Articles tagged with Insulin
A new study by American Society of Nephrology confirms that intensive insulin therapy (IIT) protects kidneys in critically ill patients, reducing the risk of acute kidney injury (AKI) and death. IIT was found to be more effective in preventing AKI after surgery compared to medical ICU patients.
Research suggests that insulin inhibits resistin expression and secretion in adipocytes, but resistin induces cellular insulin resistance in hepatocytes and myoblasts. Serum resistin levels correlate negatively with insulin sensitivity in diet-induced obesity rats.
University of Florida researchers have successfully triggered insulin production in diabetic mice by injecting them with the naturally occurring protein Pdx1. The study found that daily injections of Pdx1 normalized blood glucose levels within two weeks, promoting regeneration of insulin-producing cells in the pancreas.
Research from the American Association for Cancer Research links weight gain and diabetes to increased risks of various cancers. Women with diabetes are 1.5 times more likely to develop colorectal cancer, while those with high C-peptide levels face a risk of death nearly three times higher than women with lower levels.
EpiVax receives $351,000 from JDRF to develop Epi-13, a novel therapeutic that reduces harmful immune responses and preserves insulin production. The approach uses natural regulatory T cells to induce antigen-specific adaptive tolerance induction.
JDRF is partnering with Osiris Therapeutics to support a Phase II clinical trial using Prochymal, an immunomodulatory cell therapy product, to preserve and regenerate insulin-producing cells in patients newly diagnosed with type 1 diabetes. The proposed research presents a novel approach for developing a immunomodulatory cellular therapy.
Scientists have successfully transplanted embryonic pig pancreatic cells into diabetic macaque monkeys, reducing the need for insulin injections without immune suppression. The transplants showed promise for curing type 1 and type 2 diabetes in humans with additional research.
Researchers found that insulin levels affect dopamine systems in the brain, which are involved in drug addiction and neuropsychiatric conditions. In diabetic animals, amphetamine-induced dopamine signaling was disrupted, suggesting a link between insulin status and brain function.
Researchers from Mount Sinai Hospital's Samuel Lunenfeld Research Institute have discovered a genetic 'roadblock' that sensitizes mice to insulin, paving the way for new treatments. The study found that eliminating the glycogen synthase kinase-3 (GSK-3) gene made insulin more effective in regulating blood sugar levels.
New findings suggest that misfolded proinsulin can cause beta cell dysfunction and death, leading to an insulin shortage. This can result in the hallmark symptoms of diabetes, including high blood glucose levels.
Researchers at UT Health Science Center have developed a smart particle insulin release system that detects blood sugar spikes and releases insulin to counteract them. The system, which consists of a blood sugar sensing protein and liposomes loaded with insulin, stabilized blood sugar levels in animal models for up to six hours.
Researchers discovered 10 mutations in the insulin gene causing permanent neonatal diabetes, a rare form of diabetes affecting young children. Early detection and treatment targeting ER stress might preserve or restore insulin production.
Researchers at the Salk Institute have identified TORC2 as a crucial biochemical control point linking feeding, insulin, and elevated blood sugar production in the liver. The study found that insulin turns off the CREB/TORC2 switch during feeding, highlighting potential drug targets for type II diabetes treatment.
Researchers found that immunosuppressive drugs suppress beta-cell regeneration in diabetic mice, casting doubt on long-term islet transplantation success. This could lead to breakthroughs in regenerative islet transplantation and improved treatment for type 1 diabetics.
Researchers at UT Southwestern Medical Center found that dietary fats can kill transplanted pancreas cells, leading to a decline in insulin production. Limiting fat formation might make pancreatic cell transplants more effective.
A recent study found that diabetics who use insulin pens have significantly lower healthcare costs compared to those who use syringes. The annual average healthcare costs were nearly $17,000 lower for pen users than for syringe users, resulting in substantial savings to diabetics and their insurers.
A new triple combination therapy has been successful in abolishing adverse autoimmunity against insulin-producing cells in a mouse model of Type 1 diabetes. The treatment eliminated inflammation and restored normal blood glucose levels by blocking its effects on fat and muscle tissues.
A study by UCF researchers found that insulin produced in genetically modified lettuce can restore normal blood sugar levels in diabetic mice. If successful in human trials, the method could affect millions of diabetics worldwide and reduce healthcare costs.
Researchers at Johns Hopkins have developed a new technique to track and protect transplanted insulin-producing cells in a diabetic animal model. The method uses magnetic capsules to encapsulate the cells, avoiding immune rejection and allowing for successful long-term function.
A study published in Science found that maintaining a healthy lifestyle through diet and exercise can extend lifespan by reducing insulin-like signaling in the brain. The researchers discovered that mice with reduced insulin receptor substrates lived 18% longer, while also showing improved metabolic health.
A new study finds that reducing insulin signaling in the brain can lead to a longer lifespan, with genetically engineered mice living up to 18% longer. This breakthrough suggests that diet and exercise may be key to preventing age-related diseases.
Researchers found that pumpkin extract promotes regeneration of damaged pancreatic cells in diabetic rats, boosting insulin levels and reducing the need for daily insulin injections. The extract's protective effect is attributed to antioxidants and D-chiro-inositol, which may provide a new source of medication for diabetics.
Two studies published in JCI uncover regulators of squamous cell carcinoma development, highlighting the critical role of p53 tumor suppressor gene mutations and chemokine receptor D6. The findings suggest that certain p53 mutations accelerate SCC progression and that inflammation sensitizes skin cells to tumor formation.
Researchers found that cord blood infusions significantly reduced insulin requirements and improved blood sugar control in children with type 1 diabetes. The treatment also increased regulatory immune cells, suggesting potential immunotherapy benefits.
Researchers at the University of Pennsylvania School of Medicine have discovered a potential new target for treating type 2 diabetes, a protein that regulates fat metabolism. The study found that insulin stimulates the addition of a phosphate group to this protein, preventing the activation of genes involved in fat metabolism.
A study by Dana-Farber Cancer Institute found that exercising lower insulin levels in breast cancer survivors, potentially improving prognosis. The research suggests exercise may also improve insulin sensitivity and reduce hip circumference, leading to improved health outcomes.
Researchers are testing an oral insulin capsule taken by mouth once a day to delay or prevent type 1 diabetes in people at risk. The study's goal is to identify ways to rein in the autoimmune attack on beta cells, potentially preventing the disease.
Researchers found that a 45-minute walk restores the muscle-growth-stimulating effects of insulin to levels comparable to those seen in normal young adults. This breakthrough suggests that moderate aerobic exercise may slow the rate of muscle loss in aging.
Researchers have successfully engineered adult stem cells from human cord blood to produce insulin, a potential breakthrough in treating type 1 diabetes. The discovery uses complex signals produced by embryonic mouse pancreas to direct adult stem cells into islet-like cells, producing C-peptide and insulin.
A new study published in Journal of Biological Chemistry reveals that glucose enables the development of healthy beta cells, which secrete insulin. Understanding how to switch on genes crucial for beta cell development may enable the creation of insulin-producing cells from stem cells.
A low-glycemic load diet was found to promote greater weight loss and improvements in HDL cholesterol and triglyceride concentrations among obese individuals with high insulin secretion patterns. However, no significant differences were observed between the two diets for those with normal insulin secretion.
Subconjunctival insulin delivery has been shown to treat degenerative and inflammatory responses in diabetic rat retinas. Low-dose periocular insulin delivery may also be a potential treatment for early diabetic retinopathy, according to researchers.
Adult stem cells are not responsible for producing insulin, contrary to previous research. Instead, beta cells slowly divide to replenish their own population. This discovery advances basic knowledge of insulin biology and could lead to eventual therapies.
Dr. Frances M. Ashcroft's research discovered a rare genetic form of diabetes, permanent neonatal diabetes mellitus, and developed a treatment allowing children to switch from daily insulin injections to a daily pill. The American Physiological Society presented her with the Walter B. Cannon Award.
Researchers at the University of Alberta found a connection between high insulin levels and impaired intestinal lipid metabolism in an animal model, supporting the role of intestinal metabolic dysfunction in cardiovascular disease. Excessive insulin slows chylomicron removal from the bloodstream, leading to blockages and heart problems.
A study suggests that stem cell transplantation can induce extended insulin independence in patients with type 1 diabetes. The therapy involved high-dose immunosuppression followed by autologous nonmyeloablative hematopoietic stem cell transplantation, resulting in 93% of patients achieving periods of insulin independence. The treatmen...
A study of 108 individuals with a HNF4A mutation found an average increase in birthweight of 790g, with over half of the babies classified as macrosomic. Low blood-sugar levels at birth were also more common in these infants.
LCT reports a major breakthrough in islet transplantation, with a human patient showing evidence of live porcine islet cells and insulin production ten years after the transplant. The study demonstrates the long-term safety and viability of LCT's encapsulated porcine islets without immunosuppression.
Researchers aim to identify defective point in insulin signalling pathway for PCOS treatment. Insulin resistance linked to PCOS symptoms, fertility problems, and type-2 diabetes risk.
A study identifies ceramide as a key contributor to insulin resistance, linked to saturated fats and obesity. Blocking ceramide's synthesis improves insulin response in obese rodents, offering potential for new therapies.
Researchers at the Salk Institute found that knocking out the urocortin 3 gene protects mice against high-fat diet's harmful effects by reducing insulin production. This study suggests a new peptide plays a role in insulin secretion, offering potential therapeutic benefits for treating type 2 diabetes.
A review published in Diabetes Technology & Therapeutics confirms chromium picolinate's benefits in improving glycemic control and normalizing lipid levels. Higher doses of chromium picolinate are required for people with type 2 diabetes, and its greater bioavailability may explain its superior effects.
Researchers studying mice and rats found that CLA supplementation led to rapid weight loss in mice but excessive liver fat accumulation, a common side effect of rapid weight loss. In contrast, rats on a CLA-supplemented diet showed decreased insulin resistance despite not losing weight.
A recent Joslin Diabetes Center-led study has discovered that the appetite hormone melanin concentrating hormone (MCH) plays a crucial role in the growth of insulin-producing beta cells and insulin secretion. This finding may lead to the development of new treatments that stimulate beta cell growth to treat type 1 and type 2 diabetes.
Researchers found maternal cells in children with type 1 diabetes that produce insulin and may aid in pancreas repair. The study indicates that microchimerism, the transfer of mother's cells to child during pregnancy, might have therapeutic benefits.
Researchers found a decline in allergic reactions to insulin, largely attributed to improved purification methods. New continuous subcutaneous insulin infusion (CSII) systems may help reduce these reactions even further.
JDRF is providing up to $2 million in funding for the 'Protégé' trial of teplizumab, a proprietary MacroGenics compound that has shown promise in slowing type 1 diabetes progression. The trial aims to assess teplizumab's capacity to reduce insulin requirements and maintain normal blood sugar levels.
A high-fat diet induces insulin resistance in mice, leading to increased beta-cell mass as the body attempts to compensate. Glucose levels are found to be a crucial trigger for this process, with GCK and IRS-2 playing key roles in the mechanism.
Scientists have discovered a gene called 'Titch' that plays a key role in the metabolism of insulin in flies and may also be relevant to humans. The finding has implications for the development of new drugs for Type II diabetes.
A new global malaria map is being developed to address the lack of accurate information on malaria endemicity, which will enable targeted treatment and resource allocation. The Malaria Atlas Project uses statistical approaches to fill in gaps in data and create a comprehensive map of malaria risk worldwide.
A study at the University of Illinois Chicago found that pioglitazone significantly slowed the thickening of carotid artery walls, reducing the risk of heart attack. The medication was shown to be effective regardless of age, sex, or diabetes duration.
Researchers found that pioglitazone reduced carotid artery intima-media thickness by .001 millimeters and improved blood glucose control, while increasing HDL cholesterol levels. These findings suggest pioglitazone may be a new approach to further reduce cardiovascular risk in patients with type 2 diabetes.
Diabetic patients using cutting-edge technologies like insulin pumps and blood glucose monitoring devices experience better disease management with reduced daily pain. However, the lack of strong scientific evidence and insufficient patient-education resources hinder their widespread adoption.
The three-dimensional structure of insulin-degrading enzyme suggests ways to develop drugs that could either speed up or slow down its activity. The researchers discovered small mutations that increased the enzyme's activity by 40-fold, providing a blueprint for developing similar effects.
A clinical trial shows that islet transplantation using the Edmonton Protocol can dramatically benefit certain patients with severe complications of Type 1 diabetes. The procedure has promising implications for treating this autoimmune disease, which affects an estimated 21 million Americans.
A multicenter clinical trial confirmed the Edmonton Protocol's ability to safely promote long-term stabilization of blood sugar levels in 'brittle' diabetes patients, with some achieving insulin independence. Investigators also reported improved measures of blood glucose control and reversal of hypoglycemic unawareness.
Researchers at Stanford University School of Medicine have made a significant breakthrough in understanding the connection between calcineurin and diabetes. By inhibiting calcineurin, they were able to prevent beta cells from increasing their numbers and producing insulin, offering new hope for treating type-2 diabetes. The findings al...
A study of 161 African-Americans with type 2 diabetes found that poor sleep quality and quantity were associated with higher HbA1c levels, indicating poorer blood glucose control. The results suggest that optimizing sleep duration and quality may improve glucose control in patients with type 2 diabetes.
A team of CSIRO scientists has determined the molecular structure of the insulin receptor, a significant breakthrough that builds on years of international research. The discovery is expected to facilitate future research into new therapies for diabetes and cancer.
Researchers at Washington University School of Medicine successfully transplanted pig pancreatic primordia into rats with type 2 diabetes, curing the condition without the need for immune suppression drugs. The approach, similar to one that cured type 1 diabetes in previous studies, uses embryonic cells to produce insulin.