Researchers found a metabolic imbalance that is oncogenic in diffuse large B-cell lymphomas, characterized by a deficiency of alpha-ketoglutarate. This imbalance disrupts dioxygenase function, leading to various disturbances. The study suggests that metabolic regulation plays a critical role in cancer biology.
A Phase III study has shown an overall cure rate of 94% for patients with a liver transplant and returning hepatitis C, and 83% for patients with advanced cirrhosis. The FDA has granted Breakthrough Therapy Designation for the investigational combination, clearing the way for expedited drug development.
A new method for making RNAs has been developed by researchers at the University of Texas Health Science Center at San Antonio, allowing for increased chemical diversity and efficiency. This breakthrough could accelerate the development of diagnostics and therapeutics using RNAs.
An observational study of San Antonio men and women aged 65+ found that frequent diet soda consumption was associated with significant increases in waist circumference over 9 years. The risk of metabolic disease, diabetes, heart attack, stroke, cancer, and mortality also rose proportionally.
The molecular structure of the cytotoxin from Mycoplasma pneumoniae has been determined, which could lead to the development of effective drugs and vaccines to neutralize its injurious effects. The discovery is a significant breakthrough in understanding respiratory infections such as asthma.
A new oral drug, ZS-9, has been shown to normalize high potassium levels in 98% of patients with chronic kidney disease treated with Renin Angiotensin Aldosterone System inhibitors (RAASI's). This effective treatment reduces the risk of fatal cardiac arrhythmias associated with hyperkalemia.
Researchers at the University of Texas Health Science Center at San Antonio have launched a groundbreaking clinical trial using tiny radioactive liposomes to treat brain cancer. The technology has shown promising results with minimal side effects in the first patient, and the team expects to start the second patient soon.
Two studies found that morphine equivalent doses of opioids over 100mg/day increase drug overdose risk, while antidepressant use can mitigate this risk. A third study revealed a 'catch-22' where patients without depression are more likely to overdose when taking opioids with sedatives.
A two-year study found that soldiers receiving cognitive-behavioral therapy were 60 percent less likely to make a suicide attempt than those receiving standard treatment. The therapy focused on managing stress and thinking in more helpful ways.
A study found that retigabine, an epilepsy drug, protected the brain against ischemic stroke damage in mouse models. The medication acted directly on nerve cells to minimize damage, showing protective effects up to five days after the stroke.
Researchers found that retigabine, an approved anti-epilepsy drug, preserved brain tissue in a mouse model of stroke and prevented loss of balance control. Histological analysis showed significantly reduced damage to the tissue after the stroke, up to five days after.
Researchers have identified how PF74 and CPSF6 molecules bind to HIV-1's capsid, preventing its disassembly. This process can be targeted for therapeutic purposes in HIV-1 infections, potentially blocking viral replication.
A study reveals that Mycoplasma pneumoniae CARDS toxin triggers excessive inflammation by activating NALP3, leading to tissue injury and airway narrowing. The discovery could lead to the development of therapeutic strategies to improve health in individuals with airway diseases.
Research shows that starting HIV therapy soon after infection significantly reduces the risk of developing AIDS and improves immune function, particularly when treatment is initiated within 12 months of seroconversion. A normal CD4+ T-cell count above 800 cells per cubic millimeter is crucial for reconstituting immune-fighting cells.
A CTRC doctor has been awarded a $1.6 million FDA orphan grant to study the efficacy of TH-302 in treating glioblastoma, a devastating brain tumor with a median survival time of four months. The drug, combined with Avastin, aims to slow tumor growth by creating a low-oxygen environment, sparing healthy cells from chemotherapy damage.
Researchers found Streptococcus pneumoniae physically damages the heart, leaving tiny lesions that can permanently scar the myocardium. A candidate vaccine has been developed to protect against this damage.
The team determined the high-resolution structure of Dbr1 enzyme, which breaks loops of ribonucleic acids and could be a new target for treating most cases of ALS. By inhibiting this enzyme's activity, researchers hope to prevent TDP-43 aggregates from forming in motor neurons.
Researchers discovered that naked mole rats maintain youthful heart function until age 90, offering insights into preventing debilitating cardiovascular disease. The rodents' natural habitat and stress resistance may hold the key to understanding these protective mechanisms.
Researchers found that patients taking COX2 inhibitors, such as aspirin or ibuprofen, had a lower breast cancer recurrence rate compared to those not taking these medications. This reduced the risk of ERα positive breast cancer by 50% and extended disease-free periods by more than two years.
The prostate cancer risk calculator has been updated to provide a more nuanced result, helping men understand their risk of low-grade and high-grade prostate cancer. The new calculator incorporates current risk factors and an advanced statistical model to distinguish between the prediction of low-grade and high-grade disease.
Researchers discovered a link between DNA methylation and stress response in the brain, predicting depression and PTSD risk. The study used functional imaging, saliva tests, and blood samples to show that small changes in gene expression can be a stronger predictor than genetic sequence variation.
Researchers have identified a combination of pills that cures 9 out of 10 hepatitis C patients, achieving a 93% cure rate in 12 weeks. The treatment was well-tolerated by patients and offers a higher cure rate than previous standard care.
Researchers at the University of Texas Health Science Center at San Antonio have discovered that capsazepine can shrink oral cancers while leaving healthy tissues intact. The study's findings suggest that capsazepine may reduce oral cancer pain by blocking tumor-secreted factors from stimulating pain-sensing neurons.
Researchers at the University of Texas Health Science Center at San Antonio have identified a protein called Grb10 as the on-off switch for converting unhealthy white fat into beige fat, a process that increases energy expenditure and reduces obesity. The finding could lead to the development of novel diabetes and obesity drugs.
Cancer research calls on institutions to increase Hispanic patient enrollment, highlighting health disparities and underrepresentation in clinical trials. The study emphasizes the need for adequate representation to ensure effective treatment and reduce disparities.
A new study reveals the link between obesity and increased risk of myeloma, a cancer of plasma cells. The researchers found that adiponectin, a protective protein, can be used to suppress fatty acid production in myeloma cells, leading to their demise.
Researchers have determined the structure of a protein produced by Candida albicans, a common fungal pathogen that causes yeast infections and other diseases. The discovery could lead to the development of targeted compounds to treat widespread fungal infections.
A new oral combination therapy has been shown to cure hepatitis C infection in over 90% of patients with liver cirrhosis, providing a significant improvement over the current treatment options. The study found that the treatment was well-tolerated and resulted in no long-term relapses.
Researchers have found that an ancient Chinese medicine extract blocks pathways to treat pancreatic cancer by inhibiting scarring and inflammation. The compound also appears to suppress Cox-2, an enzyme that causes inflammation, and has been shown to be safe for use in patients.
Researchers have developed a new laboratory screening technique to find novel treatments for pediatric neuroblastoma. MicroRNAs play an important role in regulating cell development and differentiation, revealing promising targets for new therapies.
Researchers at UT Health Science Center identified a key role of the WTAP protein in AML development and found that suppressing it with Hsp90 inhibition greatly suppressed proliferation and induced differentiation. This discovery opens up new avenues for effective therapies for children and adults with newly diagnosed AML.
Research found that neutralizing a specific cytokine in the brain impaired cognitive flexibility in stressed and nonstressed rats. However, restoring low levels of this cytokine in a specific region of the brain corrected the deficit.
A multinational project led by Dr. Tyler Curiel aims to develop an antibody that can block a specific cancer metabolic pathway and reduce its ability to suppress the immune system.
Researchers have discovered a novel method of treating traumatic brain injury by stimulating 'caretaker cells' to reduce swelling. The treatment, using compounds like 2-methylthio-ADP and MRS2365, has shown promise in reducing edema and prolonging the life of neurons.
Elevated tyrosine levels in obese individuals are linked to a higher risk of developing diabetes. Researchers propose that tyrosine may directly affect insulin signaling, leading to increased blood sugar levels.
Researchers at the University of Texas Health Science Center at San Antonio suggest that cell transplants could be a promising treatment for schizophrenia. By transplanting interneurons into the brain, they were able to restore normal function in rats with impaired dopamine systems, which are involved in cognition, movement, and emotions.
Researchers identified two pathways that recombine DNA repeats to rearrange chromosomes, which can be targeted to prevent cancer and inherited disorders. The study used mouse embryonic stem cells and found large, complicated rearrangements on multiple chromosomes.
Researchers found that food-restricted mice exhibited increased susceptibility to cocaine and other illicit drugs due to heightened dopamine neuron firing in the substantia nigra region. This association may help develop new treatments for psychostimulant abuse by targeting adaptations in brain function.
Researchers found that muscle cells in knockout mice grew larger, but lost strength due to oxidative stress. The study suggests that limiting oxidative stress could help prevent age-related muscle loss and improve overall health.
A long-term study confirms that finasteride reduces the risk of prostate cancer by 43% in low-grade tumors and by 30% overall. This means thousands of men can avoid unnecessary treatments and burden on society.
Researchers found that regulatory elements (DEREs) control multiple target genes in response to estrogen stimulation, contributing to tumor development. Decreasing DERE copies may have therapeutic potential for treating women with estrogen receptor-positive breast cancers.
Children's perceptions of living with asthma may differ significantly from those of their caregivers, a new study shows. The study found that both children and caregivers should be interviewed during doctor visits to ensure accurate understanding of the child's condition.
Researchers have discovered novel compounds that fine-tune the activity of cells' protein-disposing machinery, which can help target solid tumors. These 'allosteric regulators' show promise as anti-cancer therapies without inducing drug resistance.
A study found that a walnut-enriched diet reduced prostate cancer formation by 18% and slowed tumor growth. The results suggest that using walnuts on a regular basis may be beneficial in deferring or preventing certain types of cancer, including breast cancer.
Patients with Type 2 diabetes who start on three medications at diagnosis have better glucose control with lower hemoglobin A1c levels and fewer hypoglycemic events compared to conventional therapy. The triple-therapy regimen also promotes weight loss and preserves beta cell function.
A synthetic compound has been discovered to enhance the effects of SSRIs, a commonly prescribed antidepressant. By blocking secondary 'vacuum cleaners' in the brain, the compound increases serotonin levels, offering new potential targets for treating depression. Researchers hope this discovery will lead to more effective treatments.
Researchers have identified a unique protein structure in the chlamydia bug that could lead to novel diagnostic methods and treatments. The discovery may help combat this sexually transmitted disease, which affects an estimated 2.8 million people in the US each year.
Children who develop Type 2 diabetes are at high risk for early complications, including heart and kidney problems. The study found that young patients were more likely to develop hypertension and fatty liver due to obesity.
A study by University of Texas Health Science Center at San Antonio found that baby marmoset monkeys who started eating solid food earlier were more likely to become obese by age one. The research also showed metabolic damage such as insulin resistance and poor blood sugar control, setting the stage for future obesity.
A study published in the New England Journal of Medicine recommends continuous hormone therapy for metastatic prostate cancer, extending lives by months to years. Continuous therapy offers a better alternative to intermittent therapy with fewer side effects.