A single dose of the Modified vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccine was found to be 58% effective in preventing mpox infection in a recent study published in BMJ. The study used real-world health data to estimate the vaccine's effectiveness against mpox infection and included over 3,200 men who received the MVA-BN vaccine.
A groundbreaking study published in Nature Medicine reports the first sustained remission of HIV infection following a bone marrow transplant in a patient without the CCR5-delta 32 mutation. Despite remaining susceptible to HIV, the virus remains undetectable nearly three years after antiretroviral treatment was stopped.
A five-year study led by Tulane University is investigating a new medication to treat trichomoniasis. The research compares secnidazole with metronidazole, finding that one-dose treatment could offer better options for the infection, which affects 156 million people annually.
A new study led by UMass Amherst and Tufts Medical Center will provide HIV prevention, diagnosis, and treatment for people with opioid use disorders who are incarcerated. The study aims to increase the number of incarcerated individuals tested and treated, addressing a critical gap in healthcare access.
A new drug has shown promise in clearing HIV from the brain by targeting infected cells and reducing viral load. The treatment, BLZ945, successfully cleared the virus from brain tissue, providing a potential new avenue for HIV treatment.
Researchers at George Mason University's Center for Infectious Disease Research have made a breakthrough in finding a functional cure for HIV. Using an HIV-like virus particle called HIV Rev-dependent lentiviral vector, the team was able to reduce viral reservoirs and boost the immune system to produce antiviral neutralizing antibodies.
A new lab test developed by Weill Cornell Medicine can detect persistent HIV strains in Africa, a vital tool in the search for an HIV cure. The test helps measure the persistence of HIV in people affected by viral strains found predominantly in Africa, where women are disproportionately affected.
The Midwest Developmental Center for AIDS Research will unite scientists and public health experts to fight the HIV epidemic in the region. The center aims to create a platform for collaboration and coordinate efforts to address the disease, with a focus on improving healthcare equity and outcomes.
The researchers developed a novel viral reporter system called HIV-Tocky, which allows for real-time visualization of HIV dynamics post-viral infection. This innovation provides crucial insights into HIV-1 latency mechanisms and establishes a foundation for developing eradication strategies.
A study found that statin therapy significantly reduces the risk of cardiovascular disease (CVD) and all-cause mortality in adults aged 60 years and older, including those over 85. Statins also did not increase the risk for adverse events such as myopathies and liver dysfunction.
The Kobe University study traced the HIV variant CRF01_AE to Thailand, where it emerged around 1977. The virus then spread through Southeast Asia and was introduced to Indonesia at least three times, with an Indonesian strain moving to Iran. Understanding these transmission trends is crucial for developing effective treatments.
Researchers compared HIV reservoirs between patients with early and late treatment initiation. Early treatment was associated with faster decay of virus reservoirs, indicating a more effective immune clearance mechanism. This study supports the potential for early interventions to combat HIV by enabling an eventual cure.
A study by UC San Diego researchers found that closing the US-Mexico border during COVID-19 increased HIV transmission due to continued drug tourism. The study analyzed data from participants who crossed the border, revealing nine new cases of HIV contraction primarily during the pandemic.
A study published in Annals of Internal Medicine found that semaglutide is an effective therapy for metabolic dysfunction-associated steatotic liver disease (MASLD) in people with HIV. The medication, approved for type 2 diabetes treatment, showed significant reductions in liver fat and improved metabolic markers.
A study of nearly 4,000 individuals found significant impairments in processing speed, working memory, and executive function among perinatally HIV-infected children and adolescents. The findings highlight the need for better diagnosis and treatment in low- and middle-income countries to improve long-term cognitive outcomes.
A study by Germans Trias i Pujol Research Institute reveals that people living with HIV who contract COVID-19 face a significant increase in cardiovascular disease risk. The researchers identified several factors associated with this increased risk, including age, previous cardiovascular disease, and chronic conditions.
Researchers found that children born to mothers with HIV infection have an increased risk of immune abnormalities, impaired growth, and development. Infants exposed to HIV had a 41% higher mortality rate than those not exposed, with systemic inflammation being strongly associated with infant mortality.
A new implementation programme highlights challenges of locating and re-engaging former prisoners and individuals living with HIV who drop out of care. The study found that retaining these patients in care is crucial to end the global HIV epidemic.
Scientists at Sanford Burnham Prebys have identified promising links between common HIV drugs and a reduced incidence of Alzheimer's disease. The study analyzed over 225,000 medical records and found that RT inhibitor exposure was associated with a statistically significant reduced incidence and prevalence of AD.
A new study reveals that a specific RNA chemical modification, m6A, is crucial for HIV-1 virus replication and production. The research found that targeting this modification could lead to the development of new treatments for HIV infection.
Researchers have identified a 'sugar signature' in the blood of people living with HIV that may accelerate biological aging and inflammation. The findings could lead to new strategies for mitigating the negative effects of chronic viral infections.
A US study found that medical cannabis enrollment increased overall between 2016 and 2022, but decreased in states with legalized recreational use. The number of patients using cannabis for medical purposes has risen by over 600% since 2016.
A study published in Brain, Behavior, and Immunity found that normal levels of interferon-β are required for normal memory function, and its absence changes nerve cell components in a sex-dependent fashion. The research also showed that higher or lower than normal levels of interferon-β affect the brain in a sex-dependent manner.
A Danish study found that PrEP use was associated with a more than twofold increase in chlamydia, gonorrhea, and syphilis diagnoses. The researchers suggest that changes in sexual risk-taking may lead people to seek PrEP rather than increased risks.
Older people with HIV are more likely to have comorbidities and become frail compared to their age groups without HIV. By 65 years old, around 70% of those living with HIV for 20 years or more are living with multiple conditions.
A new nanofluidic implant has been shown to deliver an HIV drug with increased potency compared to existing oral medications, providing a potential breakthrough in addressing treatment nonadherence. The device is intended for long-term controlled release and avoids repeated systemic treatment, which can lead to adverse side effects.
Researchers successfully demonstrate CRISPR-Cas gene editing technology to eliminate all traces of the HIV virus from infected cells in laboratory settings. The study aims to develop a robust and safe combinatorial regimen to target diverse HIV strains across various cellular contexts.
Researchers have identified a potential path to eliminate the viral reservoir that prevents people from being completely cured of HIV. A new drug candidate, called a proteolysis targeting chimeras (PROTAC) molecule, triggers the degradation of the Nef protein, which suppresses HIV replication and restores immune system detection. This ...
A study published in JAMA found that three months of social worker follow-up support improved HIV clinic attendance and antiretroviral therapy initiation, but did not reduce mortality after one year. The intervention, known as Daraja, was highly effective at addressing barriers to care such as stigma and lack of social support.
A randomized clinical trial found that linkage case management intervention did not improve 12-month mortality outcomes for hospitalized people with HIV. The study involved 500 participants and sheds light on the potential role of this intervention among hospitalized individuals with HIV.
A large clinical study conducted in South Africa, Uganda, and Zimbabwe found that the dapivirine vaginal ring and daily oral pre-exposure prophylaxis to be safe for HIV prevention among pregnant women. The study involved 248 pregnancies and showed no increased risk of stillbirth or miscarriage.
A new study shows that HIV antiretrovirals can be taken together with gender-affirming hormone therapy without losing potency of either drug. The study found that estrogen and testosterone levels remained unchanged when participants took HIV medications alongside their hormone regimen.
A large international clinical trial found that standard tools underestimate cardiovascular event risk in people with HIV, particularly in high-income regions and those with detectable viral loads. The study highlights the need for updated screening tools to provide precision care for the diverse population living with HIV.
A new study by the University of Washington found that condom use has been declining among younger gay and bisexual men, even when not taking PrEP. The study highlights the need for continued education about the benefits of using condoms during sex to reduce HIV transmission rates.
The Almodóvar lab is studying the link between HIV and pulmonary hypertension, a condition that increases pressure in lung arteries. By examining the interactions between different cell types and using a humanized mouse model, researchers hope to propose novel therapies to prevent lung diseases in people with HIV.
Researchers found a significant connection between disrupted gut microbiomes, increased intestinal permeability, and faster biological aging in people living with chronic HIV infection. The study highlights specific bacteria as potential accelerators of aging, opening new avenues for developing strategies to mitigate these effects.
A new study has found that heavy alcohol use and illicit opioid use are linked to a higher risk of falls and fractures among people living with HIV. The study suggests the need for targeted clinical screening and interventions to prevent falls and related injuries, particularly among populations already at risk.
A UCLA-led study found that a combination of telehealth coaching, peer support, and automated text messages increased PrEP uptake among younger Americans by more than doubling it. The intervention's success suggests the importance of behavioral interventions and wraparound services in supporting HIV prevention.
A new approach to fighting HIV has been developed using RNA, specifically small interfering RNAs (siRNA), which regulate gene expression in cells. This nanomedicine was shown to reduce HIV replication by 73% and is intended for vaginal application to prevent sexual transmission.
A recent study by Rutgers Health professor Stephanie Shiau and colleagues found that women with HIV experience accelerated DNA aging, linked to poorer physical function. The research highlights the unique challenges faced by women with HIV as they age, emphasizing the need for tailored interventions.
Researchers at the University of Minnesota Medical School have explored a new approach to combat HIV by enhancing Natural Killer cell function. The study found that providing healthy NK cells and an anti-HIV drug resulted in significant reductions in infection burden, offering a potential cure strategy.
Researchers at City of Hope successfully treated the oldest person to achieve remission for both leukemia and HIV, demonstrating the effectiveness of reduced intensity chemotherapy before a stem cell transplant. The patient, Paul Edmonds, received donor cells resistant to HIV and was cured after nearly three years without antiretrovira...
A new clinical trial demonstrates a small reduction in the latent reservoir of HIV-infected cells using a combination of vorinostat and immunotherapy. While the results are promising, further research is needed to create more effective approaches to flush out the virus and attack it when it emerges from latency.
The new guideline aims to improve diagnosis and treatment of cryptococcosis, a fatal fungal infection that affects mainly the lungs and brain. It provides practical guidance for medical staff to recognize and manage invasive fungal infections, with the goal of improving patient survival rates.
Researchers at Duke University have discovered a critical structure on the HIV virus that plays a crucial role in its infection process. By understanding this structure's dynamics, scientists may be able to design broadly neutralizing antibodies for an AIDS vaccine.
Researchers discover HIV uses its capsid to bypass cellular defenses and transport genetic material into the cell nucleus. The 'smart' FG phase of the nuclear envelope allows the capsid to slide through, concealing the genomic payload from anti-viral sensors.
Researchers discovered how HIV enters the cell's centre by mimicking host proteins, enabling it to produce genetic copies and infect other cells. The study provides insight into host-pathogen interactions beyond HIV biology.
A study by Texas Biomed researchers identified mesenteric lymph nodes, spleen, and inguinal lymph nodes as the leading sources of HIV rebound infection. The findings have implications for potential new therapies targeting these tissues to prevent viral spread.
A new study using an animal model has identified a window of opportunity for early treatment to promote long-term control and remission of HIV infection. Starting treatment four weeks after infection promotes viral control after discontinuation of treatment, highlighting the importance of early diagnosis and treatment.
Researchers are exploring 'priming, shaping, and polishing' techniques to develop an HIV vaccine targeting rare immune cells that produce broad-neutralizing antibodies. The Amsterdam UMC-led project aims to create an effective vaccine for low- and middle-income countries with a €4.5m grant.
Researchers found that intradermal administration of the JYNNEOS smallpox vaccine induces an efficient immune response, protecting people living with HIV from contracting the monkeypox virus. Individuals with low CD4 T cell levels require a booster dose to compensate for their immunosuppressed status.
The MAMAH trial found that preventive treatment with DHA-PPQ significantly reduces the risk of malaria infection and disease in pregnant women living with HIV. Women in the treatment group had almost eight times lower risk of clinical malaria and half the risk of becoming infected compared to the placebo group.
Research finds that people with higher HIV viral loads have higher recombination rates, enabling the virus to diversify and evade the immune system. This study contributes to a deeper understanding of how recombination drives HIV evolution.
A new study will analyze electronic health records to identify facilitators and barriers of successful pediatric-to-adult HIV care transitions among youth in South Carolina. The research aims to develop guidance to improve systems and protocols for vulnerable populations.
Suicide rates in the US increased across all racial groups between 1999 and 2020, with highest rates among White people and American Indian/Alaska Native persons. Firearms and hanging were the top methods used, with a sharp increase in hangings among women.
Studies published in Nature Medicine show that implementing updated WHO screening guidelines could reduce cervical cancer death rates by over 63% in low-to-middle-income countries. Women with HIV have a sixfold risk of developing cervical cancer, and primary HPV testing can save up to 38 women's lives for every 71 screened.
Researchers are shedding light on the molecular mechanisms underlying HIV replication and viral integration, opening new avenues for tackling the virus. Discoveries suggest that targeting the cell nucleus and harnessing innate immunity may be key to blocking viral replication and persistence.
A new study published in Nature Microbiology suggests that providing easy access to HIV treatment and care for heterosexual men could rapidly cut transmission to their female partners. Closing the viral suppression gap in men is estimated to halve rates of new infections among women and eliminate gender disparities.
A study of over 50 babies with HIV found that starting antiretroviral therapy within hours of birth can safely suppress HIV in the blood to undetectable levels. The treatment regimen was shown to halt the formation of hard-to-treat viral reservoirs, potentially leading to ART-free remission.
Scientists identify a link between HIV's gp120 protein and chronic inflammation, leading to premature aging and comorbidities. A clinical trial aims to test the effect of Fostemsavir on reducing cardiovascular diseases and improving quality of life for women living with HIV.