Articles tagged with Genetic Analysis
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers expand the genetic alphabet from four to eight letters, demonstrating a double increase in information density. The new DNA and RNA-like systems may be useful for future synthetic biological applications, including larger molecular structures.
A team of scientists at Houston Methodist has identified a previously unknown trigger that turns group A streptococcus infections into flesh-eating diseases. The discovery may lead to the development of a childbed fever vaccine, which is estimated to cause 10% of maternal deaths globally.
A University of Guelph DNA barcoding study found 14% of Canadian sausage samples contained mislabeled meat species, a decrease from the initial 20% rate. The study's findings suggest that scientific innovation, such as DNA barcoding, plays a crucial role in protecting Canada's food supply.
A new assay can identify patients with lung cancer and quantify PD-L1 expression levels using small, unfixed tissue samples collected via minimally invasive bronchoscopy. This approach can guide therapeutic decisions and potentially save time and money.
Research in zebrafish reveals that clock genes determine daily behavioral rhythms and activity levels. The study found that eliminating these genes reduces energy supply, leading to lower locomotion and more resting behavior.
A 34,950-33,900 year old skull from Mongolia has been identified as the oldest known modern human in the region. The ancient skull's presence confirms its link to the Early Upper Palaeolithic industry, which is typically associated with modern humans.
A type of mosquito known to transmit malaria has been detected in Ethiopia for the first time, posing a public health concern. The Anopheles stephensi species was identified in Kebri Dehar, an eastern Ethiopian city, and its presence may lead to an emergence of malaria in new regions.
Researchers used a massive insurance database to analyze the effects of genes and environment in 560 common conditions among over 56,000 twin pairs. The study found that nearly 40% of diseases had a genetic component, while 25% were driven by environmental factors.
A study reveals that winged insects likely evolved from a ground-dwelling common ancestor with long antennae and segmented abdominal appendages. The findings suggest that wings did not evolve in aquatic environments, but rather for aerial descent, as the ancestral Pterygota species returned to life on the ground.
A study of the European gypsy moth genome found divergent proteins involved in muscle development, which may affect flight. The research also identified altered gene expression in response to viral infections, suggesting new avenues for biological control.
Researchers at Oregon State University have developed a novel method for counting Pacific salmon by analyzing DNA from the slime left behind in their spawning streams. This new approach, funded by The National Geographic Society, uses environmental DNA (eDNA) to accurately count fish in many more streams than currently monitored.
A study identified 14 gene variants associated with polycystic ovary syndrome (PCOS), including three new variants. The findings suggest shared genetic architecture for different diagnosis criteria and links to other conditions like metabolic disorders, depression, and male pattern baldness.
Researchers from UNIGE analyzed skin and blood cells from five women, identifying 55 genes that escape inactivation of the second X chromosome. The team found that XIST gene expression is key to inactivation, but also discovered five other genes playing a crucial role in the mechanism.
Researchers at New York University have developed a method to visualize genetic mutations in single cells, allowing for early detection of rare events and high-resolution analysis of evolutionary tempo. This breakthrough has significant implications for studying mutations in pathogens and human cancers.
A Genetic Data Protection Act is needed to control access to medical genetic data by law enforcement agencies, according to a University of Queensland analysis. The researchers warn that current laws do not fit well with genetic data, putting vulnerable individuals and their descendants at risk.
A new epigenetic-based cervical cancer test outperformed Pap smear and HPV tests, detecting 100% of invasive cancers in a large study. The test also predicted early cancer development up to five years in advance.
Researchers studied 91,105 UK Biobank participants and found 14 genetic regions related to physical activity, including seven new discoveries. The analysis also showed that increased physical activity lowers blood pressure and has a causal link to better health outcomes.
Researchers identified conserved genes involved in regeneration across species, including flies, mice, and zebra fish. They also discovered new types of regulatory elements that can be activated to boost organ regeneration.
Researchers have developed a new test called gene expression profiling that identified one in 10 patients with diffuse large B-cell lymphoma as being half as likely to be cured with existing treatments. The 'molecular high grade' group has a three-year survival rate of only about 37% after standard treatment.
A study analyzing over 50,000 genomes identified 12 specific DNA fragments related to ADHD vulnerability, highlighting a polygenic hereditary basis and functional relevance. The research also reveals genetic overlaps with major depression, obesity, and other conditions.
Researchers sequenced and compared the genomes of 332 yeast species, revealing an extensive picture of their evolution over hundreds of millions of years. The study suggests that yeasts evolved through reductive evolution, losing traits to specialize in specific food sources, with modern yeasts having narrower appetites.
A team of scientists used CT imaging to identify a new Panamanian species of thorn snail, Carychium panamaense. The study revealed details about the snail's shell and its potential for conservation.
A study published in Communications Biology found that changing an enzyme's surface density can alter its ability to bind different substrates. By swapping single components on the surface, researchers were able to convert one enzyme into another, with implications for biotechnology applications.
Historical analysis of over 22 million UK baby names reveals shifts in societal values and cultural diversity from Victorian era to present day. The use of distinctive names has become increasingly popular, with experts attributing this to increased exposure and desire for individuality.
Researchers discovered that modified LDL particles trigger an immune response in macrophages, leading to chronic inflammation. The study found 27 transcription factors involved in the process, highlighting the importance of inflammation in atherosclerosis pathogenesis.
A new approach to genetic analysis identifies novel associations between genetic variants and ecological zones, replicating previously known associations with environmental variables. This study paves the way for further investigation into environmental factors and genomics, aiming to address unequal representation in clinical genomics.
A recent GWAS analysis of latent autoimmune diabetes in adults (LADA) has uncovered new connections to type 1 and type 2 diabetes, suggesting a hybrid nature of the disorder. The study found that genetic signals linked to LADA were mainly shared with established variants known to be linked to T1D.
A study in South Africa found that certain strains of Mycobacterium tuberculosis are resistant to the two primary antibiotics prescribed for TB. The resistance is not detected by standard DNA tests, leading to unsuccessful treatments and increased mortality.
Sunita Chandrasekaran is designing frameworks to adapt code to increasingly powerful systems, focusing on complex patterns like wavefronts. She aims to improve performance and portability while keeping scientists in mind, enabling them to concentrate on science rather than software.
Researchers analyzed genetic data from 15 Ural-speaking populations and found a small genetic component in common among most populations, suggesting a shared history of origins in Western Siberia. The study also revealed that geography plays a significant role in shaping the gene pool of Ural-speaking populations.
Researchers developed a computational method to link individuals in ancestry databases to those in law-enforcement databases, achieving accurate matches for over 30% of close relatives. The approach could have significant implications for forensic genetics and genomic privacy.
A new study published in The BMJ suggests that genetics play a significantly larger role in the development of high serum urate levels than diet. Despite long-held assumptions about diet's impact on gout, researchers found that only a small percentage of variation in urate levels could be explained by food choices.
A massive genetic analysis of over one million people has revealed 535 new genes linked to high blood pressure. The discovery sheds light on new biological pathways for blood pressure regulation and holds promise for improved cardiovascular disease prevention.
A study on scarab beetles found that horns developed from the same head regions, with common genes controlling their formation. The research suggests deep parallels in horn evolution between distant species.
A new poll by Michigan Medicine found that over half of older adults (50-64) are interested in DNA testing to guide medical care, understand health risks or know their ancestry. However, two-thirds expressed concern that genetic testing could lead to worrying about future health.
Researchers identified six main combinations of five Hoxd genes involved in digit development in mice, providing a higher resolution and clarity in understanding how architect genes orchestrate the rhythm of development. This study offers a new perspective on limb patterning motifs and could pave the way for future genetic work.
The Brigham Genomic Medicine program uses state-of-the-art genomic technologies to diagnose and discover genetic underpinnings of disease. By analyzing genomic data with a multidisciplinary team, the program has identified culprit genes for 30 families, providing critical information for diagnostics and treatment.
The Center for Sub-Cellular Genomics will develop new technologies to measure genomics elements at the scale of sub-cellular structures in single cells. This may enable new insights into neurogenerative and neuropsychiatric conditions, such as autism and Alzheimer's disease.
The study reveals that at least 11 individuals were likely male and that burial rites were sex-biased. The site is divided into two groups, with Niederstotzingen North showing kinship structure similar to modern northern and eastern European populations.
Researchers have identified KIN3 as a crucial enzyme connecting cellular signalling pathways involved in fungal developmental processes. The study found that mutants lacking this enzyme were sterile and exhibited developmental disorders.
Researchers identified 42 locations associated with 99 genes of interest in a genome-wide association study of over 500,000 people. The analysis found genes related to connective tissue cells and pathways, which could inform the development of new treatments for diverticulitis.
Researchers outline a novel view of biochemistry as a signaling game between genes and their associated macromolecules, where sender and receiver interactions lead to biochemical reactions. This approach reveals the presence of molecular deception and conflict of interest between gene players, with potential implications for understand...
A new assay has been developed to detect genetic abnormalities in sarcomas, which outperform conventional techniques in analysis of multiple target genes simultaneously. The assay was validated on 81 samples and showed high sensitivity, allowing for accurate diagnosis even in small sample sizes.
Researchers found that e-cigarette users experience increased DNA damage related to acrolein exposure, which could increase their cancer risk. The study suggests that vaping may modify the genetic material in oral cells, highlighting the need for further research on the long-term health effects of e-cigarettes.
A new method for screening frogs has been developed by an undergraduate researcher, allowing scientists to detect the deadly pathogen Perkinsea. The test, using qPCR assay, found that 25% of sampled frogs were infected, with the highest prevalence in Gold Head Branch State Park.
A team of researchers at RIKEN Center for Sustainable Resource Science has discovered a gene in plants called Heat Inducible Lipase 1 (HIL1) that helps protect them from excessive heat. This gene enables plants to modify their fats, which stabilize chloroplast membranes and prevent damage from high temperatures.
Researchers at Caltech developed an artificial neural network made of DNA that can accurately identify handwritten numbers. The network, designed by Kevin Cherry, uses a 'winner take all' competitive strategy and undergoes complex reactions to classify molecular information.
Research found people selectively identify with ethnicities they view as positive while disregarding others. White respondents were more likely to embrace new racial identities if they felt others would still accept them.
Researchers at the University of Washington found that measuring beak size can accurately determine the sex of Galapagos penguins, a simple and fast method for field studies. This knowledge will help scientists study the impact of climate change on this endangered species.
Researchers analyzed data from three major brain banks and found that human herpesvirus DNA and RNA were more abundant in the brains of Alzheimer's patients. The study suggests that viruses may be involved in regulating genes associated with increased Alzheimer's risk, and could offer potential new paths for treatment.
Researchers developed a new blood test that uses Raman spectroscopy to estimate the age of victims and suspects. The test was able to distinguish between different age groups with high accuracy, making it a potentially useful addition to current forensic science techniques.
A new DNA test has identified 63 genetic variations that increase the risk of prostate cancer, with men inheriting these variants having a 5.7 times higher risk. The test combines multiple genetic variants to predict individual risk, offering hope for early detection and prevention.
The study found that matching targeted therapies to tumor-specific gene mutations improved progression-free and overall survival in patients with advanced disease. Receiving matched targeted therapy was also an independent factor for predicting longer overall survival.
A study analyzing ancient Icelandic genomes of 25 individuals from the island's colonization period (870-930) found that present-day Icelanders have a 70% Norwegian genetic fingerprint. The analysis also revealed a gender bias in the population, with men of Scandinavian origin having more offspring than women of Celtic origin.
The mountain gorilla population in the Virunga Volcanoes has more than doubled over the past three decades due to concerted conservation efforts. A recent census found a minimum of 604 gorillas, representing a 26% increase from the previous estimate in 2010.
A new study presents a novel statistical algorithm called GSA-SNP2 that can identify potential disease genes more accurately and cost-effectively. The algorithm is effective with less genomic data and provides high power and decent type I error control.
By analyzing ancient DNA from Southeast Asian individuals, scientists identified two major waves of genetic mixture indicative of specific migration events. These migrations, occurring during the Neolithic period and Bronze Age, reflect the introduction of farming and cultural shifts in the region.
A study published in Nature Communications has found an unexpected overlap between the causes of rheumatoid arthritis and Huntington's disease. The researchers developed a novel algorithm to analyze epigenetic data, identifying new cell signaling pathways and potential treatment options for both conditions.
A team of scientists found four separate species of mice evolved from one common ancestor on Mindoro Island, which is the smallest known island to support this type of evolution. The discovery provides valuable insights into how mammals can diversify in small areas and has implications for conservation planning.
Researchers discovered that altered body odor can indicate malaria infection, even when microscopic tests fail. Machine learning models using volatile biomarkers reliably identify asymptomatic infections with 100% sensitivity.