Articles tagged with Biospecimens
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The project addresses data fragmentation in biodiversity sciences, connecting fragmented data to tackle biodiversity loss, climate change, and emerging public health threats. A collaborative effort developed five cross-cutting themes to guide data integration, emphasizing the need for large-scale community action.
A new study found that many home washing machines are insufficient for decontaminating healthcare worker uniforms, allowing antibiotic-resistant bacteria to survive. The researchers propose revising laundering guidelines or using on-site industrial machines to improve patient safety.
A study published in the Journal of Medical Entomology found a gene mutation in bed bugs that may contribute to their resistance to insecticides. The researchers, led by Warren Booth, discovered the mutation in 134 unique populations of bed bugs collected from North America between 2008-22.
Researchers detected widespread contamination of retail chicken meat in Bangladesh with antibiotic-resistant E. albertii, a lesser-known but deadly pathogen. The study highlights the need for improved hygiene measures and stricter regulations to prevent foodborne infections.
A novel AI-based method called scNET combines gene expression data with networks of possible gene interactions to identify biological patterns in response to drug treatments. The system reveals complex mechanisms underlying cellular behavior, providing insights for new therapeutic approaches.
A team of researchers from the University of Kansas has confirmed that the Leyte Chorus Frog is a hybrid of two species with overlapping ranges whose intermingling was driven by deforestation. The discovery sheds new light on the impact of human activities on the environment and highlights the importance of conservation efforts.
Researchers studied pumice rafts from the 2021 Fukutoku-Oka-no-Ba eruption in Japan, finding three phases of evolution involving rounding, fragmentation, and biodiversity increase. The study provides valuable information for mitigating the impact of future eruptions on shoreline communities.
Researchers found a biomarker, RNA Polymerase II (RNAPII), associated with tumor aggressiveness and recurrence in meningioma and breast cancers. The study developed a novel profiling technology, Cleavage Under Targeted Accessible Chromatin (CUTAC), to measure gene transcription activity from DNA, which predicted cancer outcomes.
A Tel Aviv University study found urban bats have shorter pregnancies and start reproducing earlier due to favorable temperatures and food abundance in cities. This is the first study linking urban living to mammalian reproductive patterns.
A team of researchers recommends incorporating principles like collective benefit and ethical governance into ecological data practices to align with existing data infrastructures. They suggest establishing collaborative relationships with Indigenous rights holders and exploring how data can be aligned with Indigenous expertise and wor...
A study in San Francisco found that coyotes' diets are heavily influenced by the presence of restaurants and impervious surfaces, with consumption of rats highest near restaurants and human-sourced food prevalent in paved areas. This research highlights the adaptability of coyotes to urban environments.
The study proposes a novel approach for simultaneous extraction of metabolites and lipids from zebrafish embryos to shed light on PFOS-induced neurotoxicity. The researchers found that sphingolipids are a reliable biomarker of PFOS-induced neurotoxicity, and the method can be expanded to various biomolecules.
Organoids, derived from stem cells, closely mimic human tissue for biomedical research and drug testing. Standardization is crucial for generating reliable results in organoid construction, requiring approved operating procedures and informed consent from donors.
Researchers found that Florida panthers are not at increased risk for contracting chronic wasting disease from eating infected deer. The study provides relief to conservation efforts, as the disease has spread through North America's deer and elk populations.
The NJIT team's Limelight Rainforest developed a drone-delivered technology capable of identifying thousands of rainforest species in mere hours. The device uses telemetry, satellite communications, and AI to interpret data from advanced microphones, cameras, and capture systems.
A recent study by Tracie Delgado and colleagues found that 18% of salmon samples from Seattle grocery stores and sushi restaurants were mislabeled. The researchers called for continued development and enforcement of legislation against salmon fraud to prevent accurate tracking of supply chains and conserve wild salmon.
Researchers at Johns Hopkins Medicine have identified a potential link between donor intestinal epithelial cells and improved outcomes for patients undergoing fecal microbiota transplants. The study found that these cells, which line the intestinal tract, may be responsible for restoring gut health in some patients.
Researchers from The University of Texas at Arlington are conducting a DNA analysis project to determine the genetic differences between the rare Dixon's whiptail and the common checkered whiptail. If the two species are found to be distinct, Dixon's whiptail may become eligible for endangered species protection.
Brachycephalus dacnis is the seventh species of flea toad identified in the genus Brachycephalus. The study published by a group at the State University of Campinas provides detailed information about its anatomy, skeleton, and internal organs.
A new study found compositional and functional differences in the gut microbiota of Chinese long-living adults (over 90 years) compared to elderly adults (65–74 years). The researchers noted lower relative abundances of bacteria in certain genera, which may regulate biological processes like autophagy and telomere maintenance. These fi...
A research team, led by Francesco Ferretti, located signs of white sharks at four sites in the Sicilian Channel, a stronghold of the endangered species. The team used improved methods and technologies, including eDNA sampling and camera traps, to detect the presence of the sharks.
Researchers discovered an extremely diverse collection of viruses on toothbrushes and showerheads, including previously unknown species. These bacteriophages target bacteria, not humans, and have potential uses in treating antibiotic-resistant bacterial infections.
An interdisciplinary study found associations between exposure to environmental phenols like BPA and triclocarban and altered cardiac electrical activity, particularly in women with higher body mass indexes. Researchers identified moderate changes to cardiac electrical activity that could exacerbate existing heart disease or arrhythmias.
A DNA-collecting drone has been developed to identify species in tree canopies, providing insights into remote habitats. The drone's specialized fabric probe collects environmental DNA from leaves and branches, allowing researchers to identify organisms such as arachnids, insects, and monkeys.
Researchers are working on a new method for preserving microbial samples using microfluidics, biomaterials, and protein engineering. The goal is to improve biosurveillance and protect soldiers and civilians from infectious diseases.
A new study provides further evidence that SARS-CoV-2, the virus responsible for COVID-19, likely originated from animals sold at the Huanan Seafood Market in Wuhan, China. The analysis of genetic data found that wildlife species such as raccoon dogs and civet cats were present at the market and may have carried the virus.
The Cancer Cooperative Group System is being re-engineered to bring new money to correlative science research through public-private partnerships, aiming to remove barriers for researchers to access biological samples. This will facilitate the integration of innovative science into cancer clinical trials.
Acoustic tweezers use Bessel beams to sort viruses from other particles in human saliva samples. The technology, called BEST, quickly and accurately separates viruses from large and small particles.
Researchers at the University of Kansas are analyzing noninfectious mosquito saliva to understand how it affects the immune system and changes at a molecular level. The goal is to identify specific proteins that can serve as candidates for vaccine development.
A new microscopy method, Tempo STEM, significantly reduces radiation required by 'shutting off' the beam at peak efficiency. This approach eliminates excess damaging irradiation and avoids sample transformation or destruction.
Researchers at UCLA have developed a wavelength-multiplexed diffractive optical processor that enables all-optical multiplane quantitative phase imaging. This approach allows for rapid and efficient imaging of specimens across multiple axial planes without the need for digital phase recovery algorithms.
A team from City University of Hong Kong has designed a compact hybrid transmission and scanning electron microscope that can operate at room temperature, offering high-resolution imaging capabilities without cryogenic temperatures. The new system reduces radiation damage to samples and provides improved image contrast using pulse elec...
Researchers sequenced genomes of 179 wild-caught flies and museum specimens, producing low-cost, high-quality DNA sequences. The new data helps refine our understanding of the evolutionary relationships among 360 species in the Drosophilidae family.
Jordan Brown, a postdoctoral research associate at UTA, received a Postdoctoral Research Fellowship from the NSF to analyze bird specimens from European museums and track changes in air pollution levels. His research aims to understand how industrialization affected wildlife and contribute to the study of climate change.
The e-COL+ project aims to capture and reconstruct France's natural history collections in 3D, covering nearly 6% of the world's total natural specimens. The project will provide modern equipment, create a comprehensive dataset of 3D models, and build AI tools to improve model reconstruction.
Researchers at Virginia Tech have discovered a possible new pathway to treat colorectal cancer by targeting the NF-kB-inducing kinase (NIK) protein. The study, led by Irving Coy Allen, identifies changes in a significant signaling pathway in human patients and presents potential targets for therapeutics.
Researchers at the University of Delaware have developed a simplified method for preparing protein samples for proteomics analysis, enabling faster, cheaper and more efficient testing. This breakthrough could pave the way for precision medicine by helping scientists better understand protein changes in the body.
Dr. Melissa Grunlan's team creates regenerative osteochondral plugs, a potential off-the-shelf device to treat OCDs and avoid total knee replacement surgery. The technology offers an alternative to autografting or total knee replacement, providing immediate support for joint function and potentially reducing post-operative complications.
Climate change has led to decreased pollen production from plants, resulting in less diversity among pollinators, which could significantly impact food production. The study, conducted in the Great Basin region, examines how shifts in flowering times and extreme weather events affect pollinator availability.
New research at Hokkaido University reveals that acoustic fat bodies in toothed whales were once jaw muscles and bone marrow. The findings suggest an evolutionary tradeoff between auditory and feeding ecology, leading to the loss of chewing muscles and adaptation to echolocation.
Researchers will characterize initial environmental exposures and collect biospecimens and data from residents potentially impacted by the disaster. Investigators will evaluate biospecimens for early signs of liver dysfunction, detecting known liver carcinogen vinyl chloride.
Researchers found high genetic diversity in Cape lions prior to their extinction, contradicting colonial descriptions. The study suggests that the species exhibited significant phenotypic variation, including diverse mane coloration.
Detailed CT scans reveal the worm-lizard's skull anatomy, including sutured bones and a singular central tooth. Researchers also discovered sexual dimorphism in one species, confirming their findings through powerful jaw muscles.
A nearly intact fossilized bat skull discovered in a 50-million-year-old cave has provided crucial insights into the evolution of bats and their use of echolocation. The find, part of an analysis published in Current Biology, suggests that early bats may have used a form of echolocation similar to that employed by modern species.
Researchers conducted a randomized trial in Canadian ICUs, finding that switching to small-volume blood collection tubes lowered red blood cell transfusion rates. The study suggests this change may improve patient outcomes and reduce the need for transfusions.
Researchers have created the first-ever map of a single animal's early visual system, reconstructing it from the eyes to neurons in a tiny parasitic wasp. The study reveals complex behaviors such as flight in an insect with just 8,600 cells compared to the human brain's 171 billion.
A recent UTSA study reveals that 51% of Texas owls have high levels of anticoagulant rodenticides in their systems. The research team recommends using natural methods to control rodents and increasing awareness of the effects on non-target wildlife.
Researchers highlight microvascular contributions to white matter injury in Alzheimer's disease, sparking calls for exploration of connections between AD, WM injury and cerebral small vessel disease. The study emphasizes the critical need to define mechanisms and diagnostic features of mixed vascular and AD neuropathological change.
Researchers sequenced the genome of Prymnesium parvum, a microscopic algae species causing toxic blooms in US waters. The study found significant genetic variation among strains, suggesting multiple populations and potential hybridization cases. This discovery could improve prediction models for algal blooms and ecosystem disruption.
The American Institute of Biological Sciences (AIBS) has been awarded a workshop grant to develop a series of discussions on enabling interdisciplinary and collaborative science through the integration of biological and environmental data. The project aims to build an Integrated, Open, Findable, Accessible, Interoperable, and Reusable ...
Researchers identified a precise mix of ingredients in male moths' pheromones that increases mating chances. The discovery reveals the role of plant-derived substances, such as methyl salicylate, in attracting females.
Researchers found that mutations in the Pro1 protein enable the rice blast fungus to thrive through increased conidia release. This finding suggests an adaptive advantage for the pathogen, potentially linked to its loss of female fertility.
A team of scientists at DESY has developed a new technique using X-rays to image biological specimens without damaging them. The method, which generates high-resolution images at nanometre resolution, could be used for applications such as imaging whole unsectioned cells or tracking nanoparticles within a cell.
The platform has enabled the transcription of over 4.7 million specimens, making a significant dent in the backlog of objects stored in museums without online information. The mission to catalog Earth's biodiversity has resulted in an inconceivably large number of specimens, with billions more collectively housed in smaller institutions.
A study by McGill University researchers found that Northern Tree Shrews' body size increased with warmer climates, contradicting Bergmann's rule. The team analyzed museum specimens and historical climate data, revealing a reversal of the Island rule as well, highlighting the complex interaction between ecological factors.
UVA researchers developed a new tool to analyze genetic data, reducing noise and bias in cancer diagnosis. The tool uses mathematical modeling to identify patterns in chromatin, helping scientists detect tiny numbers of disease cells.
The Van Andel Institute has been awarded a five-year contract to continue serving as the biorepository for the Cancer Moonshot Biobank study. The institute will assemble and distribute kits to collect tumor tissue, blood, and other biospecimens from over 1,000 participants, contributing to a greater understanding of cancer.
Researchers developed a novel way to visualize densely packed molecules using expansion microscopy, allowing for the first time their imaging. The technique enables visualization of nanostructures found in neurons and Alzheimer's-linked amyloid beta plaques.
A new paper outlines principles for reducing power imbalances in biological fieldwork, including procedures for permitting and licensing developed at the University of Kansas. The guidelines aim to ensure safety, legal, and ethical conduct, prioritizing communication and transparency in fieldwork planning.
A new study suggests that members of the public want to know if their health information or samples from their bodies will be used in research or to help develop new biomedical products. The study found that patients are more likely to want notification about research use of their health information than biospecimens.