A recent study found that apoptotic factors in eukaryotes have a bacterial or mitochondrial origin, suggesting conservation over 1.8 billion years. The researchers proposed an alternative scenario where early protoeukaryotes domesticated bacteria to produce toxins, which eventually evolved into apoptotic factors.
SourceSMBE Journals (Molecular Biology and Evolution and Genome Biology and Evolution)·JournalGenome Biology and Evolution·TypeObservational study·DateOct 12, 2023
Mayo Clinic researchers found that cells expressing PD-1 and PD-L1 within a certain distance of each other can predict the success of immunotherapy in patients with colorectal cancer. This spatial analysis may help select patients most likely to benefit from treatment, improving outcomes and minimizing unnecessary treatments.
SourceMayo Clinic·JournalClinical Cancer Research·DateAug 31, 2023
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Autophagy helps protect cardiomyocytes from damage caused by anthracycline drugs like Doxorubicin. The study found that a protein regulator called ER-phagy alleviates Dox-induced cardiomyopathy, promoting cell survival.
SourceTokyo Medical and Dental University·JournalJACC CardioOncology·DateAug 31, 2023
Researchers discovered that Nerofe and Doxorubicin can downregulate KRAS signaling, leading to enhanced apoptosis in colorectal cancer cells. The combination also activates the immune system against tumor cells, increasing immunostimulatory cytokines and recruiting NK cells and M1 macrophages.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateJul 5, 2023
Researchers investigate MCL-1i-induced Mcl-1 protein accumulation and its implications in B-cell malignancies. The study reveals a complex mechanism contributing to MCL-1 protein stability upon treatment with MCL-1 inhibitors.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateJun 28, 2023
Researchers characterize a unique molecular mechanism in early stages of programmed cell death (apoptosis), a crucial process preventing cancer. By studying Bax protein interactions with mitochondrial lipids, they found that pore creation drives apoptosis initiation.
SourceUK Research and Innovation·JournalScience Advances·TypeExperimental study·DateJun 2, 2023
Researchers discovered that FDA-approved HDAC-inhibitors can impact energy metabolism in solid tumor cells, including glioblastoma. The combination of HDAC-inhibitors and imipridones may synergize to enhance killing of GBM cells by reversing cellular respiration.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateMay 19, 2023
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers have identified ATAD3A as a molecular determinant that favors the development of head and neck cancer. The protein is involved in various cellular processes, including energy metabolism and apoptosis. Targeting ATAD3A could offer a novel approach to developing effective anti-cancer therapeutics.
SourceImpact Journals LLC·JournalOncoscience·TypeCommentary/editorial·DateApr 28, 2023
Researchers found that CUDC-907 selectively induces apoptosis in cells driven to senesce by p53 expression. The compound showed senolytic properties in different models of stress-induced senescence, depending on its inhibitory effects on HDACs and PI3K.
SourceImpact Journals LLC·JournalAging-US·TypeExperimental study·DateApr 25, 2023
Researchers found that necroptosis promotes metastasis in breast cancer models, and blocking it leads to inhibition of metastasis. Necroptosis may be a key factor in tumor progression, and targeting its regulators could be critical for mitigating metastasis.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateApr 24, 2023
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Researchers found that TaMADS29 interacts with TaNF-YB1 to regulate early grain development in bread wheat. The complex helps prevent excessive ROS accumulation, promotes nutrient transport into the endosperm, and allows normal grain filling.
SourceScience China Press·JournalScience China Life Sciences·DateApr 12, 2023
A team of scientists from City University of Hong Kong and HKUST discovered novel, tridimensional compounds with high anticancer activity and low toxicity. These compounds can overcome drug resistance in cancer cells by inducing a different cell death pathway.
SourceCity University of Hong Kong·JournalNature Synthesis·TypeExperimental study·DateApr 6, 2023
A study reveals that neutrophils destroy liver cells undergoing apoptosis by burrowing into them, contradicting previous beliefs about their role in immune responses. The findings also suggest that a lack of neutrophils may contribute to human autoimmune liver disease.
Researchers have discovered that Shigella bacteria can infect humans but not mice due to differences in the shape of a key protein, gasdermin-B. The protein has six different forms, and some isoforms cause cell death while others do not, explaining why Shigella is unable to infect mice.
SourceUniversity of Connecticut·JournalNature·TypeExperimental study·DateMar 30, 2023
Researchers have found that valosin-containing protein (VCP) is essential for KRAS-mutant pancreatic ductal adenocarcinoma cell growth and survival. Inhibiting VCP, combined with autophagy inhibition, enhances efficacy in preclinical studies.
SourceImpact Journals LLC·JournalGenes & Cancer·TypeObservational study·DateMar 24, 2023
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
Scientists from USC Stem Cell laboratory discovered a mechanism linking leukemic mutations to varying disease potentials, identifying RNA splicing regulator Rbm25 as a critical factor. The study found that over-contributing clones of blood stem cells produce excessive myeloid cells, leading to potential leukemia development.
SourceKeck School of Medicine of USC·JournalBlood·TypeExperimental study·DateMar 23, 2023
Researchers discovered that combining ferroptosis induction with immune checkpoint inhibition reduces liver tumour growth and metastases, offering a promising new approach for treating liver cancer
SourceGoethe University Frankfurt·JournalGut·TypeExperimental study·DateFeb 17, 2023
The addition of antioxidants to cell cultures can improve the production of monoclonal antibodies by reducing oxidative stress and increasing cell viability. This has potential benefits for therapies targeting cancer and autoimmune diseases.
SourceSociety of Chemical Industry·JournalJournal of Chemical Technology and Biotechnology·TypeExperimental study·DateFeb 15, 2023
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
A new study published in The American Journal of Pathology suggests that promoting autophagy with rapamycin restores intestinal barrier function during sepsis. The study also identifies the PLK1-mTOR axis as a crucial regulator of autophagy and intestinal barrier dysfunction, providing novel insights for treatment of sepsis.
SourceElsevier·JournalAmerican Journal Of Pathology·TypeExperimental study·DateJan 26, 2023
Researchers developed a cancer-selective therapeutic agent that targets cancer cells' unique acidic pH microenvironment, inducing mitochondrial dysfunction and killing only cancer cells. The agent, Mito-SA, forms charge-shielded nano-assemblies that selectively disassemble in the tumoral environment.
SourceUlsan National Institute of Science and Technology(UNIST)·JournalAdvanced Functional Materials·DateJan 26, 2023
Researchers identified 17 clusters of single cells in peripheral blood, showing upregulation of antigen processing and presentation pathways and downregulation of genes involved in ribosome pathways with age. The study also found senescent T cells resistant to apoptosis, potentially targeted for treatment.
SourceImpact Journals LLC·JournalAging-US·TypeObservational study·DateJan 17, 2023
Researchers discovered that 15-deoxy-prostamide-J2 induces ER stress-mediated apoptosis selectively in tumor cells, reducing melanoma growth. The molecule activates PERK, IP3R, and the mitochondrial permeability transition pore, leading to cell death.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateJan 12, 2023
Researchers have discovered a possible cause of neurodegeneration in the early stages of Alzheimer's disease using fruit flies. The study found that an overabundance of the TOMM40 gene causes marked cell death in the retina, which corresponds to the level of protein produced by the gene.
SourceWalter and Eliza Hall Institute·JournalScientific Reports·TypeExperimental study·DateJan 9, 2023
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Researchers found that MMTV-NeuT/ATTAC mice treated with anti-PD-1 therapy developed increased tumor-associated macrophages, EMT, fibroblast proliferation, and enhanced extracellular matrix. These findings suggest potential therapeutic avenues to enhance PD-1 immune checkpoint sensitivity.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateJan 5, 2023
A recent study published in Frontiers in Cell and Developmental Biology has found that the unique checkerboard pattern of cells in the organ of Corti is essential for proper hearing. The researchers discovered that when hair cells adhere to each other abnormally, it leads to apoptosis and a decrease in hair cell numbers, resulting in h...
SourceKobe University·JournalFrontiers in Cell and Developmental Biology·TypeExperimental study·DateDec 27, 2022
Caulobacter crescentus uses a toxin-antitoxin system to regulate programmed cell death in response to oxygen limitation, releasing DNA that promotes sibling dispersion. This mechanism helps maintain biofilm balance and prevents overcrowding.
SourceUniversity of Montreal·JournaleLife·TypeExperimental study·DateDec 12, 2022
A new study has discovered that MTCH2, a protein essential in various cellular processes, acts as a 'door' for proteins to access the mitochondrial membrane. The finding opens up potential avenues for cancer treatments by harnessing apoptosis, a programmed cell death mechanism.
SourceWhitehead Institute for Biomedical Research·JournalScience·TypeExperimental study·DateOct 20, 2022
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
A new study found that a protein called apoptosis inhibitor five (API5) protects most people with the mutation linked to Crohn's disease from developing the illness. Norovirus infection blocks API5 production in mice with Crohn's, killing gut-lining cells and tipping the balance towards autoimmune disease.
SourceNYU Langone Health / NYU Grossman School of Medicine·JournalNature·TypeExperimental study·DateOct 5, 2022
Researchers found that mTOR inhibition is crucial for p53-mediated tumor suppression, delaying cancer and increasing lifespan. In the absence of mTOR inhibition, cancer-promoting senescent cells drive tumor growth.
SourceImpact Journals LLC·JournalOncoscience·TypeCommentary/editorial·DateSep 12, 2022
Researchers found that neonatal serum ketone body production determines the quantity and quality of primordial follicles, reducing ROS-induced apoptosis. This mechanism is crucial for maintaining ovarian capacity and preventing premature ovarian aging.
SourceHigher Education Press·JournalLife Metabolism·TypeExperimental study·DateSep 5, 2022
Researchers at Cornell University have discovered a new CRISPR system called Craspase, which has the potential to develop promising antiviral and tissue engineering tools in animals and plants. The study uses cryo-electron microscopy snapshots to explain how Craspase identifies RNA targets and activates proteases.
Researchers discovered how coronaviruses use caspase-6 to cleave and neutralize the host's interferon response, facilitating viral replication. By inhibiting or overexpressing caspase-6, researchers reduced coronavirus replication in various models, suggesting a potential target for antiviral treatment.
SourceThe University of Hong Kong·JournalNature·TypeExperimental study·DateAug 5, 2022
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
A study reveals that an ADAR1 gene mutation activates ZBP1 protein, leading to programmed cell death and inflammatory responses. This causes damage to organs like the kidneys and liver in genetically modified mouse models.
SourceUniversity of Washington School of Medicine/UW Medicine·JournalNature·TypeExperimental study·DateAug 1, 2022
Leukemia cells exploit metabolic pathways to evade programmed cell death, but researchers identified a weak spot in acute lymphoblastic leukemia that can be targeted with experimental drugs. Inhibiting glutathione metabolism induces ferroptosis, leading to the death of malignant lymphocytes.
SourceJosep Carreras Leukaemia Research Institute·JournalRedox Biology·TypeExperimental study·DateAug 1, 2022
Researchers identified CUDC907 as a dual phosphoinositide-3 kinase/histone deacetylase inhibitor that promotes apoptosis in NF2 schwannoma cells. The compound reduced viability and induced cell cycle arrest in human merlin deficient Schwann cell models.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateJul 26, 2022
Researchers have identified a key chemical controlling hair follicle cell division and death, shedding light on a potential cure for baldness. The discovery also holds promise for speeding up wound healing by harnessing the regenerative properties of stem cells found in hair follicles.
SourceUniversity of California - Riverside·JournalBiophysical Journal·DateJul 25, 2022
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Researchers from Tokyo University of Science developed novel complex-peptide hybrids that induce programmed cell death in apoptosis-resistant cancer cells through paraptosis. The compounds, syn-6 and anti-6, inhibit cell death by uncoupling mitochondrial calcium uptake and inducing cytoplasmic vacuolization, leading to cell death.
SourceTokyo University of Science·JournalBioconjugate Chemistry·TypeExperimental study·DateJul 11, 2022
Researchers have found a new approach to treat cancer by using plasma treatment, which induces apoptosis in cancer cells without harming normal cells. The equivalent total oxidation potential (ETOP) has been defined as a plasma dose, providing a dose-response relationship for different cell types.
SourceAmerican Institute of Physics·JournalPhysics of Plasmas·DateJun 28, 2022
Researchers have discovered a novel treatment approach for chromophobe renal cell carcinoma (ChRCC) by targeting ferroptosis, a form of programmed cell death. This strategy may provide an effective treatment option for patients with this rare and currently untreatable disease.
SourceBrigham and Women's Hospital·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateJun 20, 2022
GQ GMC-500Plus Geiger Counter
GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
Researchers at University of Missouri, Georgia Tech and Harvard University have successfully demonstrated a new Type 1 diabetes treatment in large animal models. By transplanting pancreatic islet cells with a molecule called FasL, they prevent rogue immune cells from destroying the transplanted cells.
SourceUniversity of Missouri-Columbia·JournalScience Advances·DateMay 13, 2022
Research suggests that EMFs can cause Alzheimer's disease by building up calcium levels in brain cells. This increase leads to changes in the brain, which develop conditions for Alzheimer's. The study highlights the importance of reducing EMF exposure to prevent or delay the onset of Alzheimer's.
SourceBentham Science Publishers·JournalCurrent Alzheimer Research·DateApr 25, 2022
Researchers have identified a new type of programmed cell death, erebosis, that takes place in the intestines of fruit flies, contradicting the long-held theory of apoptosis. The process involves gradual cell death without nuclear membranes, mitochondria, and cytoskeletons, and is thought to play a role in gut metabolism.
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Researchers at Okayama University have created a new method to kill cancer cells using light-activated protein AR3, reducing the risk of adverse reactions. The approach uses green light to trigger apoptosis in targeted cells, offering a promising alternative to conventional treatments.
SourceCactus Communications·JournalJournal of the American Chemical Society·TypeExperimental study·DateMar 30, 2022
Researchers at Niigata University identified a novel Olig2 binding protein called Ddx20, which regulates RNA metabolism and transcription. Ddx20's interaction with Olig2 helps maintain cell survival and prevents apoptosis in neural progenitor cells.
SourceNiigata University·JournalCell Death and Differentiation·DateMar 13, 2022
Researchers found that the Klotho gene can suppress glioblastoma cell viability and induce apoptosis, leading to a significant decrease in tumor growth. The study contributes to the development of new diagnostic and treatment approaches for malignant brain tumors.
SourceUral Federal University·JournalJournal of Molecular Neuroscience·TypeExperimental study·DateMar 10, 2022
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers at UNIGE find that near-death experience in primary tumors triggers pro-metastatic states in cells, leading to metastasis. These 'PAME' cells reprogram themselves and trigger a cytokine storm, forming new tumors.
SourceUniversité de Genève·JournalCell Reports·TypeNews article·DateMar 9, 2022
A research team has devised a novel strategy to overcome chemotherapy resistance in cancer by boosting the pro-apoptotic BAX protein and targeting its inhibitor, BCL-XL. The two-drug combination achieved significant success against apoptosis-resistant human tumor cell lines and xenograft models, with minimal side effects.
SourceAlbert Einstein College of Medicine·JournalNature Communications·DateMar 7, 2022
Researchers have discovered that sigma 1 receptor plays a crucial role in protecting retinal ganglion cells from damage in glaucoma. The protein enables astrocytes to secrete supportive factors for neurons, improving their survival and function.
SourceMedical College of Georgia at Augusta University·JournalInvestigative Ophthalmology & Visual Science·DateMar 1, 2022
A team of researchers from Charité – Universitätsmedizin Berlin have elucidated the process underlying drug resistance in aggressive pancreatic cancer. They found that inhibition of the RUNX1 protein limits cancer growth and may lead to effective treatment options.
SourceCharité - Universitätsmedizin Berlin·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateFeb 24, 2022
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Dixit's work on programmed cell death and inflammation has led to therapies for autoimmune disorders and rheumatoid arthritis. The Vilcek Foundation recognizes his contributions as an immigrant scientist in the US.
A preclinical study identified a protein complex critical for regulating apoptosis and necroptosis. Inhibiting this complex may help prevent excessive cell death and tissue damage associated with heart attacks, autoimmune disorders, and COVID-19. Researchers believe that targeting the PPP1R3G/PP1γ pathway could lead to new treatments f...
SourceUniversity of South Florida (USF Health)·JournalNature Communications·TypeExperimental study·DateFeb 18, 2022
Research in C. elegans reveals that intestinal stress signals can control oocyte chromosome stability, influencing egg quality control and heritable euploidy. This study opens new possibilities for eliminating environmental influences and preventing malformations.
SourceUniversity of Cologne·JournalNature Communications·TypeExperimental study·DateFeb 4, 2022
A new study published in Nature Communications identifies a harmful cellular pathway that causes pancreatic beta cell death, leading to type 1 diabetes. Blocking this pathway preserved beta cells, increased insulin production, and prevented or delayed diabetes in mice models.
SourceBoston Children's Hospital·JournalNature Communications·DateFeb 3, 2022
A team of researchers at UMass Amherst identified the specific genes responsible for growth suppression in maize flowers, including GRASSY TILLERS1 and RAMOSA3. These findings provide insights into the evolution of life on earth and have implications for plant breeding, benefiting humans from apples to corn.
SourceUniversity of Massachusetts Amherst·JournalProceedings of the National Academy of Sciences·DateFeb 1, 2022
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
Researchers developed a multifunctional microfiber probe for real-time monitoring of cellular molecules and changes in cell morphology. The nanowire probe enabled sensitive detection of refractive index distribution in single living cells during apoptosis.
SourceSPIE--International Society for Optics and Photonics·JournalAdvanced Photonics·DateJan 18, 2022
Researchers at the University of Cologne have identified a new direct link between proteins BAX and DRP1 and apoptosis. The study reveals that DRP1 can serve as a direct cell death activator by binding to BAX, potentially leading to new cancer therapies.
SourceUniversity of Cologne·JournalThe EMBO Journal·TypeExperimental study·DateJan 13, 2022
Researchers at UTA have discovered commonalities among caspases 3, 6, and 7 that could allow for the isolated activation of proteins in tumor cells without disrupting healthy cells. By understanding how effector caspases work in healthy conditions, they hope to develop methods to destroy abnormal cells while preserving healthy ones.
SourceUniversity of Texas at Arlington·JournalJournal of Biological Chemistry·DateJan 11, 2022
A marine-dwelling creature, Trichoplax adhaerens, has been found to resist cancer and repair DNA after radiation damage. Researchers are exploring its unique properties to develop new therapies for cancer.
SourceArizona State University·JournalPLOS Biology·TypeObservational study·DateDec 22, 2021
Researchers discover tBID can induce programmed cell death through mitochondrial damage, revealing a new function for a previously thought signal transducer protein. This finding has implications for treating malignant cells and combating infections like Shigella.
SourceUniversity of Cologne·JournalThe EMBO Journal·TypeExperimental study·DateDec 21, 2021
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
A recent study has identified a new mechanism by which oral cancer cells acquire radioresistance through the transfer of microRNA, specifically miR-503-3p. This discovery brings hope for the development of new treatments for radiation-resistant oral cancer.
SourceKumamoto University·JournalJournal of Extracellular Vesicles·TypeExperimental study·DateDec 15, 2021