Articles tagged with Drug Candidates
A new study finds that CP201, a nerve-cell-protecting snippet of ADNP protein, normalizes disrupted neural connectivity and improves vocal communication in ADNP-deficient mice. The research paves the way for a clinical trial to treat social, motor, and vocal communication impediments in ADNP syndrome patients.
A new subclass of compounds, dubbed geroneuroprotectors (GNPs), has been identified as potential AD drug candidates and slow the aging process in mice. The study suggests that these compounds could provide therapeutic benefits for Alzheimer's disease and other diseases associated with aging.
Researchers at WSU Spokane have created candidate drugs to slow down the breakdown of nicotine in the body, aiming to reduce tobacco consumption and quit smoking. The substances target liver enzyme CYP2A6, which metabolizes nicotine, potentially alleviating withdrawal symptoms like anxiety and irritability.
An artificial-intelligence approach called ReLeaSE can teach itself to design new drug molecules from scratch. The system comprises two neural networks that learn and improve over time, generating molecules with specified properties.
Researchers at Case Western Reserve University School of Medicine have identified dozens of drug candidates that share a common mechanism to repair damaged brain cells in multiple sclerosis. These new targets and potent early-stage drug candidates could lead to regenerative medicines for the debilitating disease.
A recent international agreement emphasizes the need for human-relevant research in drug discovery, citing a significant decline in successful new drug approvals. The agreement proposes standardized data sharing, consistent ontologies, and prioritization of human-based methods to revitalize the drug development process.
A Korean research team developed a deep learning-based framework, DeepDDI, to predict 86 types of drug-drug and drug-food interactions. The model accurately predicts interactions for drug-pair constituent pairs with a mean accuracy of 92.4%.
Researchers have identified mifepristone, an FDA-approved drug for chemical abortion, as a promising candidate for treating vestibular schwannoma. The study found that treatment of the tumor cells with mifepristone reduced their proliferation rate by 80 percent.
Researchers at ETH Zurich have developed a new screening method that speeds up the search for drugs using a 35 million compound DNA-encoded chemical library. The library consists of drug candidates with a stable ring-shaped basic structure and varied attachments, allowing for highly-specific binding to proteins.
Researchers have developed a new method to predict drug stability, which could lead to the creation of more effective medicines. The technique uses optical and mechanical measuring techniques to determine when and how a solid will crystallise, a process that can affect a drug's solubility in water.
McMaster University engineers have developed a printed paper-based device that speeds up and improves the accuracy of drug screening. The technology uses a printable hydrogel to filter out inaccurate results, reducing the time and cost associated with drug discovery.
Researchers are re-examining old antibiotics to find new ones, applying modern science and technology to test their potential. A compound identified in the 1940s is now being considered as a realistic contender for a new antibiotic drug, with the potential to combat certain types of bacterial infections.
Scientists at ICIQ discover a novel methodology to create carbynes using visible light and photocatalysts. They use these molecules to add chiral fragments to existing compounds, accelerating the drug discovery process.
Research identifies common molecular mechanism underlying diabetes-induced nerve damage, paving way for potential drug candidates. The study found that reactive oxygen species play a key role in the process and that pharmacological inhibition of ROS can prevent nerve damage.
Case Western Reserve University researchers have received a $2.8 million grant to identify FDA-approved medications that can be repurposed to treat Alzheimer's disease. The project aims to develop computer algorithms and test promising drug candidates using patient electronic health records and animal models.
Researchers developed a long-acting compound that targets HIV's replication, suppressing the virus and protecting immune cells. The compound works synergistically with current treatments, enhancing their potency and potentially improving treatment for 37 million people worldwide affected by HIV.
Boris Striepen has received a $1.8-million grant from the Bill & Melinda Gates Foundation to support drug development efforts against cryptosporidiosis, a disease that sickens approximately 750,000 people annually in the US. The project aims to identify and validate therapeutic targets to guide medicinal chemistry.
Compound I, a non-nucleoside reverse transcriptase inhibitor, exhibited synergistic properties and suppressed viral loads in HIV-1-infected humanized mice. The compound sustained plasma drug concentrations and effectiveness for approximately 3 weeks in mice, suggesting potential in pre-exposure treatments.
A new methodology for correlating compound identity to CYP1A2 potency of inhibitors in metabolic mixtures has been developed, providing direct identification of compounds with inhibitory properties. This approach allows for rapid assessment of pharmacokinetic properties of drugs and their metabolites, improving drug development.
The GHIT Fund has announced significant investments in new treatments for malaria, including an antimalarial drug candidate DSM265 and a diagnostic tool for detecting dormant Plasmodium vivax parasites. These breakthroughs aim to combat the growing threat of artemisinin resistance and eliminate the 'hidden reservoir' of vivax malaria.
Scientists from RUDN University have developed a new way to synthesize 1,2,4-oxadiazole derivatives, including the active ingredient of genetic disorder treatment drugs. The new method simplifies production while reducing costs and enabling high-yield synthesis without expensive reagents.
Researchers created micro hearts, lungs, and livers that can mimic human organ responses to medications. The 'body-on-a-chip' system aims to improve drug development by identifying toxic side effects early on.
Researchers develop computer-designed mini-proteins that bind to specific therapeutic targets with high selectivity, stability and potency. The approach has potential applications in fighting infectious diseases and neutralizing toxins.
A widely used drug screening tool has been found to be seriously flawed, incorrectly flagging many active compounds as potential PAINS. The University of North Carolina study analyzed thousands of compounds and found that majority do not exhibit interference with drug-candidate screening technology.
Researchers have discovered a new way to identify and test new drugs using differential mobility spectrometry (DMS), which analyzes drug molecules based on their response to an electrical field. This technique can measure drug properties in seconds, allowing for high-throughput testing of hundreds or thousands of drugs.
Researchers have identified B0AT1 inhibitors as a potential replacement for gastric bypass surgery in treating obesity and related disorders. These compounds, including benztropine, could replicate the effects of gastric bypass by reducing nutrient absorption, offering a new treatment option.
A breakthrough study by Dr. Xinglong Wang has linked ALS and dementias to TDP-43 toxicity in mitochondria, offering new hope for treatment. His team discovered a small-molecule peptide that can reverse symptoms of ALS in mice, paving the way for potential therapeutic approaches.
Researchers discover over 31,000 repurposable drug candidates for various diseases, including Parkinson's and tuberculosis. The study uses computational methods to identify shared properties between genes, drugs, and diseases, promising a more efficient and cost-effective approach to pharmaceutical discoveries.
Researchers from Duke University have identified two specific receptors, CXCR2 and LTBR, that play a key role in the development of drug-resistant multiple sclerosis. The study found that targeting these receptors may lead to successful treatment for patients who do not respond to interferon-beta treatment.
A new study suggests a dual-targeting drug candidate could treat both type 2 diabetes and bone disease by expanding bone formation and turnover. The compound has shown promise in increasing bone mass regardless of body mass index.
Researchers identified a new drug target, BRD9, in acute myeloid leukemia and developed a candidate drug, BI-7273. The team discovered that replacing the native bromodomain with a functionally synonymous one allowed them to prove how the drug works, providing valuable information for drug development.
Researchers found that a plant-virus-based carrier successfully delivers the drug candidate phenanthriplatin, outperforming cisplatin in mouse models of triple-negative breast cancer. The nanoparticles target tumors, accumulating inside lysosomal compartments and releasing the drug to block transcription, leading to greater cell death.
Researchers have created a drug candidate that targets and neutralizes the RNA structure causing an incurable progressive disease, spinocerebellar ataxia type 10. The compound, 2AU-2, improves several aspects of cells taken from patients with SCA10, offering new hope for treating dozens of incurable diseases.
Scientists at Scripps Research Institute designed a drug candidate that targets cancer-causing RNA, eliminating side effects and reducing tumor growth. The study demonstrates a clear breakthrough in precision medicine, using computational approaches to develop designer compounds.
Scientists at Scripps Research Institute have identified a novel drug candidate that targets serine biosynthesis in cancer cells, inhibiting their growth. The new compound, CBR-5884, specifically targets the enzyme PHGDH, which is responsible for serine production, and shows promise in treating breast cancer, lung cancer, and melanoma.
A spider toxin analogue, PnPP-19, has shown promise in relieving pain by targeting nervous system receptors similar to opioids and cannabis. The compound is also being studied for erectile dysfunction treatment.
Lawrence Livermore National Laboratory researchers developed a simulation to predict the permeability of drug molecules across cell membranes, enabling faster testing and development of nerve-agent treatments. The simulation shaved weeks off compound testing, reducing the time required from six weeks to just 16 hours.
Researchers developed a family of reagents to add ring-shaped structures to drug candidates, reducing multiple steps in synthesis. This innovation may help speed up the development process for numerous pharmaceuticals.
The Phase I study confirms the therapeutic dose and safety profile of SCYX-7158, a first oral drug candidate specifically developed to combat human African trypanosomiasis. The study results translate into prolonged exposure with just one dose, targeting the late stage of the disease where the parasite crosses the blood-brain barrier.
Researchers at Scripps Research Institute have received a nearly $4.5 million grant with the possibility of up to $10 million to complete preclinical studies on a new anti-migraine drug candidate. The compound has shown promising results in treating stress-induced migraine and may be developed into a once-a-day pill.
Researchers at Johns Hopkins Medicine have developed a high-throughput screening technique using zebrafish embryos to identify 24 potential new diabetes drugs. The novel method may also be applied to other diseases, including heart disease and neurodegenerative conditions.
Scientists at Scripps Research Institute have discovered a bacterial enzyme that can degrade nicotine, offering a potential alternative to smoking cessation aids. The enzyme, NicA2 from Pseudomonas putida, has shown promising characteristics for drug development, including stability in lab settings and minimal toxic byproducts.
Researchers at Scripps Florida will study RORs, molecules that regulate circadian rhythm and carbohydrate metabolism, to better understand their role in neurological disorders. The new grant aims to expand the understanding of these receptors and develop experimental compounds for treating conditions like depression and bipolar disease.
A new algorithm, DeMAND, is helping scientists identify the full repertoire of proteins affected by a drug. By analyzing gene expression changes and protein interactions, DeMAND provides a more comprehensive picture of a drug's effects.
EPFL scientists identified lansoprazole as an excellent candidate against tuberculosis, a global pandemic, by screening thousands of approved drugs. The study found that lansoprazole kills the bacterium after being converted into a sulfur-containing metabolite, targeting a crucial enzyme for energy production.
Scientists from Scripps Research Institute aim to develop drugs targeting the IP6K1 enzyme to treat obesity and related metabolic diseases. The new grant will help identify underlying mechanisms of energy storage regulation.
Researchers have discovered a promising new treatment for Ebola by screening compounds from existing malaria and flu drugs. The treatment showed a high success rate of up to 90% in treating infected mice with no observable side effects.
Revolution Medicines has developed a unified 'building blocks' approach for synthesizing multiple classes of complex natural chemicals that could be valuable backbones for new medicines. The company's technology can produce a broad range of molecules, including those with diverse types of chemical bonds and highly complex cyclic struct...
DeuteRx has discovered a method for in vivo stabilization and differentiation of thalidomide analogs, improving anti-inflammatory and antitumorigenic properties. The company's 'deuterium-enabled chiral switching' platform enables the testing and development of single enantiomers with improved therapeutic properties.
Researchers from Scripps Florida have developed an anti-HIV agent that blocks all strains of HIV-1, HIV-2, and SIV, offering potential protection for at least eight months after injection. The new compound binds to the virus's envelope, preventing entry into host cells.
Dartmouth investigators develop new algorithms that employ molecular modeling to optimize deimmunized drug candidates. The approach resulted in highly-active and stable biotherapeutic designs that addressed immunogenic hotspots not easily targeted by earlier methods.
Researchers at Scripps Research Institute have identified drug candidates targeting biological pathways involved in brain cell destruction in Parkinson's disease. The new compounds selectively inhibit JNK kinases, which play a central role in the disease, and show promise as potential therapeutics.
A new drug candidate called DBIBB increases the survival of mice suffering from radiation syndrome, even when treatment was delayed by three days. The compound protects against DNA damage and enhances the survival of various types of cells, showing promise for treating acute radiation syndrome.
Scientists developed a new compound that targets the 'receptor' responsible for pain caused by chili peppers. The compound, tested in clinical trials, has shown promise in treating various types of pain.
Researchers at Uppsala University discovered that Upsalite, a highly porous magnesium carbonate, can improve the solubility and bioavailability of poorly soluble drugs. By using Upsalite, about 40% of newly marketed drugs with poor solubility may have their therapeutic efficacy enhanced.
A drug candidate developed to treat sickle cell disease has been acquired by Baxter International, advancing its clinical development activities. Aes-103 significantly reduces patients' pain in Phase II clinical trials, offering a potential breakthrough treatment.
A new transdermal selective androgen receptor modulator (SARM) drug may help older cancer patients build muscle without harming liver function or HDL levels. The novel compound, AUSRM-057, avoids negative impacts on prostate health, making it a promising treatment option.
Pharmacists at Jena University have developed three potential therapeutic agents that may improve the healing of inflammatory illnesses. The agents suppress a key enzyme in the body's own cascade of inflammation, specifically targeting 5-LOX, which plays a pivotal role in synthesizing leukotrienes. This breakthrough could lead to more ...
A new study identifies three potential drug candidates for treating autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and psoriasis. The researchers used genome analysis to target a specific molecule within immune cells that drives these diseases.
Researchers have developed a new technique for making unnatural amino acids, which are sought after by the pharmaceutical industry for their medical uses. The method employs special ligand compounds to enhance the ability of a palladium catalyst to break carbon-hydrogen bonds.