Articles tagged with Esophageal Cancer
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Researchers developed an AI tool called ONCO-ACS to predict the risk of secondary heart attacks in cancer patients after a heart attack. The tool combines cancer-related factors with standard clinical data to provide reliable information for doctors to balance treatment benefits and harms.
The report shows a notable increase in medication treatments, such as chemotherapy, immunotherapy, and hormone therapy, used before surgery to treat many cancers. Neoadjuvant systemic therapy increased notably for certain cancers, including gynecologic cancers, pancreatic cancer, and rarer abdominal lining cancers.
Researchers developed a technology to map pre-malignant gene mutations and their effects in solid tissues, finding over half of cells contained clonal driver mutations. The study used esophageal tissue samples from six older adults, discovering NOTCH1 and TP53 driver mutations that induced clonal overgrowth and impaired cell development.
A new clinical trial, PAGODA, seeks to minimize treatment interruptions and help patients complete their chemotherapy as planned. The trial will test a structured plan to guide doctors in making small, proactive changes to chemotherapy doses to prevent treatment delays.
Research from Florida Atlantic University strengthens evidence that alcohol consumption increases cancer risk, particularly for breast, colorectal, and liver cancers. Higher intake and specific groups, such as African Americans and those with obesity or diabetes, are found to be more vulnerable to the risks.
The new American Gastroenterological Association guideline emphasizes the need for regular monitoring in many patients with Barrett's esophagus who do not exhibit dysplasia or cancerous changes. The guideline also recommends using high-definition white-light endoscopy in combination with chromoendoscopy to improve detection of Barrett'...
Researchers at Fox Chase Cancer Center demonstrate that pulsed low dose rate (PLDR) chemoradiation therapy can significantly reduce severe side effects, such as painful swallowing problems, while maintaining treatment effectiveness for patients with esophageal and non-small cell lung cancer. The study's key findings show that PLDR brea...
A new guideline from the Canadian Task Force on Preventive Health Care provides a menu of effective options to help people quit smoking, including behavioural and medication options. The guideline aims to address the challenges of nicotine addiction and offers personalized choices for quitting tobacco.
Scientists have developed a monoclonal antibody to combat life-threatening inflammatory diseases like sepsis and ARDS. The antibody shows promise in blocking the immune system's hyperactive response and restoring healthy function without unwanted side effects.
A new technology enables early detection of esophageal cancer by combining optical coherence tomography and optoacoustic imaging to visualize tissue structure and function. This could reduce treatment costs from €140,000 to €10,000 per patient.
Researchers found that decompression with a nasogastric tube is linked to reduced complications in patients after oesophageal cancer surgery. This challenges declining trend of abandoning the tube post-surgery, which was previously thought to be safe.
Early-onset gastrointestinal cancers are rising globally, particularly among younger adults. Colorectal cancer is the most common early-onset GI cancer, accounting for over half of cases, and its incidence is increasing faster than any other type of early-onset cancer.
A study by Baylor College of Medicine reveals that altered genes SOX2 and CDX2 drive Barrett's esophagus formation. The team created organoids from patient tissue, showing that the balance between these genes determines cell identity. This new understanding supports earlier intervention and diagnosis for this potentially deadly cancer.
Researchers developed patient-specific Cancer Chips to model esophageal tumor microenvironments, enabling accurate prediction of chemotherapy responses. The approach can rapidly stratify patients into responders and non-responders, paving the way for personalized medicine.
Researchers developed biomaterial patches loaded with basic fibroblast growth factor to enhance esophageal anastomosis healing. The study showed improved mechanical strength, increased fibroblast proliferation, and enhanced collagen secretion in the experimental group compared to controls.
A new study has found that the capsule sponge test, a less invasive alternative to endoscopies, can accurately stratify patients with Barrett's oesophagus into high, moderate, and low risk categories. This allows for tailored monitoring, reducing unnecessary procedures and improving patient outcomes.
Researchers identified six overexpressed and mutated tumor antigens strongly associated with poor prognosis in esophageal cancer. The study's findings suggest BTN2A1, MICA, and HHLA2 as promising targets for anti-ESCA mRNA vaccines.
A pilot study found that exercising during chemotherapy can increase the number of immune cells fighting cancer, including CD8+ T cells and natural killer cells. The exercise programme improved patients' aerobic fitness, leading to stronger immune responses inside tumours.
Researchers developed a patient-derived organoid library to study chemotherapy resistance in esophageal cancer. Lab-grown mini-tumors showed increased activity in the NRF2 pathway, suggesting potential biomarkers for predicting chemotherapy resistance.
A new study analyzed trends over time in alcohol-linked cancer mortality across the US, finding nearly double the number of alcohol-related cancer deaths between 1990 and 2021. The burden is highest among men over 55, with liver, colorectal, and esophageal cancers seeing significant increases.
Two new predictive algorithms use health data and blood tests to identify high-risk patients, offering improved accuracy in diagnosing cancers. The models identified additional medical conditions associated with increased cancer risk and new symptoms indicative of multiple cancer types.
Researchers from the University of Southampton engineered a new type of super-strong antibody that triggers a stronger response from the immune system compared to naturally produced antibodies. The study confirms that making subtle increases in rigidity stimulates immune activity, creating a powerful immune response against disease.
Excessive alcohol consumption causes severe digestive problems, including liver damage, stomach disorders, and increased cancer risk. Chronic alcohol use can lead to conditions like cirrhosis, pancreatitis, and colorectal cancer.
Researchers at Case Western Reserve University and University Hospitals will test EsoCheck and EsoGuard technologies to detect Barrett's Esophagus, a precursor to esophageal cancer. The goal is to improve detection in an at-risk population with limited endoscopy resources.
A genetic predisposition to type II diabetes mellitus is associated with a reduced risk of esophageal cancer. Metformin use has been shown to decrease the prevalence of esophageal cancer, while insulin and gliclazide have no significant association.
Increased visceral adipose tissue density and decreased skeletal muscle area are predictors of post-esophagectomy pulmonary complications. Decreased skeletal muscle density is associated with poorer overall survival. Routine morphomic analysis can help identify patients at risk and tailor perioperative care.
A team of researchers at Johns Hopkins Medicine has developed a biomarker algorithm that can detect Barrett’s esophagus and esophageal cancer using a noninvasive method. The algorithm uses methylation patterns in genes to identify biomarkers, achieving an AUC of nearly 0.97 in distinguishing healthy tissue from esophageal cancer.
A genetic fault long believed to drive oesophageal cancer development may actually play a protective role early in the disease, according to new research. The study found that defects in CDKN2A were more common in people with Barrett's oesophagus who never progressed to cancer.
A critical study sheds light on the growing global burden of esophageal cancer, with Asia accounting for 75% of new cases and deaths. The research highlights tobacco use and high body mass index (BMI) as leading risk factors, responsible for nearly half of deaths and disability-adjusted life years in men, and a fifth in women.
Achalasia is associated with an increased risk of esophageal squamous cell carcinoma, highlighting the need for close surveillance in high-risk patients. Chronic inflammation and food stasis can lead to malignant transformation, emphasizing the importance of timely intervention.
A phase II clinical trial showed that combining radiation, chemotherapy, and immunotherapy can shrink tumors and allow surgery, resulting in significantly improved outcomes. The study found that patients who underwent surgery had a 82% reduction in risk of death at one year follow-up.
Researchers found that using a multi-step strategy with less-invasive devices can identify patients with Barrett's oesophagus before an endoscopy. This approach is promising for cost-effective screening, which could lead to earlier diagnosis and treatment of oesophageal cancer.
A recent clinical trial found that the Nivolumab and Anlotinib combination therapy significantly reduced tumor size in nearly one-third of patients, while most experienced stability in their condition. The treatment also showed improved survival outcomes compared to historical data, with a manageable safety profile.
Researchers have found that natural killer cells instinctively recognize and attack the XPO1 protein, which drives cancer growth. By targeting this protein, scientists may be able to activate more killer cells to destroy cancer cells. The study suggests that this approach could lead to personalized cancer treatment with less side effects.
Esophageal cancer is a major public health concern in China, with late diagnoses contributing to poor prognosis. Early detection through screening methods like endoscopy and biomarker detection has shown significant outcomes, particularly in high-risk areas.
The study analyzes six major digestive system cancers worldwide and in China, revealing correlations between country HDI and cancer prevalence. Colorectal cancer is the most prevalent, while Asia accounts for 60.5% of new gastrointestinal cancer cases globally.
A clinical trial found that fecal microbiota transplants can boost the effectiveness of immunotherapy in a range of gastrointestinal cancers. The study identified specific bacterial strains associated with better or worse responses, and showed promise for improving treatment outcomes.
A distinct TNF-α signaling program has been identified as a key driver of epithelial cancer development, contributing to cell proliferation and invasion. The researchers found that this program is active in both normal tissues and tumors, but its level of activity correlates with tumor aggressiveness.
A novel inhibitor HVH-2930 targeting heat shock protein 90 (HSP90) demonstrates efficacy against drug-resistant breast cancer cells. It selectively downregulates HER2 signaling, crucial for breast cancer progression, without triggering the heat shock response.
A robotic device mimics natural esophageal and intestinal movement to aid digestion, helping patients with blockages caused by tumors or stents. The device has the potential to improve quality of life for the aging population.
The American Gastroenterological Association recommends considering endoscopic eradication therapy for patients with low-grade dysplasia after discussing risks and benefits. For patients with high-grade dysplasia, the AGA suggests removing abnormal pre-cancerous cells to reduce esophageal cancer mortality.
Researchers have shed light on the complex communication between cells at the gastro-esophageal junction, revealing specific pathways and cellular composition. The study provides new starting points for understanding, preventing, and treating gastrointestinal diseases.
New findings in The American Journal of Pathology indicate that periostin promotes esophageal squamous cell carcinoma progression by enhancing cancer and stromal cell migration in cancer-associated fibroblasts. Periostin may be a promising therapeutic target for treating ESCC.
A new study from Johns Hopkins Medicine found that circulating tumor DNA levels can accurately assess how gastroesophageal cancers respond to treatment and predict future prognosis. The study tracked minimal residual disease by analyzing ctDNA, showing a correlation between ctDNA clearance and cancer-free survival.
Researchers found Mad2 gene expression levels correlate with chromosomal abnormalities in esophageal squamous cell carcinoma, highlighting potential as a clinical biomarker. The study also revealed the deregulation of the Rb-E2F1 circuit and its impact on histone modifications.
A multidisciplinary team created a new algorithm to provide optimal personalized treatment options for individuals with esophageal cancer. The framework uses various heterogeneous factors that facilitate the progression of the disease and demonstrated high accuracy in controlling esophageal cancer.
A recent study published in Cell Reports reveals that cancer cells can prevent the immune system from attacking them by inhibiting key checkpoints. Researchers found that monotherapy agents targeting these checkpoints may not be effective without an inflammatory trigger, explaining why some immunotherapies work while others fail.
A recent study from Drexel University's College of Nursing and Health Professions aimed to understand the challenges and supports affecting individuals with GI cancer and their caregivers when it comes to maintaining a healthy diet and avoiding malnutrition. The research highlighted the importance of creating dietary interventions that...
A new method has been developed to rapidly identify genes that drive tumor growth in various types of cancers. Organoids were used to test candidate genes, revealing promising targets for precision oncology. The study's findings may lead to the development of targeted therapies for patients with esophageal squamous cancer.
Researchers found that tumor-resident T-cell receptor sequences showed high complementarity with the cancer testis antigen DDX53, suggesting an immune response that selects for DDX53-negative cells. This association was correlated with worse disease-free survival rates, highlighting a potential early esophageal cancer antigen.
A UCLA study found that hospitals with high patient diversity are less likely to offer core cancer services, including hospice care, chemotherapy, and robotic surgery. The lack of these resources can impact treatment quality and outcomes for patients diagnosed with cancer.
Men who are overweight or obese at age 18 have a higher risk of developing 17 different cancers later in life. Higher BMI is also associated with an increased risk of mortality after cancer diagnosis for certain types of cancer.
A team of researchers at Case Western Reserve University has identified a genetic defect in Caveolin-3 that increases the risk of developing esophageal adenocarcinoma. The discovery could lead to early screening, lifestyle modifications, and targeted treatments for individuals with a family history of the disease.
A large-scale study from three Nordic countries shows that the majority of patients with reflux disease do not have a higher risk of cancer. Only those with changes in the oesophageal mucosa are at increased risk.
A novel liquid biopsy technology developed by UCSC Assistant Professor Daniel Kim's lab leverages RNA 'dark matter' to enhance cancer diagnosis. The test detects both protein-coding and repetitive noncoding RNAs in the blood, showing improved sensitivity for early-stage cancer detection.
Patients with cancer who live in rural Pennsylvania counties are more likely to receive complex surgeries at high-volume hospitals due to their perceived better outcomes. However, for less complex surgeries, rural patients are less likely to opt for high-volume hospitals despite potential benefits from centralization.
Researchers discovered that nine percent of esophageal adenocarcinoma patients harbor cancer-predisposing gene mutations, which may trigger progression from Barrett's esophagus. This finding supports the idea that genetic testing can help risk-stratify EAC patients and potentially accelerate development of new treatments.
A large international database analysis found nearly a quarter of esophageal adenocarcinoma patients had normal endoscopies but were still diagnosed within a year. The study suggests using high-quality equipment, rigorous sampling protocols, and future research on biomarker panels to improve screening effectiveness.
Three University Hospitals and Case Western Reserve University research teams received $50,000 Collaborative Science Pilot Awards to explore innovative research projects. The awards aim to increase competitiveness and capacity for major external funding opportunities in key areas such as cancer, brain health and genetics.
Researchers have developed a new technique to generically treat several kinds of cancer, showing tumors grew almost three times less and survival rates reached 100% after just one injection. The method targets cancer cells with alpha radiation, sparing healthy tissue.