Articles tagged with Clinical Trials
A phase IIR/III clinical trial investigates whether surgery or stereotactic body radiation can control metastasis while continuing breast cancer therapy. Researchers aim to define parameters for determining which patients benefit from this 'weeding the garden' approach.
A phase 1B clinical trial of the novel antidepressant NSI-189 has shown that the compound appears to be safe and may be effective against depression. The study found improvements in depressive and cognitive symptoms in study participants, with effects persisting for several months after treatment discontinuation.
A new study from Brigham and Women's Hospital found that sacubitril-valsartan can extend life expectancy by one to two years for heart failure patients with reduced ejection fraction. The therapy, currently used as standard care, was shown to improve overall survival by 16% and reduce hospitalization rates.
The new risk management plan aims to prioritize data quality, reduce costs, and decrease attrition rates in imaging biomarker-driven trials. By identifying risks at trial initiation and allocating resources effectively, the framework can help minimize variability and ensure reproducibility of data.
Scientists have unraveled the abilities of multinucleated giant cells, which help the body deal with bulky items that obstruct physiological processes. The treatment for systemic amyloidosis has been found to be effective due to the complement system's role in marking and destroying protein deposits.
A five-year trial of progesterone supplements for recurrent miscarriage shows no improvement in outcomes. Despite disappointing results, the PROMISE trial provides valuable insights into potential alternative treatments and highlights the importance of continued research into reducing miscarriage risk.
A Phase 2 clinical trial is underway to test a chikungunya vaccine in 400 healthy adult volunteers. The trial aims to assess the safety and immune response of the vaccine, which has shown promising results in previous studies.
A University of Pittsburgh-led trial found that a text message-based program successfully reduced binge drinking among 18-25 year olds. After 12 weeks, participants who received the full program reported an average of one less binge drinking day per month and a 12% reduction in binge drinking.
The EORTC trial 26101 found that bevacizumab treatment in progressive glioblastoma patients did not confer a survival advantage despite prolonged progression-free survival. The combination of bevacizumab and lomustine may prolong PFS but does not impact overall survival.
The TATORT-NSTEMI trial found no significant difference in major adverse cardiac events at 12 months between thrombectomy and standard PCI in NSTEMI patients. Thrombus aspiration also did not affect quality of life or functional class.
A new Ebola vaccine has been found to be well-tolerated and stimulate strong immune responses in adults in Mali and the US. The study's findings could offer crucial protection for contacts of patients with confirmed Ebola disease, helping to interrupt transmission.
A phase I clinical trial found that pevonedistat, a small-molecule inhibitor of the NEDD8-activating enzyme, was safe and tolerable in heavily pretreated patients with relapsed/refractory lymphoma. The therapeutic showed modest activity in these patients, with three achieving partial responses and 30 experiencing stable disease.
A new study improves BrainGate's user experience and performance with three software innovations, allowing users to control electronic devices without frequent recalibration. The advancements enable longer use sessions and improved accuracy, paving the way for a practical BCI assistive technology.
A large-scale randomized control trial found that computerized cognitive behavioral therapy (cCBT) offered little to no benefit over usual GP care in treating depression. Patients generally struggled with sustained engagement and highlighted difficulties with logging onto computer systems while clinically depressed.
A participatory breeding program assisted organic tomato growers in identifying key plant traits needed for optimal production, with flavor as the top priority. The program also revealed differences in fruit quality characteristics between organic and conventional growers, highlighting the importance of disease resistance and nutrition...
A meta-analysis of randomized clinical trials found that endovascular therapy improved functional outcomes and higher rates of independence at 90 days, but no significant difference in symptomatic intracranial hemorrhage or all-cause mortality. The study included data from 8 trials involving 2,423 patients with acute ischemic stroke.
Researchers from Brigham and Women's Hospital found that low-fat interventions were no more successful than higher-fat interventions in achieving and maintaining weight loss for periods longer than one year. Low-carbohydrate weight loss interventions resulted in greater weight loss compared to low-fat diets.
A follow-up study found that cognitive behavioural therapy (CBT) and graded exercise therapy (GET) improved fatigue and physical functioning in patients with Chronic Fatigue Syndrome, maintaining these improvements over time. The treatments also reduced the likelihood of seeking additional therapy.
The NRG Oncology/RTOG 0813 trial found SBRT to be well-tolerated in early-stage, centrally located non-small cell lung cancer patients. The highest dose level allowed by the protocol was reached without significant toxicity.
A team of Penn researchers analyzed 114 large animal studies on cartilage repair to determine adherence to federal guidelines. They found that most studies did not follow the guidelines, particularly when evaluating study outcomes, and suggested that a standardized reporting structure be implemented to improve translation.
A recent study published in Neurology found that only a quarter of headache clinical trials were registered in an approved clinical trial registry, despite a 2005 decision by major medical journals to prioritize trial registration. The study suggests significant selective reporting and potential issues with the peer review process.
A trial found that a collaborative care model using health risk assessment and counseling reduced the number of risk factors and preventative care deficits among older participants. The study demonstrated improved 8-year survival rates, with a mortality rate of 3.16 per 100 person-years in the intervention group.
The RTOG 9601 study found that adding anti-androgen therapy to salvage radiotherapy improved overall survival and reduced prostate cancer death. The treatment also showed no significant increase in radiation toxicity.
Current 20- to 29-pack-year smokers are at similar risk for lung cancer as 30+ pack-year former smokers who meet current guidelines. The study's findings suggest caution when recommending LDCT screening to this group due to untested assumptions and potential harms.
Patients with lower household income below $50,000 had 32% lower odds of participating in clinical trials compared to higher income patients. The study found that trial participation decreased as annual household income decreased from $50,000 or higher to between $20,000 and $49,999 and to less than $20,000.
The PARTNER II Trial showed promising findings for TAVR with the latest generation of balloon-expandable (SAPIEN 3) device, demonstrating low one-year mortality rates and improved symptom relief. The study also found a low rate of disabling stroke and paravalvular aortic regurgitation.
Consensus statements on intracranial pressure monitoring in sTBI provide a clear interpretation of clinical trial results. The statements help guide practicing physicians and researchers in managing patients with severe traumatic brain injury.
Researchers found no significant difference in new polyp formation between patients with vitamin D and/or calcium supplements and those without. The study's results contradict previous findings in models and smaller human trials, highlighting the need for further research on promising cancer prevention strategies.
A new study found that lowering systolic blood pressure to 120mmHg can reduce the risk of left ventricular hypertrophy by 39%, compared to the standard target of 140mmHg. This reduction in blood pressure was associated with a lower risk of heart failure, stroke, and sudden cardiac death.
Rettsyndrome.org has made a financial commitment to support Phase 2 and Phase 3 clinical trials of trofinetide in adult women and children with Rett syndrome. The organization is hopeful that these trials will be successful and lead to the first potential treatments for Rett syndrome.
A major study found that brain cooling therapy, induced hypothermia, does not improve patients' chances of recovery from traumatic brain injuries. Despite reducing brain pressure, the therapy was associated with worse functional recovery after six months.
A new study found that US clinical trials of chronic pain drugs experienced a steady increase in placebo response over time. The analysis revealed that trials conducted only in the US showed this trend, whereas European and Asian trials did not.
Two studies found that minimally invasive laparoscopic-assisted resection did not provide better cancer outcomes compared to open resection for patients with stage II or III rectal cancer. Laparoscopic resection was also shown to be inferior in terms of cancer control and adequacy of removal.
A randomized clinical trial published in JAMA found that laparoscopic surgery for rectal cancer has not yet been established as a routine procedure. The ALaCaRT trial showed similar success rates and fewer complications compared to open surgery, but with some concerns about margin involvement.
The University of Pittsburgh will lead a $15 million, five-year initiative to manage national clinical trials for breathing disorders. The program aims to develop new treatments for conditions like COPD and pulmonary hypertension.
The Collaboration for Alzheimer's Prevention (CAP) brings together researchers from six clinical trials to share information, resources, and expertise. CAP aims to accelerate the evaluation of preclinical Alzheimer disease treatments through data harmonization and standardization.
Researchers at UCSC are conducting field trials of two strategies to protect bats from white-nose syndrome, a deadly fungal disease that has devastated bat populations in eastern North America. The team aims to understand how some populations are surviving and develop effective treatments to improve their chances of survival.
The TAILORx trial found that 99.3% of patients with low Oncotype DX scores had no distant recurrence at 5 years after treatment with hormonal therapy alone. This study provides evidence supporting the clinical utility of Oncotype DX to risk-stratify patients with early stage breast cancer.
A major clinical trial reports that hormone replacement therapy (HRT) is safe and may improve survival chances in women with epithelial ovarian cancer. The study followed 150 women with the common type of ovarian cancer and found that HRT did not reduce overall survival, but rather increased it.
New study results show atezolizumab has remarkable activity in large number of patients with refractory lung cancer, regardless of treatment line. Efficacy is correlated with PD-L1 expression on tumours and immune cells.
The CheckMate 025 phase III clinical trial shows that nivolumab significantly prolongs survival in patients with advanced kidney cancer, regardless of PD-L1 expression. The study found a median overall survival of 25 months for nivolumab-treated patients compared to 19.6 months for those treated with everolimus.
A new study published in the Journal of Oncology Practice found that patients participating in stage III renal cell cancer drug trials are often younger and healthier than those who ultimately receive the drugs. The study highlights concerns about the direct applicability of trial data, particularly for patients with more advanced canc...
A new study found that patients on one-fourth the suggested dose of beta-blockers survived at the same rate or even better than those on higher doses, increasing survival by 20-25%. The research suggests that beta-blocker dosing needs to be personalized for individual patients.
A Mayo Clinic study examines the adoption and cessation of calcium magnesium (CaMg) use for oxaliplatin-induced neuropathy, highlighting the challenges of translating research into clinical practice. The study reveals a decade-long cycle of rapid changes in treatment, driven by emerging evidence and public perception.
Newborns in clinical trials are often denied analgesia for minor painful procedures, despite international guidelines. A recent review found that up to 70% of control group babies received no pain treatment.
A randomized trial found that yoga improved physical health, pain, energy, mood, and daily activities in people with arthritis. The study also showed long-term improvements in physical function and walking speed.
A 20-year follow-up of the EORTC boost no-boost trial found that young age, high-grade invasive tumor, and ductal carcinoma in situ were associated with increased local recurrence rates. The study showed substantial benefits from academic clinical research, enabling long-term follow-up and analysis.
A multiple myeloma patient experienced complete remission after receiving a personalized cellular therapy called CTL019, which targets cancerous white blood cells. The treatment was combined with chemotherapy and an autologous stem cell transplant, and the patient remains in remission over 12 months after infusion.
A systematic review of animal studies on MVA85A vaccine found insufficient evidence to support its effectiveness as a BCG booster. The delay in publishing the largest monkey trial with the longest follow-up also raised concerns about scientific integrity.
The UK's largest breast cancer physiotherapy trial, PROSPER, will investigate the impact of physiotherapy on women after breast cancer surgery. The study aims to inform national guidelines and improve treatment outcomes for women experiencing shoulder problems and chronic pain after their treatment.
A Phase 3 clinical trial has been launched to evaluate the efficacy and safety of a novel RNAi investigational agent for treating patients with transthyretin-mediated familial amyloidotic cardiomyopathy (FAC). The first US patient, Leon Silas, 76, was enrolled in the study after being diagnosed with congestive heart failure in 2011.
A retrospective case series found specific epidural steroid injections to be effective in treating short-term pain from lumbar spinal stenosis. The study contradicts a previous NEJM study and suggests future trials using interlaminar injection with long-acting steroids.
The XANTUS study found that rivaroxaban is safe and effective for stroke prevention in atrial fibrillation patients with low rates of bleeding and stroke. The study confirmed the positive benefit-risk profile of rivaroxaban established in clinical trials, demonstrating its efficacy and tolerability in real-world practice.
A sub study of the MR CLEAN trial found that patients with larger thrombi had better neurological recovery after intra arterial treatment. Thrombi size was associated with clinical outcome, and retrieving larger pieces may lead to improved patient results.
Researchers have identified a new protein fragment, amyloid-η, which antagonizes the hyperactive effect of beta-amyloid on nerve cells. This finding has immediate implications for ongoing clinical trials targeting beta-amyloid, suggesting that unanticipated side-effects may occur if eta-amyloid levels increase
A new trial suggests that pacing may not be effective in preventing cardiac remodeling and improving functional or clinical outcomes in patients with large myocardial infarctions. The study, known as PRomPT, found no significant difference between patients who received pacing and those who did not.
Researchers found that degenerating neurons in patients with Alzheimer's disease responded to gene therapy treatment by showing heightened growth, axonal sprouting, and activation of functional markers. The study suggests that nerve growth factor is safe over extended periods and merits continued testing as a potential AD treatment.
A new MRI study found that having the opportunity to learn from failure can turn it into a positive experience. The study showed that certain circumstances can prompt the brain's reward mechanism instead of avoidance learning, leading to improved understanding and behavior.
A review of survey data from over 300 obese participants found those who rated their primary care doctor's support as helpful lost an average of 11 pounds, compared to just 5 pounds for those with low-rated support. High-quality patient-doctor relationships are linked to better adherence and weight loss outcomes.
Doctors at Ohio State University Wexner Medical Center have successfully implanted lab-grown cartilage into a patient's knee, offering a potential long-term solution for patients with knee injuries. The implant is made from the patient's own cells and has shown promise in improving patient outcomes.