Articles tagged with Gene Expression
Researchers proposed an algorithm to create patient-specific models describing electrical excitation of human heart cells. The model uses gene expression profiles to predict action potential in other patients. This could lead to personalized treatment and drug design for heart conditions.
A new pre-clinical study identified genes linked with the development of brain folds in the grey matter of the brain. The research found differences in genetic expression and neuron shape during the folding process, which can lead to cognitive deficits and neurological conditions such as autism and schizophrenia.
A study found that survivin positivity by IHC correlates with shorter survival in Neuroendocrine tumors. Radiation exposure increases BIRC5 gene expression, which is associated with an inferior survival. Survivin long peptide-mimic vaccine shows promise in preclinical studies.
Researchers used statistical physics models to study biological complexity and found that organisms are restricted to a low level of dimensionality. This means that their essential building blocks appear to be linked to each other, with variations fitting a one-dimensional curve or low-dimensional surface regardless of the environment.
Developing frog embryos damaged by nicotine exposure can be repaired with ionoceuticals that restore bioelectric patterns, leading to normal anatomy and gene expression. The discovery offers a roadmap for exploration of therapeutic drugs that could help repair birth defects in humans.
Mount Sinai researchers found lower ACE2 expression in younger children, increasing with age. This could help explain why children are less likely to get COVID-19 and account for only 2% of identified cases.
A study published in Journal of Internal Medicine found that weight loss surgery changes gene expression in fat tissue, leading to metabolic improvements and reduced type 2 diabetes risk. These changes persisted even after weight regain, suggesting a long-term impact on health outcomes.
A new study has identified a group of genes with altered expression in autism spectrum disorder, affecting communication among neurons. The discovery could lead to improved diagnosis and treatment by targeting these genes.
Researchers found a 25% increase in ACE2 expression in lung tissues from ever-smokers compared to nonsmokers, suggesting an increased risk for viral binding and entry. Smoking also remodelled gene expression, making it easier for the virus to infect human cells.
A marine heatwave in 2015-16 triggered different genetic responses in five coral reef fish species, showing varying levels of vulnerability to climate change. The study found common molecular pathways associated with increased oxygen uptake and cellular stress responses among all species.
A research team has identified reliable reference genes for studying wheat meiosis, enabling precise measurements of gene expression. The discovery will aid future genetic improvement efforts, potentially allowing for manipulation of chromosome associations and integration of genes from other species.
A twin study conducted by Monash University researchers found that even low levels of air pollution can affect gene expression, leading to long-term health consequences. The study suggests exposure to air pollutants, even at low levels, has real-life implications for the current COVID pandemic.
Researchers at Oregon Health & Science University developed a synthetic molecule that targets and corrects a mutated gene causing Usher syndrome in mice. The technique may be used to deliver drug therapy through amniotic fluid to the fetus, potentially treating and preventing several types of congenital hearing and balance disorders.
A study published in Nature reveals that the low-density lipoprotein receptor-related protein 1 (LRP1) plays a key role in the spread of pathological tau proteins between neurons. By inhibiting LRP1 expression, researchers were able to reduce tau spread in mice, offering new hope for potential treatments.
Researchers found that DOT1L inhibition significantly reduces MM cell viability in vitro and inhibits xenograft growth in mice. Concomitant targeting of SETD1B enhances this effect, suggesting a novel therapeutic angle for cancer treatment.
Research reveals glucose acts as a molecular switch regulating SIRT1's function, impacting gene expression and metabolic flexibility. Glucose modification affects organismal health, with both over-activation and under-activation linked to diseases.
A study published in Blood Cancer Discovery found that deleting one copy of the miR15a/miR16-1 gene cluster accelerated the development of multiple myeloma in mice, while also enhancing disease aggressiveness. The researchers also analyzed a genetic dataset of multiple myeloma patients and found similar associations.
A study found that bisphenol S, a BPA substitute, causes changes in gene expression and neurotransmitter levels in the mouse placenta, similar to BPA. The findings suggest that BPS may be toxic to humans, despite some differences in human and mouse placentas
Researchers developed a new high-throughput technique to study gene splicing, tracking thousands of genes in real-time. The results show that splicing occurs far more often than previously thought, with significant variability in gene expression timing.
A study published in PNAS reveals that the blood-brain barrier's impermeability is linked to depression symptoms and that restoring its integrity may lead to improved treatment outcomes. Researchers found that a decrease in claudin-5 protein and increased HDAC1 enzyme are associated with depressive symptoms.
Researchers at University of Bath identified a molecule called DIRC3 that acts as a tumour suppressor to block melanoma cell growth and spread. High levels of DIRC3 expression in patients were linked to increased survival rates, suggesting its potential as a new treatment for skin cancer.
A new study in rats suggests that caffeine may offset some of the negative effects of an obesogenic diet by reducing lipid storage and limiting weight gain. Caffeine decreased lipids in adipose cells by 20%-41% and downregulated genes associated with obesity.
Researchers found that a problem in gene-regulatory process can cause normal cells to turn malignant and produce Wilms' tumor. The implicated reader protein causes problems by acquiring a new property and being too active, leading to abnormal gene expression and tumor formation.
Researchers from Brigham and Women's Hospital develop a computational approach to study anxiety, uncovering over 209 genes with varying activity across anxiety categories. The study identifies new targets for drug development, including genes related to synaptic plasticity, hormones, and G-protein coupled receptors.
87 LCMs show potential for persistent and bioaccumulative properties, affecting gene expression in embryonic chicken cells. Several LCMs found in indoor dust samples, highlighting environmental concerns.
Researchers at UConn's Ecology and Evolutionary Biology Department shed new light on the evolution of the treehopper's distinctive helmet. By analyzing RNA sequences, they found that the gene expression lines up with wings rather than the dorsal body wall, suggesting a unique developmental pathway.
Researchers found no link between e-cigarette vapor and pneumonia in mouse models, contrary to earlier concerns about vaping's health risks. However, e-cigarette vapor did alter gene expression of pneumococcus bacteria, which may impact immune response.
Researchers have made significant breakthroughs in cell-free gene expression, enabling high-yielding protein synthesis and expanding genetically encoded chemistry. This has opened doors to create new types of enzymes, materials, and therapeutics. Northwestern University's Center for Synthetic Biology is at the forefront of this field.
A study by Duke-NUS Medical School researchers has uncovered new insights into how individual cell types in the brain contribute to Alzheimer's disease progression. The study found distinct gene expression profiles and networks across different cell types, providing potential druggable targets for future drug development.
Researchers at Michigan State University have found that cellular RNA levels change significantly following infection or vaccination. The study's findings could help identify new targets for building better flu vaccines and aid in the design of a universal vaccine.
A study analyzing data from four types of mouse Alzheimer's models found consistent changes in cell number and gene expression throughout the disease stages. The research provides new targets for intervention and therapy, highlighting the immune system's involvement in early stages of Alzheimer's.
Impaired SHMT2 expression impacts mitochondrial respiration and cellular growth, leading to age-related disorders. The study suggests that epigenetic processes contribute to aging by altering metabolic pathways.
Researchers create algorithm to identify stable traits that capture mouse behavior, revealing unique individual characteristics and genetic basis. The method has potential to advance knowledge of mouse personality and its relation to mental health and disease.
New research challenges traditional idea about relationship between alcohol use and brain size, suggesting that reduced brain volume may represent a genetically-conferred predispositional risk factor for heavier alcohol consumption. Longitudinal and family data from three independent brain imaging studies confirm this association.
A recent study published in JAMA Network Open reveals that analyzing gene expression in tumor cells can reveal new targets for therapy in pediatric cancer patients. The study found that 68% of children with cancer showed potential for treatment through gene expression analysis, compared to 46% who responded to DNA mutation analysis.
A recent study found that acetate, a byproduct of alcohol metabolism, affects the brain's memory system and contributes to cravings. The research team discovered that alcohol metabolism impacts histone acetylation in the hippocampus, leading to increased gene expression and memory formation.
Researchers at the University of Arizona discovered that cellular sleep has different levels, with too deep sleep leading to shutdown. They found that manipulating gene expression patterns could slow aging by adjusting cellular recycling function.
Researchers analyzed brain samples from two mutant HD gene positive individuals and found massive inflammation and similar gene expression patterns in the striatum compared to the prefrontal cortex. Unique patterns were also observed in the striatum, suggesting active neurogenesis during the disease process.
Researchers discovered unique brain cell types specific to male and female mice in the hypothalamus region, which governs aggression and mating behaviors. The study found 17 distinct cell types, with some abundant in males and others only in females.
Researchers discovered a genetic mechanism that promotes cocaine craving during prolonged abstinence, increasing the likelihood of relapse. The study found that gene expression changes in response to chromatin remodeler INO80 and E3 ubiquitin ligase TRIM3, facilitating drug-craving behavior.
A study of stickleback fish found that male parental care is accompanied by changes in gene activity in the brain, similar to those experienced by mammals. The researchers identified genes associated with mothering and aggression, suggesting a molecular link between fish and mammal parents.
A recent study published in Aging Cell has discovered that human aging processes may actually hinder the development of cancer. In most human tissues, aging-related gene expression changes are contrary to those found in cancer, suggesting a protective effect on cell growth.
Researchers found that levels of filarial antigens increase after treatment in individuals with adverse events, suggesting a host response to dying parasites. Gene expression analysis also identified elevated levels of immune molecules and 744 genes involved in immune signaling in those with adverse events.
Researchers at the Champalimaud Centre for the Unknown discovered that the brain's circadian clock controls the function of immune cells in the gut, which are crucial for maintaining gut health. Disrupting this clock leads to reduced immune cell numbers, severe inflammation, and increased fat accumulation.
A new study reveals that psychopathic violent offenders exhibit abnormal expression of genes and immune-response-related molecular pathways, which have also been linked to autism. The findings suggest that targeting the opioid system could be a feasible treatment approach for psychopathy.
Researchers studied nanoparticle uptake in human stem cells and found minor effects on gene expression. The nanoparticles were encapsulated in lysosomes, ensuring their storage and preventing cell damage.
Researchers discovered a group of genes whose activity was associated with longevity in response to various interventions. The study used mice as a model organism and identified biomarkers that could facilitate the search for new longevity interventions.
Researchers developed a simple, high-throughput protocol to assess the maturation of hepatic-like cells (HPCs) from induced pluripotent stem cells. The protocol enables quick assessment of stem cell differentiation efficacy and helps optimize differentiation conditions for regenerative medicine.
Researchers have developed a novel chemical treatment that can segregate X-bearing sperm from Y-bearing sperm, enabling dramatic alteration of the sex ratio in offspring. This technique has potential for simplifying sex selection in human assisted reproduction and artificial insemination.
Researchers at the University of California San Diego have developed a groundbreaking system for determining gene expression based on machine learning. The new method leverages chromatin biology and molecular features to identify expressible genes with high accuracy, providing a genetic 'Rosetta Stone' for biologists.
Researchers have found that gene expression patterns in the brain are highly disrupted in people with schizophrenia, suggesting a link to the disease's molecular mechanisms. The study's findings could help researchers better understand schizophrenia and identify potential therapeutic targets.
Scientists have developed a new computational method that reveals genetic patterns in individual cells, enabling the diagnosis of specific genetic defects and potentially rectifying them with CRISPR. This breakthrough advances precision medicine by providing personalized treatment options for patients with unexplained infertility.
Short periods of social isolation can lead to significant changes in neuronal remodeling and gene expression in forebrain regions involved in higher-order cognition. These neurogenomic changes may influence brain health and the processing and perception of experience.
Researchers discovered genome-wide variations in gene expression between females and males in mammalian species. The study revealed hundreds of conserved sex-biased gene expressions contributing to differences in traits.
A study found that women tend to procrastinate due to a genetic predisposition towards high dopamine levels, which affects brain regions involved in decision-making and impulse control. This trait is not observed in men, who show no correlation between the tyrosine hydroxylase gene and action control.
Researchers at Karolinska Institutet have developed a new method to divide patients with ulcerative colitis into two groups based on conserved gene expression across species. The study found that 87% of patients in one group responded poorly to treatment, while 60% in the other group showed improvement.
A new study by McGill's Goodman Cancer Research Centre uncovers novel microRNA polycistron functions and their impact on cancer. Researchers discovered a mysterious step in microRNA biogenesis that occurs in cell nuclei, shedding light on the role of microRNAs in cancer.
A new study reveals that the complement system, part of the innate immune system, plays a protective role in slowing retinal degeneration in a mouse model of retinitis pigmentosa. The research suggests that the complement system helps to clear away dead cells and maintain homeostasis in the retina.
A team of researchers delivered a therapeutic gene to the spinal canal of infant rhesus monkeys, resulting in sustained expression of the alpha-I-iduronidase enzyme. The study's findings suggest a promising approach for treating severe forms of neuropathic storage diseases.
Researchers at Saint Louis University found that low levels of the hormone adropin predict increased weight gain and metabolic dysregulation in male monkeys fed a high-sugar diet. Adropin regulates glucose and fat metabolism, and its expression is controlled by biological clocks.