A new study shows that a single injection of AAVB1-GAA gene therapy prolonged survival and improved enzyme activity in a mouse model of Pompe disease. The therapy also targeted the respiratory system, improving ventilatory measures.
Scientists have discovered a repeatable pattern in how space weather activity changes with the solar cycle, enabling better understanding and planning for space weather. The breakthrough allows for more accurate forecasting of potential threats to Earth from solar flares and extreme space weather.
Research reveals key physical properties of giant cancer cells, including stiffness and ability to move further than standard cancer cells. This understanding may lead to the development of targeted treatments.
Research shows that babies with cystic fibrosis are born weighing less than those without the condition, even accounting for premature births. The study found a link between CF mutation and intrauterine growth, highlighting the need for further research into improving health outcomes before birth.
Researchers discovered that cannabis's endocannabinoids help regulate gut inflammation by turning off an aggressive immune response. This mechanism provides a new drug target for treating patients with inflammatory bowel diseases.
Scientists discovered that neural stem cells in spinal cords are the limiting factor for tail regeneration. Unlike salamanders, lizard neural stem cells cannot produce diverse cell types needed for bony vertebrae development. This finding may aid understanding of why humans can't regenerate their tails.
A new genome analysis method predicts risk for coronary artery disease, breast cancer, and type 2 diabetes based on genetic variants. Up to 25 million people in the US may be at triple the normal risk for coronary artery disease, highlighting the potential for early interventions.
Tropical Storm Hector has weakened and moved into the Northwestern Pacific Ocean, with fragmented thunderstorms detected. The storm is currently moving west-northwest near 17 mph, with maximum sustained winds of 50 mph.
A recent study found that gastric bypass surgery increases the risk of fractures, particularly in individuals without diabetes. The researchers compared data from over 38,000 patients who underwent gastric bypass operations with a control group and found a significant increase in fracture rates, with risks ranging from 26% to 32%.
A new study by Cornell University researchers will analyze how voters' views on issues like race, immigration, and gender influence the 2018 midterm elections. The survey will track nearly 1,400 likely voters across three waves, allowing for a nuanced understanding of shifting attitudes leading up to the elections.
A study of 200 patients undergoing hip fracture repair found that lighter sedation did not reduce the risk of postoperative delirium in severely ill patients. However, for healthier adults, deep sedation more than doubled the risk of delirium compared to light sedation.
The new strategy combines design of a chemical library, virtual screening, automated synthesis, and in vitro study of biological activity. This approach accelerates and automates the process of prototype molecule optimization, increasing chances of finding potential medicinal molecules.
A study at Thomas Jefferson National Accelerator Facility found that protons in neutron-rich nuclei have higher momentum than neutrons due to short-range correlations, which may impact neutron star dynamics. The research, published in Nature, confirms earlier hints and quantifies the effect for the first time.
Heavy rainfall caused flash floods and power outages in Virginia and Texas, while NASA's IMERG program estimated rainfall totals of over 8 inches in some areas. The analysis was based on satellite data from the GPM mission and used algorithms developed by NASA's PMM science team.
Researchers at UIC are developing a new exosome-based approach to regenerate bone and tissues, with the goal of reducing side effects and advancing therapies. Engineered exosomes may aid regeneration faster than growth factors, with fewer complications.
Researchers at EPFL developed a computational method to grow 2D carbon surfaces inside zeolite pores. The resulting structures resemble negatively curved surfaces called Schwarzites, which have unique properties and potential applications in supercapacitors, catalysis, and gas storage.
The MDI Biological Laboratory has established the Morris Scientific Discovery Fund, providing up to $250,000 per year for eligible research programs. This fund aims to foster short-term pilot project support for research that demonstrates federal funding potential.
A study of 506 black youths found that African American boys felt less safe in areas that were modestly more white than their usual hangouts. The researchers tracked the teens' locations using smartphones and asked them to rate their safety levels. Black boys felt less safe in poorer neighborhoods as well as those with higher white pop...
Recent study analyzes chemical makeup of tools used to create giant statues, suggesting a sophisticated society where people shared information and collaborated. The results contradict the popular narrative that Easter Island's inhabitants ran out of resources and warred themselves into extinction.
Researchers have identified a blood biomarker called KIM-1 that can predict the risk of developing kidney cancer over the next 5 years. Measuring levels of KIM-1 in the blood may help detect kidney cancer earlier, potentially improving survival rates.
Researchers studying ocean temperatures in West Antarctica found a complex cycle of warming and cooling that affects ice shelf melting rates. The findings suggest that changes in deep ocean temperatures can lead to significant variations in ice sheet melting, with potential implications for global sea-level rise.
A new study published in Nature Ecology and Evolution exposes connections between tax havens, deforestation, and illegal fishing. On average, 68% of foreign capital to Amazon rainforest sectors was transferred through tax havens, while 70% of IUU fishing vessels were flagged under a tax haven jurisdiction.
A recent study found that benzodiazepine use is associated with a modestly increased risk of Alzheimer's disease. The research, conducted in the nationwide MEDALZ cohort, suggests that the threshold for prescribing these medications should be high due to their adverse effects and potential risks.
Researchers used terahertz frequency quantum cascade lasers to study laser stabilisation process, measuring wavelength changes in femtoseconds. This ultrafast detection capabilities provide unprecedented levels of detail, leading to more efficient devices and systems.
According to a new analysis by New York University researchers, US cities have become dramatically safer since 1991, with most becoming less violent over the last year. However, recent fluctuations in selected cities suggest temporary disruptions in this 17-year decline, with some cities experiencing rising violence from 2014 to 2017.
The National Science Foundation has awarded $45 million to 31 projects under the Hispanic-Serving Institutions Program, aiming to increase retention and graduation rates for STEM students at these institutions. The program invests in building capacity and increasing STEM education and research capacity at HSIs.
A large study of over 80,000 children found no increased risk of autism spectrum disorder after prenatal Tdap vaccination. The study's lead author says pregnant women can be reassured that receiving the vaccine is not associated with an increased risk of autism.
A recent study published in The Lancet suggests that remifentanil during labour could halve the number of women needing an epidural, providing effective pain relief with reduced risks. The trial involved 400 women and found that remifentanil was associated with lower rates of instrumental deliveries and consequent morbidity.
A study published in the Journal of Pediatrics found that grip strength in children is a strong predictor of their future health, including risk of developing diabetes and cardiovascular disease. Researchers suggest that improving muscular strength during adolescence could help prevent these outcomes.
The Women's Preventive Services Initiative recommends annual screening for urinary incontinence in all women, assessing symptom presence and impact on activities. Early intervention may reduce symptom progression and limit costly treatment needs.
Researchers discover that PLD3 and PLD4 play a crucial role in degrading DNA and preventing autoimmune reactions. The proteins were found to regulate endosomal nucleic acid sensing, which may contribute to new approaches in cancer immunotherapy and treatment of autoimmune disorders.
Scientists have described the detailed structure of proteins enabling sperm-egg fusion in two species: Arabidopsis thaliana and Trypanosoma cruzi. The study reveals similarities and differences between the proteins, shedding light on how they work and potentially leading to new insights into human fertilization.
Researchers have developed a method for sex-specific genetic engineering in silkworms, enabling the creation of fluorescent females for easy sex sorting. The technique uses a targeted gene integration approach that can be adapted for pest control by inducing female-specific embryonic lethality.
An AI platform identified diseases in CT scans faster than human diagnosis, with a total processing and interpretation time of 1.2 seconds, significantly outperforming human triage systems.
A natural field experiment found that social nudges decrease electricity consumption with potential policy implications for energy markets. The average effect of receiving both nudges was similar to the sum of individual effects, suggesting limited crowd-out effects.
Researchers create a 'smart bandage' that wirelessly monitors heart signals, brain activity, eye movements, respiration, skin temperature, and body motion. The device can also be used to remotely control a robotic arm and lasts for over six months without performance drop.
Researchers explore novel concepts and approaches to stroke rehabilitation, highlighting the potential of biomarkers to predict motor recovery and outcomes. Brain-machine interfaces are also shown to promote recovery in patients with severe paralysis.
Reinforced mortar coating improves the compressive strength of clay bricks, increasing their capacity to withstand external loads. The experimental results indicate an increase in both coated and non-coated prisms, with a significant improvement in the load-carrying capacity.
A study found that Medicare preventive care visits are lower in racial and ethnic minority patients, with income and education partially explaining the difference. The rate of use increased modestly since its introduction but remains low, highlighting the need to promote its use among beneficiaries and providers.
A study found that regular conversations with young children strengthen connections between critical brain regions for language, regardless of socioeconomic status. The research suggests that early language exposure can promote language skills and brain development.
Researchers have identified altered brain waves and movement abnormalities in young children with autism spectrum disorder, which can be detected as early as infancy using non-invasive neuroimaging techniques. These findings may represent an objective approach to diagnosing autism in young children.
Amputees can be tricked into feeling their prosthetic limb belongs to their own body by combining visual and tactile sensations. The study used virtual reality goggles and artificial tactile sensations to induce embodiment, reducing phantom limb issues.
Indigenous Latino immigrants are learning Spanish to aid integration and gain access to social services and job opportunities. In contrast, non-indigenous Latinos tend to learn English after arrival in the US.
Researchers have mapped how peptides reduce infection and inflammation by deactivating toxic substances formed in the process. The study reveals that these peptides form a C-shaped structure which enables the capturing and inactivation of lipopolysaccharides, a necessary part of our immune defence system.
Researchers at Mount Sinai will investigate the use of inhaled corticosteroids to treat sickle cell disease, a condition that affects 100,000 Americans and has high healthcare costs. The IMPROVE 2 study aims to improve patient outcomes and reduce ED visits.
Researchers found that in neutron-rich objects, protons carry a disproportionate part of the average energy, moving faster than neutrons. The team analyzed data from CLAS experiments and observed a significant increase in the probability of protons having high energies as the number of neutrons increased.
A research team led by Professor Su-Il In has developed high-efficiency photocatalysts that can selectively convert carbon dioxide into methane or ethane. The catalysts have shown promising results, with conversion rates higher than conventional reduced titanium dioxide photocatalysts.
Researchers found that children with a history of mild traumatic brain injury do not have an increased genetic risk for attention-deficit/hyperactivity disorder (ADHD), contrasting with developmental ADHD. The study suggests at least two forms of ADHD, one linked to inherited genes and the other to traumatic brain injury.
NASA's Aqua satellite reveals strong thunderstorms with cloud top temperatures as cold as minus 80 degrees Fahrenheit, indicating heavy rainfall potential. The storm is forecast to move slowly around the seas off western Guangdong, lingering near Hong Kong.
Researchers found that higher oxidative stress in males reduces the production of nitric oxide, a powerful blood vessel dilator. An antioxidant treatment restored similar production levels of protective nitric oxide between males and females.
A study published in CMAJ found that women with intellectual and developmental disabilities have a nearly double rate of having another baby within a year of delivering. Rapid repeat pregnancies are associated with smaller babies, preterm birth, and other adverse effects.
A new technology developed by McGill University scientists can detect hundreds of proteins with a single blood sample, improving the analysis of biological markers and providing key information on health. The technique uses multicolour fluorescent dyes to barcode micro-beads, enabling detection of multiple proteins in parallel.
A new natural history study of Amish nemaline myopathy provides a platform for exploring gene replacement therapy. The study's findings show promise for treating the lethal disorder, which is linked to a mutation of the TNNT1 gene.
Researchers found that in people living with HIV, a type of antibody called immunoglobulin G3 (IgG3) stops B cells from doing their normal job of fighting pathogens. This phenomenon appears to be one way the body tries to reduce immune-system hyperactivity caused by HIV.
Research found a strong correlation between blood omega-3s and executive function in children from Northern Ghana. Children with higher omega-3 levels were more likely to perform better on cognitive tests, suggesting potential benefits for brain development.
A new mathematical model explains the formation of zebrafish stripes by highlighting the crucial role of a single pigment cell type. The model shows that iridophores lead the process, providing redundancies to ensure reliable stripe formation even when cellular processes go wrong.
A new study finds that brief motivational interviewing interventions during routine HIV care can significantly reduce heavy drinking and improve condomless sex behavior among MSM living with HIV. Over a year, participants who received the intervention reported fewer drinks per week and days of heavy drinking.
Researchers found that groups that interacted only intermittently preserved the best of both worlds, having an average quality of solution nearly identical to those that interacted constantly. However, this intermittent interaction allowed high performers to learn from low performers and achieve even better solutions.
A recent study published in the Journal of Neurochemistry reveals that long-term use of cannabis or cannabis-based drugs impairs memory in mice, with significant effects on brain function and communication between learning and memory regions. The research highlights the potential negative side effects of long-term cannabinoid exposure.
Tropical Storm Leepi is weakening as it moves northwest, with maximum sustained winds near 63.2 mph. The storm's interaction with nearby System 98W is contributing to its decline.