Researchers at Fred Hutchinson Cancer Center found that a protein secreted by cancer cells, angiopoietin-like-7, promotes tumor necrosis and metastasis in breast cancer. The study used a new rat model to investigate mechanisms of breast cancer metastasis and identified the protein as a potential target for treatment.
SourceFred Hutchinson Cancer Center·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateFeb 27, 2023
Researchers developed a new device that detects and analyzes cancer cells in blood samples, enabling doctors to avoid invasive biopsies and monitor treatment progress. The Static Droplet Microfluidic device uses metabolic signatures to differentiate tumour cells from normal blood cells.
SourceUniversity of Technology Sydney·JournalBiosensors and Bioelectronics·TypeExperimental study·DateFeb 27, 2023
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers re-examine molecular characteristics of WNT-subgroup patients to identify optimal treatment strategies for low-risk medulloblastoma. Key findings suggest that therapy-related late toxicity remains a concern, despite comparable survival rates between children and adolescents with this disease subtype.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateFeb 27, 2023
Researchers have discovered a new mechanism of immune surveillance by liver-resident macrophages called Kupffer cells that prevent liver metastasis from escaping. They successfully cleared tumors in various animal models using a new method for in situ targeted expression and remodels of KCs' anti-tumor function.
SourceUniversity of Science and Technology of China·JournalJournal of Clinical Investigation·DateFeb 23, 2023
A study finds that aggressive end-of-life care remains common among older adults with metastatic cancer, particularly in nursing home residents. Multilevel interventions targeting hospital admissions and in-hospital death are crucial to reducing its prevalence.
SourceJAMA Network·JournalJAMA Network Open·DateFeb 22, 2023
Researchers discovered that combining ferroptosis induction with immune checkpoint inhibition reduces liver tumour growth and metastases, offering a promising new approach for treating liver cancer
SourceGoethe University Frankfurt·JournalGut·TypeExperimental study·DateFeb 17, 2023
Researchers at NUS Cancer Science Institute discover FAM3C in tumor-derived extracellular vesicles promotes distant lung tumour colonization. FAM3C enhances cellular transformation and stimulates metastasis potential, offering new therapeutic strategy targets.
SourceNational University of Singapore·JournalTheranostics·TypeMeta-analysis·DateFeb 16, 2023
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Researchers have developed a novel prognostic index to predict survival outcomes in gastric cancer patients. The inflammation-combined prognostic index (ICPI) combines three biomarkers - lymphocyte-to-monocyte ratio, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio - to provide a personalized prognosis for each patient.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateFeb 14, 2023
Researchers at Helmholtz-Zentrum Dresden-Rossendorf developed a new strategy to increase target molecules for radionuclide therapy in pheochromocytoma tumors, delaying tumor growth. The combination of valproic acid and decitabine prior to therapy doubled the radiation dose absorbed by the tumor.
SourceHelmholtz-Zentrum Dresden-Rossendorf·JournalTheranostics·TypeExperimental study·DateFeb 9, 2023
Researchers found that primary cancer tumors have a sluggish conversion of nutrients to usable cellular energy, conserving energy for growth and metastasis. The discovery has vast implications for anti-cancer strategies, directing attention to slow energy metabolism.
SourcePrinceton University·JournalNature·TypeExperimental study·DateFeb 6, 2023
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
A new study published in Cell Reports Medicine identifies four pan-cancer molecular subtypes of metastasis, each with distinct transcriptional programs and potential therapeutic targets. The research provides valuable insights for personalized treatments of metastatic cancer.
SourceBaylor College of Medicine·JournalCell Reports Medicine·TypeData/statistical analysis·DateFeb 1, 2023
A research team led by Professor Kwang-Hyun Cho at KAIST has developed a fundamental technology to revert metastatic lung cancer cells to a non-metastatic state. This breakthrough could lead to the elimination of drug resistance and metastatic potential in cancer cells, while increasing their responsiveness to chemotherapy.
SourceThe Korea Advanced Institute of Science and Technology (KAIST)·JournalCancer Research·TypeMeta-analysis·DateJan 29, 2023
A combination of two novel immunotherapy drugs has shown promising clinical activity in treating patients with refractory metastatic colorectal cancer. The study found that 23% of patients had a tumor reduction, and the disease control rate was 76%. The treatment was well-tolerated, but adverse events were common.
SourceDana-Farber Cancer Institute·TypeRandomized controlled/clinical trial·DateJan 21, 2023
A Phase 3 clinical trial has shown that a four-drug chemotherapy regimen significantly increases overall survival and progression-free survival in patients with stage 4 pancreatic ductal adenocarcinoma. The study's results suggest that this more aggressive treatment approach may be considered for eligible patients.
SourceUniversity of California - Los Angeles Health Sciences·TypeRandomized controlled/clinical trial·DateJan 20, 2023
Researchers at Bar-Ilan University have discovered a new molecular blocker that successfully halted breast cancer metastasis by targeting the Pyk2 and cortactin interaction. The study's findings provide significant hope for fighting breast cancer, as the blocker inhibited metastasis formation in breast cancer-bearing mice.
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers found that EWS::FLI1 induces Slit2 expression, which activates Robo receptors and enhances Ewing sarcoma growth. Silencing Slit2 strongly inhibited Ewing sarcoma cell growth, providing an opportunity for targeted therapy.
SourceImpact Journals LLC·JournalGenes & Cancer·TypeObservational study·DateJan 13, 2023
Researchers identified a link between sphingolipids and complement signaling that regulates cancer cell migration and metastasis. High levels of S1P inside cancer cells activate the complement molecule C3, leading to inflammation-promoting complex formation and driving cancer spread.
SourceMedical University of South Carolina·JournalCell Reports·TypeMeta-analysis·DateJan 12, 2023
A new study found that COVID-19 primarily affected patients with a moderate to critical course, often with comorbidities, whereas many had mild courses despite metastatic melanoma and systemic therapy, recommending continued treatment whenever possible.
SourceImpact Journals LLC·JournalOncotarget·TypeObservational study·DateJan 11, 2023
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
Ringlike peripheral high iodine concentration maps from dual-energy CT can help guide management in patients with known lung cancer and an indeterminate solitary nodule. This finding showed excellent interobserver agreement, high specificity, and independently predicted pulmonary metastasis.
SourceAmerican Roentgen Ray Society·JournalAmerican Journal of Roentgenology·TypeObservational study·DateJan 11, 2023
A new study has identified a protein called LAP1 that makes melanoma cells more aggressive by changing their nucleus shape. The protein allows cancer cells to migrate and spread throughout the body, leading to poor outcomes in patients.
SourceQueen Mary University of London·JournalNature Cell Biology·TypeExperimental study·DateJan 9, 2023
The study found that methylation of the HLA-A gene and focal deletions resulted in reduced immune cell activity against cancer cells, leading to fewer immune cells being available to attack cancer cells. The researchers also discovered differences in immune cell response between various sites of metastasis.
SourceUNC Lineberger Comprehensive Cancer Center·JournalNature Cancer·TypeExperimental study·DateJan 9, 2023
PSMA PET/MRI successfully determines prostate cancer likelihood of return within two years after prostatectomy, aiding treatment decisions. High uptake in primary lesion and metastasis are associated with rapid recurrence.
SourceSociety of Nuclear Medicine and Molecular Imaging·JournalJournal of Nuclear Medicine·DateJan 6, 2023
Researchers have made a breakthrough in precision oncology for patients with metastatic urothelial carcinoma, identifying that certain cell surface molecules decrease or are absent in these patients, making them resistant to the new drug enfortumab vedotin.
SourceUniversitatsklinikum Bonn·JournalClinical Cancer Research·DateDec 30, 2022
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
A study found that Medicare costs for metastatic prostate cancer increased significantly between 2007 and 2017, with average annual spending per patient rising from $28,311 to $37,055. The majority of the increase was attributed to new treatments under Medicare Part D, such as radium-223, sipuleucel-T, abiraterone, and enzalutamide.
SourceWolters Kluwer Health·JournalUrology Practice·DateDec 20, 2022
A new AI-based predictive method has been created to detect radiotherapy failure in brain metastasis, showing an 83% accuracy rate compared to the human eye's 65%. The technique uses deep learning and attention mechanisms to analyze MRI images and provide more informed treatment decisions.
SourceYork University·JournalIEEE Journal of Translational Engineering in Health and Medicine·TypeComputational simulation/modeling·DateDec 19, 2022
Researchers found that tumor cells directly interact with blood vessel cells, altering their normal clockwise orientation to a counterclockwise position. This interaction may play a role in cancer metastasis and could be targeted for prevention and treatment.
SourceAmerican Institute of Physics·JournalAPL Bioengineering·DateDec 6, 2022
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
A new mechanism has been uncovered that enables cancer cells to move throughout the body, allowing them to spread and form metastases. This discovery provides a potential new target for stopping these deadly spreads, which are responsible for 90% of cancer deaths.
SourceUniversity of Alberta·JournalNature·DateDec 5, 2022
For adrenal lesions evaluated by single-phase dual-energy CT, fat fraction had significantly higher sensitivity than virtual noncontrast attenuation at both clinically optimal threshold and traditional ≤10 HU threshold. Fat fraction-derived metrics can help definitively diagnose incidental adrenal lesions as adenomas.
SourceAmerican Roentgen Ray Society·JournalAmerican Journal of Roentgenology·TypeImaging analysis·DateDec 1, 2022
A new study suggests that blood tests can predict survival odds for patients with metastatic cancer by analyzing the proportion of tumor DNA in the bloodstream. Patients with higher levels of tumor DNA in their bloodstreams were found to have poorer survival rates across all cancer types studied.
SourceMichigan Medicine - University of Michigan·JournalAnnals of Oncology·DateNov 29, 2022
Researchers at the Fred Hutchinson Cancer Center discovered that oral bacteria like Fusobacterium nucleatum can infiltrate tumors, influencing their growth and response to treatment. The findings suggest a link between oral health and cancer, highlighting the potential for microbiome-based therapies to combat cancer.
SourceFred Hutchinson Cancer Center·JournalNature·TypeExperimental study·DateNov 16, 2022
A study of 11,945 people found that those with type 2 diabetes are more likely to be diagnosed with advanced cancer if the condition is not screened for routinely. Researchers identified a 26% increased risk of metastasis in patients with pre-existing type 2 diabetes.
SourceEuropean Organisation for Research and Treatment of Cancer·TypeObservational study·DateNov 15, 2022
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Research at Tel Aviv University found that high-intensity aerobic exercise increases glucose consumption in internal organs, reducing energy availability for tumors. The study reduced the risk of metastatic cancer in humans and animal models by up to 72%.
SourceTel-Aviv University·JournalCancer Research·DateNov 14, 2022
Researchers discovered that the Memo1 protein binds copper ions, blocking toxic redox reactions that damage or kill cancer cells. The protein's interaction with copper also protects against metastasis formation in breast cancer cells. This finding opens up potential new treatments for cancer.
SourceChalmers University of Technology·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateNov 10, 2022
Researchers found that oral cancer cells releasing EVs under TGF-β induce EndoMT in endothelial cells, leading to vascular destabilization. This process may facilitate cancer cell entry into the bloodstream, promoting metastasis.
SourceTokyo Medical and Dental University·JournalInflammation and Regeneration·DateNov 10, 2022
A new treatment approach using surgery or radiation therapy has been shown to slow cancer progression in patients with solitary prostate cancer metastases. The study found that this approach, called metastasis-directed therapy (MDT), can delay the need for hormone-blocking treatments and improve survival rates.
SourceWolters Kluwer Health·JournalThe Journal of Urology·DateNov 10, 2022
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
Researchers at IRB Barcelona have identified the tiny fraction of tumour cells that remain hidden after surgery, leading to metastatic recurrence. These 'High Relapse Cells' can be eliminated through genetic techniques, preventing metastases and opening the possibility for new therapeutic strategies.
SourceInstitute for Research in Biomedicine (IRB Barcelona)·JournalNature·DateNov 9, 2022
Researchers at Binghamton University discover that sodium/proton exchanger 1 (NHE1) and SWELL1 proteins regulate cancer cell migration, offering insights into metastasis. The study's findings could have wide implications for slowing down or halting the deadly disease.
SourceBinghamton University·JournalNature Communications·DateNov 8, 2022
Researchers found that overexpressing matriptase reduced myeloma cell proliferation and inhibited migration. Matriptase also blocked Src kinase activation, supporting its potential as a tumor suppressor in multiple myeloma. The study provides new insights into the role of matriptase in hematological malignancies.
SourceImpact Journals LLC·JournalOncotarget·TypeObservational study·DateNov 7, 2022
Assistant Professor Nourridine Siewe developed a new mathematical model to assess different approaches for treating metastatic cancer. The model evaluates the interactions among immune cells and cancer, helping clinicians decide on the best treatment strategies.
SourceRochester Institute of Technology·JournalJournal of Theoretical Biology·DateNov 4, 2022
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
A recent study found worsening disparities in cancer drug trial participant diversity from 2000 to 2018, highlighting systemic biases and unequal access to new treatments. The findings underscore the need for increased diversity in phase 1 clinical trials to ensure equitable access to life-saving treatments.
SourceJAMA Network·JournalJAMA Network Open·DateNov 3, 2022
A recent study published in Oncotarget reveals that Nectin-4 is widely expressed in head and neck squamous cell carcinoma (HNSCC), with significant correlations to clinico-pathological parameters. Non-smokers and p16-positive HNSCC showed higher expression of Nectin-4, leading to better survival rates for positive tumors.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateNov 3, 2022
Researchers develop hybrid brightfield-darkfield transport of intensity approach, expanding accessible sample spatial frequencies and achieving 5-fold resolution increase. This method enables precise detection and quantitative analysis of subcellular features in large-scale cell studies.
SourceSPIE--International Society for Optics and Photonics·JournalAdvanced Photonics·DateNov 3, 2022
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
Researchers found that cancer cells can migrate faster in higher viscosity environments due to the formation of denser actin networks and cooperative signaling pathways. This discovery provides a new framework for understanding metastasis and may lead to the identification of potential targets to combat cancer spread.
SourceJohns Hopkins Medicine·JournalNature·DateNov 2, 2022
Researchers found that a quarter of cancer patients want to know their life expectancy, while almost half want to know about their functional prognosis. The study suggests that doctors should consider various options for informing patients about their future to cater to individual needs.
SourceUniversity of Tsukuba·JournalAnnals of Palliative Medicine·DateOct 31, 2022
In the ARROS-1 trial, 48% of patients achieved partial responses to NVL-520, with responses seen across all dose levels and in heavily pre-treated patients. The treatment also showed promise for brain metastases, with three out of three patients experiencing measurable response or no emergence of new metastases.
SourceEuropean Organisation for Research and Treatment of Cancer·TypeRandomized controlled/clinical trial·DateOct 28, 2022
Advanced nanoparticles carrying a bacterially derived compound target the STING pathway, disrupting blood vessels and stimulating an immune response. This approach suppresses tumor growth and metastasis in several types of cancers.
SourceUniversity of Chicago·JournalNature Nanotechnology·TypeExperimental study·DateOct 27, 2022
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers at Baylor College of Medicine found that initiating bone repair triggers bone metastasis, with cancer cells 'riding' NG2-positive stem cells to tumor sites. This finding offers new directions for preventing tumor recurrence and controlling bone metastasis.
SourceBaylor College of Medicine·JournalCancer Discovery·TypeExperimental study·DateOct 26, 2022
Researchers have identified a messenger substance called ANGPLT4 that promotes tumor growth locally but suppresses metastasis when released into the bloodstream. This discovery sheds light on why metastases often appear after the original tumor has been surgically removed.
SourceGerman Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)·JournalJournal of Experimental Medicine·DateOct 26, 2022
A new study finds that combining radiation with hormone therapy can improve outcomes for patients with oligometastatic prostate cancer. The trial showed that patients who received both treatments experienced longer progression-free survival and better testosterone levels after treatment.
SourceAmerican Society for Radiation Oncology·DateOct 25, 2022
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
A large-scale analysis of VA medical centers found that facilities with lower yearly PSA screening rates had higher rates of metastatic prostate cancer in subsequent years. The study supports the benefits of prostate cancer screening in reducing metastatic prostate cancer risk, particularly for high-risk groups like Black patients.
SourceAmerican Society for Radiation Oncology·JournalJAMA Oncology·DateOct 24, 2022
In a first-in-human trial, FLASH radiation treatment was found safe and effective for pain relief in patients with bone metastases. The study showed significant pain relief in 7 out of 10 patients, with minimal side effects.
SourceAmerican Society for Radiation Oncology·DateOct 23, 2022
A phase II trial suggests that radiation can reduce painful complications and hospitalizations, and possibly extend overall survival in patients with advanced cancers. The study found that treating asymptomatic lesions with radiation reduced skeletal-related events and extended overall survival compared to those who received no radiation.
SourceAmerican Society for Radiation Oncology·DateOct 23, 2022
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
A novel polysorbate-based formulation enhances carboplatin's therapeutic response in lymph nodes, amplifying antitumor effects and increasing drug penetration.
SourceTohoku University·JournalCancer Science·DateOct 18, 2022
A study from Tokyo Medical and Dental University reveals that the TGF-β signaling molecule can induce EMT in oral cancer cells, leading to high motility and metastatic potential. KRTAP2-3 expression is associated with poorer overall survival, suggesting its role as a prognostic biomarker.
SourceTokyo Medical and Dental University·JournalCell Reports·DateOct 18, 2022
A gene signature of four specific genes (SAA1, SAA2, APOL1, and MET) predicts the risk of tumour spreading and survival in kidney cancer patients. The study identified a link between the microenvironment and immune system inhibition.
SourceKarolinska Institutet·JournalNature Communications·DateOct 17, 2022
Researchers at the University of Bonn have identified a mechanism that helps dendritic cells migrate more quickly to lymph nodes. The discovery reveals that forming multiple centrosomes enables these immune cells to stay on course longer before continuing their search.
SourceUniversity of Bonn·JournalJournal of Cell Biology·DateOct 14, 2022
Research reveals that individuals with inflammatory breast cancer are at a higher risk of brain metastases, which can lead to improved survival rates and quality of life. The study suggests that patients with triple-negative breast cancer face an even higher risk, emphasizing the need for earlier detection and more aggressive treatment.
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
Researchers found that certain fungal species in tumors are linked to inflammation and reduced cell-to-cell adhesion, features associated with late-stage cancer spread. High levels of these fungi may serve as biomarkers for metastasis risk and lead to more effective treatment choices.
SourceWeill Cornell Medicine·JournalCell·DateOct 3, 2022
Scientists have identified two new epigenetic biomarkers that can predict the development of aggressive prostate cancer, enabling clinicians to develop more personalized treatment plans. The study used comprehensive molecular analysis of 185 biopsies from men with prostate cancer diagnosed between 1990 and 2000.
SourceGarvan Institute of Medical Research·JournalClinical and Translational Medicine·TypeExperimental study·DateOct 2, 2022
Scientists have identified a protein that regulates cancer cell spread and normal tissue cell shedding, potentially leading to new treatments. The research suggests that metastasis is not an abnormal process limited to cancer but a normal process used by healthy cells.
SourceCancer Research UK·JournalNature Genetics·TypeExperimental study·DateSep 29, 2022