Articles tagged with Drug Candidates
Researchers have developed a new class of antibiotics that can overcome drug-resistant bacteria by targeting the physical and functional integrity of the bacterial cell wall. This could be a game-changer in treating infections, particularly those caused by resistant strains.
ATH-1105, a small molecule positive modulator of the neurotrophic HGF system, demonstrates significant neuroprotective effects and extends survival in preclinical models of ALS. The study highlights the therapeutic potential of ATH-1105 in slowing or stopping neurodegeneration.
The lack of synergy between academia and industry in drug discovery hinders the development of effective treatments. Researchers discuss why many therapeutic molecules fail to reach clinical trials despite pre-clinical efficacy.
UAB researchers have created a 3D, three-layer nanomatrix vascular sheet that mimics human atherosclerosis, enabling high-throughput drug screening. The model replicates key features of the disease and has been validated with two classic atherosclerosis drugs.
Researchers at NTNU have developed a new method to study how bacterial signaling proteins react to treatment, paving the way for effective killing of MRSA. The method has shown a combination of two substances kills MRSA more effectively than when used separately.
Researchers at the University of Bath have created a novel bacterial system to mass-produce cyclic proteins and peptides, addressing a significant bottleneck in the development of new therapeutic treatments. By harnessing the natural cyclization process from the Oldenlandia flower, they improved heat and chemical stability, as well as ...
Researchers at the University of Pittsburgh have discovered a potential new target for treating Barth syndrome, a rare genetic disease with devastating consequences. They identified a molecular culprit that could be targeted to potentially reverse the disease course and developed a small-molecule drug candidate to correct genetic tafaz...
Researchers identified a promising dual-purpose target, KDM1A, using AI analysis of transcriptomic data from 16,740 healthy samples and 11,303 tumors. KDM1A was found to significantly extend lifespan in Caenorhabditis elegans and has anti-cancer activities established in preclinical and clinical studies.
Researchers have identified a small molecule that reverses four types of chronic pain in animal studies without troublesome side effects. The compound, CBD3063, binds to the inner region of a calcium channel, indirectly regulating its activity and reducing neurotransmitter release.
Researchers at the University of Illinois have developed a new antifungal molecule that targets fungal cells without harming human kidney cells or other tissues. The molecule, dubbed AM-2-19, has shown significant efficacy against various fungal infections in vitro and in vivo studies.
A new international clinical trial found that a drug candidate is highly effective in treating Acanthamoeba keratitis with medical cure rates of 87%, reducing the risk of poor visual outcomes and surgery. The treatment, low concentration polihexanide (PHMB 0.08%), follows a novel and evidence-based protocol.
Scientists at Nagoya University developed a new gastric acid inhibitor with a binding affinity nearly 10 times higher than existing drugs. The AI-driven approach led to the creation of compound DQ-18, which exhibits stronger binding to the gastric proton pump.
Researchers at Hokkaido University identified 2-thiouridine as a broad-spectrum antiviral drug candidate targeting ssRNA+ viruses. It inhibits viral replication and increases survival rates in mice models for dengue and COVID-19.
A promising drug candidate CDNF has been found to prolong the lifespan of ALS patients and alleviate symptoms in rats and mice. The study suggests that CDNF may rescue motoneurons by reducing ER stress response and cell death.
The US Army Medical Materiel Development Activity has developed a shelf-stable treatment for snakebite envenoming that is safe, easy to use, and independent of snake species. Clinical trials are ongoing in the US and India, with pre-clinical studies suggesting its potential use worldwide.
Researchers at Michigan Medicine have discovered a potential treatment for diffuse midline glioma, a type of childhood brain tumor with no effective treatments. The compound ONC201 nearly doubled survival rates in patients with the disease, and the underlying mechanism behind its success has been explained.
Researchers at TUM develop an RNA agent for a lung spray that slows macrophage activity, reducing lung inflammation and fibrosis. The active substance RCS-21 is delivered via an inhaler through a special sugar molecule, showing promise in treating acute inflammatory lung damage.
Researchers at UMass Amherst have discovered a potential new medical therapy for Lyme disease using lactate dehydrogenase inhibitors typically used to combat cancer. The study found that these inhibitors substantially impacted Borrelia burgdorferi growth, making them promising candidates against Lyme infections.
Researchers at Tokyo University of Science successfully synthesized tanzawaic acid B in large amounts, paving the way for new antibiotic development. The breakthrough method could lead to creation of various compounds for pharmaceuticals, including new antibiotic candidates.
Researchers at Uppsala University developed a modified lactic acid bacteria treatment that accelerated wound healing in humans. The study showed improved outcomes and safety with ILP100-Topical, a potential new treatment for complex and hard-to-heal wounds.
Researchers have engineered a new CRISPR-based drug candidate targeting E. coli directly while preserving the microbiome. The innovative treatment has shown promise in reducing E. coli burden in mice and is now in phase 1 clinical trials to treat blood cancer patients and prevent deadly infections.
Researchers at Nagoya University have successfully developed an ultrafast and simple synthetic method for producing indole derivatives. The new microflow synthesis method enables precise control of short reaction times, limiting unwanted dimerization/multimerization and increasing the yield of desired products.
TRIO Pharmaceuticals is developing a proprietary platform of dual-action tumor immunity-enhancing drugs aimed at treating cancers with high unmet medical needs. The company's innovative approach selectively eliminates immunosuppressive cells, enhancing antitumor activity.
Researchers have developed a glycine-based tripeptide that successfully treats nonalcoholic fatty liver disease in non-human primates and mice. The compound, DT-109, reverses fat buildup and prevents scarring by stimulating fatty acid degradation and antioxidant formation.
A team from Osaka University discovered that celastrol blocks the progression of rheumatoid arthritis by inhibiting a protein complex that promotes autoimmune responses. The researchers found that celestrol binds to COMMD3 covalently, preventing the formation of the COMMD3/8 complex and impairing antibody production.
A small molecule discovered by University of Houston researchers could potentially shorten the course of SARS-CoV-2 infection, offering a new alternative treatment option for COVID-19. The compound, CD04872SC, has shown promise in neutralizing the virus and its variants Delta and Omicron.
Researchers at Goethe University Frankfurt have identified nitroxoline as a potential treatment alternative for mpox. The antibiotic demonstrates effectiveness against both the current mpox virus and a tecovirimat-resistant strain, offering a promising solution to combat the outbreak.
Researchers used AI to analyze literature describing compounds that enhance mitophagy, a process damaged in Parkinson's disease. Probucol, a cholesterol-lowering drug, was identified as the most effective compound with improved motor function and neuron loss in animal models.
A study by Emory University researchers found that extracts from two wild plants, tall goldenrod and eagle fern, inhibited the ability of the SARS-CoV-2 virus to infect living cells. The active compounds are present in miniscule quantities, making it ineffective for self-treatment, but may hold promise as medicines against COVID-19.
A study identified an antibody candidate that blocks the protein VEGF-B, presenting a possible therapeutic option for fatty liver disease. The treatment method involves keeping fatty acids in adipose tissue to prevent liver accumulation.
Researchers found that plasma GH levels are a potential biomarker for predicting treatment outcomes in patients with advanced HCC treated with Atezo/Bev. The study showed significantly superior overall survival and non-significant trend in favor of GH-low patients compared to GH-high patients.
A retrospective cohort study of 1,404 subjects with type 2 diabetes found that metformin use reduced the risk of delirium by 50% and decreased 3-year mortality rates. The study suggests that metformin may be a potential benefit for patients with diabetes, particularly in reducing age-related disorders such as dementia.
A research team led by City University of Hong Kong neuroscientist Dr. Geoffrey Lau Chun-yue identified a new drug candidate, D4, that selectively blocks connexin hemichannels to suppress neuroinflammation and curbs TLE seizures in a mouse model. The findings suggest a promising new treatment strategy for epilepsy.
Scientists at KAUST have identified dynamic regions, called cryptic binding sites, that can be targeted by drugs to treat cancer. The study reveals how molecular motion influences ligand binding to BTB domains, a critical part of many proteins involved in disease.
A comprehensive database, CoviRx, has been developed to repurpose drugs against mutated SARS-CoV-2 viruses. The platform allows scientists to narrow their search from 7,817 potential candidates to a 'top 200', with 12 tested and showing promise for further investigation.
Opaganib, an oral small molecule pill, shows potential as a nuclear radiation injury therapeutic for homeland security medical countermeasures and antitumor radiotherapy. The compound protects normal tissue from radiation damage and improves antitumor activity and response to chemoradiation.
The West Texas Pharmacology Core laboratory at TTUHSC will focus on two primary areas: drug development and pediatric cancer. The core aims to address obstacles in drug development, including limited pharmacology expertise for small biotech companies and low profitability for pediatric cancer drugs.
Researchers at the University of Helsinki have identified a promising drug candidate, TYK2 inhibitor, for preventing type 1 diabetes. The study found that inhibiting TYK2 expression reduces the destruction of pancreatic beta cells, but may also reduce beta cell production in earlier stages.
Researchers have designed a potential therapeutic that dampens the activity of regulatory T cells, which can prevent the immune system from unleashing its full potential against tumor cells. The molecule, known as FOX3P, acts as a transcription factor for many Treg genes but isn't vital for other types of T cells.
A comprehensive study reveals SARS-CoV-2 viral-to-human protein interaction network, showing how the virus hijacks human proteins. Researchers identified 23 candidate drugs, including an FDA-approved beta-blocker that shows promise in inhibiting viral infection.
Scientists are conducting a first-of-its-kind study to investigate the origin of psychedelic compounds in fungi, including psilocybin found in 'magic mushrooms'. The research aims to understand the evolution of these compounds and their potential applications in medicine and conservation.
Researchers found that metformin targeted 30 genes associated with atrial fibrillation, showing direct effects on gene expression for eight. The study suggests metformin may be a promising candidate for treating atrial fibrillation due to its potential to reduce the risk of complications such as stroke and heart failure.
Researchers from Xi'an Jiaotong-Liverpool University found that brain stimulation combined with a nose spray containing nanoparticles can improve recovery after ischemic stroke. The treatment increased cognitive and motor functions, and weighed more quickly than those treated with TMS alone.
Researchers developed an AI-based screening method that models drug and target protein interactions using natural language processing techniques. The technique achieved high accuracy in identifying promising drug candidates, which can accelerate the exploration of new medicines and repurpose existing ones.
Researchers found that mTOR inhibition is crucial for p53-mediated tumor suppression, delaying cancer and increasing lifespan. In the absence of mTOR inhibition, cancer-promoting senescent cells drive tumor growth.
A new oral drug candidate, JSF-2659, has been developed to eradicate the bacteria causing gonorrhea. It works by simultaneously targeting two molecular targets, making it effective against resistant strains and reducing the risk of drug resistance.
Researchers at Karolinska Institutet have developed a potential curative treatment for neuroblastoma, using DHODH blockers in combination with chemotherapy to cure mice with the disease. The treatment has shown promising results and could improve survival rates for children with neuroblastoma.
Researchers have identified three natural compounds that bind to a key enzyme in the coronavirus, potentially blocking its replication. Hydroxyethylphenol, hydroxybenzaldehyde, and methyldihydroxybenzoate showed reduced activity against the papain-like protease enzyme, with effects ranging from 50-70%.
Researchers at Nanyang Technological University in Singapore have developed a series of chemical-based compounds that could be potential drug candidates for treating pulmonary tuberculosis. The compounds were licensed by US-based Neuro-Horizon Pharma LLC for commercialization.
Researchers identified CUDC907 as a dual phosphoinositide-3 kinase/histone deacetylase inhibitor that promotes apoptosis in NF2 schwannoma cells. The compound reduced viability and induced cell cycle arrest in human merlin deficient Schwann cell models.
Researchers used chemoproteomics to profile 53 HDAC drugs and found many had additional targets beyond their intended HDACs. The study identified MBLAC2 as a common off-target protein that affects extracellular vesicle accumulation.
Researchers at Karolinska Institutet have successfully repurposed a cancer drug to target neuroinflammatory diseases like multiple sclerosis. A novel drug carrier was developed to deliver the treatment specifically to microglia, reducing inflammation and disease progression.
The NIAID has awarded $577 million to establish nine Antiviral Drug Discovery Centers to develop candidate COVID-19 antivirals. The centers will conduct innovative research to identify novel viral targets and develop small molecules and biotherapeutics to block viral targets.
Researchers developed a droplet-based microfluidic technology to produce micro-organospheres from cancer patient biopsies within an hour. These miniature tumors retain the original microenvironment and can be used for testing many drug conditions, showing almost perfect correlation with actual clinical treatment outcomes.
Researchers developed a deep learning-based model to predict drug-drug interactions using gene expression data. The DeSIDE-DDI model can identify potentially dangerous pairs and act as a drug safety monitoring system, helping establish the correct usage of drugs in the development phase.
Key signalling pathways blocking by existing drug candidates limit CCHF virus reproduction. The findings offer hope for patients affected by this deadly disease, which has a high mortality rate in humans.
Researchers investigated the structure‒tissue exposure/selectivity relationship (STR) in correlation with observed clinical efficacy/toxicity using seven selective estrogen receptor modulators. The results showed that tissue exposure/selectivity of SERMs was correlated with clinical efficacy/safety, while plasma exposure was not.
Current drug optimization prioritizes potency/specificity over tissue exposure/selectivity, leading to clinical failures. A new approach, STAR, classifies drugs based on potency/selectivity, tissue exposure/selectivity, and required dose to achieve clinical efficacy/toxicity balance.
Scientists at the University of Bath have developed a new technique called Transcription Block Survival (TBS) to accelerate the discovery of cancer-fighting drugs. TBS identifies molecules that can shut down dangerous proteins before they wreak havoc, by blocking their interaction with cell DNA.
Researchers have developed a method to chart the first-ever map of allosteric sites in two common human proteins, revealing they are abundant and identifiable. This could lead to safer, smarter, and more effective medicines by targeting these 'secret doors'.