A new technique allows scientists to trace and spatially map 'mosaic' mutations in the brain, providing a significant advance for genetics research. This capability enables the study of both normal brains and brain disorders such as epilepsy and autism, offering new avenues for investigation.
Researchers at NYU Langone Medical Center developed new technology that tracks eye movements to assess brain injuries, offering a potential biological marker for brain function and recovery. The study found abnormal eye movement ratios in patients with nerve damage or swelling in the brain, which were restored after surgery.
A new study reveals that traumatic brain injury can accelerate dementia by disrupting the brain's waste removal system, specifically the glymphatic system. This impaired system allows toxic proteins to accumulate in the brain, setting the stage for neurodegenerative diseases.
A new study shows that gut microbiota can influence the integrity of the blood-brain barrier, which protects the brain from harmful substances. The findings suggest that alterations to our indigenous microbiota may have far-reaching consequences for the blood-brain barrier function throughout life.
Researchers discovered that estrogen-producing glial cells play a crucial role in controlling inflammation within hours of brain injury, potentially leading to new therapies. This rapid response could help preserve vital brain function and hasten recovery from brain injuries such as stroke.
A new study suggests that repeated head injuries can disrupt the brain's energy use, leading to inflammation, degeneration of brain cell segments, and problems with learning and memory. The discovery could help explain the development of chronic traumatic encephalopathy, a brain disease seen in professional athletes.
Researchers at the University of Washington have replicated a direct brain-to-brain connection, allowing them to transmit signals and control hand movements between individuals. The study involved six pairs of participants and achieved accuracy rates ranging from 25 to 83 percent.
Researchers at the University of Illinois have created a new online tool to study postnatal brain growth in human infants based on similarities with the piglet brain. The tool, an MRI-based brain atlas for four-week-old piglets, offers a three-dimensional averaged brain and anatomical regions of interest.
Researchers identified significant alterations in the thalamus and putamen of premature babies, which may lead to designing effective prevention strategies and early interventional treatments for cognitive disabilities. These findings suggest that brain structure and circuitry changes related to prematurity can affect important functio...
Researchers discovered genetic patterns that predict when breast cancers will spread to the brain, offering a potential early detection method. Faulty gene switches in the original tumor may serve as an early warning signal for brain metastasis.
Researchers at UT Dallas' Center for Vital Longevity found that brain networks become less segregated and specialized as we age, leading to poor long-term memory. This study may lead to new clinical diagnostic criteria for age-related memory disorders.
Researchers discuss the limitations of brain simulations, citing the need to account for individual experience and social context. They also raise concerns about the potential creation of artificial consciousness and the technical challenges of simulating complex biological systems.
Scientists have developed an immune-based treatment that reduces brain damage after head injuries by blocking the activation of immune cells. The treatment, called CAP, was tested on mice and found to be effective in reducing brain lesions.
The European College of Neuropsychopharmacology awards Dick Swaab with the 2014 ECNP Media Award for his book 'We are our Brains'. The award recognises outstanding contributions to destigmatising disorders of the brain. Swaab's work aims to promote a better understanding of brain function and its impact on mental health.
A team of researchers will study the complex connections between brain cells that allow us to make and retrieve lasting memories. The project aims to build a complete computational model of a neural network in vertebrates using experimental data, with potential transformative insights into mammalian brain abilities.
A new study suggests decreased brain connectivity between pain-related and sensorimotor areas may contribute to deficient pain regulation in fibromyalgia. Fibromyalgia patients exhibit impaired normal pain perception due to functional decoupling of pain-processing brain regions.
The NIH is developing an advanced electrode array system that will enable researchers to better understand how the brain works through unprecedented resolution and scale. The system, which will pack over 1,000 tiny electrodes, will allow scientists to simultaneously study thousands of neuronal cells in various brain regions during comp...
Researchers at Salk Institute will create an epigenetic map of each cell type in the brain, allowing for deeper understanding of neurons' identity and functional differences. The study aims to reveal possible windows into brain development and disease.
Four CSHL scientists will conduct research in the Brain Research through Advancing Innovative Neurotechnologies Initiative, aiming to map the human brain and understand brain disorders. The initiative seeks to develop transformative tools for studying the brain's structure and function.
Researchers found a unique signature of aging in the choroid plexus, which separates blood from cerebrospinal fluid, and discovered that interferon beta has a negative effect on the brain. Blocking this protein's activity restored cognitive abilities in older mice.
Researchers at Beth Israel Deaconess Medical Center identified brain networks that can help guide site selection for brain stimulation therapies. The findings suggest that stimulating sites in the same connected brain network can improve treatment outcomes across multiple neurological and psychiatric disorders.
Researchers discovered that a single dose of antidepressant can dramatically change the human brain's functional architecture within three hours. The study found increased connectivity in two specific brain regions, while reducing intrinsic connectivity elsewhere.
Researchers identified theta and beta wave activity associated with fear processing in the brain, including early increases in theta activity and a left lateralized desynchronization of the beta band. This study provides insight into how the brain prioritizes threatening information over other cognitive processes.
Researchers at UCLA School of Nursing have found that people with sleep apnea have weaker brain blood flow, which may be damaging the brain. The study used a non-invasive MRI procedure to measure global blood volume and oxygen-dependent signal in the brain, revealing changes in oxygenated blood across the whole brain.
Researchers at Yale School of Medicine have found a synthetic molecule called PreImplantation Factor (sPIF) that protects against neuronal death and brain injury. The study suggests that sPIF mitigates brain damage through a novel pathway, potentially treating perinatal brain injuries and neurodegenerative disorders.
A team of neuroscientists and robotics engineers has demonstrated direct brain-to-brain communication in humans, transmitting information via the internet between two human subjects separated by 5,000 miles. The study used advanced precision neuro-technologies to directly transmit a thought from one person to another without them havin...
A study published by the American Academy of Neurology found a link between sleep difficulties and rapid brain volume decline in adults. The research, which included 147 participants aged 20-84, revealed that poor sleep quality was associated with faster declines in brain regions including frontal, temporal, and parietal areas.
A new study led by Northwestern University anthropologists reveals that energy is funneled to the brain early in life, dominating metabolism and leading to slow body growth during childhood. The study finds that brain development peaks at age 5, when it consumes glucose at a rate comparable to 66% of the body's resting metabolic rate.
Brain tumors grow exclusively within narrow spaces between and along the brain's thousands of small blood vessels, contrary to the theory of neoangiogenesis. This 'autovascular' growth allows tumor cells to draw energy and fuel their growth like normal brain tissue.
Researchers have successfully created functional 3D brain-like tissue that exhibits grey-white matter compartmentalization and can survive in the lab for over two months. The tissue displays physical properties similar to rodent brain tissue, enabling scientists to study traumatic brain injury in real-time.
Researchers have yet to identify a specific cause or risk factor for brain tumors, but ionizing radiation is recognized as a risk factor in therapeutic doses. Recent studies have ruled out associations between brain tumors and cell phone use, cigarette smoking, or other environmental factors.
A new study found that amyloid buildup in one brain region can impair metabolism and activity in a distant, unaffected region. The findings suggest a long-distance effect of amyloid pathology on brain function.
Researchers have recreated the complex blood-brain barrier in a laboratory model to study the obstreperous bouncer proteins that protect the brain. The model can be used to test drive difficult ways into the brain and investigate complex phenomena in simple experiments.
A study published in Neurology found that even mild traumatic brain injury can cause brain damage and disrupt nerve axons in white matter. Cognitive tests showed a 25% decline in verbal letter fluency task scores for patients with injuries, strongly related to imaging measures of white matter damage.
New technologies solve bottlenecks in CLARITY, a technique for peering into the brain, making it easier to understand brain wiring and probe brain diseases. The advancements enable faster data collection and reduce risks associated with imaging valuable clinical samples.
A fungal protein has been found to cross the blood-brain barrier, allowing it to infect the brain and cause deadly meningitis. This discovery opens up new avenues for treating brain infections and cancers by targeting the protein or using it as a drug delivery system.
A new study published in Frontiers in Neurology found that eight-session gist-reasoning training can significantly improve higher-order thinking and other key frontal lobe functions in chronic recovery stages. Participants showed improved abstraction of meanings, executive functions, and memory for facts.
A new study published in Radiology found that moderate and late preterm birth is associated with smaller brain size and less developed myelination, suggesting a disruption in the expected trajectory of brain growth. The research provides insight into brain-behavior relationships in this group of children.
A recent study from the University of California, Davis suggests that random fluctuations in brain activity may contribute to our ability to make choices. The researchers found that patterns of brain activity before a decision can predict the outcome of the decision.
A new study reveals that the brain uses two distinct regions to navigate: one calculates the straight-line distance and another tracks the path along the way. The findings have significant implications for our understanding of brain function and navigation.
A new study published in the Creativity Research Journal found that brain integration, or mind-brain development, is strongly correlated with creativity in product-development engineers. Higher levels of brain integration were associated with greater flexibility and originality in verbal and figural creativity tests.
Researchers at Mayo Clinic have demonstrated a potential delivery vehicle for brain cancer chemotherapy drugs, enabling the transport of eight different molecules across the blood-brain barrier. The breakthrough method mimics a normal physiological process and could aid in evaluation of new drugs for brain cancer treatment.
A recent Rutgers University study published in Frontiers in Neuroscience found that young rats who mastered a learning task had newborn brain cells survive for longer periods. The study suggests that learning helps keep brain cells alive and could impact how the brain functions after puberty.
A $26 million research project employs advanced technology to understand and treat psychiatric disorders by analyzing brain networks. The project aims to develop neural stimulation therapies to 'unlearn' detrimental signaling patterns, potentially eliminating symptoms.
The new diffuse optical tomography (DOT) technology tracks brain processes in multiple regions and networks, providing a non-radiation alternative to fMRI. DOT has the potential to be helpful in many medical scenarios as a surrogate for functional MRI.
Duke-NUS researchers identify key player in brain DHA uptake, shedding light on omega-3's crucial role in brain function. The study's findings have implications for improving nutrition and addressing DHA deficiency, particularly in pre-term babies.
Researchers at MIT have developed a technique that allows them to track neural communication in the brain over time, offering a new window on brain function. The technique uses magnetic resonance imaging (MRI) along with a specialized molecular sensor to monitor dopamine levels in specific regions of the brain.
A study published by the American Academy of Neurology found that people with apathy symptoms have smaller brain volumes than those without apathy. Apathy is a lack of interest or emotion, and the findings suggest it may be an indicator of accelerated brain aging.
Researchers at Aalto University have developed a method to observe immediate changes in brain function during movie viewing. The study found similar brain signals in individuals watching the same movie, suggesting that the contents of the film affected certain brain functions in a similar manner.
Researchers discovered reduced dimensions of key cerebral veins after deep brain stimulation in Parkinson's disease patients. This finding suggests that bilateral subthalamic nucleus stimulation affects cerebral venous blood flow.
The Allen Mouse Brain Connectivity Atlas provides a comprehensive wiring diagram of the mammalian brain, revealing specific patterns in connections between brain regions and varying connection strengths. The atlas offers unparalleled details into how structures are connected inside the brain.
Researchers have created a high-resolution blueprint for the developing human brain, mapping where genes are turned on and off during mid-pregnancy. This atlas provides insight into diseases like autism and the origins of human uniqueness, revealing key genetic hubs linked to social behavior and cognitive features.
A study found that autism is caused by disruptions in early brain development, specifically in the formation of cortical layers. The researchers analyzed 25 genes in post-mortem brain tissue and discovered focal patches of disrupted development in most children with autism. These findings suggest that the brain can sometimes rewire con...
Researchers found that autism is caused by disrupted development of cortical layers in the brain, which leads to absent genetic markers and focal patches of abnormality. The study suggests that early treatment can lead to clinical improvement as the brain rewire connections to circumvent these defects.
A new mathematical model predicts where different types of neurons are located in the brain based on their molecular identity. This approach enables scientists to draw an increasingly accurate map of neuronal distribution in the brain.
A new cell type has been identified as a contributing factor to post-traumatic epilepsy caused by traumatic brain injury. The study found that damage to interneurons disrupts neurotransmitter levels, leading to increased epileptic activity.
Researchers discovered that cancer cells hug capillaries and express specific proteins to survive in the brain. The tumor cells produce a protein acting like Velcro to attach themselves to blood vessels, allowing them to grow into new tumors.
New research from Washington University School of Medicine finds that increased brain cell activity boosts brain fluid levels of tau protein, a hallmark of Alzheimer's disease. The study suggests that brain cells may be secreting tau when they send signals, potentially leading to the spread of disease.
The European Human Brain Project, Allen Institute for Brain Science, and US BRAIN Initiative are developing new methods to study the brain in health and disease. Researchers aim to reconstruct brain structure in computer models and analyze vast amounts of brain data.
A study found that people with both parents having Alzheimer's disease showed more severe brain abnormalities, including increased brain plaques and reduced brain volume. The research suggests a possible genetic link to the development of Alzheimer's disease.