Articles tagged with Clinical Trials
Researchers found that high-intensity blue light reduces inflammation and organ damage at the cellular level in mice before surgery. This potential pre-treatment light therapy could improve outcomes in patients undergoing procedures with blood restriction.
A phase II clinical trial showed that watercress extract significantly inhibits the activation of tobacco-derived carcinogens in cigarette smokers, with a stronger effect in those lacking certain genes involved in processing carcinogens. The extract also detoxifies environmental carcinogens and toxicants found in cigarette smoke.
Researchers are exploring new treatments for heart failure using transplanted umbilical cord cells, activated endogenous cardiac stem cells, and immune therapy. A clinical trial assessing the safety of allogenic umbilical cord lining sub-epithelial cells is also underway.
The four-week intervention program significantly reduces psychological impacts of child sexual abuse, with a 25% reduction in PTSD scores and fewer children experiencing depression and anxiety. The Be Brave Ranch offers comprehensive treatment to child survivors, providing individual and group therapies alongside peer support.
The Women's Health Initiative has received the AACR Team Science Award for its pioneering research on hormone therapy and nutrition in cancer risk prevention. The program, which involved over 161,000 postmenopausal women, found significant increases in heart disease, stroke, and breast cancer risks with combination hormone therapy.
A low-fat diet for eight years improved breast cancer survival rates and reduced mortality in postmenopausal women. The study, conducted by the Women's Health Initiative, found that a sustained low-fat diet increased survival rates among women diagnosed with breast cancer.
Researchers found that observing others' risk-taking behavior changes one's own attitude towards risk, with the brain responding to this change in activity levels. The study also found that participants could learn and predict the risk-taking preferences of an observed peer.
A study published in JAMA found that a multifaceted quality improvement intervention involving daily checklists and clinician prompting did not reduce in-hospital mortality among critically ill patients in ICUs. The intervention improved adherence to guidelines, reduced infections, and clinical outcomes, but its impact on mortality was...
A UK-based clinical trial is being conducted to explore the effectiveness of a holistic rehabilitation program for people with and beyond cancer. The study aims to address the lack of support for those living with cancer in the UK, who often experience physical and emotional challenges after treatment.
Patients with grade 2 glioma who received combined chemotherapy and radiation therapy experienced longer progression-free survival and overall survival compared to those who received radiation therapy alone. The study's findings suggest that initial therapy of RT followed by PCV is necessary to achieve longer survival.
Patients with grade 2 glioma who received radiation therapy plus PCV chemotherapy experienced longer progression-free and overall survival times compared to those who received radiation therapy alone. The treatment combination improved survival rates by up to 10 years.
Researchers from the Icahn School of Medicine at Mount Sinai present new findings on CABG alone or with mitral valve repair for moderate ischemic MR, as well as rate versus rhythm control in patients with postoperative atrial fibrillation after cardiac surgery.
A new study finds that end-stage heart failure patients who received stem cell therapy experienced a 37 percent reduction in cardiac events, including deaths and hospital admissions. The treatment showed fewer side effects and complications compared to the placebo group.
A new implantable medical device intended to stimulate the vagus nerve in heart failure patients did not significantly reduce hospitalization or death rates. However, it showed improvements in walking endurance and quality-of-life measures, with significant gains in distance walked and quality of life scores.
A phase 2 clinical trial shows significant benefits from stem cell therapy in patients with class III and IV heart failure. After 12 months, patients receiving the treatment had a lower rate of deaths, cardiovascular hospitalizations, and clinic visits for sudden worsening of heart failure symptoms compared to those receiving a placebo.
A survey of program directors found that flexible work hour schedules improve the continuity of patient care without compromising patient safety. Directors also believed that flexible duty hours would positively affect patient safety, continuity of care, quality of resident education, and resident well-being.
Researchers found that intravenous beta blockers before angioplasty in STEMI patients did not reduce heart attack severity or improve blood flow, according to the EARLY-BAMI trial. The study showed a slight decrease in ventricular arrhythmias but no significant differences in other endpoints.
Intermediate-risk patients who received TAVR with SAPIEN 3 had improved outcomes compared to surgical aortic valve replacement after one year. The trial showed reduced rates of death, stroke, and moderate or severe aortic insufficiency in TAVR patients.
A recent study found that patients with severe, symptomatic aortic stenosis who underwent transcatheter aortic valve replacement (TAVR) with the SAPIEN XT device had similar two-year clinical outcomes to those who underwent surgical aortic valve replacement. Additionally, TAVR was associated with reduced severe bleeding, length of stay...
The Phase 2 clinical trial results indicate that AC6 gene transfer safely increased left ventricular peak -dP/dt and left ventricular ejection fraction in non-ischemic heart failure patients. Symptoms of heart failure were also reduced in participants treated with RT-100.
Cell therapy is an emerging medical science focusing on innovative therapeutic approaches to treat blood diseases and infections. The EBMT Cellular Therapy and Immunobiology Working Party aims to foster cellular therapy in Europe by promoting exchanges, cooperation, and the development of new technologies.
The American Heart Association recommends a wearable automatic defibrillator as an option for patients at risk of sudden cardiac death due to erratic heart rhythms. This device can provide a short-term alternative to an ICD and is especially suitable for patients who cannot undergo surgery.
A new study published in the Journal of Consumer Psychology suggests that incorporating rough textures, such as sandpaper, into fundraising materials can increase donations. Participants who touched sandpaper were more willing to donate to lesser-known charities due to increased empathy.
RetroSense Therapeutics has successfully completed the first dose of its lead compound RST-001 in a phase I/II clinical trial for patients with retinitis pigmentosa. The study aims to assess the safety and potential efficacy of optogenetics in restoring vision.
Researchers at York University found that integrating motivational interviewing (MI) into cognitive behavioral therapy (CBT) is more effective in treating severe generalized anxiety disorder. This approach helps patients overcome conflicting feelings and enhances motivation for change, leading to improved long-term outcomes.
A study found that only 15.5% of available clinical trials were requested through open access platforms, suggesting underutilization due to lack of awareness or funding support. The researchers called for promoting the use of shared clinical trial data to increase transparency and validation studies.
The narrative review discusses current status of adolescent and young adult cancer, highlighting areas for improvement and opportunities for progress. The authors emphasize the need for increased accrual to therapeutic clinical trials and enhanced investment in psychological support.
A randomized trial reveals that Parent Mentors are significantly more effective than traditional Medicaid/CHIP methods in insuring uninsured minority children. Parent Mentors save $6,045.22 per child and potentially could save the nation $17-$20 billion.
A randomized clinical trial found that treatment with inhaled xenon gas combined with hypothermia resulted in less white matter damage compared to hypothermia alone. The study suggests potential benefits for comatose survivors of out-of-hospital cardiac arrest, but further evaluation is needed.
A clinical trial showed that the experimental vaccine TV003 protected all 21 volunteers from infection, while placebo recipients developed infection. The study's results inform a phase 3 efficacy trial and offer new hope for dengue prevention.
Researchers at the University of Vermont and National Institutes of Health have developed a highly effective dengue vaccine requiring only one dose. The vaccine has shown promise in protecting against all four dengue strains, with no adverse reactions reported among test subjects.
A controlled human challenge study shows a dengue vaccine candidate can fully protect healthy volunteers from infection. The results support further evaluation of the vaccine and may help identify promising candidates and eliminate poor ones.
A new study found that a 21-gene test can identify patients with early breast cancer who can be spared chemotherapy and still survive five years after diagnosis. The trial showed a 94% disease-free survival rate among low-risk patients treated with hormone therapy alone.
A clinical trial found that approximately a quarter of women with HER2 positive breast cancer who received combination treatment experienced significant tumor shrinkage or disappearance within 11 days. This discovery offers the possibility of tailoring treatment for each woman, potentially reducing the need for chemotherapy.
A new study by SWOG found that negative cancer trials have a significant impact on cancer research, despite initial skepticism. The study analyzed 94 randomized Phase III cancer trials and found that the scientific impact of negative trials was similar to that of positive trials over time.
Rutgers University has developed a promising antimalarial compound, SJ733, which could help fight the long-dreaded disease. The compound works by blocking a malaria parasite protein, causing water to rush in and 'blowing up' the parasite inside human blood cells.
A clinical trial has found that regular peanut consumption begun in early infancy and continued until age 5 reduced the rate of peanut allergy in at-risk infants by 80% compared to non-peanut-consumers. After a one-year period of peanut avoidance, only 4.8% of original peanut consumers were found to be allergic.
A pilot study analyzed 1,516 tweets containing lung cancer-related content, finding that most were about support or prevention, while clinical trials were underrepresented. The study suggests that Twitter may be a useful tool for clinical researchers but also poses challenges related to privacy and noncoercive content.
Researchers found that nearly 18% of lung cancer tweets were about clinical trials, with many focused on immunotherapy. However, none of these tweets were used for recruitment and did not provide links to enrollment websites.
A large clinical trial found no significant effect on caesarean sections or adverse outcomes in older pregnant women. The study, which induced labour at 39 weeks, proved the safety of this approach, supporting the 'induce more women' advocates.
Researchers are being called upon to share data from a landmark trial that raised concerns about the use of starch solutions in critically ill patients. The CHEST trial, published in 2012, led to regulators suspending use of hydroxyethyl starch (HES) products worldwide.
A recent phase II clinical trial found that prucalopride significantly reduces the duration of intestinal paralysis after abdominal surgery. In the study, patients taking prucalopride experienced a reduced risk of prolonged ileus compared to those receiving a placebo.
A University of Colorado study reveals a weak link between MN1 and aggressive AML, suggesting EPZ-5676 as a potential tool to break this link. The drug inhibits chromatin regulators Mll1 and Dot1l, which are essential for MN1's leukemia-causing effects.
A new clinical trial has begun at Oxford and Sheffield to test a potential vaccine for prostate cancer. The vaccine aims to stimulate the immune system's attack on cancer cells by recognizing a specific protein found on their surface. If successful, future studies will assess its effectiveness in preventing disease progression.
Scientists have discovered a way to specifically target and inhibit the most harmful behavior of the amyloid precursor protein in Alzheimer's disease. This new therapeutic strategy could potentially treat AD without causing major side effects.
Two investigational vaccines against Ebola virus disease induced an immune response among 1,000 participants in the Phase 2 PREVAIL I trial. The cAd3-EBOZ and rVSV-ZEBOV vaccines were well-tolerated and elicited measurable and demonstrable antibodies, respectively.
Researchers found testosterone treatment improved all aspects of sexual function, including sexual activity and desire, in men with low testosterone levels. However, the study did not confirm earlier concerns about cardiovascular safety.
Less than 40% of clinical trial results were shared within two years, according to a new study published in the British Medical Journal. Researchers at Yale School of Medicine found significant variation across academic medical centers, highlighting the need for timely and transparent result sharing.
A 10-year clinical trial found that both surgery and stenting reduce the risk of stroke by about 7%, with low rates of restenosis over time. The procedures are safe and durable for preventing stroke in various patient groups.
A recent study found that only 29% of completed clinical trials led by investigators at major US academic centers were published within two years of completion, highlighting the need for improved timely reporting and publication. The study also revealed marked variation in rates of dissemination across institutions, with no center publ...
A clinical trial found no significant difference in stroke prevention between carotid stenting and endarterectomy for asymptomatic patients. The study, published in the New England Journal of Medicine, included over 1,400 participants with severe carotid artery narrowing.
The Testosterone Trials found that testosterone treatment increased blood testosterone levels and improved all aspects of sexual function, including desire and ability to get an erection. The treatment also showed benefits in mood and depressive symptoms, but not energy or distance walked.
Researchers at Yale University found that testosterone therapy significantly improved sexual function, including sexual activity, desire, and erectile function, in men over age 65. Additionally, testosterone treatment showed modest benefits in terms of improved mood and fewer depressive symptoms.
Researchers found testosterone treatment benefits older men with low testosterone levels, improving sexual function, walking ability, and mood. The treatment also had no significant impact on energy but reduced depressive symptoms.
A Phase 1 clinical trial began at WRAIR to evaluate the safety and immune response of a vaccine candidate for MERS, a severe respiratory disease with a high fatality rate. The vaccine is being co-developed by Inovio Pharmaceuticals and GeneOne Life Science Inc., and will be administered to 75 participants.
Recent advances in T cell therapy have brought the idea of fighting chronic infections and cancers closer to reality. The use of potent cells with a safety mechanism has been demonstrated, and clinical trials have yielded highly promising results.
Involving patients, families, and healthcare professionals in clinical trial design has been shown to increase recruitment rates by 30% and retention rates by 27%. This approach ensures that the needs of all stakeholders are considered, resulting in more accurate and relevant study outcomes.
Research reveals that targeting lower oxygen saturation levels (85-89%) for extremely preterm infants increases the risk of death by up to 45% compared to higher targets (91-95%). This finding confirms previous studies and has significant implications for neonatal care.
A national multicenter randomized trial found that extending surgical trainees' shifts does not compromise patient safety. The study showed flexible duty hour policies reduced handoffs and increased residents' satisfaction with their training. The findings provide high-level evidence to inform resident duty hour policies.
Researchers will compare surgery and active surveillance in women with low-grade DCIS, evaluating quality of life and psychosocial outcomes. The four-year study aims to answer whether invasive surgery is necessary for non-fatal disease.