A University of Illinois study shows rumen-protected lysine can improve uterine health in dairy cows during the transition period. The supplement reduced genes involved in inflammatory proteins and increased genes keeping the uterus clean, leading to less inflammation and improved reproductive outcomes.
SourceUniversity of Illinois College of Agricultural, Consumer and Environmental Sciences·JournalJournal of Dairy Science·DateSep 19, 2022
A lab study found that high cholesterol intake worsens fatty liver disease progression by driving inflammation and scarring. The researchers also discovered long-lasting dysfunction in immune cells responsible for fighting liver damage. Moderation is key to maintaining a healthy diet, according to the study's findings.
SourceKeck School of Medicine of USC·JournalFrontiers in Immunology·TypeExperimental study·DateSep 14, 2022
Researchers from Tokyo Medical and Dental University have developed a new approach to analyze splicing variant data to identify disease-associated genetic variations. The study reveals that analyzing the coding sequences of gene splicing variants can help uncover the genetic basis of many diseases.
SourceTokyo Medical and Dental University·JournalNature Communications·DateSep 8, 2022
Diabetes-resistant mice develop a protective beta cell cluster with reduced glucose uptake and increased beta cell division, while diabetic-prone mice experience metabolic stress and beta cell failure. This study reveals the key role of adaptive gene expression in protecting against type 2 diabetes.
SourceDeutsches Zentrum fuer Diabetesforschung DZD·JournalDiabetes·TypeExperimental study·DateAug 31, 2022
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
The study analyzed blood samples from bottlenose dolphins in the northern Gulf of Mexico, finding changes in gene expression related to immune response and oxidative stress. The results provide new insights into the health impacts of oil spills on marine life.
Researchers at Terasaki Institute create micro-organospheres for direct viral infection, immune cell penetration, and high-throughput therapeutic drug screening. The technology holds promise for personalized medicine, tumor therapy and rapid drug testing.
SourceTerasaki Institute for Biomedical Innovation·JournalStem Cell Reports·TypeExperimental study·DateAug 18, 2022
Researchers identify LINE-1 RNA as a key player in premature aging, revealing its role in progeria and potential therapeutic targets. By inhibiting LINE-1 RNA, scientists reverse signs of aging and extend lifespan in mice.
SourceSalk Institute·JournalScience Translational Medicine·DateAug 10, 2022
Recent studies show that grape consumption can reduce fatty liver and extend lifespans, with Dr. John Pezzuto's team finding changes in genetic expression and antioxidant genes in mice. Adding grapes to a high-fat diet also had positive effects on behavior and cognition.
SourceCalifornia Table Grape Commission·JournalFoods·TypeExperimental study·DateAug 8, 2022
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
A new study provides critical insights into the pGC-A membrane receptor, a vital component of cardiovascular regulation. The research offers a clearer understanding of this complex receptor and its signaling mechanisms, paving the way for new anti-hypertensive drugs.
SourceArizona State University·JournalScientific Reports·TypeExperimental study·DateAug 5, 2022
Researchers at the University of Pittsburgh have discovered that even terminally exhausted T cells retain some capacity to function again. They identified approaches to overcome exhaustion by targeting co-stimulation pathways and reprogramming T cells to be resistant to hypoxia, a common tumor microenvironmental signal.
SourceUniversity of Pittsburgh·JournalScience Immunology·TypeExperimental study·DateAug 5, 2022
Researchers at Gladstone Institutes developed a tool called Retro-Cascorder, which logs a cell's genetic activity for days at a time. This allows scientists to create living biosensors that can record changes to their environment.
A set of genes promoting sweet taste sensation also regulate protein management in flies, according to a new study. The finding suggests a connection between taste-related genes and disorders of protein aggregation.
SourcePLOS·JournalPLOS Biology·TypeExperimental study·DateJul 21, 2022
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
A UC Riverside study reports that switching from combustible cigarettes to electronic cigarettes does not restore the nasal epithelium to that of a non-smoker. The researchers found alterations in gene expression profiles associated with cigarette smokers, indicating potential harm from prolonged EC use.
SourceUniversity of California - Riverside·JournalToxics·TypeExperimental study·DateJul 12, 2022
Researchers at Hokkaido University have discovered a molecular pathway by which stress affects lupus, revealing a potential target for treatment. The study found that sleep deprivation caused the activation of microglial cells in the brain, leading to increased levels of IL12 and IL23, a diagnostic marker for neuropsychiatric SLE.
SourceHokkaido University·JournalAnnals of the Rheumatic Diseases·TypeExperimental study·DateJul 11, 2022
Researchers discover that neurons directly contribute to Krabbe disease destruction through enzyme galactosylceramidase. This finding presents a new approach to developing therapies for the rare neurodegenerative disorder.
SourcePLOS·JournalPLOS Biology·TypeExperimental study·DateJul 5, 2022
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
A new study uses gene expression patterns to reconstruct the evolution of the placenta and predict its characteristics in early mammals. The research suggests that the placenta was invasive in the last common ancestor of eutherian mammals, with non-invasive placentas evolving multiple times among mammals.
SourceUniversity at Buffalo·JournaleLife·DateJul 1, 2022
Researchers found that the eyes of tadpoles undergo significant changes in gene expression and photoreceptor cell sensitivity to adapt to life on land. The study reveals that 42% of genes involved in vision changed between tadpole and juvenile frog stages, enabling better adaptation to a bluer light environment.
SourceYork University·JournalBMC Biology·TypeExperimental study·DateJun 28, 2022
A novel single-cell RNA sequencing technique, TAS-Seq, has been developed to provide higher-precision data than current methods. The new method detects more genes and identifies highly variable genes, making it a sensitive high-throughput scRNA method.
SourceTokyo University of Science·JournalCommunications Biology·TypeExperimental study·DateJun 27, 2022
A recent review article highlights the crucial role of macrophages in the progression from acute kidney injury (AKI) to chronic kidney disease (CKD). The study suggests that targeting specific signaling pathways and altering macrophage activation can prevent renal fibrosis and CKD. Therapeutic strategies such as clodronate liposomes an...
SourceCactus Communications·JournalChinese Medical Journal·TypeLiterature review·DateJun 20, 2022
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers from the University of Bath have made significant breakthroughs in understanding how a type of gene regulates essential nerve cells. Long non-coding RNAs (lncRNAs) play a crucial role in controlling brain development and function, particularly during embryonic development and early life.
SourceUniversity of Bath·JournalPLOS Genetics·TypeExperimental study·DateJun 16, 2022
Researchers have developed a new protocol for differentiating human embryonic stem cells into retinal pigment epithelial (RPE) cells, which can be used to treat age-related macular degeneration. The study shows that the protocol produces a pure population of RPE cells that can continue maturing after transplantation, paving the way for...
SourceEcole Polytechnique Fédérale de Lausanne·JournalStem Cell Reports·DateJun 14, 2022
Researchers used stem-cell models to uncover hidden genetic markers of glaucoma, a leading cause of permanent blindness. The study identified 312 genetic variants associated with retinal cells and 97 genetic clusters linked to damage caused by glaucoma.
SourceGarvan Institute of Medical Research·JournalCell Genomics·TypeExperimental study·DateJun 8, 2022
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
A recent study identified 34 novel genes that contribute to endocrine resistance in breast cancer using dynamic gene expression analysis. The researchers found that these genes are differentially expressed in both estrogen receptor-positive and triple-negative breast cancers, suggesting shared genetic mechanisms underlying resistance d...
SourceImpact Journals LLC·JournalOncotarget·TypeComputational simulation/modeling·DateJun 8, 2022
Researchers developed a simple physical model to explain DNA deformations caused by ions and temperature changes. The model reveals that salt-induced twist changes are driven by electrostatic interactions, while temperature-induced changes are related to DNA diameter variation. These findings provide new insights into the molecular mec...
SourceCity University of Hong Kong·JournalScience Advances·TypeObservational study·DateJun 6, 2022
Researchers have elucidated principles of human brain organisation across visual, auditory, somatosensory, and motor functional systems. The study revealed systematic changes in receptor architecture and gene expression within each system, reflecting increasing complexity of information processing.
SourceHuman Brain Project·JournalNeuroImage·DateJun 2, 2022
Researchers at Cedars-Sinai have identified a key gene, NLRP11, that plays a crucial role in the innate human immune system. Deleting this gene prevented an immune sensor from triggering an inflammatory response, highlighting its potential as a target for therapies to prevent or treat inflammatory diseases.
SourceCedars-Sinai Medical Center·JournalNature Immunology·DateJun 1, 2022
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Researchers discovered how electric fish evolved electric organs by modifying a sodium channel gene. The finding highlights the potential for this genetic mechanism to contribute to human diseases. By studying electric fish, scientists can gain a better understanding of evolutionary processes and their applications in human health.
SourceUniversity of Texas at Austin·JournalScience Advances·TypeExperimental study·DateJun 1, 2022
Researchers discovered that ancient retroviruses embedded in human genome can undergo retrotransposition into iPS cells, potentially posing a risk for regenerative medicine. The study found that HERV-K is expressed in SOX2-expressing cells and may cause cancer and neurological diseases by altering gene expression profiles.
SourceKumamoto University·JournalJournal of Virology·TypeExperimental study·DateMay 27, 2022
The São Paulo School of Advanced Science on Pathogenic Trypanosomatids will bring together experts from different fields to discuss the fight against leishmaniasis and Chagas disease. Researchers will share state-of-the-art science and results of new research on epigenetics, drug discovery, and molecular biology.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·DateMay 19, 2022
Sky & Telescope Pocket Sky Atlas, 2nd Edition
Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.
Researchers developed CancerOmicsNet, a graph neural network model that integrates multiple heterogeneous data to predict cancer cell growth rate after drug treatment. The model achieved significantly higher cross-validated accuracy than other approaches on the same data.
SourceImpact Journals LLC·JournalOncotarget·TypeComputational simulation/modeling·DateMay 19, 2022
Researchers at UNIGE discovered that temperature changes trigger organ-specific effects in all tissues, leading to distinct gene expression profiles. The study's web-based application provides access to thousands of gene expression profiles, enabling further research and potential therapeutic applications.
SourceUniversité de Genève·JournaleLife·TypeNews article·DateMay 17, 2022
Researchers developed PASTE, a method to analyze spatial transcriptomics data in three dimensions, enabling biologists to better understand cell environments and identify rare cell types. The technique can integrate information from multiple tissue slices, providing a more complete picture of gene expression within tissues.
SourcePrinceton University, Engineering School·JournalNature Methods·TypeExperimental study·DateMay 16, 2022
Scientists created a comprehensive map of cells across multiple human tissues, revealing new insights into the cellular and genetic underpinnings of complex diseases. The study's findings have the potential to improve our understanding of disease risk and develop more targeted therapies.
SourceMass Eye and Ear·TypeComputational simulation/modeling·DateMay 12, 2022
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Researchers created multi-tissue cell atlases to transform our knowledge of biology, infection, and disease. The studies revealed novel cell functions, immune cell types, and disease genes across the human body.
SourceWellcome Trust Sanger Institute·JournalScience·TypeExperimental study·DateMay 12, 2022
Researchers developed an algorithm to quickly identify two cancer drugs that work well together, reducing testing time from three years to eight weeks. The new method uses gene expression data to prioritize potential combinations and has been confirmed in lab tests.
SourceMedical College of Georgia at Augusta University·JournalPLOS ONE·DateMay 12, 2022
Researchers found that genes expressed in the brains of fearless birds differ from those of fearful birds, influencing their behavior and adaptation to new environments. This study provides insights into the genetic basis of fear and boldness in wild animals, potentially leading to novel approaches for addressing anxiety disorders.
SourceLouisiana State University·JournalPLOS ONE·TypeExperimental study·DateMay 10, 2022
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
Researchers have developed a new method for precisely altering gene expression by supplying and removing electrons, enabling controlled biomedical implants and bioreactors. The improved system allows for accurate control of gene expression in the presence of oxygen, opening up new possibilities for synthetic biology.
SourceImperial College London·JournalScience Advances·DateMay 4, 2022
Researchers discover that type 1 TPCs encode SV channels in plant vacuoles, while type 2 TPCs likely encode distinct ion channels. This study provides functional and evolutionary insights into the TPC family in plants, shedding light on their role in plant growth and defence mechanisms.
SourceTokyo University of Science·JournalPlant and Cell Physiology·TypeExperimental study·DateMay 2, 2022
Researchers have identified the Xist gene as a critical regulator of fetal development in mice, leading to miscarriage and abnormal placentas when epigenetic instructions are missing. The study's findings suggest that failed Xist imprinting can be 'cured' by targeting specific genes involved in histone modifications.
A study by Kyoto University reveals that crickets' wings form from the lateral tergum of their wingless ancestors. The researchers used gene knockouts and microsurgery to identify key cell types involved in wing formation.
SourceKyoto University·JournalNature Communications·TypeExperimental study·DateApr 22, 2022
Researchers at the Lewis Katz School of Medicine defined 11 subsets of cells found in esophageal tissue using single cell gene-expression profiling. This study could help clinicians diagnose or treat certain types of cancer by identifying functional cell types contributing to cancer progression.
SourceTemple University Health System·JournalNature Communications·DateApr 20, 2022
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
Scientists discovered that bacteria adapt their gene expression to evade bacteriophages in the gut environment, reducing susceptibility to infection. This finding paves the way for improved use of phages in therapeutic purposes.
SourceInstitut Pasteur·JournalCell Host & Microbe·TypeExperimental study·DateApr 15, 2022
Researchers found that low-density neutrophils are associated with chronic inflammation in obesity, which can lead to comorbidities like type 2 diabetes and cancer. Bariatric surgery reduces these cells in circulation, improving metabolic syndrome components.
SourceLouisiana State University Health Sciences Center·JournalEBioMedicine·TypeCommentary/editorial·DateApr 14, 2022
Researchers used CRISPR gene editing to understand how deletions in one area of the genome affect nearby genes. They found that deleting a small region led to increased foetal globin expression and reduced adult globin levels, suggesting a key mechanism for asymptomatic patients with sickle cell disease.
SourceUniversity of New South Wales·JournalBlood·DateApr 8, 2022
Researchers have successfully rejuvenated mouse organs through cellular reprogramming, improving their health and potential applications for cell therapy. The study identified key changes in metabolism, gene expression, and DNA status during aging, which are partially reversed by reprogramming.
SourceInstitute for Research in Biomedicine (IRB Barcelona)·JournalAging Cell·DateApr 6, 2022
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
Researchers at Northwestern University used CRISPR to identify human genes important for HIV infection in blood cells, finding 86 genes that may play a role in replication and disease. The study proposes a new map for understanding how HIV integrates into the DNA and establishes chronic infections.
SourceNorthwestern University·JournalNature Communications·DateApr 1, 2022
Researchers have created a biobank of breast cancer organoids from 87 patient tumor samples, including nearly half that are 'triple negative', an aggressive form of the disease. The biobank allows scientists to test specific drugs on those cancers in a dish, potentially leading to better treatment options.
SourceCold Spring Harbor Laboratory·JournalCancer Research·DateMar 29, 2022
Researchers developed a computational approach called CellTrek to combine parallel gene-expression profiling methods, creating spatial maps at single-cell resolution. The tool provides detailed information on individual cell types' location within tissues, enabling unique biological insights.
SourceUniversity of Texas M. D. Anderson Cancer Center·JournalNature Biotechnology·DateMar 21, 2022
Researchers found early and persistent activation of neutrophils in patients who developed severe COVID-19. The study suggests that identifying specific gene signatures could lead to effective treatments targeting high-risk patients. This discovery may also inform the development of simple blood tests to prioritize treatment.
SourceUniversity of Illinois Chicago·JournalJCI Insight·TypeComputational simulation/modeling·DateMar 14, 2022
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Researchers have discovered that bioprosthetic heart valve patients develop an immune response against foreign sugars in the valves, leading to calcification and deterioration. By genetically engineering these sugars out of the valves, durability can be increased, offering a potential solution for patients.
SourceTel-Aviv University·JournalNature Medicine·DateMar 1, 2022
A recent study by La Jolla Institute for Immunology researchers has identified new subsets of CD4+ 'helper' T cells that are linked to autoimmune disease risk. The team used single-cell RNA sequencing to compare gene expression in over 1 million CD4+ T cells from 89 healthy donors, revealing sex-based differences in immune cell functio...
SourceLa Jolla Institute for Immunology·JournalScience Immunology·TypeExperimental study·DateFeb 25, 2022
A new study found that an anti-tumor drug, camptothecin, can activate a natural hunger-suppressing pathway in mice, leading to significant weight loss. The mechanism involves the elevation of growth differentiation factor 15 (GDF15), which suppresses food intake and reduces body weight.
SourcePLOS·JournalPLOS Biology·TypeExperimental study·DateFeb 24, 2022
Xue Sherry Gao has won a prestigious CAREER Award to create versatile toolkits for controlling gene expression. Her research aims to develop broadly applicable platforms for gene regulation, with a focus on precision dosing and safety features.
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
A study published in Immunogenetics found that male Kentish Plovers have stronger immune systems than females due to the presence of two active copies of immune genes on their Z chromosome. This may explain why males tend to survive longer than females in this species.
SourceUniversity of Bath·JournalImmunogenetics·TypeObservational study·DateFeb 21, 2022
A new study using blood samples from professional soccer players reveals that headers affect brain activity by altering microRNAs, which can serve as biomarkers for brain injury. The research also explores the effects of accidental head impacts and high-intensity exercise on microRNA levels.
SourceTaylor & Francis Group·JournalBrain Injury·TypeExperimental study·DateFeb 16, 2022
A team of researchers from MIT created a comprehensive atlas of cerebrovascular cells in human brain tissue, identifying 11 subtypes and their functions. The study reveals differences between healthy and diseased cells, potentially leading to new targets for treating Huntington's disease.
SourceMassachusetts Institute of Technology·JournalNature·DateFeb 15, 2022
GQ GMC-500Plus Geiger Counter
GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
Gene expression tests examine how active genes are in tumour cells and have shown that even random genes can be prognostic. Combining multiple tests increases the probability of identifying patients who will not benefit from chemotherapy.
SourceUniversität Leipzig·JournalPLOS ONE·TypeData/statistical analysis·DateFeb 11, 2022
Neuroscientists have designed neural organoids with both mature neurons and astrocytic glial cells to study interactions between brain cells. The new technology enables the emulation of brain activity during healthy and disease states, opening doors to rapid drug screening for neurological diseases.
SourceHouston Methodist·JournalJournal of Cell Biology·TypeExperimental study·DateFeb 9, 2022
Dresden researchers reveal how liquid-like protein droplets collectively read DNA regions to switch on genes. Thousands of individual transcription factors work together, interacting and identifying clusters of binding sites on the DNA surface.
SourceMax Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)·JournalNature Physics·TypeExperimental study·DateFeb 3, 2022
Researchers developed a method called 6mASCOPE that measures DNA tagging system accuracy and distinguishes bacterial from human DNA. The study found high levels of methylation in plant, fly, mouse, and human cells, but mostly attributed to contamination.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalScience·TypeExperimental study·DateFeb 3, 2022