Articles tagged with Neurotrophic Factors
Researchers successfully increase inner ear synapses in young mice to produce supranormal hearing, supporting a hypothesis on the cause of hidden hearing loss in humans. The study suggests that preserving or increasing synapses may improve auditory processing and offer new treatment options for certain hearing disorders.
A recent study found that oleacein increases BDNF expression in human neuronal cells and reduces depressive behavior in mouse models. Gene expression analysis reveals the activation of cell cycle and neurogenesis processes, as well as a decrease in inflammatory response.
Researchers found that 1,5-AF activated AMPK, leading to upregulation of the PGC-1α/BDNF pathway and alleviating aging-related decline in motor cognitive function. The study suggests that 1,5-AF can induce endogenous neurovascular protection, potentially preventing aging-associated brain diseases.
A muscle-building supplement called beta-hydroxy beta-methylbutyrate (HMB) has been shown to reduce plaques and increase factors for neuronal growth in mice with Alzheimer's-like pathology. The study found that HMB stimulates a nuclear hormone receptor to improve memory and learning in mice with Alzheimer's disease.
Researchers discovered a novel waste removal factor, CDNF, that treats brain haemorrhage by accelerating lesion resolution, reducing brain swelling, and improving functional outcomes. The treatment also alleviates cell stress and promotes scavenging by immune cells, leading to better recovery.
Researchers have successfully used AAV1.NT-3 gene therapy to improve muscle physiology and prevent age-related sarcopenia in mice. The treatment resulted in restored muscle mass, strength, and neural connections, offering a potential new option for managing this debilitating condition.
Scientists used single-cell integrative secretion profiling technology to map the interaction between neurons and immune cells, revealing heterogeneity in secreted factors and their roles in regulating neuronal function. The study found that infiltrating macrophages inhibit neuronal secretion of exosomes, while microglia promote neuros...
Research suggests exercise-induced activation of peripheral systems, such as muscle, gut, and liver, may affect neural plasticity and cognitive health. Circulating cathepsin B (CTSB) and brain-derived neurotrophic factor (BNDF) have been found to possess robust neuroprotective effects.
A new study reveals that running increases dopamine release and brain-derived neurotrophic factor (BDNF) levels, leading to improved learning, memory, and motor skills. The findings provide insight into the long-term effects of exercise on the brain and may lead to new treatments for Parkinson's disease.
Researchers found high levels of an enzyme called HDAC9 in healthy neurons, which decline with age and more drastically with Alzheimer's. The study suggests adjusting the enzyme's level may be a potential treatment for both conditions.
Researchers from Russia and Germany discovered that activation of GDNF helps protect brain cells from death during hypoxic damage, maintaining neural network activity. This finding can lead to the development of an effective method for correcting CNS pathologies developing under oxygen deficiency.
Research found that strength training reduces endurance muscle fiber number by producing brain-derived neurotrophic factor (BDNF), which remodels neuromuscular synapses. This results in a decline in endurance muscles and an increase in strength muscles.
Researchers at Lobachevsky University have discovered the TrkB receptor system's role in forming neural networks. Activating this system increases complex functionally active neural networks with high transmission efficiency of nerve impulses, essential for learning and memory.
Researchers found NGF has therapeutic properties for diseases like cutaneous ulcers, glaucoma, and Retinitis Pigmentosa. Early studies led to the development of safe dosages and new treatment routes with NGF-based therapy.
Researchers from the Buck Institute report that MANF regulates metabolism and immune response, and replenishing it shows promise as an anti-aging treatment. MANF deficiency has hallmarks of age-related diseases, including inflammation and liver damage.
Researchers found that fibroblast growth factor 2 (FGF2) promotes sperm production by expanding a subset of spermatogonial stem cells. FGF2 also acts on the testicular microenvironment to facilitate retinoic acid action, revealing its novel function in mouse testis.
Lobachevsky University scientists discovered that GDNF protects cultures from cell death and maintains network activity during hypoxia. The neurotrophic factor partially negates the consequences of hypoxia by influencing synaptic plasticity.
Research suggests that EGR3 and brain-derived neurotrophic factor (BDNF) play critical roles in the impaired cellular resilience seen in bipolar disorder. The study's findings may lead to new therapeutic strategies by modulating EGR3 expression.
Lauren Sciences will use the grant to customize LAUR-301 with neurotrophic factor and deliver it to disease sites in central nervous system ALS mice. The company aims for LAUR-301 to enter human clinical trials and become a transformative V-Smart TM Nanomedicine for treating ALS.
Researchers developed a chemically extracted acellular allogeneic nerve graft that combines with ciliary neurotrophic factor (CNTF) to promote sciatic nerve repair. The study found this method to be superior to bridging alone, but inferior to autologous nerve anastomosis.
The study found that Shuganjieyu capsule increases brain-derived neurotrophic factor and phosphorylated cyclic adenosine monophosphate response element binding protein expression levels, reversing depressive-like behaviors. This increase may be one of the anti-depressant mechanisms of Shuganjieyu capsule.
The ALS Association granted Lauren Sciences LLC a grant to develop a V-Smart therapeutic for amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. The project aims to deliver neurotrophic factors across the blood brain barrier using the company's novel V-Smart nanovesicle platform technology.
The study found that Shuganjieyu capsule increases brain-derived neurotrophic factor and phosphorylated cyclic adenosine monophosphate response element binding protein expression levels, which may be one of the anti-depressant mechanisms. This increase in expression reverses depressive-like behaviors in rat models of depression.
A rat model of heroin relapse showed improved brain structure and increased neurotrophic factor expression after acupuncture treatment. The study suggests that acupuncture at specific points may protect brain neurons against injury and promote recovery from heroin addiction.
A study by University of Illinois researchers found that a single polymorphism in the BDNF gene affects intelligence after traumatic brain injury. Individuals with a specific genetic variation showed improved cognitive function, while those without it experienced impaired recovery.
Researchers found that mannotriose improves hippocampal neuron survival rates after corticosterone-induced injury. Mannotriose also restored protein levels of glucocorticoid receptor, serum and glucocorticoid-regulated protein kinase, and brain-derived neurotrophic factor.
Researchers found that brain-derived neurotrophic factor suppressed glucose intolerance by improving insulin receptor expression and inhibiting gluconeogenesis in the liver. This suggests a potential therapeutic hypothesis for treating glucose intolerance after cerebral ischemia.
Researchers developed a therapeutic principle using Poxue Huayu and Tianjing Busui Decoction to break blood stasis and replenish essence. The treatment demonstrated significant reductions in brain water content, intracerebral hematoma volume, and neurologic impairment in cerebral hemorrhage rat models.
Researchers found that Xingnao Jieyu capsules upregulate synaptotagmin expression in rats with post-stroke depression, improving depression symptoms. The therapeutic effects of Xingnao Jieyu capsules are similar to those of fluoxetine.
Researchers from Ruhr-University Bochum have discovered that vitamin P can protect motor neurons from dying off in culture. Unlike BDNF, which has limited effectiveness and potential negative consequences, vitamin P triggers a different signaling pathway to promote survival of isolated motor neurons.
A new mouse model has been developed to study supertasting, a condition where people strongly detect food flavors like bitter and sweet. The model, which overexpresses brain-derived neurotrophic factor, may provide insights into the protective cardiovascular effects of avoiding sweet and fatty foods.
A new study has identified elevated levels of four neurotrophic factors in a mouse model of pancreatic cancer, which could be responsible for the development of pain in patients. These findings suggest that tumor-nerve interactions play a significant role in cancer progression and pain.
The Michael J. Fox Foundation has awarded a grant to develop cerebral dopamine neurotrophic factor (CDNF) as a potential treatment for Parkinson's disease. CDNF has shown promising properties in pre-clinical models and future studies aim to evaluate its efficacy.
Researchers found high serum BDNF levels among alcohol-dependent individuals, which may predict relapse. Abstinence and non-abstinence conditions showed increased BDNF levels over time, indicating neurological transformations reflected by peripheral BDNF levels.
A paracrine pathway involving glial cell-derived neurotrophic factor (GDNF) regulates the migration of pancreatic cancer cells along nerves. The pathway plays a crucial role in preventing nerve invasion and has potential as an adjuvant therapy for pancreatic cancer.
A new study found that three months of aerobic exercise decreased body fat and calorie intake in overweight and obese people, with increased levels of brain-derived neurotrophic factor (BDNF) linked to reduced hunger and weight loss.
Researchers at University of Helsinki discover novel neurotrophic factor CDNF that protects and rescues damaged dopamine neurons, recovering function after experimental lesion. This breakthrough may lead to new treatment strategies for Parkinson's disease.
A study by Max-Planck-Gesellschaft researchers found that disabling Ret-receptors in mice leads to earlier death of dopaminergic neurons, similar to Parkinson's disease. The loss of these neurons is a hallmark of the disease, and the study suggests that preserving this function may be crucial for preventing neurodegeneration.
A study by Chiara Cirelli and colleagues shows that the quality and intensity of wakefulness affect slow-wave activity (SWA) during subsequent sleep. High exploratory activity during wakefulness leads to increased brain-derived neurotrophic factor (BDNF) expression, which in turn affects SWA.
A new study by Dr. Greg Steinberg reveals that CNTF activates skeletal muscle AMP kinase, increasing fat metabolism and reducing the risk of metabolic abnormalities associated with excess weight. This finding opens the door to new strategies for obesity treatment.
Researchers found BDNF is as effective as VEGF in inducing growth of tiny blood vessels in organs with TrkB-expressing cells. It recruits blood stem cells that contribute to neo-angiogenesis, providing a novel therapeutic protein for organ-specific angiogenesis.
Researchers discovered that choroid plexus cells can stimulate stem cell production and release neurotrophic factors after a stroke, reducing damage in animal models. The study suggests potential for new therapy to supplement the natural healing response of this tissue.