Articles tagged with Cohort Studies
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A study of 20 cohort studies found that high fruit and vegetable intake was associated with a lower risk of estrogen receptor-negative (ER-) breast cancer. The results suggest that increasing vegetable consumption may help lower ER- breast cancer risk, which accounts for only 15-20% of breast cancers.
The NIH panel suggests renaming PCOS due to its association with ovarian cysts, which is neither necessary nor sufficient to diagnose the condition. The new name will enhance recognition of the disorder and facilitate expansion of research support.
Women with severe pelvic girdle pain during pregnancy should opt for vaginal delivery over caesarean section to avoid increased risk of persistent pain. The study found a significant association between planned or emergency caesarean sections and severe pelvic girdle syndrome six months after delivery.
A study published in Medical Care suggests that attempting to correct false beliefs about health care reform can backfire among individuals with positive views of Sarah Palin and high levels of political knowledge. The researchers found that more aggressive fact-checking increased misperceptions and opposition to the Affordable Care Ac...
A new study published in Cancer found that smoking intensity affects the course of bladder cancer, with more aggressive and deadly disease developing in those who smoke intensely. A panel of nine molecular markers can predict which cases are at highest risk for a fatal outcome.
A new 33-item protocol checklist has been released to enhance trial protocols' content and quality, providing crucial information for critical appraisal and interpretation.
Italian immigrants from Switzerland have a significantly lower mortality risk compared to native-born Swiss, largely due to the 'healthy migrant effect'. However, subsequent generations born in Switzerland show a higher risk of mortality, likely due to lifestyle differences.
The UMass Medical School is enrolling expectant mothers from Worcester County in a pilot program of the National Children's Study. The study aims to determine how environmental factors impact children's growth, development, and disease onset. Data collectors will meet participants at home twice during pregnancy and again after birth.
A recent analysis of data published in Archives of Disease in Childhood found that boys whose testes fail to descend at birth are almost three times as likely to develop testicular cancer. The condition affects around 6% of male births and has been linked to a higher risk of developing the disease.
A new study published in JAMA found that chronic kidney disease and its complications are associated with a higher risk of death regardless of age. Both low kidney function and high albuminuria were independently linked to mortality and end-stage renal disease, according to the findings.
A Yale University study found that residents in areas with existing solar installations are more likely to adopt the technology, with a 54% increase in adoption when the installed base grows by 10%. The visibility of panels and word-of-mouth also play a role in larger installations.
Researchers found that high levels of activated Stat5 protein in prostate cancer after surgery are associated with increased risk of recurrence and death. The study suggests Stat5 could serve as a biomarker to help guide patients and physicians for future treatment.
A study of children in Massachusetts found that low-level prenatal mercury exposure is associated with a higher risk of attention-deficit/hyperactivity disorder (ADHD)-related behaviors. Conversely, fish consumption during pregnancy appears to be protective, particularly for impulsive/hyperactive behaviors.
A comparative analysis of elderly individuals found that benzodiazepine use was associated with a 50% increased risk of developing dementia. The study recommends limiting prescriptions to periods of a few weeks and ensuring proper use to mitigate potential adverse effects.
A panel of 13 blood proteins has been identified as potential biomarkers for detecting malignant mesothelioma, a rare and aggressive form of lung cancer linked to asbestos exposure. The discovery could lead to the development of more accurate and less invasive diagnostic tests, improving patient outcomes.
A new study links heavy caffeinated coffee consumption to an increased risk of developing exfoliation glaucoma, the leading cause of secondary glaucoma worldwide. Women with a family history of glaucoma are also at higher risk.
A recent study found that African American diabetic patients experienced higher rates of end-stage renal failure but lower rates of coronary heart disease, heart failure, and stroke compared to white diabetic patients. The study also showed female diabetic patients had lower rates of complications than male patients.
The UK Cohorts and Longitudinal Studies Enhancement Resource (CLOSER) aims to maximize the use, value, and impact of nine leading longitudinal studies. By strengthening links between these studies, researchers can make better use of rich data on people's lives, gathered over many years in the UK.
A Canadian study found that vigorous physical activity is associated with reduced body mass index z score, waist circumference, systolic blood pressure, and increased cardiorespiratory fitness in youth. The study included 605 youth aged 12.1 years and found that performing more than seven minutes of vigorous PA daily was linked to lowe...
A University of Michigan study proposes eliminating social security payroll taxes starting at age 55 to encourage workers to stay on the job. This would result in a 10.6% increase in take-home pay and a 1.5-year extension of working life.
New-onset diabetes in normal-weight adults is associated with significantly higher mortality rates compared to overweight/obese individuals. The study found that older adults and non-white participants are more likely to experience normal-weight diabetes, highlighting the need for targeted health screenings.
A large group of patients with diabetes showed a lower risk of total and cardiovascular mortality with higher levels of physical activity, including leisure-time PA and walking. Moderately active individuals had the lowest mortality risk compared to those who were physically inactive.
A Swiss study found that colonoscopy with polypectomy significantly reduces colorectal cancer incidence and mortality. The screened group had 12 cases, while the non-screened group had 213 cases, resulting in lower cancer-related death rates.
A new study found that vitamin D deficiency is associated with worse lung function and faster decline in smokers. Vitamin D sufficiency was linked to improved lung function and reduced rate of decline.
A University of Michigan report found that Generation X is lukewarm about climate change, with a small but statistically significant decline in concern between 2009 and 2011. Only 5% of surveyed Gen Xers were alarmed, while 18% were concerned, with education and scientific knowledge being key factors in explaining levels of concern.
The CDC's Expert Panel on Protective Factors for Youth Violence recommends a new research approach to identify protective factors that can reduce the likelihood of violence. The findings highlight the importance of understanding factors that protect youth from engaging in violent behavior.
A recent study published in the Journal of the National Cancer Institute found that high vitamin E intake from diet or supplements is associated with lower liver cancer risk. The analysis included 132,837 individuals and showed a clear inverse dose-response relation between vitamin E intake and liver cancer risk.
A large cohort study found that high vitamin E intake from diet or supplements is associated with a lower risk of liver cancer. The study included over 132,000 individuals and analyzed data from two population-based cohort studies conducted in China.
The July 2012 Genetics Society of America's journal features research on increasing association mapping power and resolution in mouse genetic studies through meta-analysis for structured populations. The study also explores the properties and power of a Drosophila Synthetic Population Resource for dissecting complex traits.
A large Danish cohort study reveals that childless women who undergo fertility evaluations have a higher risk of hospitalizations for psychiatric disorders, particularly anxiety and depression. The study found significant correlations between childlessness and increased rates of substance abuse, schizophrenia, and eating disorders.
Researchers from Duke University Medical Center found that tPA is safe to use in acute stroke patients on warfarin, contradicting previous concerns about high intracranial bleeding risk. The study included over 23,000 patients and found similar intracranial hemorrhage risks for those on warfarin and non-warfarin users.
The new book concludes that American science is in good health, with traditional values helping the nation maintain its strength. While there are areas of concern, such as declining scientists' earnings and a decline in academic positions, the authors argue that globalization promotes efficiency through knowledge sharing.
A French cohort study of 6,000 women aged over 65 found that high levels of estrogen are associated with an increased risk of myocardial infarction and strokes. The study challenges the long-held assumption that estrogen has a protective effect on the heart and blood vessels.
A novel assay analyzes fetal cell-free DNA in maternal blood to screen for trisomy 21 and 18. The test is nearly 100% accurate, with a low false positive rate of 0.03%. It has the potential to replace current aneuploidy screening methods.
A new study found that relatively few black and white families are moving into multi-ethnic neighborhoods, with many instead staying in homogenous communities. The study analyzed mobility patterns of over 44,000 black and 57,000 white families between 1977 and 2005.
A study published in Molecular Psychiatry found that maintaining healthy nerve connections as we age helps keep us sharp. The research suggests that intelligence is not located in a single part of the brain, but rather in its overall network of connections.
A recent study has found that sarcoidosis accounts for 25% of all deaths among black women with the disease, emphasizing the need for early detection and treatment. The study also highlights the severity of pulmonary disease in black women with sarcoidosis, with respiratory failure being a leading cause of death.
A study by the University of Wisconsin found an association between sleep disordered breathing and increased cancer mortality. The researchers analyzed data from 1,522 subjects and found that those with mild, moderate, or severe SDB had a higher risk of cancer mortality compared to those without SDB.
A study by University of Michigan anthropologists finds that religious rituals can foster cooperation among group members, while sacred values can sustain intractable conflicts. However, participation in collective religious ritual can also increase parochial altruism and opposition to compromise.
A new study by University of Michigan researchers found that people are more likely to disclose sensitive information via text messages than in voice interviews. Texting also led to more precise answers, as respondents had less time pressure in an asynchronous mode.
A new risk prediction equation has been developed to predict death and end-stage renal disease in patients with impaired kidney function. The CKD-EPI equation provides more accurate classification of individuals at risk, leading to better prevention and management of kidney disease-related outcomes.
A U-Mich study tracks changes in retirement plans after the Great Recession, finding that people who postponed retirement also expected to leave less for their heirs. Most respondents planned to work an additional 1-3 years due to financial losses, but few aimed to recoup their entire economic loss
A University of Michigan study finds a significant correlation between world GDP and CO2 concentrations, highlighting the need for drastic changes in economic habits to combat global warming. The research suggests that carbon taxes could be an effective solution to reduce emissions and stabilize the climate.
A longitudinal study found that parenthood does not significantly improve parents' diets compared to non-parents, with both groups showing similar decreases in saturated fat intake and increases in fruit and vegetable consumption over time. However, parents lag behind their childless counterparts in making healthier dietary changes.
A new report from the University of Michigan reveals that GenX adults prepare an average of 10 meals a week and eat out or buy fast food three times a week. Men are surprisingly involved in cooking and grocery shopping, with men cooking an average of 8 meals per week. The study also highlights the importance of families gathering toget...
A study by researchers from the University of Michigan and others found that brain scans of a small group of people can predict the actions of entire populations. The neural reactions of a few individuals can forecast the responses of many other people to ad campaigns promoting specific behaviors.
Cardiac device infective endocarditis (CDIE) is a serious complication with high in-hospital and 1-year mortality rates, especially if valve involvement occurs. Coexisting valve infection and heart failure were also common complications.
A longitudinal study of 900 individuals found that under-controlled temperament in early childhood is a significant predictor of disordered gambling in adulthood. Those with restless, impulsive, and negative behaviors were twice as likely to develop problems with gambling.
Researchers propose a new classification of severe early childhood caries, which affects mostly young children living at or below poverty levels. The condition is characterized by structurally damaged primary teeth and is linked to developmental dental defects such as enamel hypoplasia.
Researchers at BUSM identified four genetic loci associated with decreased hippocampal volume, a trait linked to Alzheimer's disease and aging. The findings suggest that specific genes may influence cell death, brain development, and memory performance.
A nationwide Danish registry study found no significant association between losartan and increased all-cause mortality in heart failure patients compared to candesartan. However, lower doses of losartan were associated with increased mortality risk, while high doses showed no increased risk compared to candesartan.
A systematic review of 17 studies found that low-energy-density diets improve weight loss and maintenance in adults. In children and adolescents, moderately strong evidence shows a relationship between higher energy density diets and increased weight. Lowering energy density is associated with enhanced satiety and reduced calorie intake.
The centre aims to understand genetic and environmental causes of common diseases in diverse ethnic groups. It will provide innovative training for the next generation of health researchers.
New research from Brigham and Women's Hospital shows that ticagrelor significantly reduces the time to a second cardiovascular event or death, in addition to reducing total events. The study found that continued use of ticagrelor after a cardiac event is both safe and effective in preventing further cardiac events.
A sharp rise in blood pressure in midlife can increase a person's risk of heart disease later in life. Early detection and treatment of rapidly rising blood pressure may be required to prevent long-term damage to the heart.
A recent study found that adding inflammatory biomarkers improves the clinical prediction of mortality in patients with chronic obstructive pulmonary disease (COPD). The addition of a panel of selected biomarkers significantly improved the ability of clinical variables to predict mortality, with a C-statistic of 0.726.
A study found that young adolescents exposed to smoking in movies are at a greater risk of smoking compared to older peers. Early exposure to smoking depicted in movies is associated with an increased risk of becoming established smokers.
A new study reveals that HIV incidence rate for US black women is five times higher than the overall estimated rate for black adolescent and adult women. The study found an HIV incidence of 0.24% among 2,099 women, comparable to rates in sub-Saharan Africa.
A recent study found that vitamin D deficiency is associated with increased mortality in female nursing home residents. The study, published in the Journal of Clinical Endocrinology and Metabolism, examined 961 nursing home residents and found that 92.8% were deficient in vitamin D.
A cohort study and nested case-control study found a statistically significantly increased risk of lung cancer with increasing diesel exhaust exposure among workers and urban populations. Studies suggest stringent occupational and environmental standards are necessary to reduce the health burden of carcinogenic diesel exhaust.