Articles tagged with Vitamin K
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Researchers synthesized hybrid vitamin K analogues with enhanced neuroactive properties, exhibiting threefold greater potency in inducing neural progenitor cell differentiation compared to natural vitamin K. The compounds preserved vitamin K and retinoic acid's biological activity via the SXR and RAR receptors.
A new study reveals how Lactococcus lactis regulates the production of a key precursor in vitamin K2 biosynthesis. By tuning substrate supply and genetic architecture, researchers can push production above natural ceilings, opening the door to engineering bacteria for enhanced vitamin K2 production.
Researchers at UCSF found that certain gut bacteria can reduce chemotherapy side effects by clearing excess drugs and producing the protective vitamin K2. Patients with more beneficial bacteria had fewer side effects, suggesting that probiotics may help mitigate chemotherapy's impact.
A new study by researchers at Tufts University suggests that a lack of vitamin K may increase inflammation and hamper proliferation of neural cells in the hippocampus, a key region for learning and memory. Vitamin K deficiency was also associated with increased neuroinflammation and reduced neurogenesis, leading to noticeable cognitive...
A new discovery by Cold Spring Harbor Laboratory's Lloyd Trotman suggests that menadione, a precursor to vitamin K, can slow prostate cancer progression in mice. The supplement depletes a lipid called PI(3)P, killing cancer cells and slowing disease progression significantly.
A randomized clinical trial found that avoiding aspirin as part of an antithrombotic regimen reduces bleeding events without increasing thromboembolism risk in patients with advanced heart failure treated with left ventricular assist devices. The study suggests that aspirin avoidance may be a viable option for these patients.
A meta-analysis found that direct oral anticoagulants (DOACs) reduced dementia risk in Asian atrial fibrillation (AFib) patients compared to traditional blood thinners like warfarin. The benefit may reverse with increased age, necessitating further study.
A large study published in ERJ Open Research found that people with low levels of vitamin K in their blood are more likely to have poor lung function and experience respiratory issues. The research suggests that vitamin K may play a role in keeping lungs healthy, but further studies are needed to confirm this link.
Octapharma's Balfaxar, a prothrombin complex concentrate, has received FDA approval for the urgent reversal of acquired coagulation factor deficiency induced by vitamin K antagonist therapy. The product demonstrated effective hemostasis in 94.6% of patients and was non-inferior to comparator Kcentra.
A long-term study found that eating more than 100 micrograms of vitamin K1 daily reduced the risk of fractures and hospitalizations by 31-49%. Dark leafy vegetables and one-to-two serves of vegetables are recommended for optimal benefits. Vitamin K1 has been shown to enhance cardiovascular health and promote bone health.
The new guideline provides evidence-based recommendations for managing patients on warfarin, DOACs, and antiplatelet drugs before and after surgeries. It aims to minimize preventable bleeding and thrombotic events by standardizing approaches and protocols.
Researchers discovered that vitamin K acts as an antioxidant, inhibiting ferroptotic cell death and identifying FSP1 as the warfarin-insensitive enzyme responsible. This finding has implications for treating Alzheimer's disease and acute organ injuries.
Researchers at Helmholtz Munich discover vitamin K's ability to inhibit ferroptotic cell death and identify the warfarin-insensitive enzyme FSP1. This finding may lead to novel therapeutic strategies for diseases associated with ferroptosis.
A new study found that vitamin K2 supplementation improved spatial memory, learning ability, and reduced evidence of cognitive impairment, depression, and anxiety in rats. The researchers suggest that vitamin K may help preserve cognitive functions by affecting biological pathways involving inflammation and antioxidant activity.
A retrospective cohort study of patients with atrial fibrillation and diabetes found that non-vitamin K antagonist oral anticoagulants (NOAC) were associated with a lower risk of diabetes complications and mortality than warfarin. The study suggests that NOAC may be a better therapeutic choice for this patient population.
Researchers found that people who eat more vitamin K-rich foods have a lower risk of heart disease and peripheral artery disease. Vitamin K2 intake was also associated with reduced hospitalization rates for cardiovascular disease.
A new study found that older adults with low vitamin K levels had a higher risk of death over 13 years compared to those with adequate vitamin K levels. The research suggests that vitamin K may have protective health benefits as we age, particularly in reducing the risk of death.
A recent study published in the Journal of Gerontology: Medical Sciences found that low levels of circulating vitamin K are associated with an increased risk of mobility limitation and disability in older adults. The study, conducted on a sample of 635 men and 688 women aged 70-79 years old, used biomarkers of vitamin K status to evalu...
A new clinical trial found that patients on warfarin benefit from increasing their vitamin K intake to maintain stable anticoagulation levels. The study recommends a daily minimum of 90 micrograms of vitamin K for women and 120 micrograms for men.
Neuroene Therapeutics is developing a vitamin K analogue to improve seizure control in patients with drug-resistant epilepsy. The company will test the efficacy and safety of its lead compounds with assistance from the University of Utah's Anticonvulsant Drug Development Program.
Researchers at Penn State have developed a novel method to enhance fermentation of Menaquinone-7, a potent form of vitamin K, using biofilm reactors. The new process is expected to reduce production costs and increase efficiency, making it a promising alternative for industrial-scale production.
Researchers discovered a protective protein activated by vitamin K is inactive and abundant in African-Americans on dialysis. High levels of the protein, matrix Gla protein (MGP), correlate with increased arterial stiffness and impaired endothelial function.
A recent study published in The Journal of Nutrition found that adolescents consuming the least amount of vitamin K1 were at a higher risk for unhealthy enlargement of their heart's major pumping chamber. This association was independent of other factors such as physical activity and blood pressure.
Researchers from the Hong Kong University of Science and Technology discovered a unique substrate-binding mode for OSB-CoA synthetase, a crucial enzyme in bacterial vitamin K biosynthesis. The study revealed distinct amino acid residues contributing to thioesterification half-reaction without affecting adenylation.
A new study from Tufts University's Jean Mayer USDA Human Nutrition Research Center on Aging has found that dairy products, including milks, yogurts, and cheeses, contain appreciable amounts of vitamin K in two natural forms: phylloquinone (PK) and menaquinones (MK).
A study found a significant association between increased use of antithrombotic drugs and subdural hematoma incidence in Denmark from 2000 to 2015. The risk was highest for patients taking multiple anticoagulant medications, particularly those combining vitamin K antagonists with antiplatelet drugs.
A new study found that oral thrombin inhibitors (OTIs) encourage blood clotting under flowing conditions, increasing the risk of heart attack. The researchers suggest considering this when designing individual therapies for patients taking OTI drugs.
Researchers are enrolling 60 obese children in an eight-week study to examine the impact of vitamin K supplements on their cardiovascular health. The study aims to determine whether vitamin K can improve insulin sensitivity and reduce lipid levels in the blood, potentially reducing the risk of diabetes and cardiovascular disease.
Patients on warfarin have poor knowledge about diet and drug interactions, which can lead to fatal side effects. Experts recommend consistent monitoring and education to improve patient outcomes.
Researchers found an association between dicloxacillin treatment and decreased international normalized ratio (INR) levels among patients taking warfarin or phenprocoumon. This finding suggests that physicians should be aware of potential interactions and monitor INR levels accordingly.
Researchers at LSU Health Sciences Center have identified a new gene mutation causing Schnyder corneal dystrophy, a rare hereditary eye disease. The mutation is linked to vitamin K metabolism and may lead to the development of a new treatment using vitamin K supplements.
Researchers at the Mayo Clinic found that people with higher vitamin K intakes from their diet had a lower risk of developing Non-Hodgkin lymphoma. Vitamin K intake was estimated from a food questionnaire and was associated with a significant protective effect against the disease.
A study of over 40,000 Danish patients found that those taking more than one anti-bleeding medication after a heart attack were at higher risk of non-fatal and fatal bleeding. Non-fatal bleeding was also associated with an increased risk of repeat heart attacks or death.
Researchers analyzed data from hundreds of published articles to test the triage theory, which suggests optimal intake levels for individual vitamins and minerals. The study found modest vitamin/mineral deficiencies are common and may contribute to age-related conditions.
Researchers found that combining vitamin K with sorafenib reduced the need for higher doses of sorafenib by more than 50% in both pancreas cancer and hepatocellular carcinoma studies. This combination also inhibited tumor growth and induced cell death, offering a potential cure strategy.
A new study in Annals of Internal Medicine found that patients connected to a specific primary care physician are more likely to receive guideline-consistent care than those without a connection. Researchers also discovered that connectedness was associated with smaller disparities in screening rates, but not race or ethnicity.
Researchers at Rice University have discovered a genetic mutation in rats that links to cardiovascular disease, osteoporosis, and potentially Alzheimer's disease. The study found that the mutation also increases susceptibility to arterial calcification.
A three-year study found that vitamin K supplementation improved insulin resistance in elderly men, while worsening it in women and those not given supplements. Vitamin K may help regulate glucose metabolism by storing in fat tissue.
A randomized controlled trial found that high-dose vitamin K1 supplementation did not protect against age-related bone mineral density (BMD) decline in postmenopausal women with osteopenia. However, the study suggested that vitamin K1 may reduce fracture and cancer risk in these women.
A trial found idraparinux causes significantly more bleeding than vitamin K antagonists in patients with atrial fibrillation at risk of stroke. The treatment requires regular monitoring and dose adjustment, but an unmonitored regimen would be preferable for improved safety.
Researchers at Tufts University have found that while older adults consume more vitamin K than younger adults, many still do not meet the recommended intake. High phylloquinone intake may be associated with better dietary habits and reduced risk of cardiovascular disease, but further research is needed.
Long-term warfarin therapy increases incidence of osteoporotic fractures by 25% in elderly patients, with men at higher risk. Regular exercise and adequate calcium intake can help maintain bone strength.
A study published in the American Journal of Clinical Nutrition found that high vitamin K intake was associated with lower incidence of hip fractures in elderly participants, while no correlation was found with bone mineral density or apo-E genotype. Researchers analyzed data from the Framingham Heart Study and discovered a significant...