A new imaging system, cryo-MOST, has been developed to monitor brain changes indicative of Alzheimer's disease in mouse models. The system uses autofluorescence to image senile plaques with micron-level resolution, improving the understanding of disease progression and facilitating the development of new treatments.
Researchers found Parkinson's disease reduces olfactory bulb glomerular volume by over half and alters their distribution, suggesting a key role for Lewy bodies in triggering the disease. The study provides new insights into the anatomical link between Parkinson's disease and impaired sense of smell.
Chronic wasting disease is a fatal neurodegenerative disease affecting deer and farm animals, with limited effectiveness of past management strategies. New research proposes controlled forest fires as a risk control strategy, aiming to reduce the spread of prions shed by animal waste and carcasses.
Research presented at ESC Congress found that poor sleep is associated with increased risk of ischemic heart disease and stroke. The study revealed different patterns of sleep disturbance between the two conditions, with patients with ischaemic heart disease experiencing shorter sleep and brief moments of waking up.
A new test has been developed to differentiate between Lyme disease and Southern Tick-Associated Rash Illness (STARI) with an accuracy of up to 98 percent. This breakthrough offers improved early detection and diagnosis for Lyme disease, a vector-borne illness affecting the US.
A new study published in The Lancet suggests that a diabetes drug may have disease-modifying potential to treat Parkinson's disease, improving motor function in patients. Researchers found that people with Parkinson's who used exenatide for one year performed better in movement tests than those who injected a placebo.
Researchers have discovered molecular basis of hereditary Alzheimer's disease, revealing a crucial role in the cleavage process of APP protein. Stabilizing Gamma Secretase-APP interaction may prevent release of toxic amyloid beta fragments, delaying or preventing the disease.
A study by Tufts University researchers found significant changes in miRNA expression levels in dogs with myxomatous mitral valve disease (MMVD) and congestive heart failure. The study identified new genomic biomarkers, including exosomal miR-181c and miR-495, which could provide insight into diagnosis and therapies for MMVD and human ...
The University of Plymouth has developed HDNetDB, the first freely available data network for scientists researching Huntington's disease. This resource links various cellular processes in a molecular network and provides a more holistic view of the disease.
A study found significant abnormalities in Parkinson's disease patients' visual systems, including optic radiations alterations and white matter concentration reductions. These changes may serve as biomarkers for early detection and monitoring of the disease.
Researchers from the Wellcome Trust Sanger Institute and their collaborators have created a high-resolution map of the disease, pinpointing 18 genetic variants with over 95% certainty. This breakthrough has significant implications for the development of new treatments and personalized medicine for IBD.
A genetic study suggests that human genes for coronary artery disease contribute to greater numbers of children, providing an evolutionary trade-off between early-life reproductive benefits and later-life disease costs. The study uses genome-wide scans and lifetime reproductive data to identify genetic variation linked to the disease.
A gene variant protecting against Alzheimer's disease significantly decreases plasma beta-amyloid levels in a population cohort. The findings provide support for the amyloid cascade hypothesis and offer insights into future research directions.
Researchers have identified a genetic modifier associated with the rate of progression in Huntington's disease. The study used high-quality data from two cohorts and found a significant result linked to the MSH3 gene.
Researchers analyzed data from over 50 million people and found that prior statin use was associated with a higher risk of developing Parkinson's disease. The association was more noticeable in people taking lipophilic statins, and was most robust for those using the medication for less than two-and-a-half years.
Researchers found that intestinal fungi exacerbate liver disease and can be protected against by antifungal treatment. Fungi overgrowth leads to inflammation, which kills liver cells and promotes disease progression.
The National Institute on Aging has renewed Penn Medicine's Alzheimer's disease genetics data repository, providing $7.7 million in funding over five years. The site gathers and organizes genetic data to aid researchers in understanding the disease's origins and potential prevention and cure strategies.
A large international study of over 3.2 million people with severe mental illness found a substantially increased risk for developing cardiovascular disease compared to the general population. People with SMI have a 53% higher risk and an 85% higher risk of dying from cardiovascular disease.
Researchers analyzed DNA samples from over 95,000 participants to examine the association between Alzheimer's disease and low BMI. The study found no causal relationship, suggesting that individuals with Alzheimer's disease are more likely to have low BMIs due to weight loss in the early stages of the disease.
Peripheral artery disease affects 200 million people worldwide, but less than half receive appropriate medication and lifestyle counseling. This study highlights the need to improve quality of care for high-risk individuals, who are at risk of adverse outcomes such as coronary heart disease, heart attacks, and strokes.
A study published in The BMJ found no association between long-term gluten intake and the risk of coronary heart disease in people without celiac disease. However, restricting dietary gluten may lead to a low intake of whole grains, which are associated with cardiovascular benefits.
A study of over 100,000 participants found that dietary gluten is not associated with an increased risk of heart disease in people without celiac disease. Limiting whole grains as part of a low-gluten diet may actually increase the risk of heart disease in these individuals.
Despite gaps in scientific understanding, Lyme disease researchers have identified key areas of agreement and promising strategies for controlling the disease. These include reducing deer populations to impact tick abundance and using acaricides to target host animals.
A new study found that increased biodiversity is not associated with reduced levels of infectious disease, and in some cases, disease burdens actually increased as areas became more forested. However, increasing urbanization was shown to reduce disease due to improved access to medical care and vaccinations.
A worldwide analysis of over 3,000 patients reveals that those with alcoholic liver disease (ALD) are nearly 12 times more likely to be referred at an advanced stage than early. Early liver disease was defined as liver disease without evidence of advanced fibrosis or cirrhosis.
A study published in the Journal of Alzheimer's Disease found that individuals with a genetic predisposition to Alzheimer's disease had difficulty distinguishing novel figures called Greebles, even when others could not. This method may allow for earlier detection and potential treatment of the disease.
A prospective observational study found a high association between grey hair and coronary artery disease in adult men. Researchers discovered that as age increases, so does the incidence of both atherosclerosis and hair greying due to similar biological pathways.
A recent study found that psychiatric disorders do not increase the risk of Alzheimer's disease, contrary to previous assumptions. However, the study suggests that some psychiatric disorders may be prodromal symptoms of Alzheimer's disease, highlighting the importance of proper differential diagnostics.
Gum disease and tooth loss are linked to a higher risk of death in postmenopausal women, according to new research. The study, which analyzed data from over 57,000 women, found that history of periodontal disease was associated with a 12% higher risk of death from any cause.
A new study found that gum disease and tooth loss may increase the risk of death in postmenopausal women, but not cardiovascular disease risk. Loss of all natural teeth was also associated with a higher risk of death.
A new study has developed a score called the Intermountain Chronic Disease Risk Score (ICHRON) that uses routine blood tests and age to measure future risk of chronic disease. ICHRON predictions are 77-78% accurate in identifying patients who'll be diagnosed with a chronic disease within three years.
Researchers assessed 6,711 adults with periodontal disease for 15 years and found participants with mild, moderate or severe gum disease were 1.9-2.2 times more likely to suffer an ischemic stroke than those without periodontal disease. The association was strongest in cardioembolic and thrombotic stroke subtypes.
Researchers found that people with severe gum disease had higher HbA1C values and were more likely to have pre-diabetes or suspected diabetes. This suggests that severe gum disease may be an early sign of undiagnosed diabetes, making screening in dental practices a feasible option.
Researchers have identified early biomarkers of Huntington's disease in a five-year-old HD sheep, revealing metabolic changes prior to physical symptoms. These findings suggest that the disease affects important bodily processes before they become apparent, and could lead to the development of new treatments.
Lyme disease affects approximately 329,000 people annually in the US, with a focus on understanding how Borrelia burgdorferi adapts to survive in tick vectors and mammalian hosts. Dr. Seshu's research seeks to find better solutions to prevent the spread of Lyme disease.
The new biobank aims to alleviate the lack of samples for researchers studying Lyme disease. With over 250 individual participants, it offers a unique opportunity to explore potential new diagnostics against various bacterial strains.
Chronic kidney disease patients spent a median $1,439 in annual out-of-pocket costs, compared to $770 for cancer patients and $748 for stroke patients. The study found that these high costs are due to the need for multiple medications and frequent doctor visits.
A USGS-led study found that high temperatures and lower humidity kill off ticks that transmit Lyme disease, making it less common in the South. The researchers discovered that southern black-legged ticks tend to stay hidden under leaves to retain moisture, increasing their survival rates.
Researchers identified genetic variants that affect Crohn's disease severity, but found these variants do not determine individual risk of developing the condition. The study suggests new pathways for treating established disease.
Researchers identified a link between Huntington's disease and dysfunction of the subthalamic nucleus, leading to progressive loss of nerve cells and debilitating symptoms. The study suggests that early problems in the subthalamic nucleus contribute to the development of the disease.
A study published in Nature Medicine identifies bone marrow-derived immature myeloid cells as the source of suPAR, a reliable marker for chronic kidney disease. Elevated suPAR levels have been linked to future chronic kidney disease, potentially enabling early intervention and prevention of recurrence after transplant.
A recent study from the University of Eastern Finland found that hip fracture risk is higher among those with Alzheimer's disease. Regular assessments of medications and targeted interventions such as exercise, home safety assessment and modification, and medication reviews are proposed as feasible approaches to reduce this risk.
A study found that gut microbes exacerbate motor symptoms in a mouse model of Parkinson's disease, but antibiotic treatment and germ-free environments reduced motor deficits. The research could lead to new treatments for the neurodegenerative disease.
A QUT study reveals foot disease affects 10% of hospital patients, with half hospitalized due to the condition. The study estimates $4.7 billion annual cost and fills nearly 5,000 hospital beds each night.
A study published in PLOS Neglected Diseases reveals that Chagas disease has a significant presence in the Rio Grande Valley of Texas, affecting up to 30% of those infected with Trypanosoma cruzi developing fatal cardiomyopathy. The research estimates 4,600 people are currently infected and 1,300 at risk for cardiac disease.
Research reveals a strong connection between fatty liver disease and cardiovascular disease, with individuals with fatty liver at higher risk of developing high blood pressure, type 2 diabetes, and cardiovascular diseases.
Research reveals that 56% of people aged 90 and above with Alzheimer's disease rely on antipsychotics and antidepressants, highlighting the need for regular assessment of drug use in older adults. In contrast, those without Alzheimer's disease used these medications less frequently.
A recent study analyzing data from the National Health and Nutrition Examination Surveys (NHANES) 2009-2014 found that celiac disease prevalence remained stable at 0.70%, while adherence to a gluten-free diet increased from 1.08% in 2009-2010 to 1.69% in 2013-2014.
Researchers at the University of Georgia have discovered a new drug that can be administered orally to treat human African trypanosomiasis, a parasitic disease affecting rural communities in sub-Saharan Africa. The study's lead author hopes to accelerate development of new treatments for this complex disease.
A gene signature in healthy brains predicts the spread of Alzheimer's disease and identifies vulnerable brain regions. The discovery may lead to preventative treatments for at-risk individuals.
Scientists have developed a new method to measure the activity of disease-causing mutations in the LRRK2 gene, a major cause of inherited Parkinson's disease. The breakthrough could help pave the way for a clinical test that could facilitate evaluation of drugs targeting this form of the condition.
A new Australian-first study found that nearly half of patients hospitalized due to diabetic foot disease were already showing symptoms. Diabetic foot disease causes significant costs, with estimated annual direct costs reaching $350 million for hospitalization alone.
Researchers have identified a molecule, NCGC607, that shows promise as a possible treatment for Gaucher disease and Parkinson's disease. The molecule helps to break down cellular waste and reduce alpha-synuclein levels, suggesting a potential treatment strategy.
A new biomarker, phosphorylated protein kinase LRRK2, has been found in patient urine samples and correlates with the presence and severity of Parkinson's disease. Elevated levels of this biomarker predict the risk for onset of Parkinson's disease and may be a promising guide for future clinical treatments.
Researchers at Johns Hopkins Medicine discovered that blocking the enzyme c-Abl prevents Parkinson's disease symptoms in specially bred mice. The study also found that a chemical tag on the protein α-synuclein may signal the disorder's presence and progression. The findings suggest both a promising target for drug research and a potent...
Researchers at the Babraham Institute have developed a technique to replicate early changes in Alzheimer's disease in a lab-dish model. This breakthrough allows for the study of the disease's progression and potential treatments without animal testing.
A systematic review of 45 studies found that higher whole grain consumption was associated with reduced risks of coronary heart disease, cardiovascular disease, and mortality from various causes. The researchers recommend increasing whole grain intake to reduce chronic disease risk.
By transplanting healthy human glia cells into mice with Huntington's disease, researchers were able to reduce symptoms and slow disease progression. The transplanted cells restored normal neuronal activity and rescued nerve cells at risk of death.
Researchers discovered a novel gene, TMEM230, associated with Parkinson's disease that affects neurotransmitter trafficking between neurons. This new link may lead to novel treatments and better understanding of neurodegenerative diseases.
Researchers found that human activities drive disease distributions at local scales for diseases like West Nile virus and Lyme disease, while climate change impacts regional scales. The study highlights the importance of considering multiple spatial scales to understand human ecological impacts on biodiversity and disease emergence.