Researchers developed TNF-α-primed mesenchymal stem cell-derived extracellular vesicles, which showed anti-inflammatory effects in treating retinal degeneration. The vesicles were found to inhibit M1 macrophage polarization and reduce pro-inflammatory gene expression, preserving retinal function.
Researchers discovered that PCGF1 is essential for maintaining H3K27me3 homeostasis during early embryonic development. Its absence leads to dysregulation of pluripotency gene silencing, causing cells to remain in a stem cell-like state and fail to commit to specific lineages.
A novel Ga–Na–PCN photocatalyst with enhanced charge separation and transfer has been developed using AI-assisted design. The built-in electric field at the heterointerface significantly improves hydrogen evolution in this work published on Acta Physico-Chimica Sinica.
Researchers Paula Cannon, Alan Epstein, Heinz-Josef Lenz, and Bodour Salhia recognized for their work harnessing the immune system, DNA, and gene expression to fight cancer and other diseases. Their innovations have led to patents, licensing, and commercialization, with potential real-world impact.
In vivo CAR-T therapy bypasses ex vivo manufacturing, preserving native T-cell function and improving accessibility. Recent clinical progress demonstrates encouraging results in hematologic malignancies and autoimmune diseases.
A new blueprint for creating research agreements enables respectful research with Tribes and on Tribal lands. The guidance defines rights of Tribes and researchers, aiming to avoid extractive practices and protect data sovereignty.
Researchers integrated natural diatom biochar with ZIF-67 to develop lightweight microwave stealth materials. The engineered hierarchical porosity enables stepwise impedance matching and multi-mechanism microwave dissipation, overcoming traditional absorber limitations.
Research suggests that mental time travel activates the brain's reward system, reinforcing behavior and making it easier to plan for the future. However, excessive mental time travel can also lead to negative emotions and maladaptive behavior, such as catastrophizing projections.
Researchers found that maternal oxycodone exposure alters the production and loading of tiny membrane-bound packets called sEVs in the placenta. These changes indicate a stressed placenta and may lead to cardiac vulnerability in offspring.
Researchers at TIFR, Hyderabad identified a mammalian protein Cnpy1 essential for vomeronasal sensory neurons in mice. The study shows that Cnpy1 acts as a specialized endoplasmic-reticulum-associated factor required to maintain functional receptor complexes in these neurons.
Violence intervention programs are reaching at-risk trauma patients with firearm injuries, but only a small percentage of eligible patients participate. The study aims to improve access and integration of these programs to enhance recovery outcomes after injury.
Researchers found that waterfowl in human-heavy landscapes move shorter distances, potentially leading to more intense disease outbreaks. By understanding these patterns, scientists can better predict where bird flu may spread next.
A new graphdiyne nano-iontronic device enables selective pH detection in single cells, showing fast and reversible responses to pH shifts. The device retains accurate proton sensing even in the presence of interferents, demonstrating its potential for real-time intracellular pH detection.
A research team has identified signalling molecules called Netrins and the corresponding receptor Frazzled/Deleted in Colorectal Cancer that control when individual cells separate from the tumour and migrate. These mechanisms can enable cancer cells to colonize new tissue, a major factor in metastasis.
A new study presents an interpretable artificial intelligence framework that improves the accuracy and transparency of genomic prediction, capturing complex genetic interactions and providing biological insight. Boosting algorithms outperform traditional statistical methods, particularly for traits with well-defined genetic signals.
A new study finds that aggressive policy action and cost reductions can accelerate the global shift to electric vehicles, reducing energy use and carbon emissions. The study suggests a uniform 20% reduction in non-energy costs could dramatically increase EV adoption rates, with market share rising from 25-50% to 70-85% globally by 2035.
A novel photocatalytic system captures and converts low-concentration CO2 from industrial flue gas into high-value chemicals using amino-functionalized bismuth catalysts. The catalyst achieves high CO2 capture rates under natural sunlight, demonstrating promising industrial application potential.
The Italian Society of Gerontology and Geriatrics has partnered with MDPI to publish its Journal of Gerontology and Geriatrics in open access. The journal, which was founded in 1953, will transition to a digital-only format starting with Volume 74, Issue 1 in March 2026.
The introduction of transition metal single atoms improves carrier separation and surface reaction kinetics, leading to enhanced photocatalytic performance. Strategically arranging metal single atoms on different components of an S-scheme heterojunction can synergistically enhance both reduction and oxidation half-reactions.
Researchers surveyed how transformers are integrated into graph-based recommender systems, improving handling of long-range patterns, sparse interactions, and complex heterogeneous data. The study proposes a taxonomy and design strategies for transformer-based recommender systems across various tasks.
The article highlights the urgent need to modernize scientific record with AI-powered discoveries trapped in a predigital system. Top-tier research universities face $10-15 million annual subscription expenditures, while author-facing processing charges range from $5,000 to over $11,000 per article.
A new study introduces a large multimodal colonoscopy dataset, ColonINST, and a lightweight colonoscopy-specific multimodal model, ColonGPT. ColonGPT outperforms existing models in three multimodal tasks and can be trained in about seven hours on two NVIDIA GPUs.
Researchers found that microorganisms in the plastisphere have more functional genes to survive under extreme ocean conditions. They can absorb nutrients effectively and utilize alternative energy sources like anoxygenic photosynthesis.
New class of moiré materials enables exploration of diverse quantum phases, including strongly correlated and topological phases. Researchers have observed various effects, such as integer and fractional quantum anomalous Hall effects, at zero external magnetic field.
Southwest Research Institute (SwRI) invested $13 million in internally funded projects in 2025, focusing on emerging industry challenges. The institute's IR&D program aims to transform novel ideas into new technical discoveries and applications.
A 12-week integrated cognitive-motor exercise program reduced core ADHD symptoms in children, producing stronger improvements in inhibitory control and immediate working memory compared to aerobic exercise alone. The combined training also eased inattention and hyperactivity-impulsivity, improving key executive functions.
The Adams Valve Institute aims to expand the treatment of valvular heart disease, focusing on complex surgeries and underserved populations. The Institute will promote innovation in advanced imaging, reconstructive surgical techniques, and breakthrough research.
Researchers have created a detailed molecular map of the thromboxane A2 receptor, which could lead to the development of safer and more effective therapies targeting this clinically important signalling system. The study reveals an unusual activation switch and provides insights into how signalling molecules interact with the receptor.
Researchers developed micro-pillar patterned electrodes with ordered ionomer structures to improve proton conduction and oxygen delivery, enhancing fuel cell performance. The design enabled robust operation under dry conditions and maintained electrochemical surface area, outperforming conventional electrodes.
People aged 50 and over who serve as unpaid family caregivers are more likely to support government-funded care, while non-caregivers prefer family or older adult payment. Concerns about long-term care costs and access persist among caregivers versus non-caregivers.
Researchers found that consuming sugar before a relaxing massage impairs the body's ability to relax by activating the sympathetic nervous system. The study, published in the International Journal of Psychophysiology, involved 94 healthy adults who received either a drink containing glucose or water before undergoing relaxation exercises.
Replacing meat and dairy with plant-based foods reduces greenhouse gas emissions by 35%, equivalent to eliminating 600 miles of driving. A low-fat vegan diet with soybeans also produces major health improvements, including a 92% reduction in severe hot flashes.
Researchers developed an intelligent monitoring pipe combining optical sensing and machine learning to monitor and predict 3D soil settlement. The system provides precision 3D measurements, capturing dynamic changes in soft or unstable soils like loess.
Treatment with i.v. furosemide plus HSS significantly decreased serum levels of inflammatory biomarkers IL-6, sST2, hsTnT, galectin-3, and NT-proBNP. The study found that this combination therapy modulated some miRNA expression and was associated with reduced miR181b expression compared to furosemide alone.
Scientists at the University of Amsterdam have developed metamaterials that learn and adapt without a central brain, allowing them to change shape and perform advanced tasks. These 'smart' materials can forget old shapes and learn new ones, enabling them to evolve and perform complex tasks.
Researchers found that viewers question the sincerity of fear or sadness expressed about climate change in simulated news reports, text messages, and TikTok posts. Emotional expression can serve an important role in helping people find a community, but it may not necessarily persuade others.
Researchers project that 28% of the global population will face heightened exposure to hot-dry extremes by the 2090s, concentrated in low-income, tropical nations. Limiting emissions could avert a lot of risk, with about 18% of the population facing this level of exposure under current climate action plans.
The Dementia Trials Accelerator is revolutionizing dementia research by streamlining the recruitment process for clinical trials. With over 10,000 participants expected to be recruited by 2027, this initiative aims to accelerate diagnosis and treatment development for those affected by dementia.
The NCCN Advocacy Academy connects oncology professionals with policymakers to drive evidence-based cancer policy. The program aims to cultivate policy leadership skills among emerging scientists and care providers.
Researchers used base editing to correct the SCN8A gene mutation responsible for severe inherited epilepsy. The approach successfully eliminated or reduced seizures and improved brain function in lab mice, offering new hope for treating genetic epilepsies.
Researchers found that an extract of turmeric and ginger helps bone implants bond strongly while killing bacteria and cancer cells. The extract roughly doubled bone bonding within six weeks around the implant site, killed more than 90% of bacteria on implant surfaces, and sharply reduced cancer-causing cells.
A new study from Norwegian University of Science and Technology suggests that observing experienced therapists can enhance psychology students' ability to talk with patients. Psychology students who observed therapists over 10 weeks improved their ability to form bonds and repair relationships with patients, according to the research.
A study from Hiroshima University found that green skepticism weakens two key drivers of green consumption: seeking trustworthy environmental information and anticipated guilt about making less sustainable choices. This challenges the common assumption that skeptical consumers will investigate more before deciding on purchases.
A new NIH-funded study predicts that HIV infections could increase by an average of 10% in 18 US states if CDC funding for HIV testing ends. The simulation model examined HIV infections across different populations and found that the number of infections varies widely across states.
National Academy of Engineering President Tsu-Jae Liu presents AI as a tool to expand engineers' problem-solving capacity and develop innovative solutions. The editorial calls for multidisciplinary education integrating AI while addressing its limitations and societal implications.
A new study reveals that natural disasters lead to a 69% spike in public protests across Latin America. Smaller communities tend to face the longest economic recoveries, with damage persisting for up to four months.
A study of 12,281 adults from 673 European sites over 10,000 years reveals a male bias in high meat consumption deciles across all eras. The results highlight significant gender disparities in access to animal proteins, suggesting root causes in food taboos and social norms.
In a study, university students chose to allocate harm to groups rather than individual people to avoid unfairly targeting one person. Brain imaging suggests mentalizing and valuation networks play a role in this moral decision-making process.
A secondary analysis of the ANGEL-ASPECT trial found EVT to be beneficial for patients with anterior-circulation LVO and a large ischemic core and absent-to-moderate white matter lesions. In contrast, those with severe WMLs showed less pronounced benefits, suggesting uncertainty about EVT's efficacy in this subgroup.
Researchers propose using electric vehicles as a backup power source for tropical cities plagued by short-lived thunderstorms. By connecting cars to the grid, they can absorb energy shortages and recharge when the sun returns. This approach reduces transmission line loads and stabilizes the grid.
Researchers found that the moon's oldest and darkest craters are also where ice has been detected, suggesting a continuous accumulation of water over billions of years. The team's findings rule out a massive comet impact as a source of water on the moon.
A study suggests that integrating wind and solar power into Ecuador's energy mix can prevent energy crises caused by droughts. The researchers found that large-scale wind and solar farms could increase the availability of hydropower, reducing the need for fossil fuels during dry periods.
The partnership aims to boost conservation impact by harnessing advanced digital technology and biobanking techniques, focusing on three core areas: knowledge transfer, innovation, and student engagement. This collaboration seeks to address pressing environmental challenges such as biodiversity threats and emerging pathogens.
Global air pollution mortality rates decreased by 45% between 1990 and 2019, with 52% of the decrease attributed to reduced vulnerability, such as improved healthcare access and poverty reduction. Integrating healthcare improvements into air quality strategies is crucial for protecting vulnerable populations.
Researchers at Umeå University have discovered a key protein that helps cancer cells survive treatment by blocking apoptosis. The study provides a deeper understanding of how proteins interact within the cell, which could lead to new cancer therapies targeting Bcl-2 and its protective function.
Researchers discovered that neuronal nitric oxide synthase drives neuroblastoma through the mTOR signaling cascade. Treating cancer cells with a selective inhibitor called BA-101 collapsed tumor growth in mice with striking force, and silencing the nNOS gene also led to significant results.
Researchers at ISTA's Materiali Molli Lab used E. coli bacteria to create an active bath that propelled sticky colloids into gel-like aggregates, rotating clockwise due to the bacteria's twisting motion. The study revealed that hydrodynamic interaction plays a key role in driving motion through the counter-rotation of body and flagella.
A study of 3,959 healthy Japanese workers found that longer working hours, including unpaid care and domestic work, are associated with a higher risk of nonrestorative sleep and poor mental health in women. The researchers call for policy changes to address time poverty and promote gender equality.
A new study published in JCOM finds that images of GMOs tend to reinforce pre-existing attitudes, amplifying polarization rather than changing minds. The study used a representative sample of the US population and found that even positive images could make people who already supported GMOs more positive, while making skeptics and uncer...
A new survey by Ohio State University Wexner Medical Center finds that only 42% of Americans are open to using AI in their healthcare, down from 52% in a previous survey. The decline in trust is attributed to concerns about AI's accuracy and the potential for it to replace human judgment in medical decision-making.