Articles tagged with Placebos
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Researchers have identified the alternative complement pathway as a key driver of IgA nephropathy, a chronic kidney disease. Iptacopan, an oral inhibitor of Factor B, has been shown to significantly reduce proteinuria and stabilize renal function in patients with IgAN, offering a new therapeutic approach.
The ACCOLADE study found that avacopan slowed C3 glomerulopathy progression by 20.6% in the placebo group but improved by 0.2% in the avacopan group, with patients with low eGFR benefiting from therapy. Avacopan also reduced proteinuria and increased eGFR in both groups.
A phase 3 clinical trial of adjuvant immunotherapy found that pembrolizumab prolonged disease-free survival rates in patients with kidney cancer at high risk of relapse. The estimated disease-free survival was 77.3% with pembrolizumab and 68.1% with placebo, translating to a 32% decrease in the risk of recurrence or death.
The COLCORONA study suggests that colchicine, an anti-inflammatory drug, could be used to prevent COVID-19-related complications in non-hospitalized patients with at least one risk factor for disease progression. The study's primary endpoint was the composite of death or hospitalization in patients with COVID-19.
The VOYAGE study found that dupilumab reduced asthma exacerbations by 59.3% in children with uncontrolled moderate-to-severe asthma. The treatment also improved lung function within two weeks, an effect sustained for up to 52 weeks.
The NAVIGATOR study showed that tezepelumab significantly reduced annualized asthma exacerbation rates across all eosinophil level subgroups, including a 70% reduction in EOS ?300. The therapy also prolonged the time to first exacerbation requiring hospitalization or ED visit.
Patients taking daily omega-3 carboxylic acid had similar rates of major cardiovascular events as those taking corn oil placebo, according to a post-hoc analysis of the STRENGTH trial. Higher levels of achieved EPA and DHA did not affect outcomes.
A phase III trial found dapagliflozin did not significantly reduce organ failure or death, but showed favorable safety data and lower numbers of serious adverse events. The study suggests that SGLT2 inhibitors may offer organ protection in acutely ill patients hospitalized with COVID-19.
A phase 1 study found that combining cagrilintide, a long-acting amylin analogue, with semaglutide led to greater weight loss compared to semaglutide alone. The combination was well-tolerated and showed an acceptable safety profile.
A new study found that semaglutide, an obesity drug, supresses appetite and food cravings, reducing energy intake in individuals with obesity. The study showed a 35% lower energy intake during a meal where participants could eat as much as they liked.
A phase two study found that an experimental treatment improved cognitive function and language in patients with fragile X syndrome. The treatment, BPN14770, increased levels of cyclic adenosine monophosphate (cAMP) in the brain, which is critically involved in memory formation.
Researchers found that high-dose omega-3 polyunsaturated fatty acids supplementation suppressed damage and boosted protection during and after stressful events. This led to sustained anti-inflammatory activity and preserved telomere length in healthy but sedentary, overweight, and middle-aged individuals.
Researchers from NIH propose a new method to estimate vaccine efficacy by following original placebo recipients after vaccination, allowing assessment of durability and potential delayed harm. This approach enables timely access to the vaccine for placebo recipients while maintaining unbiased estimates.
A new study found that participants with moderate to severe IBS who received an open-label placebo reported clinically meaningful improvements in symptoms, similar to those receiving a double-blind placebo. The study suggests the placebo effect can be harnessed without deception.
A combination of metoclopramide and diphenhydramine has been shown to reduce headache pain by more than five points in people who experienced a head trauma. However, the study's results may not be generalizable due to the participants' limited socioeconomic access.
A study analysis found that daily vosoritide treatment for two years improves height gain and body proportionality in children with achondroplasia. This is the first robust evidence of a precision therapy for this condition, which typically affects short stature and bone growth.
A study analysis suggests bremelanotide has very limited effectiveness as a treatment for HSDD in women. Trial participants preferred taking a placebo over the drug, with higher dropout rates and adverse event-induced discontinuation. The findings also highlight issues with the validity of HSDD as a diagnosis.
The DESIRE study found that efficacy was the strongest determinant of participants' stated modality choice, followed by delivery method and side effects. Participants preferred a douche used 30 minutes before sex with 95% efficacy, offering three to five days of protection.
A meta-analysis of 20 neuroimaging studies finds that placebo treatments reduce pain-related activity in multiple brain areas, including the thalamus and somatosensory cortex. The study, led by Tor Wager, demonstrates that the brain constructs pain experiences through a mix of processing stations and motivational circuits.
Researchers found that adding colchicine to standard treatment reduces the need for oxygen therapy and length of hospital stay in patients with moderate to severe COVID-19 infection. The study also shows that colchicine is safe and well-tolerated with few side effects.
A two-dose regimen of the adenovirus-based vaccine offers high efficacy against symptomatic COVID-19, with no serious adverse events reported. The vaccine is well-tolerated across different age groups, including older adults.
Researchers found that combining ipilimumab with pembrolizumab did not significantly improve overall survival or progression-free survival for patients with NSCLC. The combination was also associated with greater treatment-related adverse events.
Two ADAURA analyses presented at the International Association for the Study of Lung Cancer's 2020 World Conference on Lung Cancer (WCLC) Singapore support the use of Osimertinib as a new treatment strategy for patients with surgically resected, Stage IB to IIIA non-small cell lung cancer. The data show significant disease-free surviva...
A new topical treatment, benvitimod cream, has been proven safe and effective for mild-to-moderate plaque psoriasis. In a phase III clinical trial, the cream achieved a 75% decrease in psoriasis size and severity compared to pre-treatment levels.
A new study confirms that treatment with Bimagrumab is safe and effective for treating excess adiposity and metabolic disturbances in adult patients with obesity and type 2 diabetes. The medication achieved a nearly 21% decrease in body fat and a 6.5% reduction in body weight, along with a gain of lean mass.
The Moderna COVID-19 vaccine has demonstrated a 94.1 percent efficacy in preventing symptomatic COVID-19 infections and severe illness, according to the results of the ongoing phase 3 clinical trial. The study enrolled over 30,000 participants and found that cases of severe COVID-19 occurred only in those who received the placebo.
The ACTIV-3 trial, sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), tested LY-CoV555 against placebo in hospitalized COVID-19 patients. The trial found that LY-CoV555 did not provide clinical benefit compared to placebo.
A new study published in Neurology found that siponimod improved cognitive processing speed in people with advanced secondary progressive MS. The medication showed a 28% higher chance of sustained improvement compared to placebo, and reduced the risk of decline by 21%.
New research from the University of Cambridge found that patients treated with dexamethasone had a lower chance of favourable recovery at six months compared to those receiving a placebo. The trial enrolled 748 patients with chronic subdural haematoma and showed that fewer patients in the dexamethasone group required repeat surgery.
A daily dose of omega-3 fatty acids failed to reduce cardiac events, including secondary heart attacks and strokes, among elderly people who survived a recent heart attack. The OMEMI Trial found no significant difference in the rate of cardiac events between the two groups after 2 years of follow-up.
Researchers found that 90% of symptoms reported by statin users were also experienced when taking a placebo. This suggests a psychological rather than pharmacological effect of statins. Despite concerns about side effects, half of participants restarted taking a statin medication six months after the trial.
The FOURIER analysis showed that Repatha reduced the risk of major coronary events by 18% in patients with prior PCI, who were at a high risk for CV events. This analysis demonstrates the benefit of PCSK9 inhibition with evolocumab in reducing major coronary events.
A clinical trial found that inhaled delivery of interferon beta-1a to hospitalised COVID-19 patients in the UK reduced severe disease and death rates. Those receiving SNG001 were more than twice as likely to recover from infection compared to placebo recipients.
A new clinical study demonstrates that a non-living strain of Prevotella histicola can treat systemic inflammation in mild to moderate psoriasis through oral delivery. The treatment showed significant reductions in Psoriasis Area Severity Index (PASI) and Lesion Severity Scores (LSS), with minimal side effects.
A randomized clinical trial by University of Minnesota researchers found that taking hydroxychloroquine once or twice weekly did not prevent COVID-19 development in healthcare workers. The study showed a significant side effect increase with hydroxychloroquine use.
A randomized clinical trial published in Clinical Infectious Diseases found that taking hydroxychloroquine did not prevent COVID-19 in health care workers. The study, which enrolled 1,483 participants, also showed increased side effects with higher doses of the medication.
A study by Johns Hopkins Medicine researchers found that methamphetamine use increases the risk of casual sex without a condom, particularly among those with higher sexual desire. The study demonstrated that intense sexual arousal leads to rapid shift in preference for using a condom.
A new study found that gabapentin, a commonly used drug for chronic pelvic pain, is no more effective than a placebo in treating the condition. Researchers recommend exploring alternative therapies such as physiotherapy and cognitive behavioural therapy instead.
The DAPA-CKD trial found that dapagliflozin reduced the risk of worsening kidney function, death from kidney disease, or hospitalization for heart failure and cardiovascular events in patients with chronic kidney disease. The study also showed a significant reduction in all-cause mortality.
The EXPLORER-HCM trial demonstrated that mavacamten significantly improves exercise capacity, symptoms, and quality of life in patients with obstructive hypertrophic cardiomyopathy. The treatment was found to be generally well-tolerated, with a favorable safety profile.
The LoDoCo2 trial found that low-dose colchicine significantly reduced the risk of major cardiovascular events by almost one-third in patients with chronic coronary disease. The study also showed that colchicine was well-tolerated over the long-term, with no significant adverse effects.
The EMPEROR-Reduced trial found that empagliflozin significantly reduced the risk of cardiovascular death or hospitalization for heart failure, as well as adverse renal outcomes. By extending benefits to higher-risk patients, this trial supports the use of SGLT2 inhibitors in heart failure treatment.
A 12-week study by Oregon State University researchers found that taking a daily multivitamin and mineral supplement with zinc and high amounts of vitamin C reduced the severity and duration of illness symptoms in older adults. The supplement improved vitamin C and zinc levels in the blood, which are important for immune function.
Researchers at Michigan State University found that nondeceptive placebos can reduce self-reported emotional distress and brain activity related to emotional events. The study showed a significant reduction in brain markers of emotional distress within just a couple of seconds, suggesting genuine psychobiological effects.
A phase 2a trial of 82 people investigated whether cannabidiol (CBD) is safe and can help people with cannabis use disorder reduce cannabis use. The study found that daily prescribed medical-use CBD use can cause reduction in cannabis use among people with cannabis use disorder.
A single dose of baloxavir marboxil significantly reduced flu infections among household contacts, with only 1.9% developing the illness compared to 13.6% on placebo. The study supports the use of baloxavir for preventing influenza in high-risk settings like nursing homes and healthcare facilities.
AJOVY (fremanezumab) demonstrates clinically significant reductions in headache and migraine-related disability in the majority of patients studied. The treatment achieves downward shifts in disability severity and improves HIT-6 and MIDAS scores, particularly for patients with difficult-to-treat migraine.
A recent study published in the New England Journal of Medicine found that teplizumab significantly delayed the onset of type 1 diabetes by three years compared to a placebo. The trial involved individuals at high risk of developing T1D, and those treated with teplizumab showed higher rates of insulin secretion and C-peptide levels.
A Phase 3 study found lumasiran to be effective in reducing 24hr urinary oxalate excretion by 65.4% and normalizing oxalate levels in patients with PH1. The treatment also showed an encouraging safety profile, with mild injection-site reactions being the most common adverse event.
The BLISS-LN study showed that belimumab added to standard therapy resulted in a significantly better primary renal response at 2 years, with 43% showing improvement versus 32% on placebo. Additionally, patients treated with belimumab had a 50% lower risk of experiencing renal events associated with poor prognosis.
A Vanderbilt University Medical Center study found that doxycycline did not reduce the growth of abdominal aortic aneurysms in patients over a two-year period. The study included 254 patients who were randomly assigned to take either doxycycline or a placebo, with no differences in aneurysm growth between the two groups.
The study found that remdesivir reduced the median time to recovery by 4 days compared to placebo, with a survival benefit and improved clinical status. The findings support remdesivir as the standard treatment for hospitalized COVID-19 patients requiring supplemental oxygen therapy.
A new clinical trial protocol has been created to rapidly assess the efficacy of hydroxychlorquine and azithromycin in treating hospitalized patients with suspected or confirmed COVID-19. The study aims to recruit up to 300 participants and monitor their progress for 14 days.
Icosapent ethyl significantly reduces first and subsequent revascularizations, including coronary stenting and cardiac bypass surgery, in statin-treated patients with elevated triglycerides. The study found a 34% reduction in first revascularization events and higher reductions in subsequent events among statin-stabilized patients.
A randomized trial of remdesivir suggests the antiviral drug is not associated with significant clinical benefits for treating COVID-19. Patients treated with remdesivir within 10 days of symptom onset showed faster recovery compared to those given placebo, but results were not statistically significant.
A new 12-week clinical trial found that heat-inactivated Bifidobacterium bifidum MIMBb75 improved IBS symptoms by at least 30% in 34% of patients compared to 19% on placebo. The treatment was also associated with a strong placebo effect, but the dead bacterial cells were still significantly better than placebo.
A randomized controlled trial found that liraglutide improves BMI SDS, body weight, waist circumference, and other weight-related outcomes in adolescents with obesity. The study also showed a similar safety profile to adults, with minimal gastrointestinal side effects.
A new study found vericiguat significantly lowers cardiovascular death and hospitalization rates in patients with worsening heart failure. With a median follow-up period of 10.8 months, the drug showed a 10% lower rate of primary endpoint events compared to placebo.
A recent study from McGill University suggests that some people may experience psychedelic-like effects from placebos alone, with 61% of participants reporting an effect. The researchers found that context plays a significant role in these experiences, and clinicians may be able to leverage contextual factors to improve the safety of p...
A preliminary study found that blue light therapy can decrease depression and other concussion symptoms in individuals with mild traumatic brain injury. Participants who received blue light therapy showed significant improvements in depression scores and other symptoms compared to those receiving a placebo.