The journal has added several Asian researchers to its Editorial Board, including Professor Huan-Yao Lei as the first Asian Editor. An Asian office will open at NCKU Medical Center in Taiwan, increasing visibility of EBM and SEBM throughout Asia Pacific scientific communities.
A research team at Weill Cornell Medical College identified two genes, Pbx-1 and Prep-1, that play a critical role in regulating interleukin-10 (IL-10) production. This discovery could lead to new avenues for understanding and treating diseases such as lupus, cancer, and HIV/AIDS.
Researchers have discovered that the immune system can enter a dormant state with cancer cells, controlling their growth without eliminating them. This finding may lead to alternative treatments for cancer, such as using immunotherapy to induce equilibrium and convert cancers into chronic but controllable diseases.
A major five-year study will analyze 32 common allergen sources, identifying T cell responses and potential epitope-based therapies. The project may lead to revolutionary new approaches for treating allergies, potentially reducing the need for lengthy desensitization treatments.
A team of Australian researchers has developed a novel treatment for obesity and extreme weight loss in late-stage cancer patients. By targeting the MIC-1 molecule, which sends a 'don't eat' signal to the brain, they hope to prevent this condition and improve chances of recovery.
Researchers identified genetic variations that significantly contribute to HIV/AIDS progression rates, including CCR5 and CCL3L1 genes. These findings may lead to the development of additional markers for predicting HIV disease course.
Researchers found that bone marrow transplant is a successful treatment option for DiGeorge syndrome, with a 75% survival rate. The study also suggests that the thymus may not be necessary for immune development after birth.
A common model of immune responses will improve understanding by providing a shared language among scientists. The Immunology Imaging and Modelling Network's theoretical and computational model will help track parasites and cells in real-time, measuring interactions between immune system components.
Researchers found a link between depression, latent viral infections, and increased inflammation, which may contribute to the development of cardiovascular disease. The study suggests that chronic depression can trigger a cascade of events that lead to the buildup of plaques in coronary arteries.
A recent study published in The Journal of Immunology found that SIV infection in monkeys does not always lead to AIDS, contradicting current thinking. Researchers propose that host/virus co-adaptation enables monkeys to limit T cell immune activation and apoptosis, a mechanism that contributes to disease progression.
Researchers found that chronic caregivers develop genetic and molecular changes that effectively age their bodies by four to eight years, resulting in a shortened lifespan. Caregivers also exhibit severe depression symptoms and weakened immune systems, contributing to the negative effects of chronic stress.
Scientists at Children's Hospital of Pittsburgh have identified a plasmid-deficient strain of Chlamydia that fails to cause disease in animal models. This finding represents a major step forward in developing a vaccine against chlamydial disease, with potential to protect against damage to reproductive organs and infertility.
Immunology researchers at Thomas Jefferson University have successfully halted a lethal rabies infection in mice by opening the central nervous system's protective blood-brain barrier. This breakthrough could lead to improved treatment for late-stage rabies infections in humans, and may also shed light on other neurological diseases.
A research team at Virginia Commonwealth University has identified a new biological function for buckyballs, discovering they can block allergic responses in human cell culture experiments. The buckyballs inhibit a basic process in cells that leads to the release of an allergic mediator, preventing mast cells from releasing histamine.
Researchers at LIAI demonstrated that retinoic acid regulates inflammation in laboratory mice, affecting pro-inflammatory T cell lineages. This finding suggests a new avenue of therapies using retinoic acid to treat autoimmune diseases.
Researchers at Albert Einstein College of Medicine found fungi can harness ionizing radiation to produce food and spur growth, recalculating Earth's energy balance. This discovery could provide a sustainable food source for long-duration space missions or planetary colonization.
A recent study by the Mailman School of Public Health found a possible link between cigarette use and the rise in childhood asthma cases. Cigarette smoke exposure is thought to contribute to the increasing prevalence of asthma among children, particularly those from low-income backgrounds.
Dr. David Serreze receives JDRF's Grodsky award for his outstanding contributions to the study of diabetic immunology. The award recognizes his leadership and innovation in accelerating the pace of diabetes research.
A recent study by researchers at the University of New South Wales and Sydney Children's Hospital found that a third of children with a predicted peanut allergy were not allergic when challenged with peanuts. This suggests that diagnostic tests for peanut allergy may have poor sensitivity and specificity.
The Juvenile Diabetes Research Foundation announced the 2007 Scholar Award recipients, providing $250,000 annually for up to five years to support groundbreaking research. The selected researchers aim to accelerate type 1 diabetes research and find a cure for this devastating disease.
Researchers at La Jolla Institute for Allergy & Immunology have made an important finding on cytomegalovirus transmission by reducing the virus in salivary glands using antibodies. The study may have implications for other chronic virus infections like hepatitis and HIV.
The Indo-US Vaccine Action Program has been renewed for another five-year period, supporting research on vaccines and immunology. Many successful collaborations have addressed critical health problems, including the development of a new hepatitis C diagnostic test and candidate vaccine against rotavirus.
A study published in Journal of Allergy and Clinical Immunology found that exposure to cat allergens at home increases the frequency of allergic sensitization in young children. The study analyzed data from over 1,000 children born between 1997 and 1999 and found that even brief contact with cat hair can lead to sensitization.
A study published in Immunology Letters describes new ways of inducing immune responses through selective B cell priming, suggesting a potential approach to rational vaccine design. This discovery could have significant practical implications for vaccination development.
Researchers have discovered a weakness in the armour that protects B. cenocepacia from antibiotics, identifying a key sugar required for its protection. This finding may lead to novel molecules to disrupt its synthesis and develop new treatments.
Immunology researchers at Jefferson University have found that blood-brain barrier damage correlates with multiple sclerosis (MS) severity. The study used mice models and found that permeability changes are critical in disease development, with even mice lacking immune system components able to develop disease.
A new study identifies a connection between allergic diseases like eczema and autoimmune diseases, suggesting that these conditions may trigger each other through immune system dysfunction. The researchers are now investigating specific triggers and exploring potential treatments, including drugs that can counter autoimmune responses.
Scientists have identified a natural mechanism by which tumors and viruses evade the immune response, leading to the development of new cancer therapies. By inhibiting an enzyme called IDO, researchers hope to restore the immune system's ability to target cancer cells. Early clinical trials are underway to test this approach.
Dr. Russell is recognized for his contributions to understanding the protein antigens on Streptococcus mutans, a bacterium associated with dental caries. His work has led to the development of immunological interventions targeting this adhesin and improved mucosal immune response strategies.
The National Institutes of Health has awarded grants to University Hospitals Case Medical Center for expanded HIV treatment development and pioneering advances in Microbicides Trials Network. This includes immunology laboratory funding at Case Western Reserve University School of Medicine and clinical trial research sites in Uganda.
Investigators at LA BioMed found evidence linking insulin-like growth factor receptor (IGF-1R) to the development of Graves' disease, a common cause of hyperthyroidism. The discovery suggests a potential therapeutic strategy for autoimmune diseases.
A new type of protein discovered by Queen's University researchers may be useful in developing treatments for antibiotic-resistant bacteria. The protein, called YihE or RdoA, has been shown to be a potentially good target in a wide range of bacteria that cause infectious diseases.
A new study published in the Journal of Allergy and Clinical Immunology found that inhaled corticosteroids are the most effective initial daily therapy for children with mild to moderate persistent asthma. The study also showed no significant adverse growth effects among any of the medicines studied.
Researchers at UCSD found fibrosis and remodeling in pediatric EE patients similar to airway remodeling in asthma. These changes increase blood vessel adhesion molecules, leading to inflammation in the esophagus.
The team of scientists deciphered the genome of Trichomonas vaginalis, a single-celled parasite causing trichomoniasis, which affects an estimated 170 million people annually. The large genome contains nearly 26,000 confirmed genes, providing new insights into pathogenesis and potential therapeutic targets.
Researchers found DNA methylation in normal-appearing areas of the breast near tumors, suggesting a potential marker for early cancer detection. Abnormal methylation levels were also identified in three other genes, which may help estimate a woman's risk of cancer recurrence.
A study published in Nature Immunology reveals that lymph node cells instruct immune system cells to leave healthy tissue alone, protecting the small intestine from attack. This finding may lead to new forms of treatment for autoimmune diseases such as Type 1 diabetes and multiple sclerosis.
The La Jolla Institute completed a first-of-its-kind study analyzing all published data worldwide on influenza A virus antibody and T cell epitopes. The study provides critical information for developing vaccines and therapies against both seasonal and pandemic influenza strains.
The University of Virginia Health System has received a $583,000 NIH training grant to train four new researchers in kidney disease research annually. This multidisciplinary program aims to address the growing problem of kidney disease by equipping researchers with skills to translate lab research to clinical practice.
Researchers found that manipulating proteins in the immune system could lead to new treatments for asthma, which shares similarities with parasitic infections. The study's findings suggest that targeting specific cytokines, such as IL-4 and IL-13, may help prevent lung damage in asthmatic patients.
A study by the University of Cincinnati has found that infants living in homes with high levels of endotoxins and multiple dogs were more than two times less likely to wheeze. The researchers suggest that pet ownership may offer a protective effect against development of lower respiratory symptoms in young children.
Research suggests that common painkillers like NSAIDs can reduce vaccine effectiveness by reducing antibody production. The study's findings have implications for people who take these medications regularly, particularly those with compromised immune systems.
In a groundbreaking pilot study, researchers at Duke University Medical Center found that children with egg allergies can build up their bodies' resistance to eggs by gradually consuming increased quantities over time. The study's findings show promising results for the development of a meaningful therapy for food allergy sufferers.
The Baylor Research Institute has received a $6.2 million grant to establish a Center for Lupus Research, which will focus on understanding the immune system's role in lupus. The center aims to identify how lupus alters cells of the immune system, leading to abnormal protein levels and disease activity.
Researchers at Albert Einstein College of Medicine successfully targeted and destroyed HIV-infected cells in mice using radioimmunotherapy. The treatment aims to eliminate the virus-infected cells that make infections chronic, potentially leading to a cure for HIV-infected patients.
Researchers at Children's Hospital of Pittsburgh have identified interleukin-23 (IL-23) as the key molecule causing destructive lung inflammation in cystic fibrosis patients. This discovery provides a specific target for developing new therapies to improve quality of life for these patients.
A research team has identified a key molecular signaling switch involved in allergic disease, which could lead to the development of new strategies and target therapies. The discovery centers around ADAM10, an enzyme that releases a major allergy regulatory protein from cell surfaces, promoting a stronger allergic response.
Researchers created a biosensor using quantum dots to mimic the clustering of MHC proteins on target cells, revealing strong contributions from non-viral peptide-MHC interaction with co-receptors. This cooperativity suggests that a single virus-MHC complex recognized in self-MHC complexes can activate a T-cell response.
Researchers at the University of Pennsylvania School of Medicine have made a breakthrough discovery about how T cells become active or inactive. They found that small fatty acids called diacylglycerols (DAGs) play a critical role in this process, and that enzymes called diacylglycerol kinases can make T cells tolerant to foreign substa...
Researchers find that fish and amphibian B cells exhibit strong phagocytosis in both in vivo and vitro experiments. This discovery suggests an evolutionary relationship between macrophages and B cells, with implications for understanding human immune systems.
Researchers studying a lancelet, a tiny primitive fish found in Tampa Bay waters, have identified key immune system proteins that share similarities with those found in humans. The study's findings could lead to improved biodefense and biotechnology for cancer treatment and disorders like rheumatoid arthritis.
OHSU researchers show that CD8+ T-cells can literally eat virus-infected cells, providing insight into the human immune system and potential new way to gauge vaccine effectiveness. The discovery may help determine vaccine efficacy by measuring T-cell response to and consumption of a candidate vaccine.
The Federation of American Scientists has developed a new educational video game called Immune Attack, which engages students in learning about immunology concepts. The game features a first-person strategy game where immune cells face off against bacterial and viral infections, aiming to make learning fun and exciting.
Researchers at LIAI have identified Borrelia burgdorferi's glycolipid as an immune system trigger for fighting Lyme disease. This discovery could lead to the development of a new vaccine against the tick-borne disorder.
Researchers at Ohio State University discovered that the protein CD86 on B lymphocytes increases antibody production when interacting with T cells. This finding could lead to new treatments for pneumonia, HIV/AIDS, and autoimmune diseases.
The Baylor Institute for Immunology Research has been awarded a $3 million grant to develop vaccines against melanoma, a deadly form of skin cancer. The research will focus on using dendritic cells to modulate the immune system and stimulate an anti-cancer response.
Researchers at Albert Einstein College of Medicine have developed a novel technique to insert genes into the P. falciparum genome, providing valuable information about its virulence and resistance to antimalarial drugs. This breakthrough should significantly speed up research efforts to bring malaria under control.
The Program in Systems Immunology and Infectious Disease Modeling (PSIIM) aims to understand complex biochemical networks regulating interactions between pathogens and human cells. The program employs Simmune software to simulate biological systems, enabling scientists to predict how drugs affect cell behavior and develop new treatments.
The International Association for Dental Research (IADR) presented several awards and fellowships to recognize outstanding contributions in dental research. The IADR Honorary Membership was bestowed upon Robert V. Blanden, while the E.W. Borrow Memorial Award went to Poul Erik Petersen. Fellowships were also awarded to Janet D.C. Kan, ...
Researchers have identified a protein in mice that regulates bone formation, finding that augmented osteoblast activity leads to elevated bone mass. The discovery could lead to new treatments for osteoporosis by targeting the Shn3 and WWP1 proteins.