Researchers at NTNU studied zebrafish brain activity while increasing temperature, finding that brains completely stopped responding to stimuli but then 'lit up' when temperatures reached extreme levels. Adding oxygen improved thermal tolerance and recovery rate in fish, suggesting a key role for glial cells in regulating oxygen supply.
SourceNorwegian University of Science and Technology·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateSep 29, 2022
A Phase 3 clinical trial is enrolling adults and children with monkeypox infection in the US to evaluate the efficacy and safety of tecovirimat (TPOXX). The trial aims to gather data on lesion healing, pain scores, disease progression, and safety.
SourceNIH/National Institute of Allergy and Infectious Diseases·DateSep 9, 2022
A new study from the University of Pennsylvania School of Nursing reveals how clinical ethicists provided consultation and guidance during the pandemic. The study's findings shed light on the experiences of clinical ethicists during this time and their impact on hospital operations.
SourceUniversity of Pennsylvania School of Nursing·JournalAJOB Empirical Bioethics·DateAug 30, 2022
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
Young people with 22q11.2 Deletion Syndrome show distinct brain activity patterns during sleep, which may influence psychiatric symptoms. These differences are associated with altered connections within and between brain areas.
A study at MedUni Vienna identified a glycerol-3-phosphate shuttle system as an essential back-up in neurons, ensuring sufficient energy supply even when one regulatory system fails. The system follows a hierarchy, with deployment triggered by the failure of other two mechanisms to function adequately.
SourceMedical University of Vienna·JournalJNeurosci·DateAug 26, 2022
Researchers outline a five-step approach to increase racial representation in cancer clinical trials through DRIVE: Diversity officer, Ranking of clinical studies, Individual diversity plan, Verification, and Training. This can lead to more inclusive and individualized treatment for diverse patient populations.
SourceAmerican Society of Hematology·JournalBlood Advances·DateAug 25, 2022
A new set of guidelines aims to increase patient diversity in lung cancer clinical trials by relaxing eligibility requirements. The recommendations, published in JAMA Oncology, suggest that patients with prior or concurrent cancers, brain metastases, and mild liver impairment can be included in trials.
SourceUT Southwestern Medical Center·JournalJAMA Oncology·DateAug 5, 2022
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
Researchers created a new scale to assess how safe patients feel, dividing it into three sub-scales: Social Engagement, Compassion, and Bodily Sensations. The Neuroception of Psychological Safety Scale (NPSS) has potential applications in tracking progress in psychological therapy or assessing hospital outcomes.
SourceUniversity of Strathclyde·JournalPsychological Trauma Theory Research Practice and Policy·TypeSurvey·DateJul 20, 2022
A FSU team found a specific protein's gradient distribution in the brain linked to neurodegeneration in individuals with temporal lobe epilepsy (TLE). The discovery using area-specific tissue analysis will help researchers narrow focus for developing therapies, promoting the discovery of more effective treatments.
SourceFlorida State University·JournalJournal of Neurophysiology·DateJul 18, 2022
A new model from researchers at the University of Southern California and Lund University suggests that spontaneous movements made by a fetus in the womb are key to getting the body's nervous system 'wired up.' This discovery has implications for treating neuromuscular disorders and designing better robots.
SourceUniversity of Southern California·JournalJournal of Neurophysiology·TypeObservational study·DateJun 22, 2022
Researchers found that walking enhances performance on cognitive tasks in 14 participants by increasing frontal brain function, while 12 others showed no improvement. This discovery highlights the flexibility of a healthy brain and has implications for understanding aging and neurological disorders.
SourceUniversity of Rochester Medical Center·JournalCerebral Cortex·DateJun 21, 2022
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
The integrated tool allows tracking of clinical trial enrollment and cost effectiveness, enabling study teams to ensure trials are the best fit for the enterprise. It also enables standardization of data collection and reporting, giving the institution a competitive edge.
SourceMedical University of South Carolina·JournalJournal of Clinical and Translational Science·TypeObservational study·DateJun 17, 2022
A phase 2 clinical trial conducted at Memorial Sloan Kettering showed a 100% clinical complete response to dostarlimab for advanced rectal cancer. Swim Across America's early-stage grant funding supported the trial, which also received funding from other partners.
SourceSwim Across America·JournalNew England Journal of Medicine·TypeRandomized controlled/clinical trial·DateJun 8, 2022
A study in a mouse model found that viral infections during pregnancy can affect the mother's brain and disrupt maternal care behavior after birth. The research team identified structural, molecular, and functional changes in the brains of mothers with viral-like immune activation.
SourceMedical University of Vienna·JournalMolecular Psychiatry·DateMay 18, 2022
The Cardiovascular Research Foundation (CRF) announced that TVT: The Structural Heart Summit will feature 12 studies as Late-Breaking Clinical Science and Featured Clinical Research. These studies highlight advances in transcatheter aortic valve replacement, mitral, tricuspid, and left atrial appendage occlusion therapies.
A new study from the Regenstrief Institute examines the effects of clinical texting on hospitalist and nurse communication, highlighting both benefits and challenges. The study suggests that clinical texting can improve communication, but also raises concerns about user buy-in and shared understanding.
SourceRegenstrief Institute·JournalApplied Clinical Informatics·DateMay 10, 2022
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
The American College of Medical Genetics and Genomics has released a new Clinical Practice Resource to guide the treatment of patients with hearing loss. The resource offers information on causes, presentations, and approaches to clinical evaluation and genetic testing.
SourceAmerican College of Medical Genetics and Genomics·JournalGenetics in Medicine·DateMay 10, 2022
Researchers investigated the structure‒tissue exposure/selectivity relationship (STR) in correlation with observed clinical efficacy/toxicity using seven selective estrogen receptor modulators. The results showed that tissue exposure/selectivity of SERMs was correlated with clinical efficacy/safety, while plasma exposure was not.
SourceCompuscript Ltd·JournalActa Pharmaceutica Sinica B·DateApr 11, 2022
A team of NYU Tandon researchers investigated the variability of mortality prediction models when applied to different hospitals and geographic regions. They found that these models exhibit a lack of generalizability due to dataset shifts in race and clinical variables, leading to disparities in performance across racial groups.
SourceNYU Tandon School of Engineering·JournalPLOS Digital Health·TypeData/statistical analysis·DateApr 11, 2022
Current drug optimization prioritizes potency/specificity over tissue exposure/selectivity, leading to clinical failures. A new approach, STAR, classifies drugs based on potency/selectivity, tissue exposure/selectivity, and required dose to achieve clinical efficacy/toxicity balance.
SourceCompuscript Ltd·JournalActa Pharmaceutica Sinica B·DateApr 11, 2022
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
A new study found that less than half of clinical trials reported race/ethnicity data, with minorities underrepresented despite efforts to increase diversity. Industry-funded studies had the greatest gaps in enrolling minority participants.
SourceBrigham and Women's Hospital·JournalThe Lancet Regional Health - Americas·DateApr 10, 2022
Researchers found that industry-sponsored clinical trials neglect to cite previous trials by up to 30%, while non-industry-funded trials do so at a rate of 20%. This omission may lead to redundant or less impactful research. The authors call for complete and impartial citation of prior studies in trial protocols.
SourceCell Press·JournalMed·TypeSystematic review·DateApr 8, 2022
Researchers found that mitochondria act as microlenses to focus light on outer segments where it's converted into nerve signals, shedding new light on the retina's optical properties. This discovery has potential clinical implications for detecting retinal diseases.
SourceNIH/National Eye Institute·JournalScience Advances·TypeExperimental study·DateMar 2, 2022
A new review highlights the need for greater gender diversity in clinical trial leadership, with women making up only 10.1% of committees. Increasing representation will help ensure medications are safe and effective for everyone, and pave the way for more women to present at scientific meetings.
SourceAmerican College of Cardiology·JournalJournal of the American College of Cardiology·TypeCommentary/editorial·DateFeb 28, 2022
A study published in Arthritis and Rheumatology characterizes grey matter volume alterations in adolescents affected by juvenile fibromyalgia, revealing a link between brain region activity and pain processing. The research suggests therapeutic strategies to modulate the activity in brain circuits involved with emotion and language.
SourceUniversity of Barcelona·JournalArthritis & Rheumatology·TypeObservational study·DateFeb 17, 2022
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
The ALS Canada Research Program has awarded nine Discovery Grants to investigate critical areas of disease processes and clinical care. The grants will support fundamental laboratory research, biomarker studies, and clinical trials.
A clinical trial of niclosamide in COVID-19 patients found signals of benefit warranting further study. The medication showed potential in reducing contagiousness and symptoms, particularly in higher-risk populations.
SourceTufts Clinical and Translational Science Institute·JournalJAMA Network Open·TypeRandomized controlled/clinical trial·DateFeb 9, 2022
Neurobiologists demonstrated that humans can unconsciously distinguish between even very similar sounds, but often don't recognize these differences. The study used EEG to measure brain responses to stimuli and found that the brain reacts differently to local and global irregularities in sound sequences.
SourceNational Research University Higher School of Economics·JournalNeuropsychologia·DateFeb 3, 2022
Researchers at Technion have developed a technology that compensates for the underrepresentation of women in clinical trials, using machine learning models. The tool improves predictions for women in various situations and also enhances overall clinical predictions, leading to better personalized medicine.
SourceTechnion-Israel Institute of Technology·JournalJournal of the American Medical Informatics Association·TypeData/statistical analysis·DateJan 31, 2022
New research reveals the brain's flexibility in multitasking while walking, improving stability and performance. The study uses a Mobile Brain/Body Imaging system to record brain activity while participants walk on a treadmill or perform cognitive tasks.
SourceUniversity of Rochester Medical Center·JournalNeuroImage·DateJan 24, 2022
Sky & Telescope Pocket Sky Atlas, 2nd Edition
Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.
A study published in Journal of Biological Rhythms found that antibody levels are higher when healthcare workers received the SARS-CoV-2 vaccine in the afternoon. The study suggests that circadian rhythms may play a role in regulating immune responses to COVID-19 vaccination.
SourceMassachusetts General Hospital·JournalJournal of Biological Rhythms·DateDec 7, 2021
Despite increases in inclusion, certain groups remain under-represented in cancer clinical trials. Black and Hispanic patients showed improved participation, while women and older adults continued to be under-represented.
The WVCTSI will deploy a mobile clinical trials unit in West Virginia, addressing health disparities and increasing participation in clinical research. The 39-foot Winnebago will provide on-site clinical trials and follow-up visits to rural residents.
A recent survey of advanced breast cancer patients in the UK reveals that only 14% have been recruited to a trial, highlighting a need for improved access. Patients often face barriers, including clinician reluctance to discuss trials and a lack of patient-friendly databases.
SourceAssociação Advanced Breast Cancer Global Alliance·TypeObservational study·DateNov 3, 2021
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Researchers at Lund University have developed a promising new pain relief method using ultra-thin microelectrodes, providing effective and personalized pain relief without common side effects. The study showed that this technique can block pain signals in the brain without affecting other sensory systems or motor skills.
SourceLund University·JournalScience Advances·DateOct 13, 2021
A study found that pediatric clinical trials in the US were underrepresented by Black children, Hispanic/Latino children, American Indian/Alaska Native, Asian, and Native Pacific Islander children. Researchers are calling for improvements to enrollment processes to increase diversity and generalizability of trial results.
A study published by Ruhr-University Bochum's Department of Neurophysiology found that the olfactory system works closely with the brain's reward and aversion systems to form and retrieve memories. Non-olfactory brain regions, such as the limbic cortex, play a crucial role in categorizing scents as pleasant or unpleasant.
SourceRuhr-University Bochum·JournalCerebral Cortex·TypeExperimental study·DateSep 16, 2021
A study found that 1/3 of cancer drugs with accelerated approval fail to show clinical benefit in post-approval trials yet remain recommended in clinical guidelines. Researchers call for reforms to improve clarity on FDA approvals and withdrawals.
SourceBMJ Group·TypeObservational study·DateSep 8, 2021
A study by KAIST scientists shows that neurons carrying somatic mutations in MTOR can lead to focal cortical dysplasia, the most common cause of uncontrolled seizures. Nearby non-mutated neurons become hyperexcitable due to adenosine kinase overproduction, triggering seizures.
SourceThe Korea Advanced Institute of Science and Technology (KAIST)·JournalAnnals of Neurology·TypeMeta-analysis·DateAug 25, 2021
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
A new study developed a wearable technology-based method to assess myoclonus symptoms in the home environment. The method, which measures electrical neuromuscular function and movement, correlates well with assessments performed by experienced physicians.
SourceUniversity of Eastern Finland·JournalClinical Neurophysiology·DateAug 5, 2021
Researchers found no evidence of increased suicide risk among patients taking recently developed antiseizure medications. The study suggests that the FDA's blanket warning on anti-seizure medications may not be justified, highlighting concerns about its impact on patient treatment and trial results.
SourceThomas Jefferson University·JournalJAMA Neurology·DateAug 2, 2021
The NIH has launched Outreach Pro, an online tool designed to improve recruitment of underrepresented populations in Alzheimer's clinical trials. The platform provides customizable participant recruitment communications and culturally appropriate outreach materials.
A novel method predicts COVID-19 clinical trial success rates by analyzing features from clinical trial reports, including keywords and drug information. The model achieved high accuracy in predicting trial status, indicating a potential tool for optimizing research efforts and reducing costs.
SourceFlorida Atlantic University·JournalPLOS ONE·DateJul 21, 2021
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Clinical ethicists discuss activist language and its impact on healthcare crises, including triage policies and racial disparities. The article highlights four calls to action: recognizing barriers, supporting antiracism work, advocating for policy change, and engaging in institutional activism.
SourceThe Hastings Center·JournalHastings Center Report·DateJul 21, 2021
Zeynep Eroglu, MD, assistant member of the Cutaneous Oncology Department at Moffitt Cancer Center, received the 2021 Cancer Clinical Investigator Team Leadership Award from the National Cancer Institute. The award recognizes outstanding clinical investigators working to improve cancer care.
SourceH. Lee Moffitt Cancer Center & Research Institute·DateJul 15, 2021
A new study suggests that varying virus dynamics among patients may contribute to inconsistent clinical trial results for COVID-19 drugs. Recruiting participants shortly after symptom onset could reduce the number of participants needed to detect significant antiviral drug effects.
A new study found that a special type of brain training based on neurofeedback enables people with attention deficit disorder to improve their ability to concentrate. The training is linked to an enhanced response from the brain's P3 wave, which reflects integration of information in the brain.
SourceUniversité de Genève·JournalClinical Neurophysiology·DateJun 29, 2021
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
Researchers successfully replicated traditional clinical trials using virtual patient populations, speeding up the trial process by months. The in-silico approach shows huge potential for optimizing medical device design and reducing risks associated with treatment.
SourceUniversity of Leeds·JournalNature Communications·DateJun 23, 2021
The Association for Molecular Pathology (AMP) has published consensus recommendations for clinical CYP2D6 genotype testing, aiming to standardize testing across laboratories and improve patient care. A minimum set of variants is recommended for inclusion in all future clinical assays.
SourceAssociation for Molecular Pathology·JournalJournal of Molecular Diagnostics·DateJun 10, 2021
A new AI-based tool has been developed to predict genomic subtypes of pancreatic cancer using histology slides, offering a potential solution for patient molecular stratification. The tool, trained and validated on machine learning models, can be used in clinical practice worldwide.
Researchers developed an AI algorithm using 20,000 nights of sleep data to improve diagnoses and treatments for sleep disorders. The algorithm can analyze patient sleep patterns in seconds, freeing up medical hours that can be used to assess and diagnose more patients.
SourceUniversity of Copenhagen - Faculty of Science·Journalnpj Digital Medicine·DateJun 8, 2021
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
The University of Minnesota Medical School is launching a new clinical trial to study the effectiveness of ivermectin, metformin, and fluvoxamine as potential treatments for COVID-19. The multi-site trial aims to prevent hospitalization and 'long COVID' in patients with COVID-19.
SourceUniversity of Minnesota Medical School·DateMay 25, 2021
The Virtual SLEEP 2021 meeting features over 60 sessions on clinical sleep science and practice, basic and translational sleep and circadian science, and technologist tracks. Keynote speakers include Eus JW Van Someren and Wendy Troxel, presenting on topics such as insomnia, COVID-19 impact on adult sleep health, and disparities in sleep.
The CASTLE study investigated the role of imaging-guided percutaneous cardiac intervention (PCI) in clinical outcomes difference between ultra-thin strut biodegradable polymer sirolimus-eluting stent (Orsiro) and durable polymer everolimus-eluting stents (Xience). The results show no significant differences in target lesion failure rat...
A recent study found that environmental enrichment leads to specific epigenetic changes in the mouse brain, activating a minority of genes involved in cognition and mental health. These changes may inform future research on therapies for mental health disorders.
SourceFrontiers·JournalFrontiers in Molecular Neuroscience·DateMay 12, 2021
A new study from the University of Missouri School of Medicine found that people of color, those with a higher income, and younger individuals are more likely to participate in cancer clinical trials. The analysis of 20,053 respondents showed an average overall clinical trial participation rate of 6.51%, with significant differences in...
SourceUniversity of Missouri-Columbia·JournalContemporary Clinical Trials Communications·DateApr 28, 2021
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers at MUSC developed RINS, a digital platform that integrates clinical study data from disparate systems, providing metrics on translational science efficiency and effectiveness. This allows for informed decisions on improving translational research practices.
SourceMedical University of South Carolina·JournalJournal of the American Medical Informatics Association·DateApr 16, 2021
Global clinical trial completion rates dropped by 13-23% during the COVID-19 pandemic, according to a new study. The decline was most significant in trials funded by government, academic or medical entities, and was attributed to reduced patient enrollment and increased challenges in following up on patients.
SourcePenn State·JournalClinical and Translational Science·DateApr 7, 2021
Researchers from the University of Turku found that hypnosis shifts brain regions into a less synchronized state, allowing for more independent action. This finding provides new insights into how hypnosis modifies neural processing and may explain its effects on behavior and perception.
SourceUniversity of Turku·JournalNeuroscience of Consciousness·DateMar 26, 2021
Researchers mapped over 400 patients with SCN2A-related disorders, linking genetic abnormalities to clinical features. The study provided a framework for precision medicine approaches to help individuals with these conditions.
SourceChildren's Hospital of Philadelphia·JournalGenetics in Medicine·DateMar 17, 2021