Articles tagged with Metabolic Disorders
A Cleveland Clinic study found that prior weight loss achieved with bariatric surgery was associated with a 60% lower risk of developing severe COVID-19. Patients who underwent weight-loss surgery had better clinical outcomes, including reduced hospitalization and need for supplemental oxygen.
Metabolic disorders, such as inflammation and insulin resistance, are key elements in the development of anxiodepressive disorders in obese individuals. Diet high in sugar and saturated fats leads to these changes in the brain, increasing the risk of depression and anxiety.
A study by Tokyo University of Science researchers identifies a novel regulatory axis targeting dendritic cell activity, suppressing autoimmune disease symptoms and bone loss. They discovered DCIR binds to glycoproteins on macrophages and osteoclasts, reducing inflammation and immune responses.
A study led by Children's Hospital of Philadelphia researchers used stem cells to implicate several genes involved in bodily functions associated with the hypothalamus. The findings could help clinicians identify potential causes of dysfunction for traits regulated by the hypothalamus, such as sleep and stress.
Researchers from the University of Tsukuba found that lifestyle factors such as smoking, alcohol consumption, and sedentary behavior significantly increase the risk of developing metabolic syndrome in non-obese individuals. Similar risk factors were identified for both obese and lean individuals, highlighting the importance of healthy ...
Researchers found that albino mice with a mutated tyrosinase gene are more susceptible to non-alcoholic steatohepatitis (NASH) than black mice. This study provides new insights into the genetic factors contributing to NASH and its progression.
Researchers discovered that childhood cancer patients treated with abdominal or total body irradiation exhibit abnormalities in their adipose tissue, similar to those found in obese individuals with cardiometabolic disease. This suggests that strategies to reduce radiation dose to fat may be necessary to prevent long-term dysfunction i...
Research suggests COVID-19 pandemic has adverse effects on women's menstrual cycles due to stress and sleep disturbance. Women are experiencing increased rates of depression, anxiety, and poor sleep.
A recent study by the University of California - San Diego team discovered that glycogen regulates and promotes fat metabolism, helping to balance energy intake and expenditure. The research suggests modulating glycogen metabolism in fat cells could provide new approaches for weight loss and improved metabolic health.
The Society for Endocrinology's annual conference will feature world-leading scientific and clinical research on endocrine clinical practice. The event will showcase the latest innovations in endocrine medicine, including Medal and Award lectures by renowned experts.
The Rutgers-NYU Center for Asian Health Promotion and Equity aims to address significant disparities in the Asian community's relationship with heart health and mental health. The center will focus on cardiometabolic disease and mental health research to inform practice and policy at local, regional, and national levels.
A two-hour glucose tolerance test is linked to cognitive decline in a 10-year follow-up study. Higher blood glucose levels measured in the test were associated with weaker performance in a memory test and a greater decline in results.
A controlled trial found that consuming an avocado daily for 12 weeks reduced visceral abdominal fat and the ratio of visceral to subcutaneous fat in female participants. The benefits were primarily seen in females, with no impact on glucose tolerance or male participants.
A new study examining the association between type 2 diabetes mellitus and skin diseases reveals a strong link between the two conditions. The research, published in Chinese Medical Journal, found that 93.5% of individuals with T2DM had skin problems, including over 47 types of comorbid skin diseases.
A recent study found that rates of minor lower extremity amputations increased between 2009 and 2017 in rural and Western American residents, Native Americans, and Asian Americans/Pacific Islanders. Major LEAs rates remained steady during the period with notable increases in White populations and rural areas.
Researchers at Radboud University have identified new biomarkers for pyridoxine-dependent epilepsy, enabling better and earlier treatment of the disease. The discovery could lead to optimized treatment and improved chances of preventing cognitive disability.
Researchers at Heidelberg University successfully introduced a rare genetic mutation into a fish model to study the causes of complex metabolic diseases. The study found that supplying fully functional ALG2 mRNA could reverse the genetic defect, allowing analysis of individual function areas of the enzyme.
Scientists have developed a Japanese rice fish model to study congenital disorders of glycosylation, including ALG2-CDG. The model replicates symptoms such as neuronal problems and retinitis pigmentosa, and demonstrates that supplying fully-functional Alg2 can prevent defects.
An international team identified an error in the cytochrome P450 oxidoreductase (POR) gene as the cause of aromatase deficiency, a rare metabolic disorder. This discovery enables precise therapy and prevents side effects associated with steroid supplementation.
Researchers have identified acid ceramidase as a key enzyme in the production of psychosine, a toxic glycolipid that accumulates in people with Krabbe disease. Removing or inhibiting this enzyme has been shown to decrease or eliminate psychosine production and disease symptoms.
A large-scale genome-wide association study identifies eight genetic variants associated with anorexia nervosa, suggesting a combination of metabolic and psychiatric components. The findings encourage considering metabolism in understanding the disorder's causes and improving treatment approaches.
A global genome-wide association study identified eight genetic variants linked to anorexia nervosa, revealing a complex interplay between metabolic and psychiatric factors. The research suggests that integrating metabolic information may help clinicians develop better treatment approaches for this potentially lethal illness.
A study by researchers at the CNIC reveals a new mechanism in intestinal bacteria regulation that prevents inflammation and promotes mutual benefit. The findings suggest that certain bacteria, such as Lactobacillus, strengthen the intestinal barrier through interaction with receptor Mincle.
Grickscheit aims to develop an 'off-the-shelf' stem cell-based therapy that might not require immunosuppression, a substantial step forward for metabolic liver disease. The UPLiFT investigation will test the effective dose and regimen of the therapy.
A new study found that longer daily fasting times improved health and longevity in male mice, with benefits seen across different diets and calorie consumption levels. The researchers also discovered that extended fasting periods enabled repair and maintenance mechanisms, which may help prevent age-related metabolic disorders.
Researchers report that tadpoles and adult female frogs exposed to endocrine disruptors develop metabolic disorders. Exposure leads to delayed metamorphosis, lower reproductive success, and smaller offspring.
Douglas Wallace receives the award for his pioneering work in mitochondrial genetics, leading to insights into human genealogy and implications for treating metabolic and degenerative diseases. The recognition acknowledges the crucial role of mitochondrial DNA genetics and bioenergetics in common disease etiology.
A study of over 189,000 initially healthy women found that working rotating night shifts for 5 years or more was associated with a small increase in coronary heart disease risk. The researchers also discovered waning risk after cessation of shift work and decreased risk among those who quit earlier.
A team of scientists discovered a molecular switch that regulates the body's circadian clock, allowing it to keep time. The 'phosphoswitch' maintains clock speed despite temperature changes and metabolic signals.
Individuals with sex development disorders face challenges forming positive relationships due to physical differences. Researchers suggest raising public awareness of the diverse nature of bodies and providing practical support mechanisms, such as private locker rooms and support groups.
A new review in Nutrition in Clinical Practice outlines main principles of chronic nutrition management of inherited metabolic disorders, highlighting failure to follow specific dietary treatment can lead to complications and death. Registered dietitians play a crucial role in the multi-disciplinary team delivering care to these patients.
MU researchers have catalogued the effects of abnormal enzymes responsible for one type of glycogen storage disease in humans. Their study, published in The Journal of Biological Chemistry, provides promising early-stage results that could aid in patient prognosis and therapeutic development.
A comprehensive computer model of human metabolism has been developed, connecting the dots between the human genome and metabolism. The Recon 2 model advances understanding of human metabolism in health and disease, enabling identification of biomarkers and prediction of drug side effects.
Researchers at VIB and Oxyrane have created a new technology that produces enzymes for metabolic disorders like Pompe disease more efficiently than current treatments. The novel method uses yeast cells instead of mammalian cells, resulting in 17 times more efficient absorption by patient cells.
A team of researchers has discovered a genetic defect in the RMND1 gene linked to severe neurodegenerative disorders. The study reveals mutations in this gene can lead to early death in infants and has implications for understanding later-onset neurological diseases.
A new treatment for argininosuccinic aciduria (ASA) has been discovered through nitric oxide supplementation. The study found long-term heart and neuropsychological improvements in mice and humans afflicted with ASA, a genetic metabolic disorder that causes ammonia accumulation and liver and nervous system damage.
Researchers created a zebrafish model to study Maple Syrup Urine Disease, which causes brain injury and severe dystonia. The model reveals abnormal swimming behavior and neurotransmitter imbalances, shedding light on disease mechanisms.
A new test can identify biomarkers for mucopolysaccharidoses (MPS), a group of inherited metabolic disorders, allowing for earlier diagnosis and potentially more effective treatment. The test detects specific carbohydrate structures in cells, blood, and urine samples, enabling differentiation between forms of the disease.
Scientists have developed flies with genetic changes similar to those found in patients with galactosemia, allowing researchers to study the disease and develop potential treatments. These models can help understand how sugar metabolism leads to disease and open the door to novel drug discovery.
Researchers at Heidelberg University Hospital have discovered that the metabolic disease glutaric aciduria type I causes not only acute but also chronic toxic damage to the developing brain. Therapy should be extended to prevent long-term brain damage and should be started early, even before birth.
A study of 2,273 registered nurses found that adverse work schedules, including shift work, overtime, and on-call shifts, significantly impact sleep quality. Nurses with inadequate sleep experience increased risk of needlestick injuries and musculoskeletal disorders, as well as long-term health consequences.
A recent study has found that umbilical cord blood transplants can be a successful treatment option for children with inherited metabolic disorders, offering improved outcomes compared to bone marrow transplants. The procedure has shown advantages in terms of availability and reduced risk of complications.
Researchers have developed a new screening method to detect MCAD deficiency in newborns, reducing the number of undiagnosed cases. Early detection improves treatment options and reduces mortality rates, with one-quarter of patients dying before diagnosis is known.
Researchers conducted a retrospective study of 31 Dutch SCADD patients and their relatives to describe genetic, biochemical, and clinical characteristics. The study found a birth prevalence of at least 1:50,000, with developmental delay, epilepsy, and hypoglycemia being common symptoms.
Despite progress, most US babies are not fully covered under newborn screening programs. Currently, 23 states screen for over 20 disorders, while others have limited or no testing.
Researchers have identified two genes responsible for defects in vitamin B12 metabolism, which can lead to accumulation of methylmalonic acid. This breakthrough could enable DNA testing for carriers and early prenatal diagnosis, providing hope for families affected by the disease.
A new study calls for UK childhood screening of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, a metabolic disorder affecting up to 1 in 9000 people. The condition can be controlled with carbohydrate intake, but severe neurological damage occurs if diagnosed late.