Scientists at Michigan State University found that a natural probiotic supplement can enhance bone density in male mice, but not female mice. The study suggests a possible new treatment for osteoporosis without the risks of traditional medications.
A new study found that chemicals secreted by good bacteria can reduce the frequency and severity of necrotizing enterocolitis (NEC) in premature infants. The treatment, which uses purified secretions from probiotic bacteria, shows promise as a targeted preventive strategy without the broad effects of steroids.
A new study published in the Journal of Applied Physiology, Nutrition, and Metabolism found that consuming high fructose corn syrup (HFCS) and sucrose at average daily levels does not increase liver fat. The findings add to scientific evidence that HFCS and table sugar are metabolically equivalent.
Researchers created an optimized parvalbumin protein, ParvE101Q, that acts as a 'calcium sponge' for heart muscle, allowing efficient relaxation after contraction. This discovery offers a promising step forward in solving diastolic heart failure, a common killer of both men and women.
Researchers used iPSCs to study the physiological basis of arrhythmias in a patient with LQTS. The results identified a specific regimen for correcting aberrant ion channel activity, offering promise for individualized drug therapies.
A study by US Department of Agriculture scientists found that a lady beetle's diet influences its feeding patterns and physiology. The research suggests that plant material provides key nutrients lacking in insect prey diets, making mixed diets healthier for the beetles.
Jonathan Wisco, associate professor at Brigham Young University and UCLA, receives the Basmajian Award for his outstanding contributions to teaching and research in anatomy. He has increased teaching responsibilities and established a laboratory to support translational anatomy research.
Researchers found that high school athletes experienced compromised focus and task-switching abilities for up to two months after brain concussions. The study's findings suggest that athletes may need longer recovery periods than current practices dictate to minimize the risk of subsequent concussions.
Research at George Washington University reveals that genetic lesions associated with autism disrupt cellular mechanisms for interneuron development. LaMantia found that the Cxcr4 cytokine receptor plays a crucial role in regulating interneuron migration.
The MBL physiology course fosters a culture of curiosity and innovation among students, leading to the generation of 23 research papers and 59 meeting abstracts. The course's unique approach combines cell biology and physical sciences, and encourages students to think beyond their comfort zones.
Researchers discovered that basal cells initiate repair and serve as progenitor cells after chlorine gas exposure, helping restore new tissue in the airways. Understanding this process can aid in developing treatments to prevent scarring and asthma-like breathing problems.
A new study investigated muscle weakness in a mouse model of Down syndrome and found that factors in the nervous system may play a more dominant role in explaining muscle weakness. The research team discovered altered pathways in DS muscle, including breakdown of proteins and neuromuscular transmission.
The Medical College of Georgia at Augusta University has been awarded a three-year, $186,200 grant to advance the education and scientific discovery in physiology. The grant supports the exchange of graduate students and postdoctoral fellows with the University of São Paulo-Ribeirão Preto in Brazil.
Researchers identified evidence of immune system involvement in autism development through novel genome analysis approaches, supporting a common molecular physiology behind the condition. Viral infection pathways were found most important in this immune-related mechanism, potentially affecting brain development.
A group of parasites hijack their victims' nervous systems, reducing them to helpless zombies. These manipulators can have a significant impact on ecology, physiology, and evolution, orchestrating the behaviour of vertebrates and invertebrates.
Researchers at OHSU School of Dentistry discovered a direct role of BDNF in regulating blood pressure, which may help prevent or treat high blood pressure. The study found that BDNF levels increase dramatically in nerve cells during hypertension.
Dr. Aristotle Voineskos has won the prestigious Polanyi Prize for his research combining brain imaging and genetics to improve diagnostic classification and treatment strategies for severe mental illness.
Researchers found that diabetic rats on a high protein diet with arginine and proline showed better wound healing compared to those without supplementation. The study suggests that arginine and proline enrichment could offer new hope for effective treatment in diabetic patients with chronic wounds.
Researchers have mapped the domestic pig's genome, uncovering genetic traits that could improve animal health and share similarities with human physiology. The sequenced genome includes genes associated with disease resistance, immune mechanisms, and protein abnormalities linked to various human diseases.
A recent study published in Journal of Applied Physiology suggests that ceramide, a fat molecule, may contribute to muscle loss in older adults. The researchers found that older men had higher levels of ceramide in their muscles compared to younger men, and this was associated with reduced leg muscle mass.
Researchers discovered MICU1's crucial role in regulating mitochondrial calcium uptake, preventing overload and cellular stress. The protein acts as a gatekeeper, setting a brake for calcium influx to maintain beneficial levels.
A new study found that sleep architecture, not just duration, affects hunger and food intake in healthy adults. Researchers discovered that shorter stages of deep sleep and less REM sleep are associated with higher hunger levels and increased calorie consumption from fat and carbohydrates.
A study found that adding the prebiotic fructooligosacharide (FOS) to the diets of pediatric patients with intestinal failure can increase gut growth and function. The prebiotic converts into butyrate, a short-chain fatty acid that enhances nutrient digestion and absorption.
Research suggests that pulmonary vaccine delivery can induce a local immune response more effectively than traditional injections, potentially combating pathogens that cause pulmonary diseases. The unique physiology of the respiratory tract makes it an attractive alternative to injections.
The editorial discusses the evolution of doping scandals from ancient times to modern-day sports, highlighting the need for continuous innovation in detection methods. Bowers emphasizes the importance of analytical skills, pharmacokinetics, and human physiology in preventing abuse in sport.
A team of scientists will enroll 250 people living with HIV/AIDS in a clinical study to compare an intervention with a Holistic Health Recovery Program adapted for Alcohol Use Disorders, aiming to enhance patients' awareness and modify behaviors that promote HIV disease progression.
A 1.5-million-year-old skull fragment from Tanzania shows signs of anemia caused by a nutritional deficiency, suggesting regular meat consumption in early hominids was common. The discovery supports the idea that early human ancestors were hunters and had a physiology adapted to regular meat consumption.
A study in The Journal of General Physiology reveals that CFTR's mechanism is akin to ABC transporters, with ATP hydrolysis underlying its unidirectional cycling. This finding provides new evidence for the functionality of a protein crucial to cystic fibrosis research.
A recent study on rhodopsin in Xenopus rod photoreceptor cells reveals that the geometry of micro-compartments formed by incisures affects its signaling. The researchers found that boundary geometry, rather than heterogeneity in diffusion or bound fraction, explains differences in rhodopsin distribution
Researchers at Rice University and three other US institutions are embarking on a five-year study to uncover the causes of hemoglobin toxicity in blood plasma. The study aims to develop strategies to prevent, reduce or reverse acellular hemoglobin toxicity.
A new study reveals that gut microbes can increase the absorption of dietary fats, allowing the body to extract more calories from the same amount of food. Firmicutes bacteria are found to play a key role in this process, and their abundance is influenced by diet.
A recent study in the Journal of General Physiology reveals that Kv potassium channels are not regulated by physiological changes to PIP2. In contrast to inward rectifier channels, various members of the Kv channel family were unaffected by PIP2 depletion, suggesting a previously unknown mechanism for their regulation.
A study published in the American Journal of Physiology found that 30 minutes of daily exercise resulted in significant weight loss and calorie burn, surpassing 60 minutes. The research, led by Mads Rosenkilde, also revealed that participants exercising 30 minutes per day had higher motivation to engage in physical activity.
A recent study published in Functional Ecology forecasts that tropical cold-blooded organisms are less likely to go extinct due to climate change. The researchers found that the 'hotter is better' theory suggests species adapted to warmer environments may evolve faster and be more resilient.
Research published in the FASEB Journal reveals a link between maternal stress and abdominal obesity in mice offspring. The study found that manipulating the neuropeptide Y system in visceral fat may prevent stress-induced obesity, offering potential insight into how to counteract the negative effects of stress.
Researchers at the University of Alberta discovered a link between sodium and calcium regulation in the body. Excessive sodium intake can lead to calcium depletion, causing thin bones and osteoporosis, while high urine calcium levels increase the risk of kidney stones.
Researchers discovered that Candida albicans can distinguish between healthy and unhealthy hosts by altering its physiology based on the levels of protein Efg1p. In immunocompromised patients, fungal cells with lower levels of this protein thrive, leading to serious infections.
The Wyss Institute is developing an automated instrument that integrates 10 human organs-on-chips to study complex human physiology outside the body. This will accelerate assessment of drug safety and efficacy, informing regulatory decision-making.
Researchers are using inactive, fat rats to study childhood obesity and its complex relationship with diseases. Studies show that children who are inactive in childhood are more likely to continue this habit into adulthood and develop consequences such as diabetes and cardiovascular disease.
Scientists have created a new laboratory opossum model to study nonalcoholic steatohepatitis (NASH), a common liver disease affecting up to 15 million Americans. The study found that high responders carried a mutated ABCB4 gene, leading to cholesterol accumulation in the liver and potential development of NASH.
Research reveals that American water shrews heat their bodies immediately before diving into cold water, increasing foraging efficiency and potentially allowing them to survive longer underwater. This unexpected behavior challenges prevailing dogma on the physiology of divers.
Researchers at the University of Alberta discovered a link between DHA intake and improved memory, with higher levels of DHA in the hippocampus leading to better cell communication. Supplementing with DHA may help prevent age-related declines in brain DHA levels.
A new study in Nature finds that the presence of lines of arrested growth (LAG) in dinosaur bones does not indicate ectothermy. Instead, LAGs provide insight into how animals adjust their metabolism in response to seasonal changes.
A natural compound found in fruits, nuts and red wine has shown improved physical performance and endurance in lab models. Researchers plan to test resveratrol on diabetics with heart failure to improve heart function and exercise capabilities.
New research from McMaster University debunks the bodybuilding myth that growth-promoting hormones stimulate strength after weightlifting. Contrary to conventional wisdom, anabolic hormones do not influence muscle protein synthesis, leading to bigger muscles.
Researchers found that elevated erythropoietin in the brain improved motivation for higher exercise performance in mice. The study suggests a potential new approach to increasing physical activity, which could benefit people with mental health disorders and other health problems.
Dr. Richardson's research focuses on the role of basic bacterial physiology in the virulence of human pathogens, with a particular emphasis on Staphylococcus aureus. His work has shown that certain compounds can be lethal to the pathogen, leading to new insights into the battle between host and bacterium.
Anthony R. Richardson has been honored with the Merck Irving S. Sigal Memorial Award for his pioneering work on the metabolic adaptations of Staphylococcus aureus to host immunity. His research has profound implications for understanding the evolution and emergence of highly virulent pathogens.
Researchers genetically modified kidney cells to produce a protein that promotes cell growth and regeneration. The transplanted cells engrafted themselves into damaged kidneys, resulting in improved function and limited physical damage. This breakthrough has significant implications for the treatment of human kidney failure.
A study published in the Journal of Applied Physiology found that runners can improve their performance and health by reducing their training time to 20-30 minutes per session. The research involved 18 moderately trained runners who followed the 10-20-30 training concept, which consists of 5-minute running intervals with rest periods.
Researchers at the University of Bristol identified a simple yet crucial neural pathway in Xenopus frog tadpoles that initiates swimming. This discovery sheds light on how locomotion starts and may lead to new treatments for movement disorders like Parkinson's disease.
A new UCLA study reveals that a high-fructose diet can slow the brain and impair memory and learning. However, adding omega-3 fatty acids to the diet may help minimize this damage.
The review article explores how extrafollicular environments regulate hair and feather stem cell activities, as well as the role of stem cells in shaping organ forms. Researchers hope to apply this knowledge to develop regenerative medicine techniques for repairing damaged tissues, including fingers and toes.
Researchers at the University of Washington have found that cells in blood vessel walls pull more tightly together when flowing past rapidly, reducing vascular leakage and potentially leading to new drug designs and improved surgical procedures. This discovery highlights the role of cellular forces in the progression of cardiovascular ...
Researchers at Harvard's Wyss Institute have created a living human gut-on-a-chip that mimics the structure, physiology, and mechanics of the human intestine. The device supports the growth of living microbes and could help understand intestinal disorders such as Crohn's disease.
Gut bacteria influence intestinal blood vessel formation through a previously unknown mechanism, according to researchers at the University of Gothenburg. The study found that intestinal bacteria promote mucosal cells to attach sugar molecules to specific proteins, inducing signaling for new blood vessel formation.
Researchers have gained a realistic insight into the operation of the P2X1 receptor, a key player in blood clotting. By visualizing the receptor's structure and detecting changes upon activation, scientists have identified a crucial mechanism that could lead to the development of new drugs to prevent strokes and heart attacks.
Research by Penn State found that breathing cold air during exercise causes uneven oxygen distribution throughout the heart, particularly in those with coronary artery disease. Healthy individuals can redistribute blood flow, but those with heart problems may not be able to compensate, making activities like shoveling snow dangerous.
A University of Colorado Boulder study found that continued practice after mastering a task can decrease overall energy costs by up to 20%, making movements more efficient. The research, led by Assistant Professor Alaa Ahmed, used robotic arm exercises to measure metabolic cost and muscle activity in test subjects.
Researchers used single-molecule fluorescence microscopy to visualize myoV molecules walking along actin filaments in real-time. The study found that myoV can take multiple hand-over-hand steps without falling off its track, making it well-suited for intracellular cargo transport.