A supervised hospital walking program has been shown to reduce nursing facility admissions for older adults by lowering the proportion of patients discharged to skilled nursing facilities from 13% to 8%. However, low participation rates and limited impact on length of stay or inpatient falls were noted.
SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·TypeRandomized controlled/clinical trial·DateJun 5, 2023
A study published in JAMA Oncology suggests that stopping immunotherapy after two years for patients with advanced non–small cell lung cancer who remain responsive may be a reasonable strategy, providing sustained clinical benefit. The findings provide reassurance for patients and their healthcare providers.
SourceJAMA Network·JournalJAMA Oncology·DateJun 4, 2023
A study found that adding ribociclib to hormone therapy significantly improves invasive disease-free survival rates in patients with stage 2 or 3 HR positive/HER2 negative breast cancer. The combination therapy reduced the risk of cancer recurrence by 25%, with a three-year invasive disease-free survival rate of 90.4%.
SourceUniversity of California - Los Angeles Health Sciences·DateJun 2, 2023
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
A UTHSC research collaboration has been awarded a national grant to develop a new treatment for ovarian cancer. The project will test a newer generation of sabizabulin, a clinical candidate targeting microtubules in cancer cells.
SourceUniversity of Tennessee Health Science Center·DateJun 1, 2023
Researchers at the National Human Genome Research Institute identified a potential treatment for disabling pansclerotic morphea, a severe inflammatory disease. They found that patients with the disorder have an overactive STAT4 protein and significantly improved symptoms with ruxolitinib, a JAK inhibitor.
SourceNIH/National Human Genome Research Institute·JournalNew England Journal of Medicine·TypeExperimental study·DateMay 31, 2023
Researchers found that MALAT1 inhibition decreased BRAF RNA and protein levels, while increasing correlation with MAPK-associated genes. MALAT1-ASO treatment also reduced melanoma cell growth and tumor size in xenograft models.
SourceImpact Journals LLC·JournalOncotarget·TypeObservational study·DateMay 30, 2023
A study by Japanese researchers identifies the involvement of angiotensin II-AT1 and prostaglandin E2-EP1 systems in high-salt-induced hypertension and emotional/cognitive impairment, offering potential therapeutic targets for dementia prevention.
SourceFujita Health University·JournalBritish Journal of Pharmacology·TypeExperimental study·DateMay 29, 2023
Two researchers will receive $1 million each for their five-year studies on new medication-based approaches to repair damaged aortas, as well as the effects of exercise on healing heart muscle and brain tissue after a heart attack or stroke. The American Heart Association's Merit Award supports innovative research with high impact.
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers developed a drug treatment that inhibits YTHDF2, improving results of radiation therapy and preventing progression of distant metastasis. The treatment also prevents the "bad-scopal" effect, where radiation causes distant tumors to metastasize.
SourceUniversity of Chicago·JournalCancer Cell·TypeExperimental study·DateMay 25, 2023
Researchers developed a novel hybrid protein complex by binding lysozyme to copper for enhanced reactive oxygen species (ROS) removal. The CuST@lysozyme hybrid protein showed high SOD activity and stability in biological fluids, paving the way for its therapeutic applications.
SourceTokyo University of Science·JournalScientific Reports·TypeExperimental study·DateMay 25, 2023
Researchers have identified a novel model and therapy to mitigate the development of REM sleep behavior disorder, which affects over 3 million Americans. Dual orexin receptor antagonists have been shown to significantly reduce dream enactment behaviors, providing a promising new treatment option.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalJNeurosci·DateMay 25, 2023
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
Researchers at Weill Cornell Medicine have successfully converted human stomach stem cells into insulin-secreting cells, offering a promising approach to treating type 1 and severe type 2 diabetes. The transplants reversed disease signs in mouse models, suggesting good durability.
SourceWeill Cornell Medicine·JournalNature Cell Biology·DateMay 25, 2023
The Alzheimer's disease development pipeline has seen an increase in promising therapies and pharma investment, driving momentum in clinical trials. The pipeline currently has 187 clinical trials, with recent FDA approvals for two disease-modifying therapies, and more on the way.
SourceUniversity of Nevada, Las Vegas·JournalAlzheimer s & Dementia Translational Research & Clinical Interventions·TypeSystematic review·DateMay 25, 2023
Researchers have developed new methods to analyze dry-coated drug particles using 3D Raman mapping, which can effectively slow down dissolution rates. Another study introduces a novel technique for detecting complex traditional Chinese medicines, preventing adulteration and counterfeiting.
SourceCactus Communications·JournalJournal of Pharmaceutical Analysis·TypeExperimental study·DateMay 24, 2023
A recent study published in JAMA Psychiatry found that fewer boys aged 15-19 commit suicide in Swedish regions with higher bipolar diagnoses. The study, which analyzed registry data from 2008 to 2021, showed an inverse association between population-adjusted bipolar diagnoses and confirmed suicides among males.
SourceKarolinska Institutet·JournalJAMA Psychiatry·TypeObservational study·DateMay 24, 2023
Researchers have found a compound that can prevent cisplatin-induced renal toxicity and improve the outcomes of cancer treatment. The aromatic ketone 2',4',6'-trihydroxyacetophenone (THA) inhibits the CCBL1-mediated metabolism of cisplatin, reducing its toxic effects without affecting its potency.
SourceFujita Health University·JournalMolecular Cancer Therapeutics·TypeExperimental study·DateMay 23, 2023
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
Researchers at Rensselaer Polytechnic Institute and Albany Medical College will use AI to develop a novel mesoscopic, multimodal preclinical imaging approach to test the hypothesis that drug distribution mediates tumor resistance. The goal is to improve targeted therapy for HER2-positive breast cancer.
A study of nearly 67,200 postmenopausal women found that the Fracture Risk Assessment Tool (FRAX) was inadequate for identifying osteoporotic fracture risk across racial/ethnic categories. However, the Osteoporosis Self-Assessment Tool (OST) was excellent for detecting osteoporosis within each category.
SourceUniversity of California - Los Angeles Health Sciences·JournalJAMA Internal Medicine·TypeData/statistical analysis·DateMay 22, 2023
A recent study found that COVID-19 infection can lead to increased infarct growth and ongoing tissue consumption even after successful reperfusion through angiography. This suggests a potentially aggressive clinical course for patients with COVID-19 and large-vessel occlusion acute ischemic stroke.
SourceAmerican Roentgen Ray Society·JournalAmerican Journal of Roentgenology·TypeCase study·DateMay 18, 2023
A Baylor team created a molecular classifier test to identify patients with HER2-positive breast cancer who may benefit from anti-HER2 therapy alone without chemotherapy. The test accurately predicts the most likely response of a tumor to specific treatment regimens, allowing for personalized de-escalation approaches.
SourceBaylor College of Medicine·JournalClinical Cancer Research·TypeRandomized controlled/clinical trial·DateMay 18, 2023
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers at Michigan Medicine have discovered a new nutrient source that pancreatic cancer cells use to grow in the absence of glucose. Uridine is found in the tumor microenvironment and its exact source remains unknown. Blocking uridine metabolism may lead to new treatment options for pancreatic cancer.
SourceMichigan Medicine - University of Michigan·JournalNature·TypeExperimental study·DateMay 17, 2023
Researchers at Dartmouth Cancer Center found that alternating estrogen stimulation and anti-estrogen therapy is an effective treatment for patients with metastatic or advanced ER+ breast cancer. The POLLY trial showed that 42% of patients experienced tumor stabilization, while no patients discontinued treatment due to side effects.
SourceDartmouth Health·JournalClinical Cancer Research·TypeRandomized controlled/clinical trial·DateMay 15, 2023
Researchers at Brigham and Women's Hospital have characterized the structure of amyloid-beta fibrils in the human brain, revealing their role in Alzheimer's disease progression. The study sheds light on how lecanemab, a US FDA-approved drug, exerts its protective effects by targeting these fibrils.
SourceBrigham and Women's Hospital·JournalNeuron·DateMay 11, 2023
A study of 5302 patients found no significant difference in bleeding events between those temporarily discontinuing and maintaining antithrombotic therapy during image-guided breast biopsies. The findings support the safety of continuing antithrombotic therapy, but counsel patients on bruising risk.
SourceAmerican Roentgen Ray Society·JournalAmerican Journal of Roentgenology·TypeImaging analysis·DateMay 10, 2023
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
Researchers used cancer proteomics data to identify gene candidates for therapeutic targeting, focusing on protein kinases in uterine endometrial cancer cells. Public molecular resources and multi-omics data analysis can prioritize genes of interest for future studies.
SourceImpact Journals LLC·JournalOncotarget·TypeData/statistical analysis·DateMay 10, 2023
Researchers at McMaster University have found that solriamfetol is the most effective treatment for excessive daytime sleepiness (EDS) in individuals with obstructive sleep apnea (OSA). A systematic review of 14 clinical trials and analysis of data from various databases revealed solriamfetol to be the best option.
SourceMcMaster University·JournalAnnals of Internal Medicine·TypeSystematic review·DateMay 9, 2023
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
SourceXi'an Jiaotong-Liverpool University·JournalNano Letters·TypeExperimental study·DateMay 8, 2023
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
A phase 2 clinical trial testing a treatment combining standard chemotherapy with azacitidine showed nearly 90% of patients with aggressive T-cell lymphoma achieved complete remission. The treatment, which targets gene-silencing marks on DNA, has an estimated two-year progression-free survival rate of 69.2%.
SourceWeill Cornell Medicine·JournalBlood·DateMay 4, 2023
The IOF-ESCEO World Congress on Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases is the largest international scientific event devoted to musculoskeletal disorders. The congress presents new clinical advances and research on osteoporosis, osteoarthritis, sarcopenia, frailty, and rare skeletal disorders.
SourceInternational Osteoporosis Foundation·DateMay 4, 2023
Researchers uncover a pathophysiological mechanism that initiates and sustains neuropathic pain in mice, identifying Tiam1 as a potential therapeutic target. Targeting spinal Tiam1 with antisense oligonucleotides alleviates neuropathic pain hypersensitivity, offering promise for treating chronic pain.
SourceUniversity of Alabama at Birmingham·JournalNeuron·TypeExperimental study·DateMay 4, 2023
Researchers identified three novel dual-purpose therapeutic targets using PandaOmics, which could treat both aging and glioblastoma multiforme. The target hypotheses include cyclic nucleotide gated channel subunit alpha 3 (CNGA3), glutamate dehydrogenase 1 (GLUD1) and sirtuin 1 (SIRT1).
SourceImpact Journals LLC·JournalAging-US·TypeComputational simulation/modeling·DateMay 2, 2023
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
A large study found no difference in cardiovascular outcomes between patients taking beta blockers and those who didn't, after a year of hospital discharge. The researchers suggest reevaluating the value of long-term beta blocker therapy in low-risk heart attack patients with normal functioning hearts.
SourceBMJ Group·JournalHeart·TypeObservational study·DateMay 2, 2023
Researchers have identified 11 somatic mutations in the RAS/MAPK pathway that contribute to treatment-resistant adult epilepsy, suggesting the potential for repurposed anti-cancer agents as new treatments. This study provides insight into the genetic mechanisms underlying this form of epilepsy and opens up new avenues for targeted ther...
SourceMass General Brigham·JournalJournal of the American Medical Association·TypeCase study·DateMay 1, 2023
A recent study reveals that many children with attention-deficit/hyperactivity disorder (ADHD) are not receiving adequate treatment. The findings highlight the need for improved communication and access to outpatient mental health care for children with ADHD.
SourceJAMA Network·JournalJAMA Network Open·DateApr 28, 2023
Researchers analyzed genetic changes in organs of recently deceased patients with metastatic cutaneous melanoma to understand how the disease spreads and evolves. They found that cancer cells take advantage of specific organ environments, pointing to the need for distinct treatment approaches.
SourceUniversity of California - Los Angeles Health Sciences·JournalNature Medicine·TypeExperimental study·DateApr 27, 2023
Researchers propose regulations around psychedelic medicine use, including risk evaluation and mitigation strategies, practitioner certifications, and decriminalization of psychedelics. They also emphasize the need for funding clinical trials on naturally occurring psychedelics to ensure a pathway for approval.
SourceBaylor College of Medicine·JournalScience·DateApr 27, 2023
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
Researchers investigated the roles of STAT3α and STAT3β in aggressive breast cancer and found that differential silencing of these isoforms leads to changes in STAT3 activation. This study emphasizes the importance of distinguishing between STAT3 isoforms for accurate cancer diagnosis and therapy.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateApr 26, 2023
Researchers at Temple University Health System found that carbonic anhydrase inhibitors reduce inflammation, restore cell function and prevent cognitive impairment in mice with amyloid buildup. CAIs also improved cerebrovascular health and enhanced amyloid-clearing capacity.
SourceTemple University Health System·JournalAlzheimer s & Dementia·DateApr 26, 2023
A study by Michigan Medicine researchers found that nitrous oxide, LSD, and ketamine induce similar changes in brain connectivity, particularly in the cortical 'hot zone' where conscious experience is determined. This common biology may hold the key to using psychedelics as therapeutics.
SourceMichigan Medicine - University of Michigan·JournalNeuroImage·DateApr 25, 2023
A majority of people over 50 are open to stopping one or more prescription medicines, but many don't discuss it with their health provider first. The poll shows that comprehensive medication reviews and cost considerations play a crucial role in deprescribing conversations.
SourceMichigan Medicine - University of Michigan·TypeSurvey·DateApr 24, 2023
GQ GMC-500Plus Geiger Counter
GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
Researchers developed a gene signature called CisSig to predict cancer patients' response to cisplatin. The approach aims to overcome the obstacle of interpreting gene signatures in the human body and has been validated in muscle-invasive bladder cancer patients.
SourceCleveland Clinic·JournalNature·TypeExperimental study·DateApr 20, 2023
Researchers found that bad medical news can make patients more likely to choose brand name drugs over generics, resulting in increased healthcare expenditures. The study suggests that simply reminding patients of the equivalency of generic drugs via text message could improve their decision-making.
SourceAmerican Marketing Association·JournalJournal of Marketing·DateApr 19, 2023
The 18th Key Symposium on Healthy Ageing and Longevity takes place in Okinawa, bringing together world experts to discuss the latest research on blue zones. The symposium aims to promote both longevity and healthy ageing to reduce age-related diseases and healthcare burden.
A team of researchers has discovered that a naturally produced chemical in the body helps glioblastoma cells go unrecognized by the immune system. The findings could lead to the development of new and more effective treatments for this aggressive brain cancer.
SourceCorewell Health·JournalNature Communications·DateApr 18, 2023
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
A new study by Brigham researchers found that 27 high-selling brand-name drugs provided little added clinical benefits despite high costs. The results suggest that Medicare can negotiate prices based on the added benefits of these drugs.
SourceBrigham and Women's Hospital·JournalJAMA·DateApr 18, 2023
Researchers at UMass Amherst microbiologists have identified an enzyme involved in TB pathogen's survival and growth. The discovery offers a potential target for drug therapies for the deadly disease, which has few effective treatments and caused over 1.6 million deaths worldwide in 2021.
SourceUniversity of Massachusetts Amherst·JournalmBio·TypeExperimental study·DateApr 18, 2023
A new target for drug-resistant ovarian cancer has been identified through a preclinical study led by researchers at Penn Medicine. An antibody-drug conjugate targeting B7-H4 showed significant anti-tumor activity and sustained response in treatment-resistant models.
SourceUniversity of Pennsylvania School of Medicine·DateApr 16, 2023
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Researchers develop mechanical nanosurgery to destroy tumour cells from within, reducing GBM tumour size universally, including in TMZ-resistant cases. The treatment uses magnetically controlled carbon nanotubes to provide mechanical stimulation, damaging cellular structures and causing tumour cell death.
SourceThe Hospital for Sick Children·JournalScience Advances·DateApr 11, 2023
The new guidelines, developed by 22 experts across three continents, provide a comprehensive approach to diagnosing and treating catatonia. The recommendations include the use of benzodiazepines and electroconvulsive therapy, with attention to special requirements for certain groups.
SourceSAGE·JournalJournal of Psychopharmacology·DateApr 10, 2023
A study of over 43,000 adults found that parathyroidectomy has no estimated effect on long-term kidney function in older adults. However, early treatment may preserve kidney function in patients younger than 60 years old.
SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·TypeObservational study·DateApr 10, 2023
Researchers developed a chelator-free-radiolabeled polymersome capable of long-term multiday PET imaging in vivo. The nanovesicle meets key requirements for targeted cancer therapy, including precision targeting, stable radiotracer binding, and biocompatibility.
SourceUniversity of Alabama at Birmingham·JournalBiomacromolecules·TypeExperimental study·DateApr 10, 2023
A new study reveals that targeting the SWI/SNF protein complex can disrupt PU-1-directed enhancer programs in AML cells, leading to therapeutic responses and rapid tumor regression. The findings also show that these inhibitors have manageable side effects on normal blood cells.
SourceBaylor College of Medicine·JournalCancer Research·TypeExperimental study·DateApr 7, 2023
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
A team of scientists from City University of Hong Kong and HKUST discovered novel, tridimensional compounds with high anticancer activity and low toxicity. These compounds can overcome drug resistance in cancer cells by inducing a different cell death pathway.
SourceCity University of Hong Kong·JournalNature Synthesis·TypeExperimental study·DateApr 6, 2023
Researchers have identified a biomarker signature that can predict which patients with kidney cancer will respond well to immunotherapy. The signature is based on the number of immune cells in and around tumors, the amount of dead cancer tissue, and mutations to a tumor suppressor gene called PBRM1.
SourceJohns Hopkins Medicine·JournalCell Reports Medicine·DateApr 6, 2023
A new imaging technique using a novel nuclear medicine tracer has been developed to improve the treatment of intestinal strictures in Crohn's disease patients. The technique allows for precise differentiation between inflammation and fibrosis, enabling targeted therapy.
SourceMedical University of Vienna·JournalRadiology·DateApr 5, 2023
Researchers find that patients with destructive nasal lesions may be suffering from cocaine-induced granulomatosis with polyangiitis, a condition often misdiagnosed. Cocaine use can trigger production of antibodies leading to symptoms similar to idiopathic Granulomatosis With Polyangiitis.
SourceOxford University Press USA·JournalRheumatology Advances in Practice·TypeObservational study·DateApr 4, 2023
A team at UC San Diego developed a biodegradable polymer system to treat rheumatoid arthritis by working with the immune system. The method uses encapsulated all-trans retinoic acid (ATRA) that transforms disease-causing cells into regulatory T cells.
SourceUniversity of California - San Diego·JournalAdvanced Science·DateApr 4, 2023
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
Researchers found that using monoclonal antibodies within two days of a COVID-19 diagnosis reduced the risk of hospitalization or death by 39% compared to those who did not receive treatment. This finding suggests that early treatment with monoclonal antibodies significantly reduced the severity of COVID-19.
SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·TypeObservational study·DateApr 3, 2023
Researchers at Rice University have created a new technology called PULSED that can deliver time-released drugs and vaccines for extended periods. The technology uses high-resolution 3D printing and soft lithography to produce microcylinders made of biodegradable polymers, which can be loaded with drugs and release them over time.
SourceRice University·JournalAdvanced Materials·TypeExperimental study·DateApr 3, 2023
Researchers analyzed 2,571 patients treated with monoclonal antibodies and found a 39% reduced risk of hospitalization or death compared to non-treated peers. The study also showed greater benefit in patients with immunocompromising conditions and those treated earlier during the pandemic.
SourceUniversity of Pittsburgh·JournalAnnals of Internal Medicine·TypeObservational study·DateApr 3, 2023
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.