Articles tagged with Extracellular Spaces
Researchers at UT MD Anderson Cancer Center have made significant progress in treating rare brain infections with a virus-specific T cell therapy, achieving an overall response rate of 56.8% in patients with progressive multifocal leukoencephalopathy (PML). The center also introduced a novel CAR T cell therapy for hard-to-treat kidney ...
Researchers have identified immune markers that can help doctors determine which breast cancer patients are unlikely to benefit from chemotherapy. The new AI-based method analyzes the body's own immune cells found near a tumor, providing additional insight to identify patients who can safely have chemotherapy withheld.
A spatial map of muscle-invasive bladder cancer reveals organized tumor cell states, immune environments, and therapeutic vulnerabilities. Luminal-like cells are found in tumor cores with relevant therapeutic markers, while basal-like cells near margins show signs of aggressiveness. This study guides treatment strategies by accounting ...
Chemokines regulate immune cell infiltration and local immunity in tumors, and targeting their receptor axis has emerged as a promising therapeutic target in cancer immunotherapy. Chemokine-modulating strategies combining with other immunotherapies have demonstrated considerable synergistic potential.
Stanford researchers have developed a novel 'scaffold-free' approach for treating damaged muscles, enabling the delivery of more healing cells to the traumatized area. The approach uses a custom molding technology to create dense muscle tissue in customizable geometric shapes and sizes, allowing for more effective muscle regeneration.
Scientists at Max Planck Institute develop a novel lab-on-a-chip system using intelligent hydrogel structures to simulate spatially and temporally controlled mechanical perturbations of biological polymer networks. The system applies precise pressure forces to cellular microenvironments, enabling research into biomechanical interaction...
Researchers have discovered that rhesus macaques shed TIGIT from immune cell surfaces when exposed to plasmin, a natural enzyme involved in blood clot breakdown. This creates a soluble form of TIGIT that can still bind anti-TIGIT monoclonal antibodies, potentially leading to misleading safety and efficacy data for human trials.
Researchers at Sanford Burnham Prebys Medical Discovery Institute found that aging accelerates pancreatic cancer progression, leading to faster tumor growth and metastasis. By understanding the impact of age on the tumor microenvironment, they developed a new approach to treating this disease in frail patients.
A new study by Texas A&M University Health Science Center reveals how TFE3 oncofusions hijack RNA to build liquid-like hubs that promote cancer growth. The researchers also created a molecular switch to dissolve these hubs, cutting off tumor growth at its source.
Researchers at UC Davis discovered how desmosomes, which stick cells together, respond to mechanical stress. They found that the intermediate filaments transmit forces to a desmosome protein, causing it to open up and expose a site for signal transmission.
Researchers discovered that a collective of epithelial cells can work together to sense beyond their direct environment, up to 100 microns away. This new ability allows cancer cells to migrate and evade detection with enhanced precision, making it a potential target for therapy.
Researchers at Sanford Burnham Prebys found that blocking macropinocytosis reshapes the tumor microenvironment, allowing more access to immune cells. This change made immunotherapy and chemotherapy more effective in treating PDAC tumors in mice.
Researchers developed self-propelled ferroptosis nanoinducers to enhance cancer therapy by inducing programmed cell death. The nanotherapeutics exhibited enhanced diffusion and deep tumor penetration while maintaining biocompatibility.
Researchers discovered special proteins that keep tiny particle membranes intact during transport, and found these proteins influence cargo function. Animal experiments showed ion channel protein is crucial for repairing heart damage in mice.
Researchers have recognized the dynamic and active role of brain extracellular space (ECS) in regulating neural activity. Dysregulation of ECS contributes to neurological disorders, suggesting therapeutic modulation as a novel treatment pathway.
A new study found that perivascular fibroblasts support the creation of an immunosuppressive tumor microenvironment, allowing glioblastoma to evade the immune system. The fibroblasts may also promote stem-like cancer cells that rarely divide, leading to poor survival outcomes.
Researchers found a total of 4,721 proteins altered with age in the murine ovary, including upregulated ECM proteins associated with fibrosis. Age-dependent changes also affect immune response pathways and unique immune cell populations.
Researchers have identified new biomarkers to detect non-small cell lung cancer in its early stages through a blood test, offering improved survival chances. The approach can also identify potential drug resistance, allowing clinicians to choose alternative treatment options.
Scientists created a shape memory polymer to promote cardiomyocyte alignment and growth, providing a platform to study heart development and disease. The research uses stimuli-responsive biomaterials to mimic the dynamic microenvironment during heart development.
Researchers discovered that HSPCs preferentially anchor at venous capillary confluence points guided by VCAM-1+ macrophages. This interaction helps regulate HSPC retention and expansion, providing new insights into the homing process.
Researchers have developed a new imaging paradigm to study the extracellular space between brain cells, revealing its complex and dynamic nature. The technique, called SUSHI, provides high-quality 3D reconstructions of brain tissue and has the potential to improve drug delivery within the brain.
A new potassium-sensitive fluorescence-imaging method enables accurate measurement and spatiotemporal mapping of the brain, shedding light on chemical activity within it. The nanosensor has improved spatial resolution, allowing for investigation into potassium micro-domains around activated neurons.
EPFL scientists have developed a gel that boosts the ability of normal cells to revert into stem cells by simply squeezing them into shape. This method paves the way for large-scale production of stem cells for medical purposes, offering new ways to treat injuries and diseases such as Parkinson's and diabetes.
Researchers have found a way to eliminate a gene that causes cells in the bone marrow microenvironment to die, allowing donor cells to replace them. This breakthrough could lead to improved bone marrow transplant therapy for patients with blood diseases such as leukemia and multiple myeloma.
Research reveals that cold temperatures trigger the return of monarch butterflies to their northern habitats, highlighting vulnerability to climate change. The study suggests that the monarch migration cycle is reliant on a specific thermal stimulus, which is critical for completion of the migration cycle.
A team of Australian researchers has received a five-year grant from the National Institute of Child Health and Development to investigate how environmental stress affects embryonic development. The study aims to understand the long-term health implications for children conceived during poor maternal health or adverse lifestyle choices.
Bioengineers at Cornell University have created a system for transplanting clusters of brain cells, together with controlled-release microcapsules of protein, to enable cell differentiation and growth. The technique has shown promise in treating neurodegenerative diseases and spinal cord injuries.