Articles tagged with Insulin
A new study found that spacing out insulin given by an insulin pump in two doses, one over eight hours, can keep glucose levels more favorable than a single dose or double dose taken over shorter periods. This method showed improved blood glucose control after a pizza meal without causing hypoglycemic events.
Researchers at Stanford University School of Medicine have developed a new method to transform human neural stem cells into insulin-producing cells. The breakthrough could potentially lead to new ways of transplanting insulin-producing cells into people with diabetes and provide a cure for the disease.
Researchers found that rat fetuses exposed to a high-carbohydrate diet in utero developed increased insulin levels, appetite stimulation, and obesity. The study suggests that such malprogramming could be interrupted if the mother's weight and insulin levels are normalized before pregnancy.
Researchers discovered that overexpressing insulin transcription factors MafA, PDX-1, and NeuroD in the liver of diabetic mice increased insulin gene expression and improved glucose tolerance. This breakthrough suggests a crucial role for MafA as a novel therapeutic target for diabetes.
A new mouse model has shown reduced blood glucose levels and lower serum insulin, indicating improved glucose tolerance in the liver. The study found that Gab1 acts as a negative regulator on insulin signal strength in the liver, suggesting potential therapeutic targets for type 2 diabetes.
Researchers at Northwell Health's Institute for Medical Research have identified a crucial gene in type 1 diabetes development, which triggers the immune system to attack and kill beta cells. Blocking this protein may halt the harmful process and allow remaining beta cells to produce insulin.
Researchers found that leptin regulates blood sugar through two brain-body pathways, one controlling appetite and fat storage, and another influencing liver glucose reserves. The study suggests that disrupting both pathways may be necessary for developing full-blown diabetes.
Insulin production in the brain contributes to Alzheimer's progression, with growth factors playing a key role. Researchers found reduced insulin levels in affected areas, opening door for targeted brain treatment.
Research at Joslin Diabetes Center reveals that prenatal undernutrition can lead to impaired insulin production and higher blood glucose levels, setting the stage for type 2 diabetes. The study found that low-birth-weight mice had abnormal insulin secretion patterns, leading to permanent impairment.
Researchers successfully transplanted islets from a single donor pancreas into eight women with type 1 diabetes, achieving insulin independence and freedom from hypoglycemia. The trial resulted in superior glycemic control in four of five recipients with sustained insulin independence.
A study found that Salacia oblonga, a herb native to India and Sri Lanka, decreases insulin and blood glucose levels when consumed with meals. The herb works by binding to intestinal enzymes that break down carbohydrates, reducing the amount of glucose in the bloodstream.
The Physicians Committee for Responsible Medicine (PCRM) has developed the world's first cruelty-free insulin assay, a significant improvement over existing methods that rely on animal testing. The new test kit uses synthetic replacement for fetal calf serum and is now commercially available.
Researchers propose a new antiviral therapy targeting the smallpox growth factor, demonstrating effectiveness in lowering morbidity and mortality in infected mice. In another study, human bone marrow-derived stem cells are shown to regenerate myocardium after myocardial infarction, providing a potential approach for heart repair.
A new study has identified a high mortality rate among advanced heart failure patients who use insulin to manage diabetes. Researchers found one-year survival rates of 62.1% for insulin-treated diabetic patients, compared to 89.7% for non-diabetic patients and 85.8% for non-insulin-treated diabetic patients.
The Genetics of Kidneys in Diabetes (GoKinD) collection provides nearly 10,000 DNA and clinical data samples from adults with type 1 diabetes in the US and Canada. The resource aims to study genes linked to kidney disease and diabetes.
Anthocyanins in cherries show promise for preventing and controlling type 2 diabetes, with a 50% increase in insulin levels observed in mouse cells. More human studies are needed to confirm these findings.
Researchers found that reducing insulin-like molecules in fruit fly brains increases the intoxicating effect of alcohol, mimicking human vulnerabilities. Insulin regulates behavior and may be crucial in determining response to addictive drugs, offering potential therapy for alcoholism.
Researchers found that DHEA supplementation reduced visceral fat by 10.2% in women and 7.4% in men, improving insulin action and glucose levels. DHEA therapy also decreased subcutaneous abdominal fat by an average of 6%.
Dr. von Andrian will focus on setting up a new microscopy model at Joslin to study the interaction between islet cells and immune cells, aiming to develop a simple model for studying islet cells in living animals. He will also collaborate with Joslin researchers on stem cell projects and vascular complications in people with diabetes.
Researchers identified a gene called PTPN1 that represses insulin response and is associated with diabetes. The study found a common variant of the gene increases the risk of diabetes in Caucasians, while another form appears protective.
A clinical trial found that insulin pump therapy was safe and well-tolerated in preschool-aged children with type 1 diabetes. Parents were also satisfied with the devices, with 95 percent continuing use after a six-month study. The benefits of insulin pump therapy are still being evaluated in terms of flexibility and convenience.
A large study found that teenagers with insulin resistance are at a higher risk of developing high blood pressure as adults. Insulin resistance, a precursor to diabetes, was linked to increased systolic blood pressure and obesity in the long-term study.
Researchers found that six days of moderate-intensity exercise improved insulin action in sedentary, overweight individuals by 40%, while traditional and novel cardiovascular risk factors showed positive trends. In contrast, those who consumed sports drinks and additional food during exercise showed no significant changes or even negat...
A retrospective cohort study of 24,918 patients with type 2 diabetes found those on more than three years of insulin therapy have a significantly higher risk of developing colorectal cancer. The study's lead author hopes the findings will lead to more effective cancer prevention efforts.
A three-month study found that patients with type 2 diabetes preferred the prefilled NovoLog(R) Mix 70/30 FlexPen(R) disposable pen due to its ease of use and flexibility. Patients who had never used insulin before reported significant benefits in perceived clinical efficacy.
Researchers at Stanford University School of Medicine have discovered a primordial pancreas in fruit flies that produces both insulin and glucagon, two hormones crucial for regulating blood sugar levels. This breakthrough could lead to the development of new drugs for treating diabetes.
A study led by Mount Sinai School of Medicine researchers found that imidazole-4-acetic acid-ribotide may be a primary cause of high blood pressure and a molecular link to diabetes. The molecule binds to receptors in the brain, leading to elevated blood pressure, which can also impair insulin release.
A team at Georgia Institute of Technology has developed heat-controlled drug implants that can release medication over an extended period, targeting conditions like diabetes. The films, made from microparticles, could be triggered by blood glucose monitors to administer insulin or other medications.
A study published in Mayo Clinic Proceedings found that intensive glucose management in ICU patients resulted in a significant reduction in mortality rates, with a decrease of 29.3% and the prevention of 49 deaths. The treatment involved monitoring blood glucose levels and administering insulin to prevent elevations.
Researchers at Baylor College of Medicine have discovered a new gene associated with an increased risk of developing type 1 diabetes. SUMO-4 plays a key role in regulating the immune system and has been found to prolong the inflammatory response when mutated, leading to cell death and destruction of insulin-producing cells.
Researchers have found that triple therapy using insulin, metformin, and a thiazolidinedione drug can control blood sugar levels without weight gain. The study showed that nearly all patients reduced their HbAlc levels below 7 percent, with some even achieving levels below 6 percent.
Researchers have discovered a promising treatment for polycystic ovary syndrome (PCOS) using rosiglitazone, an insulin sensitizer that reduces excess androgen levels and improves menstrual cycles. The study showed significant benefits in insulin resistance and ovarian function, offering new hope for women with PCOS.
Removing abdominal fat by liposuction did not improve insulin sensitivity or reduce risk factors for heart disease. However, the procedure was found to be safe for large-volume fat removal.
A new study found that insulin detemir significantly reduces day-to-day variability in blood glucose levels and nighttime hypoglycemia risk compared to NPH. Insulin detemir also leads to less weight gain in patients with type 1 diabetes.
The INITIATE study found that NovoLog Mix 70/30 achieved better A1C levels and improved post-mealtime glucose control than insulin glargine. This suggests a physiological approach to controlling insulin needs, which may encourage clinicians to adopt this treatment option.
Studies presented at the American Diabetes Association annual meeting showed ACTOS to be effective in reducing fasting insulin levels and improving A1C levels, with significant benefits seen when used alone or in combination with other oral antidiabetic medications.
The study confirmed that islet transplantation works for patients with serious and unstable type 1 diabetes, allowing them to be free from daily insulin injections for up to one year. Few treatment-related complications were noted, with minor side effects such as mouth ulcers and diarrhea.
A study published in Nature reveals that insulin regulates tissue aging and extends the lifespan of genetically modified flies. By blocking insulin's action in specific cells, the entire body stays healthier longer, staving off age-related diseases.
Researchers found that insulin and glucose in type-2 diabetics' urine increases E. coli's adherence, leading to a greater risk of UTIs. Insulin also affects the bacteria's surface characteristics, potentially providing some protection against antibiotics.
A pilot study from the University of Michigan Health System found insulin pumps to be as effective as injections in controlling blood sugar levels and reducing parental stress. Parents reported lower worry and emotional stress with pump therapy, while those on injections experienced more anxiety.
ACTOS, an insulin sensitizer, is shown to improve diabetic dyslipidemia components when administered in combination with other diabetes therapies. The study found significant increases in average and peak LDL and HDL particle size, accompanied by a decrease in particle density.
Researchers at UCSB are studying cinnamon's effects on mice with diabetes, finding a compound that has insulin-like activity and may help alleviate the condition. The study aims to explore the potential of cinnamon as a natural treatment for type II diabetes, which affects over 170 million people worldwide.
Researchers at U of T's Molecular Design and Information Technology Centre have created the first small molecules that bind to the insulin receptor, paving the way for oral insulin development. The breakthrough could lead to a new treatment option for over two million Canadians with diabetes.
A team of researchers developed an optical glucose sensor that functions as a continuous glucose monitor capable of operating under physiological conditions. The sensor shows outstanding glucose response over the full range of glucose levels, which could reduce pain, costs, and deaths in ICU patients.
Scientists successfully transplanted embryonic pig pancreas cells into rats with diabetes, halting the disease without immune suppression drugs. The breakthrough could lead to a new treatment option for humans, bypassing challenges associated with human insulin-producing cells.
Researchers found that insulin can reduce concentrations of C-reactive protein and serum amyloid A by 40% and 50%, respectively, during the 48 hours following a heart attack. Insulin also appeared to stem the increase of plasminogen activator inhibitor and reduced creatinine kinase levels, indicating improved heart muscle protection.
Researchers have discovered insulin-producing cells in various tissues in diabetic mice, which can be triggered by high blood sugar. The findings suggest that these cells could be harnessed to generate insulin-producing cells from other tissues, offering a potential breakthrough for diabetes treatment.
Type I diabetics experience bone loss due to insufficient amylin production, which reduces osteoclast cell activity. Amylin injection or pathway activation may help correct this issue and alleviate osteoporosis.
A Baylor College of Medicine study reveals that the hormone amylin inhibits bone loss and resorption. Mice without amylin have less bone mass due to increased bone destruction, suggesting a potential therapeutic avenue for preventing osteoporosis in Type 1 diabetes patients.
Understanding insulin-regulatory pathways is crucial to identifying health-enhancing and disease-endangering manipulations. Research has identified components of key insulin-controlled signaling pathways, including IRS1 and IRS2, which regulate body growth, glucose homeostasis, and female fertility.
Research suggests that GLP-1 can generate new insulin and increase the growth of new islet cells in human pancreas tissue. This treatment delayed cell death by up to 45% and improved insulin secretion in response to glucose, offering a potential therapeutic approach for Type 2 diabetes.
Researchers have found that PARP inhibitors can protect brain cells from damage caused by insulin shock, a common complication of severe hypoglycemia. The study shows significant reductions in brain cell death when rats received PARP inhibitors after being induced into a hypoglycemic coma.
Researchers at UT Southwestern Medical Center have found that insulin family signaling plays a critical role in male sex determination. The discovery furthers the understanding of testes formation and may lead to new treatments for reproductive disorders. Insulin-like genes, including Insl3, also play a key role in this process.
Research shows that moderate white wine consumption after meals can significantly decrease insulin levels, potentially leading to serious health consequences. The study suggests that drinking white wine alone may activate a new energy system in the human body, influencing glucose production and usage.
Scientists discovered a chemical relay that controls whether the body burns sugars or fats for energy. The discovery may help design better treatments for insulin resistance and ultimately prevent adult-onset diabetes.
Monitoring waistline fat, insulin levels, and lipid particles can detect early signs of heart disease in women. Targeted interventions can be initiated to prevent progression of the disease.
Researchers have discovered a new protein, TUG, that controls the movement of GLUT4, a glucose transporter in cells. This finding may lead to new drug targets for treating Type 2 diabetes.
The study found that gastric bypass surgery significantly improved diabetes outcomes in patients, with nearly all achieving normal blood sugar levels and reducing their reliance on anti-diabetic medications. Patients with shorter disease durations and milder type 2 diabetes saw the greatest improvements in glycemic control.
Exercising and losing weight can significantly reduce excess insulin production and lower blood pressure in patients with Syndrome X. The study found that overweight patients experienced a 47% reduction in hyperinsulinemia with combined exercise and weight loss.
Researchers successfully transplanted embryonic pancreatic tissue into rats with Type 1 diabetes, producing enough insulin to maintain normal blood-sugar levels. This breakthrough method has promising results and could potentially overcome the shortage of human organs for transplant.