A 30-year follow-up study of patients with early breast cancer found that radiotherapy does not improve overall survival rates after 10 years but reduces the risk of recurrence in the same breast. The study's findings challenge traditional concepts of long-term anti-cancer benefits of radiotherapy.
Researchers found that HER2-positive breast cancer patients with high levels of tumour infiltrating lymphocytes in residual disease have significantly shorter overall survival. High levels of TILs are associated with poorer outcomes, while lower levels are linked to improved survival rates.
Researchers at Clinica Universidad de Navarra found that ultrasound-guided surgery (IOUS) is more effective and quicker than traditional wire-localisation methods for treating ductal carcinoma in situ (DCIS). This technique reduces the risk of positive margins, a common cause of second operations.
A recent study published in JAMA Surgery found that self-reported loneliness is associated with an increased risk of death at 30 days post-surgery among Medicare patients. The research suggests that loneliness may be a significant social determinant affecting postoperative outcomes, particularly for non-elective care.
A randomized controlled trial found that both total ankle replacement and ankle fusion improve quality of life and have similar clinical scores in patients with end-stage ankle osteoarthritis. However, TAR is associated with greater wound-healing complications and nerve injuries, while AF is linked to more blood clots and nonunion of t...
A Rutgers study of 86,964 adults with obesity and NAFLD found that bariatric surgery reduced the risk of major cardiovascular events by 49% compared to nonsurgical care. This is significant because heart disease is a leading cause of death in the US, and NAFLD can lead to liver damage and inflammation.
Researchers have discovered that targeting a specific mutation in fibrolamellar tumors can reduce tumor growth in mice, offering a promising approach to treating this nearly incurable cancer. The findings highlight the potential for novel therapies against an intractable disease.
A randomized clinical trial will examine the efficacy of two supportive programs delivered by telephone and video conference in improving pain, psychological distress, and sleep disturbances in women undergoing surgery. The study aims to address the whole person's mental and behavioral health to optimize surgical outcomes.
A new study of 200,000 patients found that those who smoke cigarettes and drink heavily are more likely to experience post-surgical complications. However, talking to a health coach about drinking-related risks before surgery can help patients cut their alcohol use in half and reduce the likelihood of surgical issues.
A new study published in JNCCN found significant disparities in ovarian cancer treatment based on patient race, ability to pay, and healthcare access. Non-Hispanic Black patients were less likely to receive guideline-appropriate treatment compared to White patients.
Researchers have discovered two novel drugs that can block the growth and shrink the size of schwannoma tumors, a type of nerve sheath tumor found in the nervous system. The treatment works by inhibiting the Hippo signaling pathway, which is dysregulated in multiple types of cancer.
The BEST-CLI trial found that patients who received Bypass had a 32% reduction in Major Adverse Limb Events and 65% fewer major re-interventions compared to Endo. Both treatments were effective, but individualized decision-making is crucial for optimal outcomes.
Researchers at UCalgary have discovered a potential new treatment for fibrosis, a condition that causes thickening of the gut wall and life-threatening blockage in people with Crohn's disease and ulcerative colitis. The study suggests that drugs targeting specific sensors may prevent inflammation-associated gut blockage.
A large clinical trial found that administering steroids during infant heart surgery did not improve post-operative outcomes compared to placebo. However, secondary analysis revealed a small net benefit for some infants, with lower odds of bleeding requiring another operation.
The new guideline covers key aspects of aortic disease diagnosis and management, including surgical intervention considerations, consistent imaging practices, genetic and familial screenings. The ACC and AHA emphasize the importance of a multidisciplinary team in providing optimal care for patients with aortic disease.
Dual-energy CT (DECT) metrics provide insight into physiologic changes after lung cancer surgery, beyond PFTs and conventional CT. Lung perfusion ratio increases were greater after lobectomy than limited resection.
A recent analysis of COVID-19-positive donor heart transplants found no significant differences in transplant outcomes compared to those from non-COVID-19 donors. The study's results suggest that COVID-19-positive hearts may be as safe for transplantation, potentially addressing the shortage of available donor organs.
Researchers found that changing gloves and instruments just before closing wounds can prevent as many as 1 in 8 cases of Surgical Site Infection. A new toolkit also helps hospitals prepare for pandemics, heatwaves, and natural disasters.
Researchers at Oregon Health & Science University have counted more than 10,000 nerve fibers in the human clitoris, exceeding previous estimates of 8,000. This discovery could lead to better outcomes for phalloplasty surgery and improved sensation for transmasculine patients.
A new study has identified a specialized and distinctive type of microglia with enhanced antioxidant function in the ischemia/reperfusion injured brain, linked to stroke. The presence of Peroxiredoxin-1 protects against acute I/R injury, reducing microglial cell death and inflammatory responses.
The Canadian Medical Association Journal (CMAJ) publishes special issues on the impact of anti-Black racism on patient health and healthcare professionals. Research by Black health scholars and practitioners sheds light on systemic inequities, including cancer care disparities and gaslighting in academic medicine.
Research found that blood transfusions following solid tumor removal in pediatric oncology patients are associated with higher rates of post-surgery infectious complications, shorter disease-free intervals, and tumor recurrence. The study aims to inform thoughtful use of blood transfusion and encourage multi-center data collection.
Research at the ANESTHESIOLOGY 2022 annual meeting found that preschool children experiencing emergence delirium post-surgery do not exhibit long-term behavioral changes. No measurable problems were observed three months after surgery.
Adults who use cannabis experience 14% more pain after surgery and consume 7% more opioids. The study analyzed 34,521 patients and found a significant association between cannabis use and postoperative pain.
The new guidelines, issued by the American Society for Metabolic and Bariatric Surgery (ASMBS) and the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO), recommend metabolic and bariatric surgery for individuals with a BMI of 35 or more, regardless of obesity-related conditions. The guidelines also endo...
A deep learning algorithm trained on adult populations shows improved sensitivity for diagnosing thyroid nodules in children, with higher accuracy than traditional ACR TI-RADS. The study suggests the potential benefits of this new approach for evaluating thyroid nodules in younger patients.
A population-based analysis of 1,193 major surgeries found that 13.4% of patients died within a year, with frail and dementia-affected individuals facing significantly higher mortality rates
Researchers found that patients awaiting surgery experienced decreased pain and improved relaxation when given a music pillow to listen to during their wait. The study, which included over 30 participants, demonstrated a positive association between music and reduced anxiety in emergency department patients.
A study of 1.6 million Medicare patients found significant disparities in surgical consultation rates based on race, with Black patients receiving fewer consultations for emergency general surgery conditions than their white counterparts.
Researchers propose an optical imaging system for real-time hypoxia imaging in cancer treatment. The technique utilizes protoporphyrin IX to enhance contrast between tumors and healthy tissues, allowing for more effective surgical removal.
Researchers developed a generatively designed patient-specific bone fixation device using Generative Design technology. The implants are tailored to each patient's anatomy and biomechanical needs, resulting in lighter, less prominent, and minimally invasive designs that promote faster healing and reduced revision surgery.
A new genetic test called PancreaSeq accurately classifies pancreatic cysts as potentially cancerous or benign, improving the accuracy of diagnoses compared to current guidelines. The test distinguishes between different types of cysts with higher accuracy than traditional forms of surveillance and current pancreatic cyst guidelines.
A secondary analysis of a randomized clinical trial found that positive patient beliefs about antibiotic effectiveness for appendicitis are linked to lower risk of surgery and faster symptom resolution. This association remains unclear, with further research needed to understand its underlying mechanisms.
Patients requiring emergency dialysis before or after surgery are at increased risk of death and functional decline. Notably, patients undergoing high-risk surgeries like esophagectomy/gastrectomy and heart surgery have significantly higher mortality rates.
The TTUHSC team will provide no-cost colorectal cancer screening and colonoscopies to underinsured and uninsured people living in South Plains region counties. The FIT-STOP program aims to find signs of early-stage colorectal cancer to prevent treatment needs, leveraging existing relationships with partners.
A study published in JAMA Pediatrics found that gender-affirming top surgery significantly improved chest dysphoria and gender congruence among transmasculine and nonbinary individuals designated female at birth. The procedure was also associated with enhanced body image, with minimal surgical complications reported.
A new, dissolvable hydrogel developed by Mass General Hospital promotes wound healing for second-degree burns while minimizing pain and trauma. The biomaterial is highly absorbent, based on green chemistry approaches, and can be dissolved in under five minutes.
The analysis found that inadequate margin widths may result in higher risks of distant recurrence and breast cancer mortality, as well as increased local recurrence. The researchers recommend a minimum tumour free distance of 1mm from the margin for optimal oncological outcomes.
A study by researchers from UTHealth Houston and the University of Miami found that adolescents with severe obesity who underwent bariatric surgery before age 22 lost significant weight and experienced complete remission of comorbidities such as diabetes, asthma, and elevated lipids. The study's results show that these young patients c...
Researchers found no significant difference in pain levels between children who received ibuprofen and those who received a placebo before stent removal. Only 7% of pediatric patients reported severe pain following the procedure, compared to 55% of adults.
A budget impact analysis found that catheter-based TAVR is an affordable and effective strategy for treating aortic stenosis patients, with lower total costs compared to surgical SAVR. The study showed that the upfront cost of TAVR is partially offset by reduced healthcare resources, making it a more efficient option.
SourceElsevier·JournalCanadian Journal of Cardiology·TypeComputational simulation/modeling·DateSep 12, 2022
A study found that resiliency and family support play a crucial role in helping Hispanic breast cancer survivors manage lymphedema. Adaptations such as modifying work tasks and seeking support from family members enable survivors to maintain their quality of life.
Researchers evaluated 35 commercial breast biopsy markers for ultrasound color Doppler twinkling, finding that three markers exhibited actionable twinkling for ≥2 transducers. Higher surface roughness was associated with actionable twinkling in C1-6 and 9L transducers.
The American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) has selected top research presentations for its 2022 Annual Meeting & OTO Experience. These include groundbreaking studies in otology, laryngology, endocrine surgery, and head and neck surgery.
A review of ERAS programs in minimally invasive gynecologic surgery reveals improved patient recovery, reduced postoperative complications, and shorter hospital stays. Implementing ERAS protocols also reduces opioid consumption without increasing complications or healthcare costs.
A group of researchers from Osaka Metropolitan University found that administering parathyroid hormone to rat Achilles tendons increased the production of cartilaginous matrix and promoted chondrogenic differentiation. This breakthrough discovery may lead to improved outcomes for meniscal reconstruction surgery, protecting knee cartila...
A new study from Harvard Medical School reveals that patients who recover well after cardiovascular surgery exhibit precise paths for white blood cell and platelet counts. These trajectories can be used to monitor recovery in a personalized way, enabling clinicians to intervene earlier when necessary.
A research team has been awarded $10 million to develop a collaborative care model to prevent Alzheimer's disease and other dementias among delirium survivors. The study aims to improve cognitive recovery and quality of life for patients after emergency surgery.
A cohort study found that reinfection rates are low after successful hepatitis C virus (HCV) treatment in people who inject drugs, suggesting a benefit of treatment in this population. The risk for reinfection was highest among those with ongoing injecting drug use and needle sharing.
A retrospective study found that patients with multiple architectural distortions on digital breast tomosynthesis were more likely to have high-risk pathology, but not significantly different frequencies of malignancy. Biopsy of all areas may be warranted for these patients.
A systematic review and meta-analysis found no significant differences in treatment success between nonoperative and operative management for acute uncomplicated appendicitis. However, the nonoperative group experienced significantly longer hospital stays and higher recurrence rates.
A study of 12,000 Medicare beneficiaries with heart failure at risk for requiring a left ventricular assist device (LVAD) found racial and sex disparities in LVAD access. Adjusting for individual poverty and community-level social determinants of health did not alter the inequity in one-year survival among groups.
Researchers from the University of Gothenburg found that assessing melanoma thickness is challenging for both human dermatologists and machine-learning algorithms. Despite differences in success rates, both groups achieved comparable results when evaluating dermoscopic images, highlighting the need for further study to improve diagnost...
Researchers examined law enforcement interactions with patients and clinicians in an urban emergency department, highlighting their impact on patient care. The study's findings suggest that effective communication between law enforcement officers and healthcare providers is crucial for safe and efficient patient treatment.
A recent Kaiser Permanente study suggests that fully vaccinated patients who have had COVID-19 may not be at an elevated risk of complications after surgery. The research analyzed records from over 228,000 surgeries and found no significant difference in postoperative complication rates between vaccinated and unvaccinated patients.
A study of nearly 3 million adults found no increased mortality among uninsured or Medicaid patients after major surgery during the pandemic compared to commercial insurance holders. The findings contradict previous concerns about unequal access to care.
The study provides guidelines for healthcare facilities to respond effectively to mass shooting incidents. The clinicians identified the importance of modified triage plans, prioritizing patients based on anatomical considerations, and clear communication with emergency responders. By implementing these strategies, hospitals can better...
A study of 1,300 patients found most thyroid cancers are discovered in asymptomatic individuals, supporting the hypothesis of ongoing subclinical disease detection. The findings contradict the notion of a rising incidence of thyroid cancer.
A study found that female patients are more likely to require re-interventions after surgical treatments for intermittent claudication. Additionally, guideline-directed medical therapy was less frequently used among females compared to males.
A recent study found that 49% of transgender and gender-diverse patients who undergo gender-affirming genital surgery travel outside their home state, resulting in significantly higher out-of-pocket medical expenses. The average out-of-state patient pays $2,645, compared to $1,781 for in-state patients.