Articles tagged with Fungal Pathogens
Scientists at the University of Birmingham discovered how a rare fungus, Cryptococcus gattii, can infect healthy individuals by exploiting the body's immune response. The fungus triggers a 'division of labour' in its invading cells, allowing it to establish itself and cause life-threatening infections.
Pathogens specifically target highly networked proteins with multiple functions to weaken their host. The plant model Arabidopsis thaliana shows that different pathogens attack the same proteins, suggesting a convergent targeting strategy.
Researchers at the University of South Florida found that frogs can develop immunity against a deadly chytrid fungus by learning to avoid it after just one exposure. This acquired resistance could aid in conservation efforts and even offer protection for other animals threatened by fungal pathogens.
Jason Stajich, a UC Riverside microbiologist, has been awarded the 2014 Alexopoulos Prize for his groundbreaking research on fungal biology and evolution. His work focuses on building new methods for comparative and evolutionary genomics.
A study recommends a systems approach to controlling fungal infections in lucky bamboo, including training and disease management at source and application of systemic fungicides. Latent presence of Colletotrichum dracaenophilum found in up to 43% of non-inoculated stalks.
Researchers have fully sequenced the Cryptococcus neoformans genome, providing a playbook to understand its pathogenesis and develop methods to combat its evolution into deadlier strains. The study reveals genetic changes that occur after laboratory handling, making the fungus more susceptible to stress and less virulent.
Researchers have determined the structure of a protein produced by Candida albicans, a common fungal pathogen that causes yeast infections and other diseases. The discovery could lead to the development of targeted compounds to treat widespread fungal infections.
Clemson University scientist Lesly Temesvari receives a $147,157 NIH grant to study the stress response in Entamoeba histolytica and potentially develop new therapeutic targets. The research aims to interrupt the parasite's survival mechanisms, which could lead to the discovery of new treatments for the disease.
A study by University of Massachusetts Amherst researchers found that flowers are ideal venues for the transmission of microbes among plants and animals. The authors identified eight major groups of animal pathogens potentially transmitted at flowers, including fungi, bacteria, and RNA viruses.
A recent study by Arizona State University researchers found that spaceflight alters the global gene expression of Candida albicans, a fungus commonly found in human bodies. The results indicate changes in cell aggregation, biofilm formation, and resistance to stress and antifungal drugs.
A UC Riverside team discovered a novel 'virulence mechanism' of Botrytis cinerea, a fungal pathogen that can infect over 200 plant species. The pathogen delivers RNA effectors into host cells to suppress immunity and cause infection.
A Kansas State University microbiologist has discovered a breakthrough medicinal compound that treats Candida albicans, a common human fungal pathogen. The nontoxic gymnemic acid compound blocks the virulence properties of the fungus, making it more treatable and reducing its risk to patients.
A team of researchers discovered a chemical compound called filastatin that prevents fungal cells from adhering to surfaces, which is the first step of fungal infections. The compound has shown significant protective effects without toxicity to human tissues.
A two-year study by Oregon State University and the University of Pittsburgh found that bullfrogs can both carry and die from a deadly chytrid fungus. The research suggests that bullfrogs may not be the primary hosts for this pathogen, contrary to previous assumptions.
A potentially lethal fungal infection can anticipate and disarm the host's immune attack by sequestering copper, shutting down copper pumps in macrophages. This study opens new options for drug development to target the fungus's detoxification machinery.
A ranking system of the ten most important phytopathogenic fungi has been developed by 495 international researchers. The rice blast fungus is at the top of the list, followed by Botrytis cinerea and Fusarium oxysporum.
Researchers found that ragweed plants will invest resources for the benefit of their group when planted with kin, leading to a larger fungal network and greater benefits. This cooperation is likely due to plant kin recognition, which can enhance altruism towards relatives and promote sustainable farming practices.
Researchers analyzed fungal genomes and transcriptomes to understand how lifestyle affects gene expression and host specificity. They discovered new functions for fungal infection organs, including sensing the presence of plants.
Researchers discovered that Candida albicans can distinguish between healthy and unhealthy hosts by altering its physiology based on the levels of protein Efg1p. In immunocompromised patients, fungal cells with lower levels of this protein thrive, leading to serious infections.
A Yale graduate student has developed a method for detecting an infectious pathogen driving amphibian extinctions worldwide. By analyzing preserved specimens, she found evidence of the pathogen in six older samples from Connecticut, revealing its early presence in the region.
Researchers have developed a new approach to speed up vaccine development by identifying immunomodulators like B2, which enhance immune response and even shrink cancerous tumors. This method uses expression library immunization to rapidly screen entire genomes for desired biological functions.
Using autonomous unmanned aerial vehicles (UAVs), researchers are creating an early warning system for high-risk plant pathogens by predicting atmospheric transport barriers. This technique aims to improve crop security, disease spread, and climate change management.
A new combination therapy has been developed to target fungal infections in implanted medical devices, effectively clearing biofilm-based infections. The therapy inhibits a protein called Hsp90, rendering antifungals effective against biofilms, offering hope for patients with device-related infections.
The Legume Integrated Pest Management Pest Information Platform for Extension and Education (ipmPIPE) provides a new option for generating, summarizing, and disseminating real-time pest data. It identifies priority pathogens and insect pests for monitoring and offers management and education tools.
Researchers have cultured and identified a new type of fungus, Archaeorhizomycetes finlayi, found in soil for millions of years. The fungus, which is slow-growing and produces spores only in soil, may play a role in breaking down dead plants.
Whitehead Institute researchers uncover a novel association between dectin-1 and galectin-3 in macrophages, enabling the immune system to discriminate between non-pathogenic and pathogenic fungi. This discovery may lead to the development of more effective antifungal drugs.
Researchers at Montana State University found a surprising condition where common lung mold causes a shortage of oxygen in the lungs. The study reveals that the mold's fermentation can influence the host immune response and adapt to low oxygen levels.
A recent study suggests that mitigating chytridiomycosis through different infection control methods could largely prevent local extinctions and outbreaks of the disease. Researchers have identified successful pilot studies in Spain, including a heat therapy treatment using itraconazole, which has increased amphibian survival rates.
Researchers identify top biotic constraints affecting soybean production, including aphids, rust, nematodes, and exotic pathogen red leaf blotch. Genetic resources, biosecurity measures, and resistant cultivars are needed to combat these threats.
A study found 62% of dishwashers contain fungi on the rubber band in door, including polyextremotolerant black yeasts that can tolerate high temperatures, salt concentrations, and detergents. These extremophilic fungi pose a significant risk to human health due to their potential for causing fatal infections.
Researchers at Duke University Medical Center discovered that larger fungal spores are more virulent and can cause worse infections. The study suggests a new way to categorize fungi based on spore size, which could lead to developing new treatments for mucor infections.
The study's genome-wide characterization of rust fungi may help develop control strategies for worldwide threats to wheat fields and tree plantations. Researchers uncovered evidence that both pathogens have large numbers of effector proteins, indicating co-evolution with host plants.
Scientists deciphered a community of soil microbes that enables a patch of soil to suppress a plant-killing pathogen. The researchers found 17 unique types of bacteria working together to reduce the incidence of fungal infection.
Researchers have sequenced the genomes of two fungal pathogens that threaten global food supplies, including wheat stem rust and poplar leaf rust. The study provides insights into the molecular underpinnings of these pathogens' pathogenicity and survival, shedding light on their complex relationships with host plants.
Researchers conclude that amphibian population declines are complex and multifaceted, driven by various natural forces and human activities such as habitat destruction, climate change, and disease. This understanding highlights the need for a comprehensive approach to address the crisis and avoid exacerbating the problem.
A special edition of Fungal Biology Reviews features 76 videos on fungal cell biology, produced by renowned researcher Professor Gero Steinberg. The collection is expected to become a primary teaching resource in the field.
Despite its large genome, powdery mildew has lost many essential genes, limiting its ability to fix nitrogen, harness energy, or produce metabolic products.
Scientists have sequenced the genomes of parasitic water fungus and water molds that cause late blight in potatoes, tomatoes, and downy mildew in cruciferous vegetables. The analysis reveals that some sections of the genome are slow to evolve, allowing for resistance genes to be targeted.
Researchers at University of Missouri identify valuable genes in Norton grape for resistance to powdery mildew, a fungal pathogen affecting winemaking grapes worldwide. The goal is to transfer these traits into other grapes to decrease fungicide use and increase global production.
Researchers discovered a novel family of pores that transport sugar out of plant cells, enabling pathogenic bacteria and fungi to hijack the nutrient supply. This breakthrough allows for the development of new crop protection techniques and potential applications in diabetes research.
Kathleen Alexander has discovered a novel tuberculosis species, M. mungi, in banded mongooses, which behaves differently from other TB infections, killing infected animals within two to three months. The pathogen's source and host range are areas of ongoing research.
Scientists have discovered how fungi subvert a single gene in wheat, triggering programmed cell death, which protects plants from pathogens. Researchers also developed DNA molecular markers to rapidly screen commercial cultivars for the gene, allowing for its elimination through selective breeding.
Fungal pathogens spread quickly through gypsy moth cadavers, while viruses disperse slower via parasitoid flies and predators.
Scientists have identified a synergistic relationship between a fungal pathogen and RNA viruses from the family Dicistroviridae as contributing factors to Colony Collapse Disorder. The presence of these pathogens in sick colonies is a strong predictor of collapse, with higher levels of the fungus compromising gut wall integrity.
Researchers found nearly 20% of cryptococcosis patients had mixed infections with multiple strains of C. neoformans, evolving during infection. This challenges the traditional concept of a single pathogen causing disease.
Researchers are developing methods to protect cacao crops from devastating plant pathogens, targeting two mechanisms critical for pathogen attack. The project aims to improve crop resilience and provide nutrition and income options for smallholder farmers in developing countries.
Ecological speciation is a main route for the emergence of new fungal diseases in plants, according to researchers. Fungi account for 30 percent of emerging infectious diseases in plants.
Researchers found that only about 30% of the genes in the corn smut genome are always activated, while the other 70% is tissue-specific, with different parts of the maize plant activating different genes. This discovery could lead to new approaches to fighting disease in plants and humans.
Researchers found that certain wild flax plants growing in poor soils can balance stress and reduce the risk of infection from a fungal pathogen. This suggests that stressful environments may be attractive to plants, providing a refuge from pathogens, but requiring adaptation to survive.
Researchers discovered fungal protein TmpL critical for pathogen development, shielding it from oxidative stress while aiding in infection. TmpL-deficient mutants were more sensitive to external oxidative stress, suggesting its role in protecting pathogens from host defense mechanisms.
Researchers discovered that Candida albicans, a human fungal pathogen, engages in same-sex mating alongside traditional opposite-sex mating. This finding expands understanding of sex mechanisms in microbial species and suggests increased opportunities for sex in natural populations.
The Ralph E. Powe Junior Faculty Enhancement Award supports Sobrado's research on iron acquisition mechanisms by Mycobacterium tuberculosis and Aspergillus fumigatus. The goal is to identify inhibitors that can be developed as antibiotics or antifungal agents.
A team of researchers has created a microdevice that uses magnetism to remove pathogens from the bloodstream, showing promise as a potential treatment for sepsis. The device, developed by Chong Wing Yung and Don Ingber, achieved over 80% clearance of fungi in contaminated human blood.
Biologists have discovered a sexual cycle in the deadly fungus Aspergillus fumigatus, revealing its ability to adapt to new environments and evade antifungal drugs. This breakthrough could lead to new treatments for patients infected with the fungus, which causes severe asthma and immune deficiency-related deaths.
The new guide provides standardized guidelines for collecting data from wild primates, aiming to identify infection patterns and prevent epidemics. By integrating research from various disciplines, the study seeks to reduce the risk of pathogens jumping from animals to humans and vice-versa.
The study found that contaminated contact lens storage cases pose a significant risk of severe eye infection, with pathogens detected in over two-thirds of cases. Refractive surgery practices for people with HIV/AIDS are also highlighted, with most surgeons taking precautions but acknowledging the need for formal study.
A novel topical therapy, NB-002, has demonstrated a unique approach to healing nail fungus by penetrating skin pores and diffusing through the skin surrounding the entire nail plate. The lotion has shown robust antifungal activity against all organisms causing nail fungus, including Trichophyton rubrum and Candida albicans.
The USDA Forest Service has named the tree-killing fungus responsible for 'laurel wilt', causing devastating disease in redbay and other laurel species. Lead author Tom Harrington and co-author Stephen Fraedrich unveiled the name, Raffaelea lauricola, after publishing an article in Mycotaxon journal.
Researchers found that disabling the ZFR1 gene reduces toxin production by 82% in Fusarium verticillioides on corn kernels. The study identified a specific sugar transporter, FST1, necessary for FB1 production, which acts as a molecular sensor for toxin creation.
A new study identifies autophagy as a crucial virulence-associated trait for Cryptococcus neoformans, a fungal pathogen that infects immunocompromised individuals. Autophagy helps the pathogen survive during nutrient scarcity and is essential for its virulence.