Articles tagged with Insulin
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Researchers have found that triple therapy using insulin, metformin, and a thiazolidinedione drug can control blood sugar levels without weight gain. The study showed that nearly all patients reduced their HbAlc levels below 7 percent, with some even achieving levels below 6 percent.
Removing abdominal fat by liposuction did not improve insulin sensitivity or reduce risk factors for heart disease. However, the procedure was found to be safe for large-volume fat removal.
Researchers have discovered a promising treatment for polycystic ovary syndrome (PCOS) using rosiglitazone, an insulin sensitizer that reduces excess androgen levels and improves menstrual cycles. The study showed significant benefits in insulin resistance and ovarian function, offering new hope for women with PCOS.
A new study found that insulin detemir significantly reduces day-to-day variability in blood glucose levels and nighttime hypoglycemia risk compared to NPH. Insulin detemir also leads to less weight gain in patients with type 1 diabetes.
The INITIATE study found that NovoLog Mix 70/30 achieved better A1C levels and improved post-mealtime glucose control than insulin glargine. This suggests a physiological approach to controlling insulin needs, which may encourage clinicians to adopt this treatment option.
The study confirmed that islet transplantation works for patients with serious and unstable type 1 diabetes, allowing them to be free from daily insulin injections for up to one year. Few treatment-related complications were noted, with minor side effects such as mouth ulcers and diarrhea.
Studies presented at the American Diabetes Association annual meeting showed ACTOS to be effective in reducing fasting insulin levels and improving A1C levels, with significant benefits seen when used alone or in combination with other oral antidiabetic medications.
A study published in Nature reveals that insulin regulates tissue aging and extends the lifespan of genetically modified flies. By blocking insulin's action in specific cells, the entire body stays healthier longer, staving off age-related diseases.
Researchers found that insulin and glucose in type-2 diabetics' urine increases E. coli's adherence, leading to a greater risk of UTIs. Insulin also affects the bacteria's surface characteristics, potentially providing some protection against antibiotics.
A pilot study from the University of Michigan Health System found insulin pumps to be as effective as injections in controlling blood sugar levels and reducing parental stress. Parents reported lower worry and emotional stress with pump therapy, while those on injections experienced more anxiety.
ACTOS, an insulin sensitizer, is shown to improve diabetic dyslipidemia components when administered in combination with other diabetes therapies. The study found significant increases in average and peak LDL and HDL particle size, accompanied by a decrease in particle density.
Researchers at UCSB are studying cinnamon's effects on mice with diabetes, finding a compound that has insulin-like activity and may help alleviate the condition. The study aims to explore the potential of cinnamon as a natural treatment for type II diabetes, which affects over 170 million people worldwide.
Researchers at U of T's Molecular Design and Information Technology Centre have created the first small molecules that bind to the insulin receptor, paving the way for oral insulin development. The breakthrough could lead to a new treatment option for over two million Canadians with diabetes.
A team of researchers developed an optical glucose sensor that functions as a continuous glucose monitor capable of operating under physiological conditions. The sensor shows outstanding glucose response over the full range of glucose levels, which could reduce pain, costs, and deaths in ICU patients.
Scientists successfully transplanted embryonic pig pancreas cells into rats with diabetes, halting the disease without immune suppression drugs. The breakthrough could lead to a new treatment option for humans, bypassing challenges associated with human insulin-producing cells.
Researchers found that insulin can reduce concentrations of C-reactive protein and serum amyloid A by 40% and 50%, respectively, during the 48 hours following a heart attack. Insulin also appeared to stem the increase of plasminogen activator inhibitor and reduced creatinine kinase levels, indicating improved heart muscle protection.
Researchers have discovered insulin-producing cells in various tissues in diabetic mice, which can be triggered by high blood sugar. The findings suggest that these cells could be harnessed to generate insulin-producing cells from other tissues, offering a potential breakthrough for diabetes treatment.
A Baylor College of Medicine study reveals that the hormone amylin inhibits bone loss and resorption. Mice without amylin have less bone mass due to increased bone destruction, suggesting a potential therapeutic avenue for preventing osteoporosis in Type 1 diabetes patients.
Type I diabetics experience bone loss due to insufficient amylin production, which reduces osteoclast cell activity. Amylin injection or pathway activation may help correct this issue and alleviate osteoporosis.
Understanding insulin-regulatory pathways is crucial to identifying health-enhancing and disease-endangering manipulations. Research has identified components of key insulin-controlled signaling pathways, including IRS1 and IRS2, which regulate body growth, glucose homeostasis, and female fertility.
Research suggests that GLP-1 can generate new insulin and increase the growth of new islet cells in human pancreas tissue. This treatment delayed cell death by up to 45% and improved insulin secretion in response to glucose, offering a potential therapeutic approach for Type 2 diabetes.
Researchers at UT Southwestern Medical Center have found that insulin family signaling plays a critical role in male sex determination. The discovery furthers the understanding of testes formation and may lead to new treatments for reproductive disorders. Insulin-like genes, including Insl3, also play a key role in this process.
Researchers have found that PARP inhibitors can protect brain cells from damage caused by insulin shock, a common complication of severe hypoglycemia. The study shows significant reductions in brain cell death when rats received PARP inhibitors after being induced into a hypoglycemic coma.
Research shows that moderate white wine consumption after meals can significantly decrease insulin levels, potentially leading to serious health consequences. The study suggests that drinking white wine alone may activate a new energy system in the human body, influencing glucose production and usage.
Scientists discovered a chemical relay that controls whether the body burns sugars or fats for energy. The discovery may help design better treatments for insulin resistance and ultimately prevent adult-onset diabetes.
Monitoring waistline fat, insulin levels, and lipid particles can detect early signs of heart disease in women. Targeted interventions can be initiated to prevent progression of the disease.
Researchers have discovered a new protein, TUG, that controls the movement of GLUT4, a glucose transporter in cells. This finding may lead to new drug targets for treating Type 2 diabetes.
The study found that gastric bypass surgery significantly improved diabetes outcomes in patients, with nearly all achieving normal blood sugar levels and reducing their reliance on anti-diabetic medications. Patients with shorter disease durations and milder type 2 diabetes saw the greatest improvements in glycemic control.
Researchers successfully transplanted embryonic pancreatic tissue into rats with Type 1 diabetes, producing enough insulin to maintain normal blood-sugar levels. This breakthrough method has promising results and could potentially overcome the shortage of human organs for transplant.
Exercising and losing weight can significantly reduce excess insulin production and lower blood pressure in patients with Syndrome X. The study found that overweight patients experienced a 47% reduction in hyperinsulinemia with combined exercise and weight loss.
Researchers have discovered an engineered mouse that can eat a high-fat diet without gaining weight or developing diabetes. The mouse lacks the SCD-1 gene, which affects fat production and glucose regulation. As a result, muscle cells are more sensitive to insulin, enabling them to absorb glucose and regulate blood sugar levels.
Researchers discuss new findings on HIV-associated dementia and its potential association with the presence of MDM. Additionally, studies suggest that treating post-Lyme disease with antibiotics does not provide benefits, while a possible link is found between insulin and Alzheimer's disease risk factors.
Researchers identify protein that bridges signaling and membrane movement, linking insulin's action to glucose uptake. This finding could provide clues for understanding type 2 diabetes, where muscle and fat tissues resist insulin.
Researchers found that pioglitazone reduced the risk of developing type 2 diabetes by 55 percent, with only one woman out of 76 participants developing diabetes after a year. The study suggests that pioglitazone can protect women from developing insulin resistance and related health issues.
Researchers at UH have discovered why insulin crystals do not form a certain defect called step bunching, which can lead to defects in crystals used in lasers. Understanding this process can help improve crystal-growing methods and lead to breakthroughs in medicine and technology.
Researchers achieved best survival to date with islet cells from swine, reversing insulin dependency in diabetic cynomolgus monkeys. The study showed no evidence of antibody-mediated rejection, a major type of organ rejection, and demonstrated the potential for xenotransplantation.
The ITN multicenter islet transplant trial has confirmed that the procedure can be of great benefit to patients with serious and unstable type 1 diabetes. However, differences in success rates between individual clinical centers were noted, highlighting the need for expertise in islet preparation procedures.
A team approach combining medical tests, operative biopsies, and precise surgery successfully cured 31 of 34 newborns with focal congenital hyperinsulinism (HI). The procedure involves removing the diseased portion of the pancreas while preserving the rest of the organ.
Researchers discovered that lisofylline treatment reduced the incidence of Type 1 diabetes in mice by 67%, indicating its potential to protect insulin-producing cells. The study published in Pancreas journal suggests that lisofylline may slow down or prevent the disease in people at high-risk.
Teggreen, a green tea polyphenols product, improves lipid and glucose metabolisms in obese rats by enhancing insulin sensitivity and balancing fat deposit and burning. The study reveals significant benefits of Tegreen treatment, including decreased fasting blood glucose and serum triglycerides.
A study by Emory researchers found that controlling blood glucose levels through aggressive insulin therapy can significantly reduce mortality in critically-ill neurological patients. The research, conducted in a neurointensive care unit, used continuous intravenous insulin drip to achieve tighter control of glucose levels.
Researchers found a link between African-origin genetic markers and decreased insulin sensitivity in children, suggesting a genetic basis for the disparity. The study also highlights the importance of genetic factors in understanding and preventing type 2 diabetes in black communities.
A study of 289 teenagers found that cardiovascular fitness and lower body fat are independently associated with greater insulin sensitivity. Improving fitness or reducing body fat could protect high-risk children from developing insulin resistance, a precursor to diabetes.
A UC Irvine study found that adding antioxidants to insulin therapy can improve its ability to reduce blood sugar and prevent organ damage. Treating rats with insulin alone only partially succeeded, but vitamins C and E spared sugars, proteins, and nitric oxide from attack.
Scientists have developed a new mouse model of lipoatrophic diabetes, which reveals the genetic pathway underlying the disease. The study also suggests that leptin therapy may be effective in treating humans with lipoatrophic diabetes.
A Keck School of Medicine study finds that black and Hispanic children are more insulin-resistant, but their bodies cope differently with resistance. Insulin resistance can worsen over time, leading to type 2 diabetes.
Researchers are developing non-invasive methods for delivering therapies, such as patches, inhalers, and ultrasound, to overcome limitations of traditional drug delivery. Tissue engineering also holds promise for growing new organs and tissues using cells and polymers, offering potential solutions for diseases like diabetes and paralysis.
A study suggests that a high-starch diet may increase the risk of pancreatic cancer in overweight and sedentary women. Women with diets heavy in starchy foods were found to be more than two-and-a-half times more likely to develop pancreatic cancer than those with low glycemic loads.
The InnoLet system features a dosing dial and reversible dose mechanism, making it easier for patients to administer accurate doses. Clinical studies show that 95% of participants rated the device as 'very easy' or 'easy' to use.
A new study demonstrates that pig cells can be transplanted into children with type 1 diabetes without the need for immunosuppressive drugs, resulting in some patients being off insulin. The use of embryonic stem cells and novel preservation methods also holds promise for increasing the availability of viable cells for transplantation.
A new study suggests that women with Polycystic Ovary Syndrome (PCOS) and their siblings with hormone problems have the same gene defect. The study found that approximately 50% of PCOS sisters had elevated androgen levels, while PCOS brothers had significantly elevated DHEAS levels.
Researchers analyzed biomarker data from over 700 healthy men and 60 rhesus monkeys, finding lower body temperatures, blood insulin levels, and higher DHEAS levels in those on a calorically restricted diet were associated with longer lifespan. The study suggests potential for developing compounds that mimic the benefits of caloric rest...
Researchers found that early treatment with insulin-resistant drugs saves about 30% more beta cells than late intervention, preventing type 2 diabetes. The study suggests that lessening the workload on beta cells can prevent or slow disease onset.
A new study by University at Buffalo researchers found that insulin sensitizer rosiglitazone (Avandia) has a significant anti-inflammatory effect in Type 2 diabetes patients. The drug decreased levels of oxygen free radicals and inflammatory markers, reducing the risk of heart disease.
Recent clinical trials found that low-dose insulin injections do not delay or prevent type 1 diabetes in high-risk individuals, contrary to earlier animal studies and pilot trials. However, the trials revealed valuable insights into immune and metabolic markers for assessing diabetes risk and identifying potential prevention strategies.
Researchers at Stanford University have created diabetic fruit flies by destroying insulin-producing cells, allowing them to study the development of pancreatic cells. The fly model could help understand the origin of insulin-producing cells in people with Type I diabetes.
A recent study by Duke University Medical Center researchers found that toddlers and preschool children with Type I diabetes can successfully use insulin pumps with proper supervision. The study involved nine children who were treated with insulin pumps for seven to 19 months, resulting in improved blood glucose control and a significa...
A UB study finds that early nutritional modification programs metabolism, predisposing to obesity. High carbohydrate diets led to changes in islet cells, overproduction of insulin, and alterations in the insulin secretory pathway.
A new study examines the relationship between adiponectin levels, body composition, and obesity-related risk factors in children. The research suggests that children from lower socio-economic backgrounds are at high risk of developing type-2 diabetes due to dysregulation of adiponectin secretion.
Researchers found that extra sugar on proteins can cause insulin resistance in cells. The discovery provides a potential target for developing new strategies to treat or prevent diabetes.