Articles tagged with Gene Expression
Scientists have created a system dubbed "NanoporeTERs" allowing cells to express themselves in a whole new light. These new reporter proteins can detect multiple protein expression levels and shed new light on biological systems, enabling deeper analysis than before.
A new study has found that the absence of Aire protein in mice leads to fertility problems similar to those affecting men with autoimmune polyendocrine syndrome type I (APS-1). Researchers discovered that Aire-dependent central tolerance plays a critical role in maintaining male fertility.
Researchers have developed a new method to measure DNA torsional stiffness, which can impact how cells work. The technique provides insights into the biological implications of twist-induced phase transitions in DNA.
Research exposes lifelong effects of prenatal oxycodone exposure on offspring behavior, social interactions, and gene expression. Mice exposed to opioids before birth show signs of impaired physical activity and social behavior even in adulthood.
The investigational therapy ficlatuzumab, targeting the extracellular hepatocyte growth factor (HGF), showed clinical efficacy in patients with relapsed/refractory acute myeloid leukemia. A 53% complete response rate was observed, with improved progression-free and overall survival rates.
Researchers have engineered a new genetic circuit called Equalizers to buffer protein output from variations in gene dosage. This allows for consistent protein expression, crucial for studying proteins and understanding their functions. The innovation combines two types of gene dosage compensation circuits, improving overall performanc...
Researchers identified a potential biomarker, A20 protein, that can predict the success of immunotherapy in treating lung cancer. Patients with low A20 expression are less likely to respond to treatment and have poorer survival rates.
A new study by University of Miami researchers documents how coral genes respond to stony coral tissue loss disease, a rapidly spreading disease killing corals in Florida and the Caribbean. The study found that a network of genes important for cell death, immunity, and tissue rearrangement are triggered in response to the disease.
A new study suggests that alternate-day intermittent fasting may offer no unique health benefits over a standard daily diet. In contrast, traditional daily energy restriction resulted in greater weight and fat loss. The researchers note that longer studies with larger groups are needed to confirm these findings.
Researchers developed a genetic editing toolkit for Culex mosquitoes, which transmit devastating diseases like West Nile virus and avian malaria. The new CRISPR tools aim to create gene drives that can disable pathogen transmission in the targeted mosquito population.
Researchers discovered that metabolites from fungi and bacteria biofilms can modulate gene expression associated with tumor growth and survival. The study found that these microorganisms can endanger homeostasis in normal and neoplastic oral epithelial cells, impairing cell viability and survival.
Clownfish develop white stripes during metamorphosis, with varying rates of formation depending on the sea anemone host. Thyroid hormone influences white bar development, with higher concentrations leading to more bars and earlier development.
Researchers discovered that phosphorylation of MECP2 protein decreases in brain cells as Alzheimer's disease progresses, while abolishing this phosphorylation enhances neuronal viability and gene expression. The study suggests that modifications of MECP2 could be a therapeutic target for developing specific therapies against AD.
Scientists at Cold Spring Harbor Laboratory have created a new tool called BARseq2 that uses genetic tags to label brain cells and trace thousands of brain circuits simultaneously. This allows researchers to examine the complex interactions between neurons, enabling a better understanding of brain function and behavior.
Researchers discovered unique genetic signatures linked to protective processes like DNA repair in people who live beyond 105 years. They found that these individuals have more efficient DNA repair mechanisms and a lower burden of mutations in specific genes.
Researchers discovered that Brd4 plays a crucial role in diet-induced obesity by modulating lipid metabolism. In mice lacking Brd4, high-fat diets did not lead to obesity, indicating an alternative energy source was used instead of sugar.
Northern Red Sea corals have been found to be resistant to higher temperatures due to their symbiotic algae and bacteria. The study reveals that these corals can withstand average temperatures up to 5°C higher than usual, offering hope for saving coral reef ecosystems.
The study found that Red Sea corals can withstand temperatures up to 32°C without major gene expression changes, but 34.5°C is above the lethal limit for some species. The corals' resilient gene expression enhances their chances of survival in a warming world.
Researchers discovered that exposure to SARS-CoV-2 spike protein can cause persistent gene expression changes in airway cells, which may contribute to COVID long-hauler symptoms. The study's findings suggest a potential genetic basis for the lingering symptoms and could lead to personalized treatment approaches.
A new study has identified interleukin 11 as a key player in the development of colorectal cancer. IL-11-producing cells, known as cancer-associated fibroblasts, were found to promote tumor growth and support the disease microenvironment.
A comprehensive analysis of the molecular signatures of aging across diverse tissue cells in mice reveals coordinated global aging behavior. The study identifies shared aging genes and develops a single-cell aging score, shedding light on the complex aging process in different types of cells.
A UConn researcher has developed a successful Zika vaccine in preclinical studies using a novel platform technology. The vaccine, based on a viral vector and enhanced expression of the virus antigen, was found to mount a strong immune response and protect against Zika virus infection.
Researchers discovered that the widely available Topotecan (TPT) inhibits inflammatory genes in the lungs of mice as late as four days after infection, improving infection outcomes. The drug, an FDA-approved Topoisomerase I inhibitor, could be a valuable global strategy for treating severe COVID-19 cases.
Researchers investigated how certain strains of herpes simplex virus (HSV-1) activate gene expression in neurons, finding that different genetic variants induce distinct patterns of gene expression. These findings may help understand why people experience varying levels of symptom severity and frequency of outbreaks.
Researchers at Penn State develop a new framework for meta-assembly, allowing for accurate reconstruction of full-length mRNA sequences from short fragments. This enables better understanding of cell machinery and potential biomarkers for diagnosis.
Researchers identified rare cell types in esophagus, stomach and small intestine using scRNA-seq. They found a cell type responsible for water secretion in humans, linking it to cystic fibrosis.
Researchers discovered that retroviruses in koala genomes contribute to elevated cancer rates, with infected cells containing multiple copies of the virus. The study highlights the detrimental health consequences of germline infection by retroviruses and underscores the need for conservation efforts.
Researchers identified two new genes linked to Alzheimer's disease, PTPN9 and PCDHA4, in a study of gene expression in the hippocampus. The findings suggest that these genes contribute to the progression of the disease through pathways related to plaque formation and cell death.
In Indian jumping ants, workers duel to establish new leadership after the death of their queen. The winners become pseudoqueens, acquiring new behaviors and roles, and laying eggs, allowing the colony to survive. Changes in gene expression in the brain can accurately predict the winners after just three days of dueling.
A new study published in Nature Microbiology reveals how Zika virus causes brain calcification, a common birth defect associated with prenatal infection. The research team identified the proteins BMP2 and NS3 as central players in the development of calcifications, suggesting novel strategies to prevent this birth defect.
Researchers discovered a large class of mammalian genes are not completely shared across spermatids, leading to uneven allele distribution and potential mechanisms for sperm-level natural selection. Single-cell RNA sequencing revealed 'genoinformative markers' that can act as selfish genetic elements.
Researchers developed polygenic risk scores using genetic data from nearly 30,000 individuals, improving IBD predictions across European, Ashkenazi Jewish, Hispanic, and UK Biobank populations. Lower predictive power was seen in African ancestry due to smaller datasets and greater genetic diversity.
The study found that polychlorinated biphenyls and dichlorodiphenyltrichloroethane impact salmon's lipid metabolism and environmental stress response. The transcriptome profiles suggest that OHC levels, rather than salmon origin, have a significant effect on the liver's gene expression.
Researchers use single-cell RNA sequencing to analyze kidney cells' gene expression, enabling the reconstruction of their spatial arrangement and functional information. The algorithm succeeds in completing a 3D puzzle, providing new insights into kidney disease.
Australian researchers have discovered a protein called SMCHD1 involved in the 'imprinting' process, where mother's proteins linger in her child's genes and switch off at least 10 different genes. This phenomenon could potentially have a lifelong impact on the offspring.
Researchers found that e-cigarette users exhibited significantly altered immune responses to a model of influenza virus infection, suggesting increased susceptibility to disease. The study also found that vaping changes the expression of genes and production of proteins in respiratory cells.
Researchers found that dietary intervention increased skin gene expression manifold, with raw food activating the immune defense system and increasing antioxidant production. This study suggests that a raw diet may help activate the immune defense of dogs, potentially reducing the risk of atopic dermatitis.
Researchers identified genes associated with decreased placental invasion and increased chemokine production in babies born with microcephaly. This finding provides insight into why only some babies exposed to Zika virus during pregnancy develop anomalies.
A new study from Baylor College of Medicine found that starting genetic analysis with RNA sequencing can increase diagnostic yield by up to 17% in rare genetic diseases. This approach allows for a more comprehensive understanding of the effects of noncoding changes and enhances confidence in diagnoses.
Researchers found that elkhorn coral has a consistent immune response to diseases, indicating it actively fights off disease. The study suggests corals may have tougher epithelia and symbiotic dinoflagellates that develop differences in gene expression over time.
A team of researchers from the University of Münster has created a groundbreaking viral expression model that can simulate and analyze various viral infections, including SARS-CoV-2. The model uses stem cells to mimic the mechanisms of action of viruses, allowing for precise investigation of disease progression and potential treatments.
Researchers at Tokyo Medical and Dental University found that laser stimulation inhibits sclerostin expression in bone without causing inflammation, providing a new treatment possibility for osteoporosis. This method may aid the development of laser-based therapies to promote bone regeneration.
Scientists from the University of Copenhagen have identified specific neurons most affected by epilepsy, which could lead to personalized medicine-based treatments. The study analyzed over 117,000 neurons and found thousands of genes changing their expression in epilepsy.
Researchers found that auxin suppresses salicylic acid-mediated plant defense responses and promotes disease in Arabidopsis thaliana. Auxin also regulates virulence gene expression in Pseudomonas syringae bacteria, leading to increased disease susceptibility.
Scientists have discovered a new piece of DNA crucial for forming male sex organs in mice, revealing the Y-chromosome gene Sry has two distinct parts. The findings suggest this discovery could be used to manipulate sex ratios in agriculture and biological pest management, but not on human embryos.
Researchers found that gene activity increases when forces are applied perpendicularly to a cell, but decreases when forces are applied along the long axis. The findings could provide insights into diseases such as fibrosis and cardiovascular disease.
Glioblastoma multiforme is the most aggressive brain cancer with low five-year survival rate due to rapid development of radioresistance. Researchers from Hokkaido University and Stanford University identified Rab27b and epiregulin as key molecules contributing to radioresistance.
A study found MAIT cells enriched in airways of severe COVID-19 patients, strongly activating and associated with poor clinical outcome. Gene expression analyses revealed specific inflammatory proteins linked to mortality.
Scientists have documented all cell types and genes in healthy human hearts, paving the way for targeted treatments. This single-cell atlas will help understand heart disease and develop new therapies by correcting genetic mutations.
A new study by University of Copenhagen scientists found that time-restricted feeding alters the rhythmic concentration of metabolites in blood and muscle, influencing gene expression and amino acid transport. The study suggests that time-restricted feeding's positive health impact may be driven by diet rather than the body's core clock.
Researchers at Johns Hopkins University have developed a computational system called Watershed to predict the functions of rare genetic variants in individual genomes. This breakthrough could lead to the identification of genetic causes for previously undiagnosed disorders and health issues, with implications for public health.
Researchers developed a tumour gene test that accurately predicts ovarian cancer survival, outperforming age and cancer stage. The test identifies high-risk patients for personalized treatment options.
Scientists discovered genes with decreased expression in individuals with Down syndrome, which may also protect people from developing solid tumors. These findings could lead to the development of gene-targeted therapies for both people with Down syndrome and the general population.
Researchers developed a blood test that can identify babies at risk of serious neurodisabilities like cerebral palsy and epilepsy just hours after birth. The test looks for specific genes being switched on or off, which may provide new targets for treating brain damage before it becomes permanent.
Researchers successfully expressed and purified recombinant human coagulation factor XIIIa in Pichia pastoris, demonstrating biological activity. This expression system offers an efficient way to produce FXIIIa for further studies and potential large-scale production.
A new study published in Molecular Ecology reveals that the genes responsible for protecting frogs may actually be leading to their demise in the face of the invasive chytridiomycosis disease. Researchers found that frogs that died from the disease had higher expression of immune system genes than those that survived.
A NIH study found consistent sex-based differences in cortical volume across 2,000 brain scans, which correspond with patterns of sex-chromosome gene expression. These findings suggest that genetic mechanisms, including those on the X and Y sex chromosomes, may influence sex differences in brain anatomy.
Research reveals subtropical species are winners in future climates due to their ability to adapt to rising temperatures, while temperate species are most vulnerable. The study provides a catalogue of genes that informs about the adaptive capacity to climate change.
Research by Elena Lopez Peredo and Zoe Cardon found that desert green algae can become active again within seconds of receiving water, suggesting a unique adaptation for survival. The study also showed that these algae upregulate protective gene expression while downregulating metabolic genes during desiccation.
Researchers proposed an algorithm to create patient-specific models describing electrical excitation of human heart cells. The model uses gene expression profiles to predict action potential in other patients. This could lead to personalized treatment and drug design for heart conditions.