Articles tagged with Histology
Researchers developed an AI approach to predict glioblastoma recurrence, allowing for targeted treatments before the cancer becomes visible on MRI. The tool uses microscopic images of fresh, unprocessed tissue and scored based on tumor infiltration, with an accuracy of predicting recurrence within 5-10 millimeters of the sampled tissue.
A new intraoperative imaging platform called ULTRA combines rapid tissue clearing, stimulated Raman scattering microscopy, and AI-based virtual staining to perform deep 3D histological imaging. This enables the visualization of key histological features across different glioma subtypes and facilitates glioma margin analysis.
Researchers have developed a versatile uncertainty-aware AI framework called TRUECAM that provides customizable accuracy guarantees for cancer subtype classifications. TRUECAM outperforms existing approaches to digital pathology AI uncertainty quantification, detecting out-of-scope inputs and improving fairness across sex and race.
Researchers at Salk Institute uncover an unexpected role for HDAC enzymes in controlling critical genes involved in DNA repair, making pancreatic cells more vulnerable to therapies that induce DNA damage. This finding paves the way for new treatment strategies combining entinostat with DNA-damaging therapies.
A study published in PLOS One analyzed microbial communities in well-preserved and degraded bones from medieval cemeteries in Norway. The researchers found distinct microbial communities associated with different levels of degradation, suggesting that microbes play a role in bone preservation and decay.
Researchers from The University of Osaka identified a unique genetic pattern in carcinoma cuniculatum, a rare type of oral cancer with slower growth and lower risk of spread. This discovery may lead to improved diagnosis and targeted treatment for this challenging-to-diagnose condition.
Researchers developed a novel tool, CytoTape, to record temporal cell activities in situ along a flexible intracellular protein fiber. This technology enables scientists to view interactions on a large scale and over long periods of time, breaking through the tradeoff between resolution and scale.
Researchers found that male fish exposed to vitamin C and potassium perchlorate showed improved fertility and less damage to their testes compared to those exposed only to the chemical. The study suggests a potential safeguard for individuals regularly exposed to these chemicals, including military personnel.
Researchers at the University of Missouri are exploring the use of extracellular vesicles to target lung cancer. By manipulating these tiny messenger particles, scientists can deliver specific instructions to kill cancer cells while sparing healthy ones.
University of Missouri researchers are helping farmers prevent disease outbreaks by teaching biosecurity practices, such as hand sanitizing and wearing farm-dedicated shoes. They also provide guidance on safe composting methods to dispose of dead livestock, reducing the risk of disease spread.
Epithelioid hemangioendothelioma is a rare and potentially malignant vascular tumor that can be mistaken for benign conditions. A new case report highlights the diagnostic challenges raised by rare tumors and emphasizes the need for vigilant evaluation of slow-growing swellings.
Researchers found that eukaryotes could survive in shallow pools of water atop ice sheets, similar to modern-day meltwater ponds in Antarctica. These environments supported diverse communities of early complex life, influenced by salinity levels.
Researchers have developed a new 3D-IHC technique that improves the speed, depth, and sensitivity of immunolabeling in thick tissue samples using nanobodies fused with peroxidase. The method enables ultra-fast and high-resolution mapping of neurons and glia in 1-mm-thick brain tissues.
The American Association for Anatomy has awarded over $238,000 to nearly 200 individuals through various awards and scholarship programs. The organization recognizes outstanding achievements in research, education, and professional development, supporting career advancement and further education opportunities.
A new AI model generates detailed images of cancer tissue that imitate what its staining would look like, reducing the need for resource-intensive lab analyses. The VirtualMultiplexer uses contrastive unpaired translation to create accurate virtual pictures of diagnostic tissue colorations.
A groundbreaking study has uncovered a significant breakthrough in the diagnosis and monitoring of kidney diseases associated with nephrotic syndrome. Researchers identified anti-nephrin autoantibodies as a reliable biomarker for tracking disease progression, opening new avenues for personalized treatment approaches.
A new animal model has been developed to study periodontitis, allowing researchers to analyze tissue components simultaneously. The study found that the expression of the Il1rl1 gene was higher in peri-root tissue five days after ligation, highlighting its role in inflammation and osteoclast differentiation.
A study reveals thyroid cancer's genetic changes contribute to resistance to BRAF inhibitors and can lead to tumor dedifferentiation. Researchers identify potential targets for new therapies, including dual-targeted treatments and immunotherapy combinations.
A newly described species of pachycephalosaur, Platytholus clemensi, has been found to have a keratin bristle structure atop its dome. The discovery was made using CT scans and microscopic analyses of fossilized slices through the skull.
A team from the University of Bonn has solved a 150-year-old mystery surrounding Aetosaurs' age. Bone examination reveals that two specimens were juvenile, not small adults as previously thought. The discovery attributes this to social behavior among juvenile Aetosaur species.
Researchers at TTUHSC will investigate common mechanisms of resistance and sensitivity in alternate telomere lengthening (ALT) cancers, with a focus on targeting ATM kinase inhibitors for therapy. The team aims to develop clinical trials for patients with ALT+ cancers.
A new confocal platform using artificial intelligence and multiple lenses improves volumetric resolution by over 10-fold while reducing phototoxicity. The platform uses Deep Learning algorithms to distinguish between high-quality images with low signal-to-noise ratio and better images.
Researchers used a new X-ray technique to capture detailed images of lung vessels affected by COVID-19. The study revealed that severe infection causes 'shunting' of blood between oxygenated and nutrient-rich systems, leading to reduced oxygenation.
Researchers shed light on the evolution of mammalian tusks by tracing them back to ancient mammal relatives called dicynodonts. Dicynodonts had protruding tusks in their upper jaws, but they were not always true tusks – instead, some had enamel-coated teeth that did not fit the definition.
Researchers have trained a neural network to detect anomalies in medical images, adapting it to the nature of medical imaging and achieving better results. The new method uses weakly supervised training and can spot small-scale anomalies, accelerating the work of histopathologists and radiologists.
A collaborative research between Owkin and Cleveland Clinic has developed an AI model that predicts liver cancer recurrence following liver transplantation. The model outperformed traditional scoring systems and showed promise for improving patient outcomes.
A study by the California Academy of Sciences and colleagues found significant tissue abnormalities in oysters from the Gulf Coast, even years after the devastating oil spill. The researchers discovered higher rates of metaplasia in Eastern oysters, which can cause debilitating health issues.
Researchers at Lund University have used synchrotron light to create high-resolution 3D images of nerve fibers in diabetes. The study reveals that damaged nerve fibers grow back in a spiral pattern, leading to regenerative clusters. Understanding this process could lead to new treatment principles for diabetes-related nerve damage.
The Cleveland Clinic has developed updated guidelines for accelerated partial-breast irradiation (APBI), a technique that targets radiation to the tumor site only. The new guidelines recommend APBI for a broader range of patients, including younger individuals and those with ductal carcinoma in situ.
The American Association of Anatomists has launched a new Virtual Microscopy Database to share high-quality digital tissue slides for education, research, and scholarship. The database was created to address the limitations of existing digital slide collections and provides a centralized repository for anatomy and histology scholars.
Researchers found that only 3% of newly diagnosed patients with stage III ILC benefited from systemic staging with FDG PET/CT, suggesting CT and bone scan are sufficient instead.
Researchers have developed a new, non-destructive method to detect white-nose syndrome in bats by using ultraviolet light. The technique, which involves shining long-wave UV light at bat wings, produces a distinctive orange-yellow fluorescence that corresponds with microscopic skin lesions characteristic of the disease.
Researchers develop protocol combining hard X-ray tomography and histology to visualize constricted vessels, enabling simulation of blood flow and targeted drug delivery. The method also characterizes soft tissues in the vicinity of calcified arteries with high precision.
A study using narrow band imaging found high accuracy for predicting polyp type and suggests leaving distal colon hyperplastic polyps in place with acceptable accuracy. The technology improved visualization of mucosal characteristics, enabling real-time assessment of polyp type.
A study found that narrow band imaging is a less time-consuming and equally effective alternative to chromoendoscopy for detecting dysplasia in IBD patients, but with a higher miss rate. The researchers concluded that chromoendoscopy remains the recommended technique for detecting dysplasia.
A preliminary study suggests that the SWIFT MRI technique can accurately detect mandibular invasion by squamous cell carcinoma, allowing for more precise planning and potentially preventing unnecessary removal of the jawbone. The researchers found a high degree of correlation between magnetic resonance images and histopathologic findings.
The ASGE has established guidelines for the use of real-time endoscopic assessment in managing diminutive colorectal polyps. The recommendations aim to minimize risk and delay while improving cost effectiveness of colonoscopy. Diminutive polyps are common, but pathological assessment can be costly and delay patient information.
Researchers can now study the mouse brain in unprecedented detail, thanks to a new atlas that provides a 3D reference point for genetics, toxicology, and drug discovery. The atlas features images with resolutions up to 21 microns, eliminating variability issues associated with conventional histology.
The ATS and ERS have issued guidelines for quantitatively assessing lung structure using advanced imaging techniques. These guidelines promote the accuracy and comparability of studies, facilitating interdisciplinary collaboration.
The PROSPECT trial reveals that most unexpected heart attacks are caused by large plaque burdens and small lumen areas, not mild lesions. Characterization of plaque composition using virtual histology improves the ability to predict future adverse events.
Researchers at Duke University have developed a new method for creating ultra-high resolution 3D images of tiny mouse brains using magnetic resonance imaging. The technology allows for the detailed visualization of brain structures and their relationship to genetics, enabling scientists to study gene-brain connections.
Researchers are testing innovative techniques to detect vulnerable coronary plaques, which cause most heart attacks. Non-invasive methods like multislice computed tomography show promise in generating colorful pictures of the coronary arteries.
A new method called microCT-based virtual histology allows scientists to quickly examine large numbers of mouse embryos with different genetic mutations or damage from toxic chemicals. This enables them to determine the normal function of many genes faster than existing methods, improving drug safety and efficacy.
Researchers at Emory University Health Sciences Center have developed a new MRI technique using manganese-enhanced imaging to study the neural circuitry of aggression in crayfish. This breakthrough enables scientists to analyze entire patterns of brain activation, providing insights into complex social behaviors.
A new womb surgery technique uses an IntraUterine Shaver to remove uterine tissue mechanically, reducing the risk of complications associated with current methods. The procedure is expected to cut substantially the number of hysterectomies and make minimal access surgery more accessible.