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Human history and migration of disease: Study tracks spread of young-onset heart arrhythmia across continents

A new study tracked the spread of a genetic mutation that causes young-onset heart arrhythmia across continents over centuries. The research found that the mutation was passed down from Northern Europe to other parts of the world through migration, and identified a specific gene, KCNQ1, as the cause of the disease.

SourceUniversity of Utah Health·JournalNature Communications·TypeData/statistical analysis·DateNov 8, 2021

Calculating a dangerous heartbeat

A team of researchers from Flinders University has developed a single mathematical equation that can accurately model and predict the behavior of ventricular fibrillation, a life-threatening heart rhythm. The equation uses principles from renewal theory to predict the population dynamics of 'rotors' found in the heart during VF.

SourceFlinders University·JournalHeart Rhythm·TypeObservational study·DateNov 7, 2021

Cost, bleeding cited as major reasons for not taking newer anti-coagulant as prescribed

A recent study found that 26-45% of people with atrial fibrillation fail to adhere to their prescribed direct-acting oral anticoagulants due to cost and bleeding concerns. Researchers interviewed 42 adults who had stopped or reduced dosing, citing these reasons as major barriers to adherence.

SourceUniversity of California - Los Angeles Health Sciences·JournalJournal of the American Geriatrics Society·TypeSurvey·DateSep 2, 2021

Ablation and biventricular pacing boosts survival in selected atrial fibrillation patients

The APAF-CRT trial shows that ablation plus cardiac resynchronisation therapy (CRT) significantly reduces all-cause mortality and hospitalization for heart failure in severely symptomatic permanent atrial fibrillation (AF) patients with narrow QRS. The therapy is superior to pharmacological rate control, supporting it as a first-line t...

SourceEuropean Society of Cardiology·JournalEuropean Heart Journal·DateAug 30, 2021

Edoxaban may be effective treatment for atrial fibrillation after transcatheter aortic valve replacement

A large-scale international study found that edoxaban is non-inferior to warfarin for efficacy in preventing adverse events, but led to higher bleeding complications. The trial suggests that treatment with edoxaban can be valuable in managing AF patients after TAVR, especially when a lower dose of edoxaban is used.

SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalNew England Journal of Medicine·TypeRandomized controlled/clinical trial·DateAug 28, 2021

Wearable devices show that physical activity may lower atrial fibrillation and stroke risk

A study of nearly 100,000 individuals found that wearing accelerometers showed a significant association between moderate physical activity and reduced risk of atrial fibrillation and stroke. The researchers suggest that wearable devices could be used to promote public health by tracking and encouraging physical activity.

SourceMassachusetts General Hospital·JournalEuropean Heart Journal·DateMay 25, 2021

Finerenone may delay onset of AFib in patients with chronic kidney disease, diabetes

Researchers found that finerenone reduced the risk of atrial fibrillation by 30% in patients with chronic kidney disease and Type 2 diabetes, regardless of their history with AFib. The study suggests that finerenone can delay the onset of heart rhythm disorder and protect the heart and kidneys from further damage.

SourceAmerican College of Cardiology·JournalJournal of the American College of Cardiology·DateMay 17, 2021

Simple surgery prevents strokes in heart patients

A large international study led by McMaster University found that removing the left atrial appendage significantly cuts the risk of strokes by more than one-third in patients with atrial fibrillation. The procedure is simple, quick, and safe for the majority of heart surgery patients with this condition.

SourceMcMaster University·JournalNew England Journal of Medicine·DateMay 15, 2021

Fish oil supplements linked with heart rhythm disorder

A comprehensive meta-analysis found that omega-3 fatty acid supplementation was associated with a significantly increased risk of atrial fibrillation, a heart rhythm disorder. The study included over 50,000 patients and suggested that fish oil supplements should be used cautiously in individuals at elevated cardiovascular risk.

SourceEuropean Society of Cardiology·JournalEuropean Heart Journal - Cardiovascular Pharmacotherapy·DateApr 28, 2021

Direct oral anticoagulants show better safety and effectiveness versus warfarin in patients with val

A study of over 56,000 patients found that new users of direct oral anticoagulants (DOACs) had lower risks for ischemic stroke or systemic embolism and major bleeding events compared to warfarin. DOACs were associated with greater effectiveness and fewer major bleeding events in adults with valvular atrial fibrillation.

SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·DateMar 29, 2021

High blood pressure causes atrial fibrillation

A new study finds that high blood pressure is causally associated with the most common heart rhythm disorder, atrial fibrillation. Elevated blood pressure was found to increase the risk by 1.8%, 2.6%, and 1.4% relative increases in atrial fibrillation for systolic, diastolic, and pulse pressures, respectively.

SourceEuropean Society of Cardiology·JournalEuropean Journal of Preventive Cardiology·DateFeb 8, 2021

CVIA has just published a new issue, Volume 5 Issue 2

This issue of CVIA features papers on current management strategies for patients with heart failure and atrial fibrillation, as well as a systematic review on epicardial adipose tissue in obstructive sleep apnea. The journal also presents research on detecting myocardial infarction using late gadolinium enhancement MRI.

SourceCompuscript Ltd·JournalCardiovascular Innovations and Applications·DateDec 22, 2020

Shot of alcohol can help an irregular heartbeat

A combination approach of catheter ablation and ethanol infusion significantly reduced atrial fibrillation recurrence rates, with 49% remaining free from AFib after six months. This finding supports the use of the Vein of Marshall Ethanol for Untreated Persistent Atrial Fibrillation (VENUS) trial's treatment as a first-line therapy.

SourceHouston Methodist·JournalJAMA·DateOct 28, 2020

Pollution exposure linked to stroke risk in people with common heart rhythm disorder

A recent study by researchers at the University of Pittsburgh School of Medicine found that people with atrial fibrillation have a 1.2-fold higher risk of stroke when exposed to greater levels of pollution. The study, which included neighborhood-specific pollution data, emphasizes the importance of air pollution alerts in advising the ...

SourceUniversity of Pittsburgh·JournalJAMA Network Open·DateSep 16, 2020

Arrhythmia-free survival is indeed survival of the fittest

A new study shows that physically fit patients are more likely to benefit from atrial fibrillation ablation, with a lower risk of recurrent arrhythmia and improved outcomes. The study found that high cardiorespiratory fitness can act as an antiarrhythmic medication, keeping patients in rhythm after the procedure.

SourceElsevier·JournalHeart Rhythm·DateAug 3, 2020