Articles tagged with Cell Death Pathways
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Researchers discovered that blocking a specific protein called ferroptosis suppressor protein 1 (FSP1) reduces tumor growth by up to 80% in mice with lung adenocarcinoma. This study provides hope for developing novel clinical therapies for cancer patients.
The treatment demonstrated early signals of efficacy, with 65.7% of patients experiencing lasting stable disease, and was generally well-tolerated, with most adverse events being mild and manageable.
Isowalsuranolide activates autophagy-dependent cell death by targeting TrxR1/2, leading to ROS-mediated lysosomal biogenesis and reduced cell growth. The study reveals the TrxR1/2-p53-TFEB/TFE3 axis as a key regulator of cellular homeostasis in cancer.
Researchers at Mass General Brigham have identified mutations in VPS35 that can prevent chemotherapy-induced cell death, leading to treatment-resistant tumors. Higher tumoral VPS35 levels were associated with improved treatment responses and overall survival rates in patients with ovarian cancer.
Researchers at St. Jude Children's Research Hospital found that removing the 'signal jammer' protein VDAC2 can improve how tumors respond to immunotherapy. This breakthrough could lead to new ways to enhance immunotherapies and make them more effective in treating resistant cancers.
Research highlights the interconnected relationship between aging, circadian rhythms, and cancer, with shared mechanisms including genomic instability, cellular senescence, and chronic inflammation. Modulating circadian rhythms may serve as a novel strategy to intervene in age-related functional decline and treat cancer.
The Damon Runyon Cancer Research Foundation has named 13 new Fellows, awarding them $300,000 each to investigate cancer causes and mechanisms. Five recipients of the Dale F. Frey Award for Breakthrough Scientists will also receive an additional $100,000 investment to catapult their research careers.
Scientists at St. Jude Children's Research Hospital have uncovered the mechanism by which retinoic acid selectively kills metastatic neuroblastoma cells, using a novel pathway to trigger cancer cell death. The findings have implications for future combination therapy approaches.
A study by Andreas Koeberle and colleagues reveals that certain natural substances can increase polyunsaturated fatty acids in cancer cell membranes, making them susceptible to ferroptosis, a type of cell death. This discovery creates new avenues for treating therapy-resistant tumours.
A synthetic retinoic acid-inducible gene I (RIG-I) agonist RNA has been shown to induce innate immune signaling and death of hepatocellular carcinoma cells in vitro. The addition of recombinant interferon-b potentiated this cell death, suggesting a potential new mechanism for treating patients with liver cancer.
A preclinical study reveals that tumors drive clot formation by releasing chemokines, prompting immune cells to release small vesicles that attach to cell fragments, forming life-threatening clots. The findings may lead to diagnostic tests and safer therapies to target the root of blood clotting risk.
UVA researchers analyzed 300 blood serum samples from babies who died from SIDS and identified specific biological indicators linked to their deaths. The study found 35 predictors of SIDS, including ornithine and a lipid metabolite critical for brain and lung health.
Researchers at MD Anderson Cancer Center have made significant breakthroughs in smoking cessation treatments, with a study finding that varenicline plus counseling is the most effective treatment for individuals with major depressive disorder. Additionally, a new radiotherapy technique demonstrates effectiveness in treating metastatic ...
A research team led by USC aims to create comprehensive maps of retinal nerve connections to understand and combat retinitis pigmentosa, a progressive eye disease affecting 2 million people globally.
Researchers have deciphered how the beneficial fungus Serendipita indica successfully colonizes plant roots of Arabidopsis thaliana. The fungus secretes enzymes that produce a molecule called deoxyadenosine (dAdo), which activates cell death in plants, enabling colonization without causing significant harm.
Researchers analyzed 84 brains to find that the first phase of Alzheimer's disease damages a specific type of inhibitory neuron, triggering neural circuit problems. The study confirms previous findings and identifies new changes during the disease.
Studies discovered that DNA sequence changes associated with diabetes predisposition alter pancreatic cell stress response, leading to reduced insulin production and increased cell death. The findings point toward a druggable target, MAP3K5, which may help prevent or treat type 2 diabetes in high-risk individuals.
A recent study by FAU researchers links copper regulation to neurodegenerative disorders like Alzheimer's. The team discovered that a specific gene, swip-10, plays a crucial role in maintaining the balance of copper in cells, which can prevent mitochondrial dysfunction and oxidative stress.
Researchers have proposed a framework encompassing all discovered host immunological pathways, including TH1, TH2a, TH2b, TH3, TH9, TH17, TH22, TH1-like, and THαβ immune reactions. These relationships can help understand host defense mechanisms against invading pathogens and provide insights for developing better therapeutic strategies.
Researchers found that high blood levels of saturated fatty acids, particularly palmitate, cause pre-activation of innate immune cells in obese non-diabetics. This leads to elevated inflammatory molecules when infected with SARS-CoV-2, increasing the risk of severe COVID-19.
Researchers develop optogenetic system to precisely target cancer cells using light, inducing inflammatory cell death and triggering immune response. The approach aims to modulate the immune suppressive environment around cancer cells, helping T cells recognize and attack the disease.
Senescent cells, 'zombie-like' cells that resist death, accumulate in the brain with age, contributing to cognitive declines and frailty. Researchers identified a specific pathway linked to senescence in fruit fly brains, potentially paving the way for therapies to delay age-associated pathologies.
The study found that programmed cell death is a prerequisite for sperm release in liverworts. MpMLO1 protein increases cytoplasmic Ca2+ levels and induces PCD, allowing sperm to enter the antheridial pore for fertilization.
Researchers found that SARS-CoV-2 spike protein interrupts p53-MDM2 interaction but does not bind with p53 protein in cancer cells. The study also shows that SARS-CoV-2 spike suppresses p53-dependent gene activation, leading to increased cell viability after chemotherapy exposure.
Researchers analyzed epigenetic modifications in motor neurons from nearly 400 ALS patients, identifying 30 locations with modifications linked to disease progression. The findings may help develop targeted treatments for specific types of ALS.
Scientists identify ZIP7 as a key player in reducing ER stress, which is responsible for misfolded protein accumulation. Overexpressing ZIP7 restores cell mobility, suggesting its potential as a therapy target for degenerative diseases.
Researchers found that BTF3L4 overexpression mediates APAP-induced liver injury by inducing inflammation and damaging mitochondrial function. Increased BTF3L4 expression is positively associated with liver injury and may serve as a biomarker.
Researchers at Michigan Medicine discovered a pathway that reverses idiopathic pulmonary fibrosis (IPF), a common type of lung scarring. The study found that inhibiting the molecular brake MKP1 is essential for spontaneous resolution of fibrosis, offering new hope for patients with IPF.
A team of researchers from Tokyo Institute of Technology identified the molecular mechanisms involved in synaptic communication using Drosophila. They found that Side-IV/Beat-IIb immunoglobulin superfamily protein molecules play a crucial role in inducing synapse formation and regulating preferential signaling among neuron pairs.
Researchers discovered that mature oligodendrocytes, critical for brain function, can survive for up to 45 days after a fatal trauma, defying the classical programmed cell-death pathway. This finding opens new avenues for understanding and potentially preventing damage caused by aging and neurodegenerative diseases.
Researchers discovered a protein complex that eliminates potentially harmful cells over time by measuring the duration of mitosis. The Mitotic Stopwatch Complex starts forming after prolonged mitosis and triggers cell arrest or death, providing new insights into cancer development.
Scientists identified key factors in developing long-lasting immunity against dengue virus through analyzing immune responses to natural infection and vaccines. The study revealed molecular markers that could be used in novel vaccine development.
Researchers deciphered a novel process helping viruses choose to be nasty or friendly to their host bacteria. Phages use the bacterial immune system to make decisions, activating violent mode when necessary.
A study by UC Davis Health found that a single dose of BCG reduced liver tumor burden and extended the survival of mice with liver cancer. The vaccine boosted the body's immunity, leading to tumor shrinkage and improved liver function.
Researchers have discovered a new way to target chemotherapy-resistant ovarian cancer cells by depriving them of cholesterol, leading to significant tumor growth reduction. The nanoparticles starve the cells of cholesterol, triggering cell death through oxidation of lipids in the cell membrane.
A groundbreaking study identifies FAM3C as a key regulator of breast cancer progression within the tumor microenvironment. The overexpression of FAM3C promotes breast cancer cell survival and metastasis, while its depletion inhibits tumor growth in genetically engineered mouse models.
Researchers identified gartisertib as a potent ATR inhibitor that enhances cell death in patient-derived glioblastoma cell lines. The study also showed synergy between gartisertib and TMZ+RT treatment, with higher sensitivity to gartisertib observed in MGMT promoter unmethylated cells.
Researchers have found that a specific pathway, cGAS-STING, is unleashed to prevent cancer formation by detecting DNA damage within cells. The discovery reveals the 'key' to unleashing this pathway, which can potentially reactivate it to treat and prevent breast cancer development.
Researchers identified Elovanoid-34, a molecule that modulates the activity of TXNRD1 protein, which regulates antioxidant defenses. This discovery opens new therapeutic avenues for degenerative brain and eye diseases, as well as promoting healthy aging.
Researchers at TTUHSC are studying a new approach to inhibit STAT3, a protein associated with 70% of human tumors. Disrupting STAT3 synthesis on ribosomes could lead to new cancer treatments.
Researchers found that SARS-CoV-2 alters mitochondria on a genetic level, leading to widespread 'energy outages' throughout the body and its major organs. This affects the heart, brain, and lungs, contributing to long COVID symptoms.
Researchers found that DNA damage accumulates in arteries with aging and contributes to impaired vascular function. In mice lacking or heterozygous for the double-strand DNA break repair protein ATM kinase, aging accelerated vascular dysfunction, including increased arterial stiffness and oxidative stress.
The team created a glycoengineering platform that simplifies the production of customized sugar carbohydrates, known as glycans, which play a crucial role in various therapeutic applications. This innovation enables the engineering of new glycans with unprecedented flexibility, addressing limitations in existing approaches.
Researchers discovered a new role for extracellular signal-regulated kinase (ERK) in a pathway activated by interferon-gamma that leads to cancer cell death. Hyperactivation of ERK causes stress in cells, triggering cell death through specific proteins DR5 and NOXA.
A special supplement presents insights on neurodegenerative diseases, including Alzheimer's and Parkinson's, affecting 55 million people worldwide. Researchers explore novel molecular pathways and therapeutic approaches, such as acupuncture therapy, to alleviate the burden of brain disorders.
Researchers at EMBL Grenoble have obtained the first structure of p38α being activated by MKK6, opening up new directions for developing drugs to stop cytokine storms. The inflammatory response is triggered by a series of kinases, and inactivating p38α could prevent inflammation from occurring.
Researchers found that ferroptosis, a form of cell death caused by iron buildup, destroys microglia cells in the brain's immune response, contributing to cognitive decline. The study's findings may lead to the development of compounds targeting microglial degeneration, offering new hope for Alzheimer's and vascular dementia treatments.
A new MU study highlights the protective role of innate lymphoid cells and interferons in reducing neurological effects of Brucellosis. The findings could lead to improved diagnostics and therapies for neurobrucellosis, a condition that can cause long-term neurological complications.
Researchers at Sylvester Comprehensive Cancer Center will investigate signaling mechanisms between myeloid-derived suppressor cells and pro-inflammatory cancer-associated fibroblasts in pancreatic cancer. The goal is to develop a nanoengineered immunotherapy that selectively disrupts these interactions to target treatment resistance.
Researchers propose a novel theory of aging that suggests cell competition is a key factor in the process. The selective destruction theory (SDT) proposes a mechanism of aging that is independent of accumulating damage and consistent with epigenetic rejuvenation.
Researchers discovered that STING, a critical immune regulator, can act as an ion channel to control immune responses. This new function allows STING to translate danger signals into ion flow, activating various defense mechanisms.
Scientists at Max Delbrück Center discovered two lead compounds that inhibit activation of IKK/NF-κB pathway only when triggered by DNA double-strand breaks. These substances make cancer cells more sensitive to chemotherapy, potentially increasing the success rate of genotoxic cancer therapies.
Researchers at IRB Barcelona have developed new p38 inhibitors that selectively impair one of the activation pathways of the protein, allowing it to perform many of its normal functions. The inhibitors show therapeutic potential for heart diseases such as cardiac cell death and cardiotoxicity.
Cell death is a crucial process in organisms, preventing tumor development and pathogen spread. Researchers at the University of Basel have now elucidated the exact mechanism of cell death, revealing that a specific protein called ninjurin-1 assembles into filaments that open the cell membrane, leading to its disintegration.
A team of scientists from City University of Hong Kong and HKUST discovered novel, tridimensional compounds with high anticancer activity and low toxicity. These compounds can overcome drug resistance in cancer cells by inducing a different cell death pathway.
Researchers have developed a preventative therapeutic approach that prevents stress-induced cell death in pancreatic cells, a hallmark of type 1 diabetes. The treatment targets the GLIS3-MANF pathway common to both major types of diabetes.
Researchers at the University of Houston have developed a protocol to reprogram human heart cells into specialized cells that conduct electricity, enabling rhythmic heartbeat and repair diseased hearts. The discovery could lead to improved cardiac function and new pharmacological therapies for heart diseases.
Researchers have discovered that mutations in mitochondrial-related genes can trigger hyperinflammation, leading to diseases such as Crohn's disease and tuberculosis. The study found that these mutations lead to a new type of cell death called necroptosis, which causes an aggressive inflammatory immune response.
McCullough's research advances the field of cardiovascular science, with a primary focus on sex differences in stroke. Her work has led to significant discoveries about cell death pathways during ischemic insults.
Researchers found that higher levels of cell-free DNA in the blood are associated with increased cognitive decline and worsening frailty over an eight-year period. The study suggests that a simple blood test could detect risk of Alzheimer's disease and other forms of cognitive decline, potentially leading to early interventions.