A new deep learning-based model called Highlights on Target Sequences (HoTS) predicts binding between drugs and target molecules, providing interpretable results. The model can predict target proteins' binding regions and interactions with drugs without a 3D complex.
SourceGIST (Gwangju Institute of Science and Technology)·JournalJournal of Cheminformatics·TypeComputational simulation/modeling·DateApr 5, 2022
Researchers have identified formononetin as a potential therapeutic for treating food allergies, which affect nearly 10% of the world population. The plant compound has been shown to decrease IgE production and influence gene and protein targets regulated in food allergy and mast cell diseases.
The National Comprehensive Cancer Network has published new consensus recommendations to improve the safety and efficiency of research studies involving investigational drugs. The recommendations focus on seven areas, including pharmacy workflows and collaboration with sponsors.
SourceNational Comprehensive Cancer Network·JournalAmerican Journal of Health-System Pharmacy·DateMar 15, 2022
Researchers from CCDC, Exscientia, and Oxford University have developed an automated method for informing the design of compound selectivity across protein families. The 'Hotspot API' uses ensemble hotspot maps to quantify the propensity for compounds to exploit interactions in preferred binding sites.
SourceCCDC - Cambridge Crystallographic Data Centre·JournalJournal of Chemical Information and Modeling·DateMar 2, 2022
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
Codiak BioSciences' exoASO-STAT6 demonstrates potent anti-tumor efficacy by reprogramming tumor-associated macrophages to an M1 phenotype, showing promise as a monotherapy candidate for hepatocellular carcinomas and other cancers. The company plans to initiate Phase 1 clinical trials in the first half of 2022.
SourceScient Public Relations, Inc.·JournalScience Advances·TypeExperimental study·DateFeb 18, 2022
A recent review highlights the potential of structural proteomics in understanding pathological processes and predicting drug candidates for neurodegenerative diseases. The field combines protein chemistry and mass spectrometry to determine protein structure and interactions, which can lead to breakthroughs in treating serious health c...
SourceSkolkovo Institute of Science and Technology (Skoltech)·JournalChemical Reviews·DateJan 27, 2022
A new study reveals that the Omicron variant is sensitive to inhibition by the interferon response, an unspecific immune reaction present in all body cells. This provides the first explanation for why COVID-19 patients infected with Omicron are less likely to experience severe disease.
SourceGoethe University Frankfurt·JournalCell Research·TypeExperimental study·DateJan 24, 2022
A research team has found a new dual benefit mode of action for the drug candidate Zapnometinib or ATR-002, which can inhibit SARS-CoV-2 virus proliferation and reduce exaggerated immune responses.
SourceUniversity of Münster·JournalCellular and Molecular Life Sciences·DateJan 14, 2022
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
An AI-driven solution identifies sites on RNA and DNA molecules where interaction with potential drug candidates can occur. This allows pharmaceutical companies to discover new medications in a more focused and efficient manner.
SourceSkolkovo Institute of Science and Technology (Skoltech)·JournalNucleic Acids Research·DateJan 11, 2022
A new drug developed to target lymphatic filariasis (LF) and onchocerciasis has started its first human trial at the Liverpool School of Tropical Medicine. The drug, AWZ1066S, targets Wolbachia, a bacterial symbiont essential for worm survival, offering a novel approach to eliminate these debilitating diseases.
SourceLiverpool School of Tropical Medicine·TypeNews article·DateJan 6, 2022
Researchers developed a dish-based model that replicates the characteristics of dry age-related macular degeneration, allowing them to screen over 1,200 drugs for their ability to slow or halt disease progression. Two drugs, Aminocaproic acid and L745, showed promise in inhibiting key phenotypes associated with AMD.
SourceNIH/National Eye Institute·JournalNature Communications·TypeExperimental study·DateDec 15, 2021
Researchers at USC Dornsife College of Letters, Arts and Sciences have created a process that increases the chances of finding effective drugs in a fraction of the time and at significantly less expense than current methods. V-SYNTHES, a virtual method developed by Vsevolod Katritch and colleagues, uses synthons to efficiently puzzle t...
SourceUniversity of Southern California·JournalNature·TypeComputational simulation/modeling·DateDec 15, 2021
Researchers at the University of Bath have optimised a peptide that prevents alpha-synuclein misfolding, a key feature of Parkinson's disease. The new molecule, 4654W(N6A), has shown significant promise in lab experiments and could lead to the development of a disease-modifying treatment.
SourceUniversity of Bath·JournalJournal of Molecular Biology·TypeExperimental study·DateDec 9, 2021
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A new study has identified a promising drug candidate to minimize uncontrolled muscle movements associated with Parkinson’s disease. PD13R reduced dyskinesia by more than 85% in animal studies, also improving sleep quality compared to other treatments.
SourceTexas Biomedical Research Institute·JournalExperimental Neurology·DateDec 1, 2021
Researchers at Duke University have identified chemical compounds that can latch onto the coronavirus's 3D RNA structures and block replication. The compounds, which target the virus's RNA specifically, offer a new mechanism of action against COVID-19.
SourceDuke University·JournalScience Advances·TypeExperimental study·DateNov 26, 2021
Cleveland Clinic researchers found that verubecestat, an Alzheimer's disease treatment, reduces glioblastoma progression by reprogramming tumor-associated macrophages into tumor-suppressing macrophages. This transformation leads to increased phagocytosis of tumor cells and reduced tumor growth.
SourceCleveland Clinic·JournalNature Cancer·DateNov 23, 2021
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
A University of South Florida Health-led team discovered a lead candidate that selectively relaxes airway smooth muscle cells with no detectable drug desensitization. The biased beta-agonist, C1-S, offers a therapeutic option for asthma and obstructive lung diseases without the rapid loss of effectiveness seen with traditional β-agonists.
SourceUniversity of South Florida (USF Health)·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateNov 22, 2021
The University of Maryland School of Medicine has been awarded a $6.5M grant to develop a treatment for alcoholic liver disease-associated kidney dysfunction. The Institute of Human Virology and MitoPower will conduct clinical trials to test the safety and efficacy of MP-04, a lead compound in treating HRS.
SourceUniversity of Maryland School of Medicine·DateNov 9, 2021
Paxlovid demonstrates significant efficacy against SARS-CoV-2 virus, reducing hospitalization and death risks in adult patients by up to 89%. The treatment's development involved cutting-edge X-ray technology from the Advanced Photon Source.
SourceDOE/Argonne National Laboratory·JournalScience·DateNov 8, 2021
Researchers developed a new online portal, DINC-COVID, to speed up the identification of potential pandemic treatments. The platform incorporates models of three drug targets and uses ensemble docking to score ligands' success in binding.
SourceRice University·JournalComputers in Biology and Medicine·TypeComputational simulation/modeling·DateNov 1, 2021
Sky & Telescope Pocket Sky Atlas, 2nd Edition
Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.
Researchers at Shanghai Institute of Materia Medica have isolated and characterized seven novel dimeric sesquiterpenoids with potent antimalarial activities. The most potent compound, Shizukaol A, exhibits an EC50 value 1000-fold more active than artemisinin.
SourceScience China Press·JournalScience China Chemistry·DateOct 27, 2021
A commonly used diuretic pill may help treat Alzheimer's disease in individuals with the apolipoprotein E gene APOE4. Researchers analyzed data from brain tissue samples and found that those taking bumetanide had a significantly lower prevalence of Alzheimer's disease compared to those not taking the drug.
SourceNIH/National Institute on Aging·JournalNature Aging·DateOct 11, 2021
Researchers have identified a molecule that slows cells' production of alpha-synuclein, a protein forming toxic aggregates in Parkinson's brains. The compound, A-443654, also reduces cell stress and may help degrade existing alpha-synuclein aggregates.
SourceUniversity of Utah Health·JournalJournal of Biological Chemistry·TypeExperimental study·DateSep 22, 2021
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
Researchers at Max Planck Institute elucidated the molecular mechanism of Molnupiravir, an antiviral agent that reduces Sars-CoV-2 coronavirus transmission. By incorporating RNA-like building blocks into the virus genome, Molnupiravir prevents further replication and transmission.
SourceMax-Planck-Gesellschaft·JournalNature Structural & Molecular Biology·DateAug 16, 2021
Researchers created a new open-access database to speed up the repurposing of old drugs as new treatments for various conditions. The NICEdrug.ch database includes information on 250,000 potential drug molecules and shows promising results in predicting drug behavior.
SourceeLife·TypeData/statistical analysis·DateAug 3, 2021
Researchers discovered that a protein called VDAC2 plays a key role in regulating calcium signaling within heart cells, which can help prevent chronic heart failure. Targeting this protein with drugs or therapeutic treatments may eventually alleviate heart failure.
SourceUniversity of Utah Health·JournalNature Communications·TypeRandomized controlled/clinical trial·DateJul 28, 2021
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Researchers at UIC are developing a potential COVID-19 treatment using VT-109, which has shown promise in animal models by restoring lung function and reducing inflammation. The new funding will be used to conduct pre-clinical studies to determine efficacy, toxicity, and dosages before human trials.
A drug candidate developed from a molecule in the venom of the Fraser Island funnel web spider can prevent damage caused by a heart attack and extend donor heart life for organ transplants. The treatment blocks a death signal sent from the heart after an attack, reducing cell death and improving survival.
SourceUniversity of Queensland·JournalCirculation·DateJul 16, 2021
Researchers from Skoltech and their colleagues discovered promising compounds among pest control chemicals that inhibit the synthesis of hyaluronic acid, a key component in connective tissue. These compounds show potential as anti-fibrotic drugs for treating liver fibrosis.
SourceSkolkovo Institute of Science and Technology (Skoltech)·JournalGlycobiology·DateJul 8, 2021
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
A study at ECCMID identifies existing drugs that could be repurposed to treat gonorrhoea by targeting efflux pumps, which remove toxic compounds from bacterial cells. The research found 57 potential drug candidates, including dequalinium and doxorubicin, which may serve as lead compounds for new gonorrhea treatments.
SourceEuropean Society of Clinical Microbiology and Infectious Diseases·DateJun 30, 2021
The FDA's approval of aducanumab for Alzheimer's disease treatment has sparked ethical issues, with billions of dollars in Medicare resources at risk. Physicians face difficult choices between facilitating unjust access to the drug or denying it to desperate patients and families.
SourceThe Hastings Center·JournalHastings Center Report·DateJun 28, 2021
Researchers at UC San Diego developed a high-throughput 3D bioprinting technology that can produce 96-well arrays of living human tissue samples in just 30 minutes, accelerating preclinical drug screening and disease modeling. This could potentially reduce the time and cost associated with drug development.
SourceUniversity of California - San Diego·JournalBiofabrication·DateJun 8, 2021
Researchers at the University of Liverpool have developed a long-acting injectable therapy using an existing and cheap drug, showing promise in treating COVID-19. The formulation uses nanoparticle technology to deliver the drug sustainably over several months.
SourceUniversity of Liverpool·JournalNanoscale·DateMay 5, 2021
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
A team of researchers identified 37 substances that bind to the main protease of SARS-CoV-2, a promising starting point for COVID-19 drugs. Seven substances inhibit the protein's activity, with two showing high antivirality and good cell compatibility.
SourceDeutsches Elektronen-Synchrotron DESY·JournalScience·DateApr 2, 2021
Chemists have developed a method to synthesize complex, three-dimensional molecules using light energy transfer, expanding the range of molecules for new drug development. The novel approach uses commercially available starting materials and demonstrates broad applicability.
The Endocrine Society emphasizes the need to study biological differences between females and males in medicine and research to improve public health. Studies have shown that SARS CoV-2 infection disproportionately affects men, while failing to consider sex differences can lead to failure of promising drug candidates.
SourceThe Endocrine Society·JournalEndocrine Reviews·DateMar 11, 2021
A research team has discovered two families of active substances that can block the replication of SARS-CoV-2 by targeting its main protease enzyme. The drug candidates show promise for therapeutic development, but extensive clinical trials are still required.
SourceUniversity of Bonn·JournalAngewandte Chemie International Edition·DateMar 3, 2021
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
OYE Therapeutics is developing a new life-saving strategy to reduce mortality and morbidity resulting from battlefield injuries. The company, in partnership with USU and HJF, aims to enhance acute pain control at the point-of-injury through its drug product pipeline.
Researchers designed a simple screening assay based on competitive binding to identify peptide candidates with high binding affinity for ubiquitin. The dimers of cyclic peptides were found to be more potent than control peptides and induced cell death in live cancer cell lines.
SourceWiley·JournalAngewandte Chemie International Edition·DateFeb 22, 2021
Ovarian clear cell carcinoma (OCCC) remains a rare subtype with poor prognosis. Simvastatin efficiently controlled OCCC proliferation and migration, demonstrating potential as a candidate drug.
SourceImpact Journals LLC·JournalOncotarget·DateFeb 1, 2021
Researchers analyze molecular dynamics of proposed COVID-19 drug candidates to understand their interactions with target proteins in human cells. They found that certain parts of the molecules can move more easily once hydrated, which could influence how efficiently a drug takes on shapes associated with different biological functions.
SourceDOE/Oak Ridge National Laboratory·JournalThe Journal of Physical Chemistry Letters·DateFeb 1, 2021
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Researchers at the University of Chicago used computational simulations to understand how remdesivir works against SARS-CoV-2. They found that remdesivir binds strongly to the virus and destabilizes its protein complex, reducing replication. This study provides insights into the molecular mechanism of remdesivir and its potential for e...
SourceUniversity of Chicago·JournalACS Central Science·DateJan 29, 2021
A team of international researchers found that certain FAK inhibitors remain bound to the protein for a long time, causing a structural change that inhibits cancer cell mobility. Computer simulations predicted the kinetics of binding well, allowing for more accurate simulation of drug dissociation rates.
SourceGoethe University Frankfurt·JournalCell Chemical Biology·DateJan 28, 2021
Researchers have secured a £1.6 million grant to develop M102, a potential breakthrough in treating motor neuron disease (MND). The drug's neuroprotective properties were discovered by the University of Sheffield's Institute for Translational Neuroscience (SITraN), which will now advance its translational development.
Scientists developed a machine-learning framework to identify potential repurposed drugs for diseases, using massive amounts of data from patient care records. The analysis suggested six candidates, including metformin and escitalopram, which are currently being tested.
SourceOhio State University·JournalNature Machine Intelligence·DateJan 4, 2021
GQ GMC-500Plus Geiger Counter
GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
A comprehensive review of plant natural products reveals 459 compounds with antibacterial activity, providing promising candidates for new antibiotic discovery. The review, led by Cassandra Quave, aims to facilitate the search for effective drugs against antibiotic-resistant pathogens.
SourceEmory Health Sciences·JournalChemical Reviews·DateNov 11, 2020
Researchers at MedUni Vienna's Institute of Pharmacology have isolated a beetroot peptide that inhibits prolyl oligopeptidase, an enzyme involved in the breakdown of protein hormones in the body. The study suggests that this peptide could be a promising drug candidate for treating neurodegenerative and autoimmune diseases.
SourceMedical University of Vienna·JournalJournal of Natural Products·DateOct 30, 2020
Researchers at Michigan State University have developed a deep learning model to predict the binding sites of known protease inhibitors targeting the SARS-CoV-2 main protease. The model can help drug developers prioritize promising candidates and save time and money in the early stages of drug development.
SourceMichigan State University·JournalChemical Science·DateOct 28, 2020
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
University of New Mexico researchers have identified three medications with potential to treat SARS-CoV-2 infection: amodiaquine, zuclophentixol, and nebivolol. These drugs showed promise in test tube experiments and could be combined with remdesivir for a more potent attack.
SourceUniversity of New Mexico Health Sciences Center·JournalACS Pharmacology & Translational Science·DateOct 16, 2020
A new drug candidate, MPH-220, has been developed to target muscle spasticity after stroke and nervous system defects. By inhibiting the effector protein of muscle contraction, it may alleviate symptoms with a single pill per day.
A new assay using HEPATOPAC model identifies drugs with high DILI risk, showing high sensitivity and specificity. BioIVT's advanced in vitro liver model provides a promising solution for preclinical DILI risk assessment.
SourceRana Healthcare Solutions LLC·JournalToxicological Sciences·DateOct 12, 2020
Researchers repurpose anti-malarial compounds to target the intestinal parasite Cryptosporidium, killing it in cell cultures and immunocompromised mice. The compounds work by inhibiting an enzyme responsible for protein production within the parasite.
SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalScience Translational Medicine·DateOct 1, 2020
A polygenic risk score has been developed to predict drug-induced liver injury, using genomic data and organoid models. The score can identify patients at risk of liver damage, allowing for safer medication choice and dosage.
SourceTokyo Medical and Dental University·JournalNature Medicine·DateSep 18, 2020
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
A $11.4 million NIH grant has funded the advancement of a novel drug candidate, SBP-9330, targeting a neuronal signaling pathway underlying addictive behaviors to treat nicotine addiction. The drug is expected to be effective in reducing nicotine self-administration and may broaden its indication to other types of addiction.
Researchers have developed novel Selenium-based compounds that can stabilize the SOD1 protein, which causes ALS. These compounds show improved in vitro therapeutic effects and demonstrate disease onset delay in an ALS mouse model. The findings hold promise for a new class of drug candidates for ALS treatment.
SourceUniversity of Liverpool·JournalEBioMedicine·DateSep 1, 2020
Researchers used machine learning to correlate information on drugs, genes, and diseases, identifying 63 drugs targeting 31 genes as potential candidates for psychiatric and neurological treatment. The approach will also be applied to search for correlations between drugs, genes, and COVID-19.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalTranslational Psychiatry·DateAug 3, 2020
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
A Nature study identified 21 existing drugs that stop SARS-CoV-2 replication, including four that work synergistically with remdesivir. These compounds have potential for COVID-19 treatment and could provide affordable alternatives if the virus becomes drug-resistant.
Researchers at Istituto Italiano di Tecnologia have discovered a novel chemical compound that shows promise in treating core symptoms of brain disorders such as Down syndrome and autism. The new compound selectively blocks the transporter NKCC1, which is dysregulated in these conditions.
SourceIstituto Italiano di Tecnologia - IIT·JournalChem·DateJul 10, 2020
Researchers identify four promising antiviral drug candidates that block SARS-CoV-2 replication by targeting the main protease enzyme. The most effective compound, GC-376, demonstrates potent chemical and structural interactions with the viral protein, making it a potential candidate for repurposing as a COVID-19 treatment.
SourceUniversity of South Florida (USF Health)·JournalCell Research·DateJul 6, 2020
A NUS-led team has developed an artificial intelligence platform called IDentif.AI to rapidly identify optimal drug combination therapies for infectious diseases. The platform uses machine learning to examine billions of possible combinations and doses, resulting in unprecedented speed and accuracy in discovering new treatments.
SourceNational University of Singapore·JournalAdvanced Therapeutics·DateApr 27, 2020