Researchers have identified SAILR, a long non-coding RNA, as a key regulator of macrophage survival. In the presence of pathogens, SAILR is rapidly silenced, leading to macrophage death and increased bacterial replication. This discovery could lead to new diagnostic markers and therapeutic targets for severe infections and inflammation.
SourceHelmholtz Centre for Infection Research·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateJul 20, 2026
Researchers have synthesized long noncoding RNA molecules with anti-inflammatory properties, demonstrating a new paradigm in drug discovery. The team identified three lncRNA sequences that regulate inflammation and used them to create nanoparticles that reduced inflammation in human cell cultures and mice.
SourceUniversity of Toronto Faculty of Applied Science & Engineering·JournalScience Signaling·DateMar 10, 2026
Researchers studied MALAT1 levels in a woman with triple-negative breast cancer, finding high levels at diagnosis and decreased while receiving treatment. Notably, levels increased at a distant metastatic site, suggesting MALAT1's role in TNBC's spread. The study informs future treatments and potential clinical trials.
SourceCold Spring Harbor Laboratory·JournalMolecular Therapy Oncology·DateNov 10, 2025
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A team of researchers has identified a common sex-determining gene called ANTSR in both bees and ants, revealing a conserved mechanism that has been present for over 150 million years. This finding sheds light on the genetic basis of sex determination in these species and may have implications for bee conservation and breeding programs.
SourceUppsala University·JournalPLOS Biology·DateNov 10, 2025
This study analyzed differential expression of long non-coding RNAs in peripheral blood mononuclear cells of women with luminal A breast cancer. Differential expression was observed, particularly for LINC RNA 974 (LINC00974), which exhibited significant associations with other oncological disorders.
SourceXia & He Publishing Inc.·JournalGene Expression·DateSep 15, 2025
A recent study reveals ADAMTS9-AS2/let-7a-5p axis inhibits the Warburg effect and OSCC progression, suggesting a promising therapeutic target for treatment. The study highlights the importance of metabolic reprogramming in OSCC.
SourceCompuscript Ltd·JournalGenes & Diseases·DateAug 14, 2025
Researchers have identified LINC01235 as a crucial regulator of NFIB expression and NOTCH pathway in TNBC, suggesting potential therapeutic targets for this aggressive form of breast cancer. The study provides new insights into the role of non-coding RNAs in cancer progression.
SourceCold Spring Harbor Laboratory·JournalMolecular Cancer Research·DateJun 30, 2025
A Chinese Medical Journal study investigates the role of non-coding RNAs in pancreatic cancer, revealing how dysregulation of these molecules contributes to tumor growth and treatment resistance. The research highlights potential therapeutic targets for this devastating disease.
SourceChinese Medical Journals Publishing House Co., Ltd.·JournalChinese Medical Journal·TypeLiterature review·DateJun 5, 2025
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Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A research team has identified a long noncoding RNA named ESSENCE as a critical regulator of tumor progression in colorectal cancer. ESSENCE stabilizes a key metabolic enzyme, CAD, to promote cancer growth and suppress ferroptosis. This discovery proposes a novel combination therapy targeting ESSENCE-high tumors.
SourceResearch·JournalResearch·TypeNews article·DateMay 16, 2025
Long non-coding RNAs (lncRNAs) play a crucial role in regulating the tumor microenvironment, influencing processes such as immune evasion, angiogenesis, and metastasis. They mediate interactions between tumor cells and their surrounding microenvironment, modulating stromal cell activities and promoting tumor growth and survival.
SourceXia & He Publishing Inc.·JournalGene Expression·DateApr 24, 2025
Long non-coding RNAs (lncRNAs) play a critical role in metabolic and fibrotic pathways, influencing lipid metabolism, inflammation, apoptosis, and fibrogenesis. Targeting pathogenic lncRNAs or enhancing protective ones may provide a dual approach for MASLD treatment.
SourceFirst Hospital of Jilin University·JournaleGastroenterology·DateFeb 28, 2025
A UC Riverside-led team, funded by the NIH, aims to uncover molecular factors governing gene regulation and chromatin organization in P. falciparum. The project focuses on long non-coding RNAs, which play a crucial role in regulating gene expression and influencing disease progression.
A new study uses CRISPR-Cas13 to identify nearly 800 noncoding RNAs that are functional and essential for cell function, including in cancer and human development. The researchers found that these RNA molecules modulate key pathways for cell proliferation and can serve as potential biomarkers and therapeutic targets for cancer treatment.
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Researchers identified three long noncoding RNAs associated with worse outcomes in colorectal cancer patients, potentially serving as prognostic markers. The study's findings could enable doctors to separate high-risk patients from those at low risk of disease recurrence, leading to more effective treatment strategies.
SourceUniversity of Otago·Journalnpj Precision Oncology·DateOct 29, 2024
Scientists have discovered a long non-coding RNA called CHASERR that regulates the production of the CHD2 gene, which is associated with neurodevelopmental disorders. The study found that patients with a deletion of this RNA had excessive CHD2 protein production, leading to severe intellectual delays and other symptoms.
SourceNorthwestern University·JournalNew England Journal of Medicine·DateOct 23, 2024
Researchers from Japan have discovered that Exportin-5 interacts with a broader spectrum of RNAs, including tRNAs, miRNAs, lncRNAs, and specific mRNAs. This study sheds light on the unique roles of Exp5 in RNA export within Drosophila cells.
SourceNara Institute of Science and Technology·JournalJournal of Biological Chemistry·TypeExperimental study·DateSep 9, 2024
A team of international researchers has discovered a surprising genetic mechanism that influences the vibrant patterns on butterfly wings. An RNA molecule controls where dark pigments are made during butterfly metamorphosis, shaping the butterfly's color patterns in a way previously unforeseen.
SourceGeorge Washington University·JournalProceedings of the National Academy of Sciences·DateAug 30, 2024
Researchers at U of T mapped the spatial distribution of long non-coding RNAs in testes, finding higher levels than previously estimated. The study suggests lncRNAs play a more significant role in male reproduction and may influence sperm development and behavior.
SourceUniversity of Toronto·JournalNature Communications·DateJul 30, 2024
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CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
The study reveals that non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, play a crucial role in regulating the Notch signaling pathway in breast cancer. These molecules can modulate gene expression and affect cancer cell proliferation, invasion, and metastasis.
SourceXia & He Publishing Inc.·JournalGene Expression·DateJul 23, 2024
A team of UC Santa Cruz researchers has identified a peptide in human RNA that plays a crucial role in regulating inflammation. The discovery provides a promising target for developing new treatments for inflammatory diseases such as arthritis and lupus.
SourceUniversity of California - Santa Cruz·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateMay 24, 2024
Long non-coding RNAs (lncRNAs) play crucial roles in regulating protein-coding gene expression and respond to environmental stresses in fruits and vegetables. Recent research reveals the formation, functional characteristics, and regulatory mechanisms of lncRNAs in these crops.
SourceNanjing Agricultural University The Academy of Science·JournalHorticulture Research·TypeExperimental study·DateMay 9, 2024
A new computational pipeline, Plant-LncPipe, significantly improves plant lncRNA identification by retraining mainstream models on high-quality plant data. The study demonstrates that species-specific retraining enhances prediction precision and reliability.
SourceNanjing Agricultural University The Academy of Science·JournalHorticulture Research·TypeExperimental study·DateMay 1, 2024
Researchers found a shared triple network of long noncoding RNAs, microRNAs, and messenger RNAs that exacerbates Parkinson's disease symptoms in the context of COVID-19 infection. The study identified key genes and lncRNAs as potential biomarkers for PD diagnosis and progression.
SourceXia & He Publishing Inc.·JournalGene Expression·DateApr 30, 2024
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Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
A team of researchers has identified two long noncoding RNA genes that control multiple traits in wild soybeans, including insect resistance and leaf growth. These findings can aid in the development of new domesticated soybean varieties with improved seed composition and nutritional traits.
SourcePurdue University·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateApr 28, 2024
Researchers identified elevated MALAT1 levels in various blood cancers, correlating with adverse outcomes. MALAT1 promotes cancer cell proliferation, migration, invasion, and metastasis through multiple mechanisms.
SourceCactus Communications·JournalChinese Medical Journal·TypeLiterature review·DateApr 24, 2024
Researchers at CRAG have made groundbreaking discoveries on seed germination, identifying key regulatory features and non-coding RNAs that drive the process. The study reveals that transcription restarts much earlier than previously thought, opening up new avenues for investigation into the role of the non-coding genome.
SourceCenter for Research in Agricultural Genomics (CRAG)·JournalNature Communications·TypeData/statistical analysis·DateMar 20, 2024
A long non-coding RNA called lncREST has been identified as a crucial component of the stress response during DNA replication. Its absence leads to impaired stress signalling, resulting in severe DNA defects and cell death. The discovery opens up new avenues for developing anti-tumour therapies.
SourceCentro de Investigación Médica Aplicada (CIMA) Universidad de Navarra·JournalNature Communications·TypeNews article·DateMar 4, 2024
A new study found that MERRICAL, a long non-coding RNA sequence, is involved in recruiting macrophages to the arterial wall and promotes atherosclerosis progression. Reducing MERRICAL expression levels using inhibitors significantly reduced atherosclerosis and aortic lesion formation.
SourceBrigham and Women's Hospital·JournalCell Reports·TypeExperimental study·DateFeb 29, 2024
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Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
A study published in Seed Biology has identified 20,893 lncRNAs associated with wheat grain development, revealing their role in regulating seed germination and end-use quality. The comprehensive atlas provides insights into the functions of lncRNAs, laying groundwork for future research on boosting wheat yields and quality.
SourceMaximum Academic Press·JournalSeed Biology·TypeExperimental study·DateSep 29, 2023
Scientists have identified a long non-coding RNA called SNHG8 that plays a crucial role in the development of toxic protein tangles in brain diseases like Alzheimer's. Replacing this RNA can prevent stress granule formation, which contributes to tau aggregation and brain damage.
SourceWashU Medicine·JournalMolecular Psychiatry·TypeExperimental study·DateSep 21, 2023
Researchers detected distinct RNA patterns in healthy and preeclampsia-affected pregnancies, identifying messenger RNA, microRNA, and long noncoding RNA as potential biomarkers. The study developed classifiers for predicting preterm and early-onset preeclampsia with high accuracy.
SourceBGI Genomics·JournalAmerican Journal of Obstetrics and Gynecology·DateJul 20, 2023
A study by Professor Tongming Yin's team reveals the proposed role of MSL-lncRNAs in causing sex lability of female poplars. The researchers detected multiple cis-activating elements in the MSL gene, which generated long non-coding RNAs promoting maleness and leading to female lability.
SourceNanjing Agricultural University The Academy of Science·JournalHorticulture Research·TypeExperimental study·DateJul 6, 2023
Researchers found that MALAT1 inhibition decreased BRAF RNA and protein levels, while increasing correlation with MAPK-associated genes. MALAT1-ASO treatment also reduced melanoma cell growth and tumor size in xenograft models.
SourceImpact Journals LLC·JournalOncotarget·TypeObservational study·DateMay 30, 2023
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Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
CARMN is a long noncoding RNA that regulates contractility in both blood vessels and the gastrointestinal tract. Without CARMN, mice cannot survive due to impaired GI tract contraction, leading to conditions like intestinal pseudo-obstruction.
SourceMedical College of Georgia at Augusta University·JournalGastroenterology·DateMay 9, 2023
Researchers have identified distinct senescence subpopulations and dynamic changes in the transcriptome of human cells undergoing senescence. The study provides new understanding of the heterogeneous nature of senescence and its impact on aging diseases.
SourceImpact Journals LLC·JournalAging-US·TypeData/statistical analysis·DateMay 9, 2023
Researchers found that lncRNA MVIH is overexpressed in cervical cancer tumors and associated with younger age, lymph node metastasis, tumor invasion depth, and squamous cell type. This suggests its potential as a diagnostic biomarker for cervical cancer.
SourceImpact Journals LLC·JournalGenes & Cancer·TypeObservational study·DateDec 9, 2022
Researchers at the University of Bern identified new targets for drug development in non-small cell lung cancer, a largely incurable type of cancer. The study focused on long noncoding RNAs, which were found to play a crucial role in NSCLC cell division and tumor growth.
SourceUniversity of Bern·JournalCell Genomics·DateOct 6, 2022
A new biomarker called SPRIGHTLY could distinguish between two aggressive types of brain tumors in children: Group 3 and Group 4 medulloblastomas. The biomarker is highly expressed in Group 4 medulloblastomas, which have a poorer prognosis.
SourceJohns Hopkins Medicine·JournalNeuro-Oncology Advances·DateSep 21, 2022
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Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Researchers have identified a group of deregulated genes in pancreatic cancer that may serve as potential therapeutic targets. These long non-coding RNAs, when silenced, reduced tumor aggressiveness and characteristics such as proliferation and invasion.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalCellular Oncology·DateJul 26, 2022
Researchers from the University of Bath have made significant breakthroughs in understanding how a type of gene regulates essential nerve cells. Long non-coding RNAs (lncRNAs) play a crucial role in controlling brain development and function, particularly during embryonic development and early life.
SourceUniversity of Bath·JournalPLOS Genetics·TypeExperimental study·DateJun 16, 2022
Researchers uncover the pleiotropic functions of hnRNPK in regulating skeletal muscle cell differentiation, including inhibition of myoblast differentiation and suppression of genes involved in endoplasmic reticulum stress. The study suggests that targeting hnRNPK could be a potential therapeutic strategy for treating human disorders.
SourceFujita Health University·JournalInternational Journal of Molecular Sciences·TypeExperimental study·DateMar 7, 2022
The study of MUNC long non-coding RNA reveals the importance of experimentally determining its structure to identify functional domains. The researchers found that two structural domains, including six common 'hairpins,' were crucial for regulating gene expression and muscle cell differentiation.
SourceUniversity of Alabama at Birmingham·JournalCell Reports·TypeExperimental study·DateFeb 21, 2022
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Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
A comprehensive review highlights recently discovered associations between lncRNAs and specific diseases, including fatty liver disease and liver cancer. The study suggests that a diverse group of molecules known as long noncoding RNAs could emerge as biomarkers for liver disease.
SourceThe Translational Genomics Research Institute·JournalAnnual Review of Pathology Mechanisms of Disease·TypeLiterature review·DateFeb 8, 2022
Researchers found that knocking down LCDR in lung cancer cells promotes apoptosis, providing a potential new target for diagnosis and treatment. Additionally, targeting LCDR shows promise as a therapeutic strategy and has diagnostic value for lung adenocarcinoma.
SourceChinese Academy of Sciences Headquarters·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateJan 17, 2022
Scientists have discovered a new layer of regulation in plant-microbe interactions using peanut studies. An antisense long-noncoding RNA, DONE40, was found to bind to a protein involved in epigenetic control, suggesting a conserved function across plants and animals.
SourceAmerican Phytopathological Society·JournalMolecular Plant-Microbe Interactions·TypeExperimental study·DateJan 13, 2022
Researchers at Karolinska Institutet have identified a specific connection between a protein and an lncRNA molecule that can help decrease fat depots in tumor cells, leading to cell division cessation and cancer cell death. The study contributes to increased knowledge of liver cancer diagnosis and future treatments.
SourceKarolinska Institutet·JournalGut·TypeExperimental study·DateJan 12, 2022
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Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.
The study found that exercise induces expression of long noncoding RNA CYTOR, which enhances myogenic differentiation and improves muscle morphology and function in aged muscles. CYTOR also re-configures chromatin accessibility at binding sites of other genes, shedding light on its mechanisms.
SourceEcole Polytechnique Fédérale de Lausanne·JournalScience Translational Medicine·DateDec 8, 2021
Researchers identified 166 prognostic biomarkers from long non-coding RNAs, with one biomarker, HOXA10-AS, showing high effectiveness in categorizing gliomas as low- or high-risk. The study provides potential therapeutic targets and insights into cancer biology.
SourceOntario Institute for Cancer Research·JournalCell Reports·DateNov 15, 2021
Researchers identified LAPAS1 as a novel E2F-regulated lncRNA that plays a role in human cancer and regulates cell-cycle progression and cell proliferation. Inhibition of LAPAS1 expression delays cell progression through S phase and inhibits proliferation of human cancer cells.
SourceImpact Journals LLC·JournalOncotarget·DateJul 12, 2021
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Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
Understanding how tau protein is regulated in brain cells could lead to better treatments for Parkinson's and other neurological conditions. Researchers discovered that similar lncRNAs control the production of tau and other key proteins involved in brain function.
Researchers identify 'antisense long non-coding RNA' regulating tau protein production, a crucial mechanism for brain cell function. The discovery may lead to new treatments for dementia-related diseases, including Parkinson's and Alzheimer's.
SourceUniversity College London·JournalNature·DateMay 19, 2021
Researchers at Michigan Medicine identified a long noncoding RNA, LIMIT, that promotes the body's immune response against cancer. By activating key genes and pathways, LIMIT boosts T cell infiltration into tumors, offering new potential therapeutic approaches to overcome immune evasion in human cancers.
SourceMichigan Medicine - University of Michigan·JournalNature Cell Biology·DateMay 17, 2021
Researchers found four lncRNAs linked to cytokine storms in severe SARS-CoV-2 infection, suggesting potential therapeutic targets. The study sheds light on immune dysfunction mechanisms and informs novel approaches for treating severe COVID-19 patients.
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DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
A new study reveals that the long noncoding RNA ADEPTR is essential for structural plasticity in neurons, forming and amassing at the synapse upon stimulation. Silencing ADEPTR prevents new synapses from forming during stimulation, highlighting its crucial role in neural adaptation.
SourceScripps Research Institute·JournalScience Advances·DateApr 16, 2021
A new study reveals that a long noncoding RNA molecule named Linc00402 plays a key role in mobilizing the immune response after bone marrow or solid organ transplantation. The researchers found that inhibiting this RNA could improve outcomes for transplant recipients, reducing the risk of graft-versus-host disease and cancer relapse.
SourceMichigan Medicine - University of Michigan·JournalScience Translational Medicine·DateMar 17, 2021
Researchers identified GAPLINC, a long noncoding RNA that regulates inflammatory gene expression and protects mice from septic shock. The study found that reducing GAPLINC levels enhanced inflammatory responses, but unexpectedly, this effect also protected mice from endotoxic shock.
SourceUniversity of California - Santa Cruz·JournalProceedings of the National Academy of Sciences·DateFeb 1, 2021
Researchers identified MAARS, a lncRNA expressed specifically in macrophages of atherosclerotic plaques, contributing to disease progression. Targeted interruption of MAARS's function reduced atherosclerotic lesion formation by 52%.
SourceBrigham and Women's Hospital·JournalNature Communications·DateDec 17, 2020
Scientists at Duke-NUS Medical School have discovered that long non-coding RNAs (lncRNAs) play a key role in pancreatic cancer development by modifying cell growth. The study highlights the importance of investigating lncRNAs in living organisms and provides potential new targets for precision cancer therapies.
SourceDuke-NUS Medical School·JournalGenome Medicine·DateNov 13, 2020
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Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Researchers at Moffitt Cancer Center discovered specific molecules, TAp63, long noncoding RNA (lncRNA), and proteins WDR26 and NOLC1 that regulate AKT signaling pathway to promote tumor development and progression.
SourceH. Lee Moffitt Cancer Center & Research Institute·JournalNature Communications·DateOct 15, 2020
Two studies published in Genome Research provide new insights into the core regulatory networks governing cell types across different vertebrate species. The research highlights the importance of understanding RNA expression in establishing cell function, morphology, and behavior. Long non-coding RNAs were found to affect cell growth a...