Articles tagged with Gerontology
CHARGE syndrome is a rare developmental disorder that may be linked to developmental senescence, a tightly controlled cellular program involved in embryonic tissue remodeling. Disruption of this program may contribute to the characteristic abnormalities associated with the disorder.
Researchers discovered that moderate-intensity exercise significantly improved cartilage health and tissue resilience in aging-related osteoarthritis. The molecular cargo of extracellular vesicles was found to be enriched with microRNA-29, which restored youthful characteristics in cartilage cells and reduced joint degeneration features.
Wiley has launched two new research journals, Advanced Medicine and Advanced Healthy Aging, as part of its expanding Advanced Portfolio. The new journals aim to elevate breakthrough science that impacts lives, reflecting Wiley's commitment to accelerating science that addresses humanity's most pressing challenges. Led by expert editori...
Long-lived organisms exhibit better DNA maintenance, stress resistance, regenerative capacity, and stem-cell populations compared to shorter-lived species. Comparative genomic studies have identified longevity-associated pathways, including apoptosis, protein homeostasis, and oxidative-stress resistance.
A new study from Wake Forest University School of Medicine found that chronic stress and social support levels are associated with changes in cognitive abilities across different demographic groups. Higher social support was linked to less decline in attention over time, while women and Hispanic participants with higher chronic stress ...
Participants with mild disabilities experienced a $1,177 annual reduction in care costs, compared to non-participants. Community gathering places promote social participation, exercise, and mutual support, contributing to healthy aging and mitigating long-term care costs.
The Gerontological Society of America's 2026 Annual Scientific Meeting will take place in National Harbor, Maryland, from November 4 to 7. The event is expected to feature nearly 600 scientific sessions, making it the country's largest interdisciplinary conference in the field of aging.
The Neighborhoods Study, a nationwide NIH-funded research initiative, investigates the relationship between social and environmental factors and Alzheimer's disease risk. Emory Goizueta Brain Health Institute is part of the study, which aims to understand how environmental exposures influence brain health and dementia risk.
A Tulane University study found that loneliness and social isolation can cost people nearly six years of life free from mental disorders like depression and anxiety. The study, published in Nature Communications, also found a smaller but still significant toll on physical health.
A new framework proposes that chronic overactivation of the DNA damage response may drive biological aging. Persistent DDR signaling can stabilize p53, increase p21 and p16INK4a, promoting cell-cycle arrest and senescence. This forms the basis of the
Researchers at MIT have developed a noninvasive way to detect biomarkers of senescence, a state of cells that stop dividing but do not die, using Raman microscopy and gene expression data. This method could lead to better diagnosis and treatment of age-related disorders.
A new Cochrane review suggests that personalized programs to prevent falls in older people may not be effective in reducing falls. The review found that multifactorial programs, which are tailored to individual risk, have little or no benefit in preventing falls compared to standard medical care, exercise, or falls prevention education.
The new NCCN Guidelines for Patients with Cancer explain the importance of assessments to tailor cancer care to every person, regardless of age. The guidelines stress the need for support and validation for older adults, who face unique issues such as memory function and treatment interactions with other medications and conditions.
A new study published in Aging reveals that a mutation affecting the immune and metabolic regulator SHP-1 reshapes liver function during aging, showing improved glucose metabolism can coexist with immune-cell accumulation and liver fibrosis. The findings separate liver inflammation and fibrosis from insulin resistance, obesity and lipi...
A study of 7,500 adults found that healthy eating is associated with slower biological aging, with no single diet being superior. The researchers examined ten dietary patterns and found that all were linked with slower aging, with some more effective than others.
Researchers found that exosomes from people with shingles pain caused nerve cells to remain inflamed and transmit pain signals even after the virus clears the body. This discovery opens the door to new approaches for predicting, preventing, and treating post-herpetic neuralgia.
Cellular senescence is recognized as a key driver of aging, linked to telomere dysfunction, chronic inflammation, and stem cell exhaustion. Experimental evidence supports its causal role, with removal of senescent cells delaying age-related pathologies.
Research shows broad consensus among ICU recommendations for elderly patients, with female clinicians agreeing more on multidisciplinary input, such as pharmacist involvement and dietitian advice. Male clinicians showed stronger agreement on life-sustaining therapy decisions.
A new framework proposes 'movement span' as a third dimension of aging beyond life span and health span. Movement span is defined as the duration of life during which an individual can move with confidence, responsiveness, and adaptive control.
Research reveals that targeting insulin/IGF-1 signaling pathway in C. elegans extends male lifespan by 446% and improves reproductive healthspan, with whole-body degradation required for reproductive benefits. The study highlights the importance of coordinated effects across multiple tissues and physiological systems.
The Gerontological Society of America (GSA) is partnering with Plans4Care, Inc. to offer a certificate course on engaging family caregivers. The course,
Researchers found three herbal extracts protect mitochondrial function in a cellular model of Parkinson’s disease, suggesting a potential treatment. The extracts, including Uncaria rhynchophylla, Gardenia jasminoides, and Scutellaria baicalensis, improved cell viability and mitochondrial function in cells with reduced VPS13C expression.
The Gerontological Society of America supports the 2026-27 respiratory season vaccine evidence review, highlighting the importance of evidence-based immunization recommendations across the life course. Vaccinations continue to provide meaningful protection against severe illness, hospitalization, and death for individuals of all ages.
The Starr Healthspan Innovation Alliance will bridge the gap between scientific discovery and life-changing treatments for age-related diseases. The partnership will expand clinical trials and support groundbreaking laboratory research to extend healthy lifespan.
A community-adapted brain health program in Kikuyo Town, Japan, has achieved significant improvements in attention scores and dietary balance among older adults. The 24-week program, combining aerobic exercise, cognitive exercises, and lifestyle guidance, resulted in high attendance rates and positive feedback.
A comprehensive molecular study of ageing found that genetic factors and environmental influences continuously interact to shape an individual's ageing journey. Researchers identified distinct biological shifts, including correlations between environmental exposures and molecular profiles, which may indicate higher risk of disease and ...
The study found that Indy gene reduction is associated with lower bacterial load and higher bacterial diversity in aging fruit flies compared to controls. Reduced Indy activity also linked to improved intestinal homeostasis, reduced oxidative stress, and maintenance of gut integrity.
Researchers found that GLP-1 treatment improved muscle and cognitive function, and reduced hallmarks of natural aging in older mice. The treatment also extended lifespan by nearly 100 days, suggesting a potential therapeutic route for slowing physiological aging.
A study found that older adults prefer chatbots that are authentic and responsive, rather than human-like, to provide companionship and support. The chatbot's ability to remember past conversations and adapt to user preferences is crucial for its success.
Researchers propose targeting the PGAM1-Chk1 interaction to stabilize HIF-2alpha and support senescent cell survival. Preclinical studies suggest the compound Nutlin 3b selectively removes senescent cells with improved safety profiles in aged mice models.
Higher TMAO concentrations were associated with older age, cardiometabolic risk factors, and brain atrophy, but not cognitive performance. The study suggests TMAO may be a marker of systemic aging processes rather than a direct mediator of neurodegeneration.
A new review suggests metformin's interactions with multiple hallmarks of aging, including cellular energy balance, nutrient-sensing pathways, and epigenetic regulation. The study identifies strong evidence for metformin's effects on aging biology, including improved insulin sensitivity and reduced oxidative stress.
A large UK study found that hormone replacement therapy (HRT) may reduce the risk of dementia, particularly for women who have undergone surgical menopause. The study, which followed over 180,000 postmenopausal women, found that HRT was associated with a 16% lower risk of developing Alzheimer's disease compared to non-users.
A new blood test detects Alzheimer's disease using plasma amyloid-β seeding activity, achieving a diagnostic accuracy exceeding 90% in the validation cohort. The test uses real-time ultrasonic protein misfolding cyclic amplification technology, marking a critical transition in AD diagnosis.
A new study from MIT researchers found that language skills remain stable in older adults, with nearly identical brain activity to young adults, while other cognitive functions decline. The study suggests that parts of the brain specialized for specific functions, such as language processing, may be more resilient to aging.
Researchers found that silencing POLG1 and POLG2 reduced mtDNA content, impaired mitochondrial function, and decreased stemness-related properties in breast cancer cells. POLG inhibition also suppressed colony formation and mammosphere growth, suggesting its potential as a therapeutic target and prognostic biomarker in breast cancer.
Researchers used AI to predict genes leading to hematopoietic stem cell aging, finding a regulatory hub in the form of gene-regulating factor Pbx1. Aged stem cells activate two gene programs, one preserving immaturity and the other preparing cells for platelet production.
The 13th Aging Research and Drug Discovery Meeting (ARDD) 2026 will bring together leading researchers, clinicians, and industry experts to advance aging research and accelerate age-related disease interventions. Aging is proud to support ARDD as a media partner, promoting the event through its digital and social media channels.
A study by Keio University researchers has identified two blood proteins, beta-2-microglobulin and cystatin C, that are consistently associated with future disability in adults aged 85 years and older. These biomarkers have the potential to enable earlier interventions and preventive support.
A new app, WeCareAdvisor, has shown promise in improving the quality of life for dementia caregivers by providing a systematic approach to manage behavioral symptoms. Caregivers who used the app reported significant reductions in distress and behavioral symptoms, as well as improved well-being.
Scientists have discovered a new connection between energy-producing mitochondria and chronic inflammation in senescent cells, which promotes age-related diseases. Blocking a related gene and using a drug called CTPI-2 reduced inflammation and promoted healthier aging in mice.
A new study reveals how memories change with age, with older adults struggling to recall specific details and general knowledge becoming more prominent. The research highlights the importance of understanding how memory evolves over a lifetime, shedding light on how to support healthy cognitive ageing.
This theme issue explores clinical efficacy, seamless support systems, and ethical AI integration for home-based care. Research topics include 'invisible' monitoring, computer vision, socio-technical drivers of AI adoption, and clinical implementation.
Researchers from the University of Osaka have found a rare type of immune cell that expands in supercentenarians, potentially helping protect against cancer and other age-related threats. The cells, known as CD4 CTLs, have been shown to be highly active and may help the body cope with persistent threats that increase with age.
Insilico Medicine introduces the Virtual Aging Cell (VAC) platform, which leverages multi-agent AI to simulate cellular processes, including differentiation, reprogramming, and aging. The VAC platform aims to support target identification, cellular fate intervention, novel drug discovery, and geroscience research.
A study found 161 differentially expressed genes in individuals with opioid dependence, including genes involved in immune and inflammatory processes. The researchers also developed a transcriptomic aging clock that predicts chronological age from gene expression patterns.
A meta-analysis of nearly 1,900 studies found that climbing stairs significantly reduces the risk of dying from cardiovascular disease. Regular stair climbing was associated with lower risks of heart-related problems and major cardiovascular conditions such as heart attack, stroke, and heart failure.
After 18 years of leadership, GSA CEO James C. Appleby is stepping down, leaving behind a strong foundation for the organization's continued growth and impact. The Board of Directors will begin a national search for a new CEO to build upon this foundation and guide the organization towards emerging opportunities.
A new study published in Diabetes Care found that older adults with type 2 diabetes are at a higher fracture risk, but bone loss alone does not explain this increased risk. Researchers used a novel bone imaging device to analyze cortical and trabecular bone density, microarchitecture, and strength, and found that changes in these areas...
A new ACC Scientific Statement highlights the importance of considering cognitive impairment and frailty in cardiovascular care for older adults. The statement outlines practical strategies for prevention, screening, assessment, and management, aiming to improve outcomes such as independence, mobility, and caregiver burden.
Misha Blagosklonny's work challenged traditional paradigms in aging biology, proposing that persistent growth-promoting signals drive age-related pathology. His hyperfunction theory integrates evolutionary concepts with molecular pathways, offering a comprehensive framework for understanding aging.
An international study of 974 participants aged 50-94 found a strong correlation between ageist attitudes and self-reported memory failures. The results indicate that individuals with more restrictive views on older adult behavior experienced greater memory problems, regardless of their country of origin.
The USC Leonard Davis School of Gerontology has received a $7.5 million grant to establish GeroSCORE, a national hub for discovery and collaboration on sex differences in aging. The center will conduct innovative research, develop new tools and analytical methods, and serve as a resource for early-career investigators.
A new research perspective proposes that developmental and growth programs continue operating beyond their beneficial period, driving aging. Programmatic mechanisms of aging are supported by evidence from animal models and experimental observations.
ISM9077 boasts potent inhibition across species, excellent exposure and permeability traits, and a favorable safety profile in preclinical studies. It modulates pathological inflammation, supporting broad indication expansion into therapeutic areas like aging and neurodegenerative diseases.
The Gerontological Society of America has announced its newest elected officers, consisting of Vice President Edward Alan Miller and Secretary Sherry A. Greenberg. The organization, founded in 1945, aims to foster excellence, innovation, and collaboration in aging research, education, practice, and policy.
A new study reveals that patients with metabolic dysfunction-associated steatotic liver disease (MASLD) have elevated lipocalin-2 levels and exhibit early signs of cardiovascular and cognitive impairment. The findings highlight the importance of considering MASLD as a systemic condition affecting multiple organ systems.
A $3.2 million NIH grant will support a five-year study investigating the role of thymulin, a hormone produced by the thymus, in age-related inflammation and cancer. The research aims to explore whether thymulin can improve cancer immunotherapy outcomes, particularly in older individuals.
The LifeAfter90 study found that women 90 and older are at two-fold greater risk for dementia, while Black participants have a 75% greater risk than Asian participants. APOE2's protective effects continue past age 90, reducing risk by 60%, but APOE4 increases the risk among men and Black participants.
A study of 5,500 individuals aged 50+ found that both conditions alone increase the risk of death, but together it more than doubles. Abdominal obesity and vitamin D deficiency create a vicious cycle, exacerbating chronic inflammation and impairing bodily functions.