Articles tagged with Gene Expression
A team of scientists developed a high-throughput approach to integrate laboratory experiments, literature data, and network analysis to study Huntington's disease. The approach revealed that changes in inflammation, cell architecture, and calcium signaling drove the disease forward, while counteracting these changes improved health.
Researchers have found a blood-based genetic biomarker, KLRD1, which determines an individual's susceptibility to the flu. Those with higher levels of this gene have better immune defenses and are less likely to fall ill.
Researchers found that a type of lung cancer's spread is facilitated by immune cells forming clots in tumors. These clots allow tumor cells to migrate and spread to other parts of the body. The study identifies a new target for potential metastasis treatment.
Juhyun Lee is using a new $251,000 grant from the American Heart Association to explore targeted delivery of messenger RNA to reverse damage caused by congenital heart disease. His goal is to modulate mechanical forces and reduce gene expressions to stimulate heart growth or healing.
Researchers found that inheriting a variation in the PM20D1 gene increases the risk of developing Alzheimer's disease, making it an excellent candidate for clinical prevention trials. The study highlights the importance of international scientific collaboration and multidisciplinary research to tackle complex diseases like dementia.
Researchers developed a method to improve electrical transmission in the heart by introducing the Connexin 43 gene into cells forming the infarct scar. Mice with overexpressed Cx43 showed reduced cardiac arrhythmias compared to control animals.
EPFL scientists have joined the Human Cell Atlas initiative, a global project mapping every type of cell in the human body. The team developed an automated single-cell analysis pipeline, enabling non-expert labs to engage in high-level genomic research.
Researchers discovered that HTLV-1 survives by evading immune surveillance through transient Tax expression in infected cells. This unique strategy allows the virus to maintain a population of infected leukemic cells, making it a potential target for new therapies.
Researchers have detailed for the first time how interneurons emerge and diversify in the brain, tracing their lineage from earliest precursor states to mature forms in mice. The study identified key genetic programs that determine the fate of developing interneurons, shedding light on their functions and potential treatment strategies.
A study by McGill University researchers found that complex interactions among roots, fungi, and bacteria drive the degradation of hydrocarbons in polluted soil. This discovery suggests a new approach to phytoremediation, highlighting the importance of interdisciplinary research.
A study on bariatric surgery reveals that changes in the intestines lead to the reversal of diabetes after weight-loss surgery. The research found dramatic changes in gene expression in intestinal tissue, explaining blood glucose improvement and body weight loss after RYGB surgery.
A new study suggests that low-calorie sweeteners can promote metabolic syndrome and increase the risk of prediabetes and diabetes in overweight individuals. The research found that these substances can lead to increased glucose entry into cells through enhanced activity of genes called glucose transporters.
Researchers developed a light-activated genetic switch that can turn genes on and off in mammalian cells using red and far-red light. The switch relies on two insights: creating an electron transfer system and placing the molecular synthesis in mitochondria, allowing for precise gene control.
Researchers have identified a range of synthetic antisense oligonucleotides that can activate the frataxin gene in FA patients. The discovery demonstrates flexible options for increasing frataxin protein expression and alleviating FA symptoms.
A new gene-editing technology has been developed to improve the efficiency of CRISPR/Cas9, allowing for safer and more efficient correction of disease-causing mutations in patients. The system uses a nano-sized porous material to coat the molecular components of CRISPR/Cas9, enabling efficient release into cells.
The Scanpy software is a candidate for analyzing the Human Cell Atlas, enabling comprehensive analysis of large gene-expression datasets. It uses graph-based algorithms to characterize cells by identifying their closest neighbors, similar to social networks.
Researchers found genetic clues to distinct susceptibility to virus infection in congenital Zika syndrome, using Brazilian twin babies with different outcomes. The study revealed a single gene cannot explain the cases of CZS development nor brain resistance to Zika virus.
Researchers find that beta amyloid protein disrupts mitochondria function, leading to early disease symptoms. Human cells can be protected from damage with a custom-designed compound, offering an exciting avenue for future drug development.
A novel chip-based gene expression tool has been developed to analyze RNA levels in cancerous tissue samples quickly and accurately, while preserving spatial information. The technique allows for the analysis of entire tissue samples and identification of cancer cells in under two hours.
Researchers at the Salk Institute discovered that genes that normally sever connections between neurons are reactivated in aging astrocytes, leading to reduced neuronal communication. This may explain age-related cognitive decline and neurological disorders such as Alzheimer's and diabetes.
A new study uses deep learning methods to identify genes involved in embryonic development, fetal transition, and cancer. The research may lead to innovative strategies for induced tissue regeneration and cancer treatment.
Gene expression in specific cells and regions provides a more precise, neuroprotective approach than traditional treatments for neurological diseases. Increasing cholesterol synthesis gene expression in astrocytes of the spinal cord can repair nerves affected by walking in multiple sclerosis patients.
A blood-based precision medicine test incorporating age, sex, and gene expression score (ASGES) helped evaluate older outpatients with symptoms of obstructive coronary artery disease. The study found higher incidence of major adverse cardiovascular events in those with high ASGES scores compared to low ASGES scores
A genetic variation linked to autism spectrum disorders stunts the growth of dendrites in rat cells and a mouse model of autism. This excessive pruning may contribute to differences in neuronal connectivity underlying social and communication deficits observed in autism.
A collaborative study has identified a novel cluster of dysregulated genes in the pancreatic islets of patients with type 2 diabetes. The findings suggest that these altered genes are responsible for beta cell failure in diabetes and may hold new insights into how to prevent and treat the disease.
A new web-based application called NeuroExpresso provides a comprehensive catalogue of brain cell type data, helping to better define their functions and properties. The tool uses marker genes to estimate cellular composition of mouse and human tissue.
New research reveals stress's negative effects on brain function, including gene expression alterations, anxiety responses, and mental illness symptoms. Potential paths for relief include astrocyte signaling control, microbiome regulation, and newborn neuron development.
Researchers analyzed gene expression changes in tendon tissue of male and female subjects aged 20-24 and 54-70. The study found opposite effects on genes expressed in males and females with age, highlighting the importance of considering gender differences in treating tendon disease.
Researchers at MPFI discovered significant regional differences among chandelier cells in the hippocampus and neocortex. Chandelier cells exhibit distinct characteristics, including expanded axonal arbors, increased connections, and differential gene expression.
Scientists at UNC School of Medicine compare two reprogramming techniques to generate patient-specific cardiomyocytes, finding that one method produces cells with embryonic cell signatures while the other yields cells with adult characteristics. This knowledge is crucial for developing new therapies and understanding cardiac disease.
A new study uses gene transfer to block the expression of an enzyme that breaks down alcohol, leading to increased acetaldehyde levels and potential treatment for alcoholism. The approach has strong proof-of-concept data and bodes well for future development of a genetic therapy.
Research on Medaka fish reveals dynamic seasonal changes in color perception, with variations in behavior, light response, and gene expression. This phenomenon may not be limited to Medaka and could be widely observed in various animals, including humans.
Researchers identified distinct gene expression patterns and immune signatures associated with asymptomatic dengue infections, revealing a supporting role for T cell protection. These findings could optimize vaccine development efforts by understanding what types of immune responses are important in defending the body against the disease.
Researchers measured the effect of low-level mercury concentrations on microalga gene expression, revealing widespread deregulation of genes involved in various processes. This study provides insight into the environmental and public health implications of mercury's entry into the food chain.
The American Society of Human Genetics has honored Dr. Arthur L. Beaudet with the Victor A. McKusick Leadership Award, recognizing his groundbreaking work on uniparental disomy and its implications for genetic diseases. His current research focuses on neuronal carnitine deficiency as a risk factor for autism.
A research team has revealed intrinsic gene expression patterns of glioblastoma tumors, which could drive more effective treatments. The study found that tumor microenvironment cells contribute to the 'ecosystem' of hundreds of GBM tumors, influencing treatment outcomes and response to immunotherapy.
Researchers at the University of Michigan have discovered a fast and short-lived spike in signaling lipid PI3,5P2 that helps protect yeast cells from high salt stress before gene expression takes over. The study suggests that this early protection pathway may exist in other organisms and respond to different types of cellular stress.
A new study found that oral prednisone reduced immune responses to AAV-based gene delivery, resulting in a 60% decrease in cytotoxic T cell infiltrates. The treatment also increased PD-L2 levels, which induce programmed T-cell death, suggesting a potential therapeutic benefit for gene therapy.
Raja Mazumder is developing databases BioMuta and BioXpress to standardize cancer genomics data, making it easier for researchers to integrate and compare data across various platforms. The project aims to connect cancer genomics mutation and expression data within an evolutionary context.
Research found that BPA exposure during early development alters genetic pathways, leading to changes in mitochondrial and ribosomal pathways. This can affect cognitive flexibility and memory. The study suggests permanent reprogramming of the brain with developmental exposure to endocrine disrupting chemicals.
A new study in mice reveals how the protein Brd4 boosts the inflammatory response, with both beneficial and harmful effects. The findings suggest that Brd4 can protect the body from infection but also contribute to chronic inflammatory diseases.
Scientists have identified key genes involved in the homing behavior of rainbow trout, which use Earth's magnetic field to navigate back to their birthplace. The study found that changes in gene expression are triggered by disruption of the fish's internal compass, pointing to a possible role for iron-based magnetite particles.
Exposure to high temperatures in Caenorhabditis elegans can lead to genetic changes that persist through both sperm and egg, affecting up to 14 generations. These changes are driven by a temperature-induced reduction in an enzyme, resulting in gene expression alterations that 'remember' the environmental stress.
Research by British American Tobacco found that e-cigarette vapour has a limited effect on gene expression in human lung cells compared to cigarette smoke. The study exposed MucilAir 3D models to equivalent or higher doses of nicotine and measured the genes affected, revealing significant differences in response.
Researchers found that methionine supplementation can increase embryo survival in dairy cows and affect gene expression in ovarian follicles. Cows fed methionine had higher estrogen production and lower inflammation levels, potentially leading to faster heat cycles and improved fertility.
A new study identifies optimal adeno-associated virus (AAV)-based gene therapy delivery vector constructs to treat Hemophilia A. The researchers successfully improved the design of AAV vectors, demonstrating significant and differing effects on liver-specific expression of the human factor VIII transgene in mice.
Scientists at La Jolla Institute for Immunology have discovered that exhausted T cells have distinct DNA structures and activate specific genes, including NFAT and Nr4a proteins. These findings provide new insights into the molecular underpinnings of T cell exhaustion and offer potential targets for improving cancer immunotherapies.
Researchers at Case Western Reserve University discovered changes in specific regions of DNA that 'enhance' harmful gene expression to promote tumor growth. These recurrent changes in DNA activate genes involved in colorectal cancer progression.
Researchers have developed a new imaging technology that sees DNA naturally fluoresce, allowing for the study of individual biomolecules and global patterns of gene expression. This breakthrough could yield insights into cancer and other diseases.
Scientists have mapped the entire methylome in pancreatic islets, revealing correlations between DNA methylation and impaired insulin function. The study found altered methylation in 25,820 genome regions, including changes in the PDX1 gene linked to type 2 diabetes.
Researchers developed a mini-intronic plasmid (MIP) system that can enhance transgene expression by up to 40-100-fold when used with adeno-associated viral (AAV) vectors. This could reduce the cost of gene therapy and lessen immune responses.
Inflammation in mice brains and spleens differed depending on when chemotherapy drugs were administered, according to Ohio State University researchers. The study's findings could lead to more effective treatment strategies and reduced side effects for cancer patients.
Researchers developed a new mouse model that faithfully reproduces the pathologies of COPD and CF, revealing two key pathways: oxidative stress and protease-antiprotease imbalance. The model shows promise for developing new medication therapies.
Researchers at Vanderbilt University Medical Center have made a groundbreaking discovery about the human immune system's response to the bird flu vaccine. They found that neutrophils, a type of white blood cell, play a previously unobserved role in vaccine response and may function as antigen-presenting cells.
Researchers at Caltech have developed a method to link magnetic resonance imaging signals to gene expression in cells, allowing for non-invasive monitoring of disease. The technique uses aquaporin reporter genes to visualize gene expression in living tissues, with potential clinical translation.
Scientists identified a gene NAMPT that fuels glioblastoma growth and resistance to radiation therapy. Inhibiting NAMPT may improve treatment outcomes for most aggressive forms of the disease.
Researchers found that Varroa jacobsoni mites are shifting from Asian to European honeybees, posing a new threat to pollinators. The study identified key genes involved in the host switch and potential control strategies.
Plant biologists have increased crop productivity by modifying genes involved in photoprotection, allowing for more efficient use of sunlight. The study shows a 14-20% increase in modified tobacco plants, which could be applied to other crops like rice.
Researchers analyzed T cell protein expression in a human cohort, identifying unique markers associated with age and genetic predisposition to diseases. The study may lead to personalized medicine approaches and diagnostic tools for autoimmune diseases.
Plant biologists at ITbM, Nagoya University, have made a key discovery that the contents in pollen tubes alone can increase the size of seeds, without the need for fertilization. This new plant phenomenon, named as POEM (pollen tube-dependent ovule enlargement morphology), shows that even in the absence of fertilization, release of the...