at UT Health San Antonio have discovered a novel therapy that reduces brain damage after traumatic brain injury (TBI) in mice, preventing seizures and reducing inflammation. The study aims to develop a simple and effective treatment for TBI patients.
A large study found chronic traumatic encephalopathy (CTE) in nearly 6% of athletes and non-athletes, with American football players at highest risk. The study's findings suggest a significant public health issue, but also emphasize the importance of safe sports practices and further research into CTE pathology.
The i-HOPE Study found that patients' priority unanswered questions include shared decision-making, patient-provider communication, and care transitions. By incorporating patient input, hospitals can improve hospitalization outcomes and provide more effective solutions.
A clinical trial found liraglutide, an existing adult diabetes medication, effectively treats Type 2 diabetes in children. The study showed a significant reduction in A1C levels and improvements in glycated hemoglobin levels, offering new treatment options for this age group.
The NASA Twins Study found changes in gene expression and metabolite alterations that support the potential health effects of long-duration spaceflight on astronauts. The study also suggests that human health can be mostly sustained over a year-long space mission, with targeted countermeasures needed for future Mars missions.
Researchers at UT Health San Antonio have created a smarter automatic defibrillator that accurately tracks stroke volume in addition to ECG readings. This update aims to deliver shocks only when needed, potentially preventing traumatic shocks and improving patient outcomes.
A study of 28,000 childhood cancer survivors found that exposure to different anthracycline chemotherapies results in variable long-term cardiovascular risk. Specifically, daunorubicin was associated with decreased cardiomyopathy risk compared to doxorubicin, while mitoxantrone appeared to have greater long-term cardiomyopathy risk.
Researchers conducted a first-in-human trial of senolytic drugs on patients with idiopathic pulmonary fibrosis (IPF), an age-related disease. The study showed significant improvements in participants' mobility, with an average increase of 21.5 meters in six-minute walk distance.
Researchers discovered MiR-584-5p, a tiny molecule, can kill medulloblastoma and sensitizes cancer to chemotherapy and radiation. This could lead to treating the tumor with one-tenth the current required dose.
Research associates higher cortisol levels with impaired memory and reduced brain volume in middle-aged adults. Cognitive data from the Framingham Heart Study found that morning cortisol levels predicted worse brain structure and cognition.
A type of cellular stress known as senescence has been linked to Alzheimer's disease and other human brain diseases. Researchers identified senescent cells in postmortem tissue from Alzheimer's patients and found them in another brain disease, progressive supranuclear palsy.
Research reveals that genetic copy-and-paste activity is increased in fruit fly models of tauopathies, leading to neuron death. Lamivudine, an anti-retroviral drug, decreases gene copying and reduces brain cell death.
Researchers at UT Health San Antonio used gene editing to decrease repetitive behaviors in mice with fragile X syndrome, an inherited cause of autism spectrum disorders. The approach resulted in significant reduction of symptoms, including digging behavior slowed by 30 percent and leaping behavior reduced by 70 percent.
UT Health San Antonio will receive funding for pilot projects in various areas, including cancer, heart disease, and regenerative medicine. The university aims to translate research discovery into improved patient care and develop biomedical professionals.
A recent study indicates that dementia is being diagnosed later in life and lived for a shorter period, with possible contributing factors such as reduced stroke risk and increased vaccination rates. Researchers suggest other causes, including lower pollution levels and better nutrition, may also play a role.
Researchers at UT Health San Antonio have created a novel technology that injects a modified virus into the mouse pancreas with pro-cancer molecules, resulting in human-like tumors. This breakthrough could lead to new insights into pancreatic cancer initiation and progression, as well as spur new drug development.
A genetic mutation in EPAS1/HIF2A gene is found to be the main reason for the development of adrenal gland tumors in adults with cyanotic congenital heart disease. The study also reveals that patients with this severe type of heart disease have a sixfold higher risk of developing these tumors.
A global study of DNA samples from 520,000 individuals identified 22 new genetic risk factors for stroke, according to researchers. The findings are significant as they will increase potential targets for stroke drug development and provide valuable insights into dementia research.
Scientists at Greehey Children's Cancer Research Institute have found a new mechanism by which BRCA1 can be rendered dysfunctional in Ewing sarcoma. The study reveals that the mutant oncogene produced by the fusion oncogene traps BRCA1, preventing it from repairing genetic damage.
A comprehensive survey of 2,279 graduate students found that they are more than six times as likely to experience depression and anxiety as the general population. The study highlights the need for mental health resources and career development programs in academia.
Exposing the gut to chlamydia provides robust protection against subsequent genital tract and other tissue infections, according to a study published in Infection and Immunity. The discovery has significant vaccine implications for preventing genital chlamydia, particularly among young people.
A new study reveals that chronic kidney disease patients have abnormal metabolites in their cells' energy centers, supporting the view of CKD as a state of mitochondrial dysfunction. Researchers hope to identify novel therapeutic targets for CKD using metabolomics.
Researchers identified NOX4 enzyme as a key mechanism in kidney cancer recurrence, finding it facilitates survival of cancer cells under drug treatment. The study's findings have potential for developing targeted therapies to reverse the mechanism and prevent further disease progression.
New research explains why mTOR inhibitors can't fully eliminate cancer cells. The drugs target a cell regulator called mTOR, which controls mitochondrial structure and function, ultimately protecting cells from death.
Anti-RAS antibodies are a critical research tool, but their poor reliability limits replicable study results. Researchers identified selectively recognizing each of the four human RAS proteins only in Western blot assays.
Scientists have created genetically encoded fluorescent sensors to measure GTP levels in cells, which can help identify potential anti-cancer compounds. This breakthrough discovery may lead to new treatments for various diseases by regulating cell movement, growth, and differentiation.
Researchers at UT Health San Antonio have developed a new, first-in-class agent called ERX-11 that blocks the growth of estrogen receptor-positive (ER-positive) breast cancer in its tracks. The new drug has shown promising results in preclinical studies and is expected to begin human trials soon.
Researchers identified the specific region of the brain affected by anoxic brain injury (ABI) in children who survived drowning. The study found that networks controlling perception and cognition remain intact, while motor pathways are damaged.
Researchers from UT Health San Antonio found that BRCA1 mutation carriers experience higher gene expression-related stress in luminal epithelial cells, which are more prone to breast tumors. This stress is also associated with estrogen-responsive genes in the breasts and ovaries, a key site for cancer predisposition.
Researchers at UT Health San Antonio have discovered epigenetic changes that contribute to one-fifth of acute myeloid leukemia cases and a large majority of low-grade gliomas. These changes may be targeted by an existing drug, improving survival rates for patients.
Researchers at UT Health San Antonio have developed a gene-transfer technique that increases insulin-producing cells, potentially curing Type 1 and improving Type 2 diabetes. The therapy has cured diabetes in mice without side effects, offering a major advance over traditional insulin therapy.
Veterans with Iraq-Afghanistan war-related epilepsy had substantially higher mortality rates than those without the condition. After controlling for comorbid conditions, IAVs with epilepsy were about 2.6 times more likely to die during a 5-year span.
Heat shock proteins collide with protein complexes, generating a force that breaks apart damaged or dysfunctional proteins. This study provides new insights into the role of heat shock proteins in maintaining proper protein function and preventing disease.
Researchers found that mice with lower adiponectin levels cannot overcome fear after a scary stimulus. Increasing adiponectin levels or activating its receptors might facilitate extinction-based exposure treatments for PTSD and other trauma-related disorders.
Researchers studied Parkinson's-affected cells before symptoms appear, finding declines in dopamine neuron function and electrical activity. The study aims to understand the root cause of the disease and develop a therapy to arrest its progression.
Researchers at the University of Texas Health Science Center have discovered that BRCA1 serves as a limiter on a gene called COBRA1, regulating breast cell growth. This finding provides new insights into how BRCA1 mutations increase breast cancer risk in women.
The UT Health Science Center at San Antonio's UltraScan software helped confirm the structure of a protein complex that enables viral infection, as reported in a recent Nature publication. The technology utilizes advanced coding and analytical ultracentrifugation to deliver sophisticated biological metrics.
Researchers found a disordered mesh-like scaffold in Alzheimer's-affected cells, which surrounds the nucleus and controls brain cell function. This discovery may lead to new treatments for the earliest biological events leading to Alzheimer's disease.
Research shows that Latino kids are more likely to be obese by ages 2-5 due to maternal obesity, less exclusive breastfeeding, and workplace issues. Breastfeeding can reduce obesity by 47 percent among Latino kids, but many Latina moms face barriers to initiating and maintaining breastfeeding.
Researchers have identified a key brain circuit involved in ketamine's antidepressant effects, offering hope for the development of fast-acting and sustained treatments for depression. The discovery could potentially reduce the risk of suicide among patients and provide a safer alternative to current medications.
Researchers at UT Health Science Center discover how poxviruses outsmart the body's immune system by targeting a key restriction factor called SAMD9. This finding has significant implications for cancer treatment and therapy, as SAMD9 also suppresses tumors.
Researchers discovered connexin protein's ability to suppress cancer growth by tethering itself to cell-proliferating molecules. This finding could lead to new cancer therapies based on connexin molecules.
A new study found that breast cancer adjuvant therapies have varying effects on patients over time. Researchers analyzed 19 clinical trials and discovered nearly half showed time-varying treatment effects.
Researchers discovered that excess IGFBP3 damages colonic stem cells, leading to intestinal lining damage and chronic gastrointestinal symptoms. A biopharmaceutical blocking circulating levels of the protein has shown promising results in reversing colon damage in diabetic mice.
A Phase 2 clinical trial found that gene therapy VB-111 increased overall survival to 15 months, compared to 8 months for those receiving chemotherapy Avastin alone. The therapy effectively starves tumors by blocking new blood vessel growth and is safe and well-tolerated.
Scientists have developed a novel process to regenerate salivary cells using silk fibers as a framework, which could help millions in the US with dry mouth due to Sjögren's syndrome. The process has been shown to retain salivary gland cell properties and is a significant step towards developing new cell-based therapeutics.
A new study by the University of Texas Health Science Center at San Antonio found that mothers with chemical intolerances are two to three times more likely than other women to have a child with autism spectrum disorder (ASD) or attention deficit hyperactivity disorder (ADHD). Children of these mothers reported having more illnesses an...