Articles tagged with Insulin
A team approach combining medical tests, operative biopsies, and precise surgery successfully cured 31 of 34 newborns with focal congenital hyperinsulinism (HI). The procedure involves removing the diseased portion of the pancreas while preserving the rest of the organ.
Researchers discovered that lisofylline treatment reduced the incidence of Type 1 diabetes in mice by 67%, indicating its potential to protect insulin-producing cells. The study published in Pancreas journal suggests that lisofylline may slow down or prevent the disease in people at high-risk.
Teggreen, a green tea polyphenols product, improves lipid and glucose metabolisms in obese rats by enhancing insulin sensitivity and balancing fat deposit and burning. The study reveals significant benefits of Tegreen treatment, including decreased fasting blood glucose and serum triglycerides.
A study by Emory researchers found that controlling blood glucose levels through aggressive insulin therapy can significantly reduce mortality in critically-ill neurological patients. The research, conducted in a neurointensive care unit, used continuous intravenous insulin drip to achieve tighter control of glucose levels.
Researchers found a link between African-origin genetic markers and decreased insulin sensitivity in children, suggesting a genetic basis for the disparity. The study also highlights the importance of genetic factors in understanding and preventing type 2 diabetes in black communities.
A study of 289 teenagers found that cardiovascular fitness and lower body fat are independently associated with greater insulin sensitivity. Improving fitness or reducing body fat could protect high-risk children from developing insulin resistance, a precursor to diabetes.
A UC Irvine study found that adding antioxidants to insulin therapy can improve its ability to reduce blood sugar and prevent organ damage. Treating rats with insulin alone only partially succeeded, but vitamins C and E spared sugars, proteins, and nitric oxide from attack.
Scientists have developed a new mouse model of lipoatrophic diabetes, which reveals the genetic pathway underlying the disease. The study also suggests that leptin therapy may be effective in treating humans with lipoatrophic diabetes.
A Keck School of Medicine study finds that black and Hispanic children are more insulin-resistant, but their bodies cope differently with resistance. Insulin resistance can worsen over time, leading to type 2 diabetes.
Researchers are developing non-invasive methods for delivering therapies, such as patches, inhalers, and ultrasound, to overcome limitations of traditional drug delivery. Tissue engineering also holds promise for growing new organs and tissues using cells and polymers, offering potential solutions for diseases like diabetes and paralysis.
A study suggests that a high-starch diet may increase the risk of pancreatic cancer in overweight and sedentary women. Women with diets heavy in starchy foods were found to be more than two-and-a-half times more likely to develop pancreatic cancer than those with low glycemic loads.
The InnoLet system features a dosing dial and reversible dose mechanism, making it easier for patients to administer accurate doses. Clinical studies show that 95% of participants rated the device as 'very easy' or 'easy' to use.
A new study demonstrates that pig cells can be transplanted into children with type 1 diabetes without the need for immunosuppressive drugs, resulting in some patients being off insulin. The use of embryonic stem cells and novel preservation methods also holds promise for increasing the availability of viable cells for transplantation.
A new study suggests that women with Polycystic Ovary Syndrome (PCOS) and their siblings with hormone problems have the same gene defect. The study found that approximately 50% of PCOS sisters had elevated androgen levels, while PCOS brothers had significantly elevated DHEAS levels.
Researchers analyzed biomarker data from over 700 healthy men and 60 rhesus monkeys, finding lower body temperatures, blood insulin levels, and higher DHEAS levels in those on a calorically restricted diet were associated with longer lifespan. The study suggests potential for developing compounds that mimic the benefits of caloric rest...
Researchers found that early treatment with insulin-resistant drugs saves about 30% more beta cells than late intervention, preventing type 2 diabetes. The study suggests that lessening the workload on beta cells can prevent or slow disease onset.
A new study by University at Buffalo researchers found that insulin sensitizer rosiglitazone (Avandia) has a significant anti-inflammatory effect in Type 2 diabetes patients. The drug decreased levels of oxygen free radicals and inflammatory markers, reducing the risk of heart disease.
Recent clinical trials found that low-dose insulin injections do not delay or prevent type 1 diabetes in high-risk individuals, contrary to earlier animal studies and pilot trials. However, the trials revealed valuable insights into immune and metabolic markers for assessing diabetes risk and identifying potential prevention strategies.
Researchers at Stanford University have created diabetic fruit flies by destroying insulin-producing cells, allowing them to study the development of pancreatic cells. The fly model could help understand the origin of insulin-producing cells in people with Type I diabetes.
A recent study by Duke University Medical Center researchers found that toddlers and preschool children with Type I diabetes can successfully use insulin pumps with proper supervision. The study involved nine children who were treated with insulin pumps for seven to 19 months, resulting in improved blood glucose control and a significa...
A UB study finds that early nutritional modification programs metabolism, predisposing to obesity. High carbohydrate diets led to changes in islet cells, overproduction of insulin, and alterations in the insulin secretory pathway.
A new study examines the relationship between adiponectin levels, body composition, and obesity-related risk factors in children. The research suggests that children from lower socio-economic backgrounds are at high risk of developing type-2 diabetes due to dysregulation of adiponectin secretion.
Researchers found that extra sugar on proteins can cause insulin resistance in cells. The discovery provides a potential target for developing new strategies to treat or prevent diabetes.
A study suggests that insulin can suppress a pro-inflammatory transcription factor that promotes clot formation in blood vessels. Insulin infusion reduced levels of tissue factor and plasminogen activator inhibitor-1, key players in the development of human and mouse atherosclerosis.
Researchers are studying abnormal beta cell function to better understand canine and feline diabetes. They found that certain proteins play a crucial role in insulin secretion, which may contribute to the development of diabetes.
Scientists discovered that mice without the myostatin protein gain less fat as they age, even though they eat the same amount of food. This could lead to a new approach for treating type 2 diabetes by increasing muscle mass, which may improve insulin sensitivity.
Research reveals insulin's impact on cardiac growth and development. Insulin signaling pathways regulate the expression of key genes involved in cardiac hypertrophy.
Researchers found that DiaPep277 modulates the immune system to prevent autoimmune diabetes progression. The study showed significant increases in C-peptide levels and reductions in insulin requirements among patients receiving DiaPep277.
Researchers at Hadassah-Hebrew University Medical School and Peptor Ltd. successfully arrested the progression of Type I diabetes in newly diagnosed patients using DiaPep277, an experimental drug that alters immune cell behavior.
Researchers discovered that Foxo1 is involved in regulating glucose metabolism and promoting insulin resistance in cultured kidney cells. Increased Foxo1 activity was linked to decreased insulin sensitivity, highlighting its potential as a therapeutic target for treating related disorders.
Researchers discovered that insulin sensitivity decreases by 32% among pubertal teens, while those who haven't started puberty experience increased sensitivity. The study suggests that changes during puberty contribute to lowered insulin sensitivity, with potential implications for preventing type 2 diabetes.
A recent study has identified a protein called Akt1 that promotes the growth and increase in size of pancreatic β cells, which can help prevent or treat type 2 diabetes. The researchers found that mice bred to produce excess Akt1 protein were more tolerant of glucose and resistant to diabetes.
A University of Otago study found that intensive exercise and specific dietary changes can improve insulin sensitivity by up to 20% in otherwise-healthy individuals. The research, which included 79 participants aged 35-60, also showed a significant improvement in insulin action among Māori participants.
Researchers develop biomimetic gel that binds to glucose molecules, potentially triggering insulin release in diabetics. The gel's sensing mechanism could be incorporated into implantable devices, providing therapy for type one diabetes.
Researchers have developed a polymer that protects insulin until it reaches the small intestine, where it can be absorbed into the bloodstream. This breakthrough offers potential relief for people with diabetes who struggle with painful injections.
Researchers at Purdue University have demonstrated a method for delivering insulin orally using microscopic particles that protect the medicine from stomach acid until they can be released in the intestines. The system has been shown to be non-toxic and effective, with the potential to revolutionize treatment for insulin-dependent diab...
A new study by University at Buffalo researchers found that insulin can reduce pro-inflammatory components in the bloodstream while increasing anti-inflammatory components. The results suggest that insulin may have anti-atherosclerotic effects and potentially reduce the risk of heart attack, contrary to previous assumptions.
IDX1's role in regulating glucose levels and insulin sensitivity has been identified, shedding light on potential therapeutic targets. Further research is needed to fully understand the mechanisms by which IDX1 influences diabetes progression.
Researchers at Beth Israel Deaconess Medical Center found that fat cells can trigger insulin resistance in muscle and liver, leading to type 2 diabetes. The study, published in Nature, reveals a potential new target for diabetes treatment and prevention by disrupting the communication between fat cells and other tissues.
A new study found that women younger than 60 had a higher mortality rate after heart attacks than men of the same age, with an almost threefold higher risk for death. Researchers also discovered that inhaled insulin shows promise for treating type 2 diabetes, improving blood sugar control without serious side effects.
A new device that combines two sensors to measure glucose and insulin levels simultaneously could provide early warning for diabetics. This technology has the potential to help predict blood sugar changes and stave off complications such as kidney failure and heart disease.
Recent advances in diabetes treatment have improved blood sugar control, allowing patients to dodge complications until late life. New drug therapies, including metformin and insulin analogs, have enhanced treatment possibilities.
A team of Type 1 diabetic athletes, including University of North Carolina M.D.-Ph.D. candidate Jeremy Ackerman, will climb Cerro Aconcagua in Argentina to raise awareness about diabetes and conduct scientific research on the effects of altitude on diabetics.
Researchers found that participants with high insulin resistance were more likely to develop high blood pressure, highlighting a potential new treatment target. The study also suggests that reducing insulin resistance may help prevent hypertension and cardiovascular disease.
Insulin reduces expression of molecule promoting inflammation and clogging of arteries, increasing production of vasodilator nitric oxide. The study's findings indicate insulin may have an antiatherosclerotic role, potentially protecting people at risk of CVD.
A diagnostic test allows physicians to identify a rare, severe imbalance of insulin levels in newborns, which can be cured with organ-sparing surgery. The test differentiates between diffuse and focal forms of congenital hyperinsulinism (HI), enabling targeted treatment.
Researchers found that Avandia had a lower rate of elevated alanine aminotransferase (ALT) levels compared to placebo and other treatments. This suggests that Avandia is a valuable option for patients with type 2 diabetes, as it can help improve blood sugar control and potentially slow disease progression.
UCSD School of Medicine scientists have successfully cultured human beta cells that can produce insulin indefinitely. The immortal cell line holds promise for treating people with diabetes through transplantation, potentially offering an unlimited source of insulin-producing tissue.
Research suggests that honey is an effective form of carbohydrate gel for athletes, providing a sustained energy boost without causing a rapid spike in blood sugar levels. The study found that honey's lower glycemic index profile makes it an ideal choice for pre-workout consumption, potentially improving endurance and reducing fatigue.
Weizmann Institute researchers find a family of amino acid analogues that effectively regulate glucose levels in diabetic laboratory animals. The new compounds have greater antidiabetic potency than vanadium alone, offering a promising treatment option for type II diabetes.
Researchers at the University of Illinois have isolated and characterized an insulin gene from the marine mollusk Aplysia californica. The study reveals a unique peptide, the 'D' peptide, which is separated from the standard two-chain insulin structure by a 'C' peptide.
Rosiglitazone reduces insulin resistance by 33% and improves pancreatic function in individuals with type 2 diabetes. The treatment also reduces insulin levels in the blood, potentially alleviating the need for regular insulin injections.
Researchers at the University of Delaware have developed a mathematical algorithm that can precisely control blood-sugar levels in people with Type I diabetes using an implantable insulin pump. The chip-based system predicts insulin needs based on glucose sensor data, reducing peak glucose levels by 44% and overshoot by 80%.
Scientists have identified a compound that mimics the effects of insulin in mice, offering hope for a pill-based treatment for diabetes. The new substance, L-783,281, is a nonpeptide molecule that can be absorbed through the bloodstream after being swallowed, potentially providing an alternative to insulin injections.
A new study reveals that adult-onset diabetics may be suffering from an 'imbalancing act' caused by a key enzyme called PFK, which regulates glucose metabolism. The researchers found that mice with abnormally high levels of the PFK-L sub-unit developed symptoms of Type II diabetes.
Researchers at Purdue University have developed an oral delivery method for insulin that may eventually treat human diabetes. The method uses a gel-like material to protect insulin from stomach enzymes, allowing it to release the drug in a location where it can work.
A new oral vaccine approach is being developed to protect pancreatic cells and prevent the autoimmune disease type I diabetes. Early trials have shown promising results using a combination of insulin and cholera toxin.
A graduate student at Purdue University has developed a gel-like material that expands and contracts in response to changes in acidity, mimicking the natural response of the body. The gel could be used as a 'molecular gate' to deliver insulin in real-time, responding to glucose levels.
Researchers at Duke University found that pre-treating insulin-producing pancreatic islet cells with glutathione preserves their ability to regulate sugar levels. This advance could overcome a major hurdle in the transplantation of islet cells into humans as a treatment for diabetes.
Brown University researchers have developed a novel oral drug delivery system using erodible plastic microspheres that can improve the efficacy of drugs like insulin. The microspheres, engineered with bioadhesive polymers, increase absorption rates and enhance therapeutic effects.