Dr. Greenblatt's discovery of distinct types of bone-building stem cells has opened new areas of research into targeted therapies for bone cancer, osteoporosis, and rare bone conditions. His work has identified potential therapeutic targets to block spine metastases in breast and prostate cancer.
Researchers have developed a stable Env protein trimer, SOSIP.664, that can elicit broadly neutralizing antibodies against HIV. The breakthrough came after decades of work and multiple modifications to the protein, which is harder to engineer than its counterpart on SARS-CoV-2.
Weill Cornell Medicine leads a $14.9M NIH grant program to remove latent HIV from cells, aiming for effective cures. Researchers will use a personalized approach to develop tailored immunotherapies and broadly neutralizing antibodies against HIV.
Neurons in the gut produce adrenomedullin 2, which expands group 2 innate lymphoid cells and provides therapeutic benefit in inflammatory bowel disease preclinical models. Elevated expression of ADM2 was found in patients with inflammatory bowel disease, suggesting a promising therapeutic target.
Weill Cornell Medicine researchers Dr. Anna Nam and Dr. Maria Cecilia Lira have been awarded prestigious Pew fellowships to support their innovative cancer and biomedical science research. Dr. Nam is investigating the genetic determinants of Hodgkin lymphoma, while Dr. Lira aims to develop novel therapies for brain tumors.
NewYork-Presbyterian/Weill Cornell Medical Center has been recognized as a mitral valve repair reference center by the Mitral Foundation for three consecutive years. The award highlights the institution's commitment to delivering high-quality care and advancing best practices in surgical treatment of mitral valve disease.
A new clinical research study found that young children lacked immunity to common respiratory viruses during the pandemic, leading to a post-pandemic resurgence. The study's findings enable more accurate predictions for future outbreaks and demonstrate the utility of longitudinal immunologic surveillance in children.
A new analysis suggests that young people with weaker connections between brain areas involved in anxiety are more likely to benefit from a self-guided anxiety care app. The study found that the app reduced anxiety symptoms for many patients, particularly those with weaker neural connections.
A new study found that one in six men with low-grade prostate cancer (GG1) actually have intermediate- or high-risk cancer when other clinical features are considered. This suggests that relying on biopsy grade alone can lead to underestimating disease risk and misclassifying individuals who may benefit from definitive treatment.
Weill Cornell Medicine researchers found that PD-1 plays a critical role in forming long-term immune defenders in the skin. Blocking PD-1 too early can disrupt this process, leading to side effects. The study challenges current understanding of PD-1 and may impact cancer treatments.
A $1.1 million grant supports a natural history study for MCHS, collecting vital information about the condition to inform future clinical trials of therapies. The Volāre Study aims to provide baseline developmental trajectory information and establish infrastructure for multicenter clinical trials.
Researchers discovered that PAR1 triggers a structural transformation in lymphatic vessels, making them more permeable to absorb excess fluid and immune cells. This finding has implications for the treatment of lung diseases and could lead to targeted therapies.
A new study from Weill Cornell Medicine sheds light on age-related liver changes that may lead to chronic diseases. The research reveals that aging disrupts the functional organization of liver cells, causing inflammation and impaired metabolism.
A new combination treatment strategy selectively targets ovarian tumor cells, reducing growth in preclinical models. The approach identifies effective regimens to treat genetically diverse cancers by blocking specific growth signaling pathways.
A recent study published in Nature Metabolism found that electrical activity in synapses can lead to the use of lipid droplets as an energy source in the brain. Researchers discovered that neurons can break down fat into fatty acids and produce ATP, even when glucose is not present.
Academic medical centers can transform patient care by adopting learning health system principles, harnessing real-time data analysis and AI to improve patient outcomes. The proposed model aims to establish a smarter, more efficient and equitable care model by integrating diverse databases and leveraging AI for personalized, proactive ...
A new preclinical study from Weill Cornell Medicine found that a combination of small molecules extended the survival of transplanted pancreatic islets in female mice, while adding two molecules to the mixture boosted cell survival in male mice. This breakthrough could allow physicians to treat more patients with fewer cells.
Researchers have discovered that a rare genetic mutation delays Alzheimer's disease by suppressing inflammatory signaling in the brain. The study found that inhibiting this pathway with a drug-like inhibitor replicated key protective effects of the mutation in a preclinical model.
A new study published in JAMA found that youth who become increasingly addicted to social media, mobile phones, or video games are at greater risk of suicidal thoughts and behaviors. The research suggests that limiting screen time may not be effective in reducing the risk of mental health problems.
The INSIGHT Clinical Research Network has received $13.5 million in funding to expand its patient data network, increasing capacity for observational studies and retrospective studies. The network will support research on conditions including depression, diabetes, breast cancer, heart disease, and Alzheimer’s disease.
Dr. Warren Johnson receives the Weill Award for his transformative work in global health, including research and training programs in Brazil, Haiti, and Tanzania. He has mentored over 70 physicians and physician-scientists, including Dr. Daniel Fitzgerald.
Using an algorithm called the Krakencoder, researchers at Weill Cornell Medicine mapped how the brain's anatomical connections and activity patterns relate to behavior. The tool accurately predicted individual's functional connectome about 20 times more than previous approaches, also mapping age, sex, and cognitive performance scores.
Dr. Ghosh's expertise combines clinical, social science, and policy research to address the impact of climate change on vulnerable populations. His initiatives focus on developing interventions against heatwaves, hurricanes, and flooding.
Dr. Nikolaos Koundouros has been awarded the 2025 Tri-Institutional Breakout Award for his research on how cells detect and respond to dietary nutrients, specifically omega-6 and omega-3 fatty acids, in relation to breast cancer development.
A new study found that tumors with multiple sites undergo significant genetic changes, including whole-genome duplication, when they metastasize. This led researchers to wonder why copy-number alterations are more common than mutations in metastatic tumors.
A large clinical trial found that switching to an experimental drug after liquid biopsy detection of treatment-resistant mutations in breast cancer patients substantially extends tumor control and overall health status. The study, conducted at Weill Cornell Medicine, showed better outcomes compared to standard care.
Weill Cornell Medicine researchers Dr. Juan R. Cubillos-Ruiz and Dr. David Lyden have been awarded a $750,000 grant to study ovarian cancer, with a focus on harnessing immune cells and detecting the disease earlier. Their research aims to develop innovative strategies for eliminating metastatic tumors and preventing recurrence.
Researchers at Weill Cornell Medicine have made new discoveries about BCG therapy, which has been shown to reprogram and amplify immune cells in the bone marrow, boosting the body's ability to fight cancer. The findings could lead to improved immunotherapies for various types of cancer.
Four Weill Cornell Medicine investigators received the Ritu Banga Healthcare Disparities Research Awards to tackle disparities in cancer care, racial and ethnic differences in pediatric Hodgkin lymphoma, and access barriers to high-quality surgical cancer care. The awards support innovative research aimed at improving health outcomes f...
A team of researchers at Weill Cornell Medicine has discovered that the malaria parasite Plasmodium falciparum can shut down a key set of genes to avoid detection by the immune system. This finding suggests that asymptomatic adults may harbor undetectable parasites, making it more challenging to eliminate malaria.
A new study has identified three social risk clusters associated with a higher risk of suicide in the US, highlighting the importance of broader community-level social conditions. The findings suggest that region-specific interventions addressing poverty, housing, and environmental stressors can help lower suicide rates.
A 72-week clinical trial found tirzepatide to be more effective than semaglutide in reducing body weight and waist circumference. The study demonstrated that tirzepatide's dual mechanism of action, mimicking both GLP-1 and GIP hormones, is key to its superior performance.
A new AI-based method accurately sorts cancer patients into groups with similar characteristics before treatment and similar outcomes after treatment. The approach showed better performance than standard statistical and machine learning methods in predicting treatment outcomes from health record data.
A new $4 million grant will test whether Prostate Specific Membrane Antigen (PSMA)-Positron Emission Tomography (PET) Computed Tomography (CT) can improve prostate cancer monitoring while reducing screening-related harms. The study aims to reduce the need for biopsies in men with low- or intermediate-risk prostate cancers.
Researchers found that a chemical modification on messenger RNAs triggers disposal while being read by the ribosome, but during cell stress, this process is halted, allowing stress-response proteins to accumulate and help cells recover. The study may have implications for cancer therapies targeting m6A modifications.
A study from Weill Cornell Medicine found that healthcare providers working together in Accountable Care Organizations (ACOs) saved Medicare between $4.1 billion and $8.1 billion from 2012 to 2019. The program incentivized clinicians and organizations to improve patient care, resulting in lower medical spending per patient over time.
The VAST project seeks to understand the normal human virome, the vast ecosystem of viruses living in and on humans. By analyzing tens of thousands of samples from diverse populations, researchers aim to identify how a healthy virome shifts with disease or environmental factors.
A recent preclinical study from Weill Cornell Medicine researchers suggests that three-dimensional gene hubs may promote brain cancer. The findings, published in Molecular Cell, offer a new way to think about cancer beyond gene mutations and highlight the importance of understanding DNA organization in tumor cells.
A new study from Weill Cornell Medicine reveals a critical protein partnership that protects chromosome ends, regulating telomerase activity and preventing cell death. The researchers discovered that the CST complex and DNA polymerase α/primase interact to maintain telomere stability, with disruption leading to telomere abnormalities.
Dr. Sabine Ehrt takes the helm of microbiology and immunology at Weill Cornell Medicine, aiming to build on the department's reputation in tuberculosis research and expand into other areas. She seeks to foster cross-disciplinary collaborations and boost junior faculty mentorship.
Researchers discovered that gut bacteria can transform cholesterol-derived bile acids into powerful metabolites that strengthen anti-cancer immunity by blocking androgen signaling. These microbially modified bile acids antagonize the androgen receptor, driving anti-tumor immunity in mice with bladder cancer.
A new method for detecting cancer from blood samples has been developed, enabling the detection of extremely low concentrations of circulating tumor DNA. The technique, which combines whole-genome sequencing with error-correcting methods, shows high sensitivity and accuracy in identifying cancer mutations.
Researchers at Weill Cornell Medicine found that decreased ceramide levels in blood vessels can cause chronic illnesses. Ceramides regulate blood vessel tone and prevent blood clots, but low levels increase inflammation, high blood pressure, and glucose levels, leading to cardiometabolic conditions.
Researchers have successfully reprogrammed part of the large intestine to function like the nutrient-absorbing small intestine, reversing malnutrition in a preclinical study. The technique, which deletes the colon gene SATB2, restored nutrient absorption and improved survival rates in mice with short bowel syndrome.
A new study published in Nature Communications found that pregnancy may offer protection from developing Long COVID. The research analyzed data on approximately 72,000 pregnant women and 208,000 non-pregnant controls, revealing lower rates of long-term complications related to COVID-19 among pregnant women.
A preclinical study found that linoleic acid, an omega-6 fatty acid, activates a major growth pathway in tumor cells, particularly in triple-negative breast cancer subtypes. A high-linoleic-acid diet enhanced tumor growth in mice with triple-negative breast cancer.
Researchers at Weill Cornell Medicine developed a new AI model that harnesses whole-slide tumor imaging data and gene expression analyses to predict how patients with muscle-invasive bladder cancer will respond to chemotherapy. The model outperforms previous models using a single data type, identifying key genes and tumor characteristi...
The Weill Cancer Hub East will unite world-class experts in cancer biology, immunology, nutrition and metabolism to drive pioneering research. The hub aims to improve the effectiveness of immunotherapy, a promising approach for many types of cancers.
Restricting telehealth prescriptions for opioid use disorder could keep thousands from accessing buprenorphine, a medication that helps people recover from addiction. Researchers found that requiring in-person visits may undo the progress made during the COVID-19 pandemic when telehealth increased access to this life-saving treatment.
Researchers found that individuals with lower acylcarnitine levels declined more slowly and showed fewer cognitive decline symptoms compared to those with high acylcarnitine levels. Healthy lifestyle interventions, such as a plant-based diet and exercise, may help lower bioenergetic age and potentially delay or prevent Alzheimer’s onset.