Research on containing and managing disease. Covers critical-illness theory, zoonotic disease, immunotherapy trials, and historical epidemics.
Research highlights ways to blend caring profession into virtual landscape, focusing on pre-visit, visit, and post-visit phases. Key findings emphasize active listening, reflective listening, and maintaining professional appearance for effective communication.
A 12.3% increase in blood pressure control was achieved among at-risk populations through community-based, self-measured blood pressure control programs. These programs, implemented in partnership with patients and healthcare professionals, utilized evidence-based interventions to address the needs of disproportionately affected groups.
Researchers from Shinshu University identified citrullination as a key mechanism in lung cancer metastasis. A novel CitFbg peptide was developed to block metastatic cell homing and reduce the risk of cancer spread.
Researchers found that pregnant mice experiencing copy number variation (CNV) showed similarities to aging, with biomarkers and genetic effects appearing during pregnancy and reversing after delivery. This study aims to revolutionize aging treatment by investigating the mechanisms behind post-labor rejuvenation.
The CDC's Adapting Clinical Guidelines for the Digital Age (ACG) initiative introduces a new integrated process for developing written and computable clinical practice guidelines. This approach allows for feedback from clinicians and can save time and costs. The goal is to achieve a seamless, efficient, accurate, and consistent transla...
Researchers discovered that aging alters the pancreas's circadian rhythm by reorganizing its transcriptome. The study found that fibroblasts play a crucial role in regulating this reorganization, which affects the organ's resilience to aging-related pathologies.
Researchers discovered a subtype of avian flu virus is undergoing mutational changes that could increase its risk of being passed on to humans. The study found the virus can cause severe animal infections and be transmitted through airborne droplets.
Researchers at UMass Amherst are investigating the connection between PFAS chemicals and breast cancer. They will examine data from postmenopausal women to determine if PFAS concentrations are associated with less breast tissue involution, which may increase breast cancer risk.
Patients with cancer had disparate COVID-19 mortality rates during the winter Omicron wave compared to the general US population. The study suggests that immune-evasive SARS-CoV-2 variants pose a significant threat, requiring prioritized efforts to prevent transmission.
A study by McGill University found that higher-income individuals and those with university education had increased rates of melanoma, while those earning less than $50,000 were more likely to work outdoors and experience occupational sun exposure. Men also had higher rates of melanoma and other skin cancers due to increased UV exposure.
A Michigan Medicine study found that pulmonary embolism death rates remained unchanged over the past decade, with higher mortality rates among men, Black patients, and those from rural areas. The study analyzed over 100,000 deaths related to pulmonary embolism between 2006 and 2019.
A new CNIC study confirms that controlling traditional cardiovascular risk factors can prevent Alzheimer's disease and dementia. Maintaining a low cardiovascular risk is linked to preserved cerebral glucose metabolism, indicating better brain health.
Research on minimally processed vegetables reveals unsatisfactory microbiological safety, with Escherichia coli and Salmonella spp. found at high prevalence rates. The study calls for best practice assurance to guarantee products with quality and safety for consumers.
New research led by Nansi Boghossian found that sickle cell disease contributes to racial disparities in severe maternal morbidity, with Black individuals at least 1.5 times more likely to experience complications. The study suggests preconception care and management are critical for improving pregnancy outcomes for patients with sickl...
Scientists have identified specific long noncoding RNAs that regulate gene expression and life cycle progression of the deadly Plasmodium falciparum malaria parasite. The discovery could lead to new therapeutic strategies against malaria.
Researchers at National Korea Maritime and Ocean University developed a close contact identification algorithm that outperforms conventional clustering algorithms. The algorithm enables accurate tracking and physical isolation of individuals in ship environments, contributing to the health and safety of passengers.
Researchers are developing a community-based digital health intervention to increase vaccination uptake among children in rural and underserved areas. The project aims to empower community health workers to deliver education on vaccinations, overcoming the digital divide and addressing challenges faced by limited health workforce.
This study found a correlation between hospital-onset SARS-CoV-2 infections and community-onset infections, highlighting the importance of ongoing surveillance and prevention measures. The findings suggest that hospitals should be particularly vigilant when community incidence rates are high, in order to reduce in-hospital transmission.
Researchers found that the incidence of gut-colonizing ciprofloxacin-resistant E. coli increased in Seattle-area women over age 50, affecting about 1 in 5 women. The study suggests prioritizing strategies to control drug-resistant E. coli's ability to colonize the gut.
New guidelines recommend avoiding unnecessary catheter use and daily review of continued catheterization to prevent infections. Non-catheter strategies include prompt toileting, urinals, and non-indwelling catheter approaches to reduce harm.
Researchers analyzed data from 31 studies and found that cattle face a higher risk of getting tuberculosis from wildlife through indirect interactions. Indirect interaction rates were 154 times higher than direct interaction rates.
A study found more than one in five infected shelter dogs with heartworm or Lyme disease, highlighting the importance of preventive medications. The research also showed that climate change is expanding the geographic range of disease-carrying ticks and mosquitoes.
Researchers tracked infections among Connecticut correctional facility residents to find that high exposure to the virus reduces vaccination and prior infection effectiveness. Hybrid immunity provides higher protection in such settings.
A new study reveals that using big data and machine learning can improve antimicrobial resistance surveillance in livestock production. The research found correlations between environmental variables, microbial communities, and antimicrobial resistance, suggesting multiple routes for improving surveillance.
A new study in the American Journal of Preventive Medicine documents a consistent risk level across race and gender for victims of partner violence and child abuse. The risk is similar among adult males and females and lower income Black and White Americans, increasing by 20-35% compared to those without interpersonal violence.
A systematic review by the University of Adelaide found combining pyrethroid insecticide with chlorfenapyr improves its effectiveness in treating malaria-preventing mosquito nets. The WHO has updated its guidelines to include these new recommendations.
Researchers found that the flu blocks lung liquid secretion, allowing staph to infect lungs. Treatment with a CFTR-activating drug like ivacaftor restores liquid secretion and protects against staph infection.
A recent study published in Cell Host and Microbe reveals how flaviviruses hijack human cells to promote replication. The discovery of KAT5γ's critical role in viral replication paves the way for designing inhibitory molecules to stop viral replication.
Researchers have discovered that gene therapy may prevent relapse in patients with serious alcohol addiction by altering dopamine function in the brain's mesolimbic reward pathway. The treatment involves sustained release of glial-derived neurotrophic factor (GDNF) in a specific region of the brain.
Researchers found significant increases in body mass index among US youth during the COVID-19 pandemic, with effects most pronounced in low-income youth. The study highlights how preexisting social inequalities were exacerbated by the pandemic, leading to greater weight gain among vulnerable populations.
A new study found that intensive lifestyle intervention, including weekly counseling on diet and exercise, is associated with increased employment among people with type 2 diabetes. Study participants without a college degree had even larger employment gains from lifestyle changes recommended by specialists.
A new scientific statement from the American Heart Association highlights the importance of shared decision-making in cardiovascular care. Key findings include improved patient understanding, acceptance, and satisfaction when healthcare teams involve patients in decision-making processes.
A new study reveals that mosquitoes use a specific receptor in their ears to modulate their hearing, which is crucial for reproduction and mating. This discovery could lead to the development of novel insecticides or mating disruptors to control mosquito populations and reduce human disease.
Researchers have created a novel animal model to study the pathogenesis of neurobrucellosis, a severe complication of brucellosis. The model reveals that innate lymphoid cells and interferons play a crucial role in limiting brain damage during Brucella infection.
A multicenter study found that long COVID symptoms can emerge months after infection and persist for at least a year in about 16% of cases. The study highlights significant impacts the epidemic has had on the US healthcare system and emphasizes the need for further research into post-COVID conditions.
Researchers demonstrate the potential of optical imaging for safely measuring vocal fold elasticity and pliability. The study found good agreement between Brillouin microspectroscopy results and conventional elasticity measurements.
Researchers at Brigham and Women's Hospital have designed a probiotic to suppress autoimmunity in the brain, which is at the core of several diseases including MS. The treatment offers a more precise way to target brain inflammation with reduced negative side effects compared to standard therapies.
A new study found consistent increases in premature cardiovascular disease (CVD) death and disability due to particulate matter air pollution globally. The analysis, published in the Journal of the American Heart Association, revealed a 8.1% rise in age-standardized CVD deaths attributed to outdoor PM pollution between 1990 and 2019.
Researchers developed innovative techniques to treat challenging cancers and manage therapy side effects. Inhibitors targeting PRMT5, a histone-modifying enzyme, alleviated cisplatin-induced hearing loss, while nano-pills delivered combination drugs to liver cancer cells.
Research by the Peter Doherty Institute found that inflammation alters plasma composition, hindering parasite maturation. This work reveals a new mechanism slowing down malaria parasite development in the bloodstream.
The first locally acquired malaria cases in the US in 20 years have been reported, highlighting the need for clinicians to be vigilant about the disease's symptoms. Malaria thrives in warmer climates and can cause serious illness and death if not treated, emphasizing the importance of rapid diagnosis and treatment.
Researchers have discovered a gene, B5, in Egyptian cotton that confers powerful resistance to bacterial blight. The gene enables strong resistance to the disease under Oklahoma field conditions and accumulates high amounts of defense chemicals.
A new study reveals a high incidence of youth with cardiovascular risk factors but inadequate resources to provide preventive care. Pediatricians and policymakers must address these gaps by investing in pediatric preventive cardiology and increasing collaboration between programs.
Researchers developed an innovative optical tool, the Schistoscope, to capture microscopy images of urine samples for efficient detection of Schistosoma haematobium eggs. A two-stage diagnostic framework using deep learning accurately identified and counted eggs in field settings with high sensitivity, specificity, and precision.
A new American Heart Association science advisory emphasizes the need for more resources and best practices in pediatric preventive cardiovascular care. The survey found that many programs are overwhelmed with referrals and have long wait times, highlighting the importance of updated guidelines and strategic action plans.
A large study found that fully vaccinated individuals have lower concentrations of inflammatory markers than unvaccinated participants after symptomatic COVID-19 infection. This suggests that vaccination significantly reduces morbidity and mortality by reducing elevated levels of cytokines and chemokines.
The widespread use of insecticides for malaria control has unintended consequences, including the development of resistance in other disease-carrying arthropods. This can lead to the spread of overlooked and dangerous tropical diseases. Understanding the behavior and insecticide susceptibility status of these organisms is crucial to pr...
A WVU study found that U.S. cities with new professional sports teams saw increased influenza mortality rates, with the NHL teams causing the largest increase. The researchers analyzed data from 122 cities and controlled for factors like population and temperature to find a significant correlation between team arrival and flu deaths.
Researchers from Leicester and Nottingham universities have received £600,000 funding to study sexual development and gene shuffling in the malaria parasite. The study aims to uncover new targets for therapies to control disease transmission.
Researchers are creating synthetic microbiomes to protect aquatic environments from bacteria, improving shrimp health and reducing the risk of disease in aquaculture farms. The team is collaborating with farmers in Ecuador to develop new microbial communities that will increase resistance to pathogenic bacteria.
Researchers at the University of Gothenburg have developed a new strategy for producing oxygen-tolerant probiotics, including Faecalibacterium prausnitzii, which can improve glucose control. The combination of bacteria increased biomass and butyrate production, making it safe for human consumption.
Researchers at Baylor College of Medicine have identified a novel strategy to control the growth of triple negative breast cancer and other cancers. By targeting the enzyme MAPK4, the team found that blocking both AKT and PDK1 can effectively suppress tumor growth, offering new options for treating this devastating disease.
Researchers aim to investigate the link between gut microbes and Type 1 diabetes. Emrah Altindis's lab seeks to understand how a protein found in certain bacteria may trigger the onset of T1D.
A study from the University of Gothenburg found that even vulnerable people with compromised immune systems achieved good antibody levels after three doses of COVID-19 mRNA vaccine. This is particularly significant for those at risk of severe Covid-19, as they showed catch-up antibody responses and high levels of hybrid immunity.
Researchers at UMass Amherst have discovered a potential new medical therapy for Lyme disease using lactate dehydrogenase inhibitors typically used to combat cancer. The study found that these inhibitors substantially impacted Borrelia burgdorferi growth, making them promising candidates against Lyme infections.
Researchers found that Alzheimer's patients exhibit heightened sensitivity to light changes, which can contribute to 'sundowning' and disease progression. Light therapy could help manage these symptoms and potentially slow disease progression.
A new study by Texas A&M University researchers found substantial public support for shifting administrative burdens away from individuals and improving communication on Medicaid enrollment procedures. The survey-based study showed that people with experience in Medicaid, political liberalism, and those who struggle with administrative...
A world-first study from the University of South Australia exposes the real weight gains of everyday Australians, finding that weight fluctuates throughout the year. The study highlights the importance of targeting temporal hot spots to curb unhealthy weight fluctuations and prevent unwanted weight gain.
Researchers from Sahmyook University found that phyllodulcin, a natural sweetener found in hydrangeas, can efficiently inhibit amyloid beta (Aβ) aggregation and dissociate its aggregates in an animal model study. The study suggests that phyllodulcin may be useful in delaying the onset and progression of Alzheimer's disease.
A study found that pdm09 influenza A virus has crossed from humans to swine nearly 370 times since 2009, resulting in evolutionary changes and potential for zoonotic transmission. The analysis suggests managing human infection can help prevent pig-to-human transmission.