Researchers at the University of Alberta have discovered that an anti-inflammatory drug, VX-765, can slow disease progression in a preclinical model of multiple sclerosis when delivered intranasally. This new therapy approach has shown promise in preserving myelin and glucose metabolism.
A new study has identified autopsy, airway suctioning, and cardiopulmonary resuscitation as aerosol-generating procedures that require enhanced personal protective equipment. The research aims to prevent healthcare workers from becoming infected with COVID-19, protecting them from severe disease and maintaining staffing levels during t...
Research at NYU College of Dentistry identifies genes highly expressed in painful, metastatic oral cancers, revealing a mechanism for cancer pain. The study's findings may lead to the development of biomarkers and objective molecular tests to diagnose risk of metastasis.
Researchers found caesarean section and prolonged labour influence infant gut microbiome, linked to childhood obesity and allergic sensitization. The study identified specific bacteria and metabolic pathways involved in these health outcomes.
A new study suggests that the gut microbiome plays a role in how prostate cancer patients respond to oral therapies like abiraterone acetate. The research found that bacteria in the gut metabolize the drug, leading to an increase in beneficial organisms with anti-cancer properties.
Scientists have documented all cell types and genes in healthy human hearts, paving the way for targeted treatments. This single-cell atlas will help understand heart disease and develop new therapies by correcting genetic mutations.
Researchers at the University of Alberta have discovered a novel mechanism of action by remdesivir against SARS-CoV-2, which affects the viral replication machinery. This finding is crucial for improving treatments and building on the existing antiviral drug.
Researchers at Karolinska Institutet have identified all cell populations in mouse teeth and young human teeth, deciphering differentiation pathways of odontoblasts and ameloblasts. The study sheds light on tooth sensitivity and the formation of enamel.
A new study found that a protein called BIK triggers failed apoptosis, leading to DNA damage and mutations in ER-positive breast cancer cells. This process makes the cancer cells more aggressive and evasive of therapy.
Researchers at the University of Alberta have discovered a protease inhibitor that effectively inhibits viral replication in cells with SARS-CoV-2. The drug has already shown little to no toxicity and is poised for human clinical trials.
Scientists at the University of Birmingham have developed a reliable method to predict an individual's susceptibility to pain using alpha wave frequency. This breakthrough could help clinicians understand how patients will react to surgery and develop more effective pain management strategies.
A collaboration between University of Toronto and National Jewish Health has yielded a new drug discovery that could combat inflammation and acute respiratory illnesses like COVID-19. The 'drug' is a combination of two naturally occurring peptides, TAT CARMIL1, which reduces collagen degradation by up to 43%.
Researchers at University of Saskatchewan are developing a unique saliva-based test to detect SARS-CoV-2 peptides in saliva, which is expected to be more sensitive, less invasive, and less expensive than current methods. The test aims to detect mild or asymptomatic COVID-19 cases and will be available by March 2021.
NYU Dentistry's Bridging the Gap program aims to expand dental workforce with skills and commitment to patients with disabilities. The five-year grant will integrate training into NYU's Advanced Education Program in Pediatric Dentistry, creating new curricula for general dentists and dental hygienists.
A new study found that fecal transplants can reduce intestinal permeability in patients with non-alcoholic fatty liver disease (NAFLD), a condition associated with metabolic syndrome and autoimmune diseases. The treatment shows promise for improving gut health and preventing further inflammation.
A University of Toronto team has been awarded a $1.5 million grant to study the impact of cannabis use on Indigenous oral health in Canada. The study will gather first evidence of the effects of cannabis on Indigenous populations, working in partnership with communities and public health authorities.
A new mobile app assesses risk factors and key biomarkers from blood tests to produce a COVID-19 severity score. The tool has been validated using data from over 1,000 New York City patients, confirming its ability to identify those at high risk for severe cases.
NYU Dentistry researcher Yi Ye has received a $2.2 million NIH grant to investigate how oral cancer cells invade nerves and cause pain. Her study aims to understand the role of Schwann cells in this process and identify potential targets for treating oral cancer-related pain.
A new study published in Scientific Reports found that teeth contain annual layers, or cementum bands, that record an individual's life experiences, including reproduction and menopause. The research uses microscopic examination to reveal connections between tooth formation and other life stages.
Researchers found that patients prescribed opioids after tooth extraction reported worse pain, and half of prescribed opioids remained unused. The study suggests that alternatives such as nonsteroidal anti-inflammatory drugs or acetaminophen control pain better and improve patient satisfaction.
A new study led by NYU College of Dentistry researchers found that vaping alters the oral microbiome, making users more prone to inflammation and infection. E-cigarette users were found to have different bacteria in their mouths compared to smokers and non-smokers.
Researchers at NYU College of Dentistry discovered that excessive fluoride causes dental fluorosis by altering calcium signaling, mitochondrial function, and gene expression in tooth enamel cells. This understanding provides a promising mechanistic view of how fluorosis arises.
A new study by West Virginia University researchers links higher concentrations of perfluorodecanoic acid in children's blood to increased tooth decay rates. The chemical, found in some drinking water systems, may disrupt the healthy development of enamel, making teeth more susceptible to cavities.
A study led by McGill University found that anti-inflammatory medications are most effective when taken during the active periods of our biological clocks, promoting post-operative healing and recovery. This discovery suggests a new approach to treating pain and inflammation following surgery.
A miniaturized tooth system, called a 'tooth-on-a-chip,' mimics a human molar to study how teeth respond to dental materials and bacteria. The device could lead to more effective cavity fillings that last longer and work better for each patient.
Researchers used specialized MRI techniques to follow patients with mild to moderate asthma over six years, finding consistent ventilation defects that persist over time. The studies refute the long-held belief that these defects are random and widespread, opening up opportunities for patient-specific treatments.
The article highlights the importance of behavioral sciences in dentistry, expanding the understanding of oral health beyond 'disease' to a broader concept. Recent studies have shown promising results in employing cognitive behavioral therapy for managing dental anxiety and pain, as well as addressing oral health inequalities.
The Journal of Dental Research Centennial article 'The Evolution of Neuroscience as a Research Field Relevant to Dentistry' highlights novel insights gained through neuroscience research into pain, sensorimotor disorders and neural pathways. The study reveals the clinical relevance of these findings for diagnosis and management of diso...
A new study published in JAMA found that patients with kidney dysfunction who were prescribed high doses of the muscle relaxant baclofen were more likely to experience cognitive-related symptoms such as severe confusion. The research team analyzed data from over 16,000 patients and found a significantly higher risk of hospitalization a...
The discovery of osseointegration has led to high clinical performance of oral implants, but peri-implant soft tissue complications can jeopardize osseointegration. Early intervention in situations with peri-implant mucositis is crucial for preventing peri-implantitis.
The article reviews the evolution of esthetic dentistry, highlighting advances in dental research and clinical interventions, including universal esthetic rules and guidelines, tooth whitening, and digital technologies.
A new CRISPR delivery system developed by Western University researchers enables targeted attacks on specific bacteria, including Staph A and E. coli. This breakthrough has the potential to create personalized antimicrobial agents and revolutionize the treatment of bacterial infections.
The International Association for Dental Research celebrates its centennial with a special article highlighting key successes in tooth bioengineering and regenerative dentistry. Researchers discuss promising developments, including whole tooth tissue engineering and the potential for improved dental repair therapies.
A pipeline program called Saturday Academy at NYU College of Dentistry has shown to increase interest in the health professions, particularly dentistry, among underrepresented high school students. The program exposes students to the field through instruction and hands-on learning, mentoring them through the college application process.
Researchers from UCLA School of Dentistry developed a new hydrogel that promotes tissue repair and regeneration, inducing stem cell migration to enhance bone healing. The clay-enhanced hydrogel has a more porous structure, improving its ability to deliver cells to defective areas.
A new study from Western University found that tRNA gene mutations can cause misreading of the genetic code, leading to protein malfunction. Researchers discovered an average of 66 variants in tRNA genes among individuals in London, Ontario, suggesting a potential link between these mutations and human diseases such as Alzheimer's.
A commentary by UCSF experts highlights the need for radical reform in addressing dental decay, citing the sugar industry's influence on dental research and professional bodies. The authors recommend policies to manage financial conflicts of interest and promote public trust.
The Lancet series, co-authored by NYU's Benzian, advocates for a radical shift in oral healthcare, prioritizing prevention over high-tech treatments. The authors propose policy changes to reduce sugar consumption and stronger regulations on advertising, aiming to improve global oral health and reduce inequalities.
Researchers at Far Eastern Federal University have discovered chromophobe cells that contribute to human tooth development. The findings provide a basis for developing bioengineering therapies in dentistry and gastroenterology, potentially leading to more effective treatments with longer-lasting implants.
Researchers at Western University and Lawson Health Research Institute have found that senescent cells contribute to the growth of ascending aortic aneurysms. The study suggests that therapies targeting these cells could prevent or slow down aneurysm growth, potentially saving lives.
Walter Siqueira, a renowned researcher, has been recognized with the 2019 Salivary Research Award for his groundbreaking work on salivary gland structure, secretion, and function. His contributions have significantly improved our understanding of oral health, and he continues to inspire new research in this field.
S. Jeffrey Dixon, a Professor at Western University, received the 2019 IADR Distinguished Service Award for his outstanding contributions to the CADR and IADR. He has published numerous papers on mineralized tissue research and served as an editorial board member.
Scott L. Tomar, a University of Florida professor, received the 2019 AADR Jack Hein Public Service Award for his efforts to understand and eliminate disparities in oral health and tobacco epidemiology. He has also made significant contributions to various reports on tobacco and public health, including those by the U.S. Surgeon General.
Marco Bottino, a University of Michigan researcher, received the IADR Academy of Osseointegration Innovation in Implant Sciences Award for his work on customized 3D-printed PEEK-AMP dental implants. The award recognizes Bottino's research on bioactive dental implants that enhance osseointegration and improve oral rehabilitation.
Asbjørn Jokstad, a Professor at Arctic University of Norway, is recognized for his contributions to prosthodontic and implant research. He received the 2019 Research in Prosthodontics and Implants Award from the International Association for Dental Research for his outstanding research accomplishments.
Dagmar Else Slot, a renowned researcher, has been awarded the 2019 Young Investigator Award by the International Association for Dental Research (IADR) for her groundbreaking work on oral infections and inflammation. She is recognized for her contributions to evidence-based dentistry and prevention of periodontal diseases.
A NIOSH-funded study is assessing how dental professionals come into contact with vapors, gases, and airborne dusts in clinics. The researchers will measure the size and concentration of particulates in real-time during common dental procedures.
Research reveals undetected glucose disorders significantly increase risk of myocardial infarction and severe periodontitis, prompting closer collaboration between dentistry and healthcare. The study emphasizes the importance of considering patients' dental health in diabetes diagnosis.
Researchers at the University of Toronto have discovered two distinct neutrophil states in blood, which vary depending on patient health and infection status. These findings may lead to new models for disease detection and monitoring, such as tracking primed neutrophils to predict inflammatory diseases.
A recent study published in the Journal of the American Dental Association found that patients who received comprehensive oral care as part of their substance use disorder treatment had a significant increase in completing their treatment programs. The results show that participants who underwent FLOSS (Facilitating a Lifetime of Oral ...
Dentist Sharukh S. Khajotia is investigating decay and tooth-colored filling materials to extend their lifespan, potentially saving patients' tooth structure and reducing healthcare costs.
A significant rise in oral cancer and pre-cancerous lesion detection by dentists in Ontario is reported, with a nearly doubling of cancers detected between 2005 and 2015. The study suggests that comprehensive training and continuing education programs for oral health professionals may be behind the dramatic increase in detection rates.
A study led by NYU Dentistry researchers reveals that a mutation in the ORAI1 gene causes calcium deficiency in enamel cells, leading to defective dental enamel mineralization. The study identified ORAI1 as the dominant protein for calcium influx and provided insights into the mechanisms by which calcium affects enamel cell function.
A Canadian study of over 2,400 families found that spending two hours or more of screen time per day is associated with clinically significant behavioral problems in preschoolers. Organized sports and good quality sleep were also identified as protective factors against the negative effects of screen time.
The new technology provides a 360-degree, three-dimensional view of surgical tools and surrounding tissue for more precise needle placement. This allows for improved dose pattern distribution to the tumour and surrounding tissue, reducing complication rates.
Primary care dentists missed 67% of bone loss and 40% of tooth decay on dental x-rays when given limited time to assess them. When not under pressure, the participants diagnosed correctly, all pathologies related to bone loss and tooth decay, on average.
A study by Newcastle University reveals that the NHS dental budget is not being spent efficiently, with too much focus on orthodontics and specialist oral surgery. The team recommends investing in prevention measures and making services more accessible, such as opening new high street practices.
Poorer cognitive function in older adults is associated with poorer oral health and a higher risk of tooth loss. A study of 4,416 UK adults found that those with lower cognitive function scores had a 39% higher odds of tooth loss compared to those with higher scores.
A new dental filling material made with thiourethane could significantly extend its lifespan, reducing the need for frequent fillings and related complications. The material has been shown to be two times more resistant to breakage than standard fillings.
A new study by NYU College of Dentistry suggests that self-care techniques, such as jaw exercises and warm compresses, should be the first line of treatment for muscle-related temporomandibular disorder (TMD). The study found that patients with TMD reported significant improvement in their pain from these non-medication treatments.