Articles tagged with Ulcers
Researchers at Université Laval have developed biomaterial-free biological wound dressings made from human skin grown in vitro. These dressings successfully treated venous ulcers in patients who had been chronically suffering from such wounds, with an average healing time of seven weeks.
A new ultrasound patch has been shown to significantly accelerate healing in patients with venous ulcers, a type of chronic wound that affects millions. The patch, developed by researchers at Drexel University, delivers low-frequency ultrasound directly to wounds and was found to reduce wound size in just four weeks.
A new study reveals that pressure ulcers in children are more common than previously thought, with medical devices such as facemasks and pulse oximeters identified as major contributors. Cincinnati Children's researchers developed a quality improvement initiative that reduced pressure ulcers by 50 percent.
Studies of newly diagnosed prostate cancer patients reveal that older, sicker men are unlikely to benefit from aggressive therapy. Researchers found that those aged 61-74 and over 75 with multiple health issues face high risks of mortality from non-prostate causes, suggesting a shift towards more conservative treatment approaches.
Researchers discovered that mycolactone, a lipid toxin produced by Mycobacterium ulcerans, disrupts the cellular skeleton through N-WASP activation. This dysregulation impairs skin integrity and cell adhesion, leading to Buruli ulcers. Blocking N-WASP activity with wiskostatin may provide a new treatment approach.
Researchers found that mycolactone, a lipid toxin from Mycobacterium ulcerans, causes cytoskeletal dysregulation by activating the protein N-WASP. This led to defects in cell adhesion and migration, impairing skin integrity. The study suggests using N-WASP inhibitors as potential treatments for Buruli ulcers.
A new clinical study by UCLA researchers found a direct correlation between pressure ulcers, or bedsores, and patient mortality, as well as longer hospital stays and readmissions. The study tracked over 51,000 Medicare beneficiaries and found that seniors with bedsores were more likely to die during their hospital stay.
A new study found that treating chronic venous leg ulcers with a topical spray containing a unique living human cell formula increases the likelihood of wound closure by 52%. The treatment, HP802-247 from Healthpoint Biotherapeutics, was tested in a Phase II clinical trial and showed promising results.
Researchers have developed a groundbreaking treatment for venous leg ulcers, which showed significant improvements in wound closure and healing time. The study found that patients who received the treatment experienced faster healing and a higher likelihood of wound closure compared to those in the control group.
A new wound care meta-review has drawn firm conclusions from Cochrane published studies, identifying strong clinical evidence for treating specific wound issues. The review covered 44 Cochrane Systematic Reviews and found evidence for treating acute and chronic wounds, including venous ulcers and diabetic ulcers.
A study found that nursing home staff cohesion improves care quality, leading to reduced incidence of incontinence and pressure ulcers. The research used data from over 45,000 residents in 162 facilities across New York State, revealing a significant association between staff cohesion and better health outcomes.
A new study published in Archives of Internal Medicine reports that gastric feeding tubes may not prevent but rather increase the risk of pressure ulcers in people with advanced dementia. The analysis of thousands of nursing home patients found that those with a feeding tube were 2.27 times more likely to develop a stage II ulcer, and ...
An interdisciplinary research team at WPI will develop an integrated application to track blood sugar levels, weight, and image analysis of lesions. The app aims to provide personalized feedback to encourage patients to make good decisions and improve outcomes.
A UCSF study found significant vision improvement in patients with severe bacterial corneal ulcers who received steroid therapy. Researchers tested 500 participants from the US and India, and results showed no harm but a benefit for those with more serious forms of ulcers.
A study published in Archives of Otolaryngology - Head & Neck Surgery found no evidence of Helicobacter pylori bacteria in enlarged adenoids of children. However, Candidatus Wolinella africanus was detected in one hyperplastic adenoid sample, suggesting occasional reflux episodes may contribute to the disease's pathophysiology.
Researchers found that pressure reduction foam mattresses and foam cleansers for incontinence care are cost-effective alternatives to standard mattresses and soap and water. The study estimated average savings of $115 and $179 per resident, respectively, with clinical benefits confirmed through further research.
A study found that pressure reduction foam mattresses and foam cleansers for incontinence care are cost-effective in reducing the risk of bedsores in long-term care residents. The researchers estimated average savings of $115 and $179 per resident, respectively.
Researchers developed an effective way to pinpoint high-risk patients with asymptomatic carotid stenosis using 3-D ultrasound to identify ulcers in the carotid arteries. The study found that three or more ulcers indicated a high risk of stroke and benefited from intervention.
The Johns Hopkins Wound Center and the Evidence-based Practice Center are conducting an evidence-based review of wound care to determine what is known and unknown about it. This study aims to inform health care providers and patients about effective state-of-the-art wound care treatments, ultimately improving outcomes for six million p...
A U of T study found that upgrading to pressure-reduction mattresses can prevent 1,005 pressure ulcers and save $7.2 million in healthcare costs annually for elderly patients in Ontario's emergency departments. The cost of upgrading would be 30 cents per patient, resulting in a savings of $32 per patient.
A study found higher pressure ulcer rates among black high-risk nursing home residents compared to white residents, with disparities largely related to facility demographics and staffing. The researchers suggest policy implications for targeted interventions to eliminate racial disparities in nursing home care.
A study comparing transarterial embolization to surgery in patients with uncontrolled peptic ulcer bleeding after endoscopy found TAE is a safe procedure with high technical success rate. It reduces the need for surgery and overall complications without increasing mortality.
A five-year study found that traditional nursing care methods, such as compression bandages and support stockings, work just as well as ultrasound therapy in healing venous leg ulcers. Laughter may also play a role in improving blood flow and overall health for patients with these conditions.
A strain of probiotic bacteria, Bifidobacterium bifidum CECT 7366, has been identified as effective in treating ulcers caused by Helicobacter pylori. The probiotic strain demonstrated significant inhibition levels against H. pylori and partially relieved damage to gastric tissue.
Researchers at the University of Toronto found a strong association between childhood physical abuse and peptic ulcers in adulthood. The study, which analyzed data from over 13,000 Canadians, showed that victims of childhood abuse were 68% more likely to develop peptic ulcers.
Researchers have discovered a hemostatic powder that effectively treats bleeding ulcers in up to 95% of patients. The powder's technique is simple and has shown high success rates with minimal complications.
A study by University of Nottingham researcher found that patients' coping styles and depression levels impact the healing process. Confrontational coping was linked to slower healing, while clinical depression resulted in reduced improvement.
Buruli ulcers, caused by Mycobacterium ulcerans, require more attention to early diagnosis and treatment. The World Health Organization's guidelines need to be adapted due to low accuracy and high relapse rates in some regions.
The incidence of calcium-alkali syndrome is rising due to widespread use of over-the-counter calcium supplements. Limiting daily intake to 1.2-1.5 grams can prevent the condition.
A series of reports find that proton pump inhibitors are associated with increased risk of fractures in postmenopausal women, bacterial infections in many patients, and higher doses do not provide additional benefits for treating bleeding ulcers. Introducing guidelines for proton pump inhibitor use may reduce inappropriate prescriptions.
Researchers identified age greater than 70 years as a significant risk factor for peptic ulcer in female patients taking low-dose aspirin. The study suggests a future strategy for prevention of LDA-associated gastroduodenal mucosal injury. A history of peptic ulcer was also found to be the risk factor common to both sexes.
Researchers found that two antimicrobial regimens were effective in treating early, limited buruli ulcer disease, with 96% of patients healing after 8 weeks and 91% after 4 weeks. No significant surgical complications occurred.
A new self-assessment score has been developed to predict diabetes risk, showing promise as a simple and effective tool. Additionally, researchers are considering alternative bacteria, Fusobacterium necrophorum, for sore throat treatment due to its association with a rare but life-threatening complication, Lemierre syndrome. Furthermor...
A research team investigated a highly-selective EP4 agonist for treatment of gastric ulcers in mice. The EP4 agonist reduced acute hemorrhagic damage, promoted mucous epithelial regeneration, and accelerated ulcer healing. In vitro, it protected human gastric mucous cells from indomethacin-induced apoptosis.
A study published in the World Journal of Gastroenterology found that vardenafil has dose-dependent gastroprotective effects against NSAID-induced peptic ulcer. This suggests that vardenafil may be used as a potential therapeutic drug to prevent NSAID-induced gastric ulcer formation.
A new study finds that a 7-day course of levofloxacin, omeprazole, nitazoxanide and doxycycline (LOAD) is more effective in eradicating Helicobacter pylori than a similar treatment with lansoprazole, amoxicillin and clarithromycin. The therapy is also found to be equally effective when reduced to 7 days.
A study published in BJS found that inexpensive dressings are just as effective as expensive silver dressings in treating venous leg ulcers. The study showed no significant differences in healing rates and quality of life between the two groups.
Buruli ulcer is caused by mycobacterium ulcerans and primarily affects poor rural communities in tropical countries. The new study aims to identify the natural reservoir for the disease, its activation, and transmission to humans.
Researchers have discovered a group of substances that block flavodoxin, a key protein for H. pylori survival, offering promise for new specific antibiotics against the bacteria that causes stomach ulcers and other diseases worldwide.
A new study uses genome sequencing to profile genetic diversity among M. ulcerans isolates, showing clonal relationships but distinct single nucleotide polymorphisms. The findings suggest a focal transmission pattern for Buruli ulcer, with local genetic variants not quickly spread over long distances.
A study found that early endoscopy in elderly patients with peptic ulcer bleeding reduced hospital stay by two days and decreased the need for surgical intervention. The study analyzed Medicare claims data from 2004-2006, finding that early endoscopy was associated with increased efficiency of care.
Research in Finland found that childhood financial difficulties and family conflicts are associated with an increased risk of developing peptic ulcers. Long-lasting financial difficulties had the greatest influence on the development of peptic ulcers.
A phase III randomised controlled trial found that famotidine reduces the development of stomach ulcers by 90% and upper-intestinal ulcers by 95% compared to placebo. The study also showed fewer adverse events in the famotidine group.
Researchers found that Helicobacter pylori is not transmitted through drinking water but rather through vomit and faeces, suggesting simple isolation and hygiene measures can prevent its spread. The study suggests isolating vomiting patients, especially children, for a short period can help prevent the bacterium's transmission.
Researchers from the University of Cincinnati, in partnership with Hill-Rom Company, Inc., have developed a "Progressive Recovery Collection" of hospital gowns that cater to different patient needs. The collection features three options for patients who are seriously ill, somewhat mobile, and fully ambulatory, respectively.
Researchers have found that human foetal stem cells can effectively treat back leg ischaemic ulcers in a model of type 1 diabetes. The culture mimics the wound-healing ability of the cells, suggesting they could be used as a 'factory' of wound-healing substances.
A recent study found that top-performing US hospitals experience a significant reduction in medical errors, resulting in fewer patient safety events and deaths. According to HealthGrades, the top five percent of hospitals in the US reduce medical errors by 43% compared to the poorest-performing hospitals.
Research found similar inflammatory cell distribution among asymptomatic tribals and duodenal ulcer patients, with increased cellular response but lower atrophy risk in tribal groups. The study suggests host factors may provide immunity to H pylori pathogenic effects.
Researchers found that H2RA therapy was effective in preventing and treating low-dose aspirin-induced peptic ulcers, while PPIs showed similar results. Cytoprotective anti-ulcer drugs were ineffective in preventing peptic ulcers. The study suggests a therapeutic strategy for managing this condition.
Researchers found that individuals with Diabetic Peripheral Neuropathy can reduce foot ulcer risk through supervised walking programs. The study suggests weight-bearing exercise is safe if properly monitored by a medical professional.
Two pivotal Phase 3 trials evaluating HZT 501 met primary endpoints, showing a statistically significant reduction in gastrointestinal ulcers compared to ibuprofen alone. The treatment also demonstrated good tolerability and was well-received by patients.
Researchers have developed a quadruple therapy regimen that shows promise in treating peptic ulcer disease, achieving an eradication rate of 68.8% in a study of 51 patients. The new treatment combines omeprazole, amoxicillin, clarithromycin, and furazolidone, with only 31.4% of patients experiencing adverse effects.
A study by PASS International found that transportation costs and lost earnings significantly contribute to abandonment of treatment. The researchers propose decentralizing treatment to reduce economic burdens on families. Decentralized approaches may improve access to efficient treatment in low-income settings.
The study found that rebamipide enema therapy significantly reduced mean fasting period and duration of hospitalization compared to conventional therapy. The degree of ulcer healing also showed a favorable trend, although not statistically significant.
Patients taking proton pump inhibitors for 7 years or more are at higher risk of osteoporosis-related fractures. The study found a significant increase in hip fracture risk after 5 years and any fracture risk after 7 years of continuous exposure.
Multidetector CT with virtual gastroscopy and post-contrast enhanced multiplanar reformation images help differentiate cancerous lesions from benign ulcer lesions. The study found high specificity in diagnosing malignant gastric ulcers, potentially improving survival rates.
A study of two naturally mummified corpses found remnants of Helicobacter pylori bacteria in gastric tissue from North American mummies. The research suggests that H. pylori infection occurred in native populations around 1350AD in the area now known as Mexico.
A trial found that aciclovir did not reduce the risk of HIV-1 infection in HSV-2 positive women and MSM. However, it did reduce incidence of genital ulcers by 47% and HSV-2 ulcers by 63%. The authors suggest novel strategies are needed to interrupt interactions between HSV-2 and HIV-1.
A team of researchers has isolated and characterized Mycobacterium ulcerans from the environment, supporting the idea that it is transmitted to humans through aquatic niches. The discovery lends support to efforts to control Buruli ulcer, a disease with massive social impact in impoverished tropical regions.
Research found that treating venous leg ulcers with honey dressings did not improve healing rates, but led to more adverse events compared to conventional care. The study suggests compression and other treatments remain the best approach for managing venous ulcers.