Researchers have developed a generative AI model called Void-X that can predict protein-protein interactions with high accuracy, enabling the design of new biomolecules for drug discovery and synthetic biology. The model achieves predictive accuracies of 78.3% for intra-chain clusters and 68.2% for inter-chain clusters.
Researchers propose a thermochemical mantle plume formation process for the Ontong Java Plateau, contradicting previous hypotheses. The model explains spatial variations in crustal thickness and lava composition across the plateau.
Researchers have identified a deep Earth dynamic mechanism responsible for the formation of widely distributed seamounts. The study extends and refines the classical mantle plume model by pinpointing asthenospheric thermal anomalies as key factors in generating volcanic activity.
The JUNO Collaboration has made the high-precision measurement of two key oscillation parameters, reducing associated uncertainties by a factor of 1.6 compared to past decades. This result validates detector performance and analysis methodology, establishing JUNO as a key player in precision neutrino oscillation physics.
A team of researchers identified a small peptide signal that senses cold during pollen development, allowing crops to shield themselves from sudden climate shocks. The discovery offers a powerful genetic strategy to protect crop yields while maintaining performance under favorable conditions.
Researchers have documented the world's deepest and largest known aggregation of whale fossils and active whale-fall ecosystems in the Diamantina Zone of the southeastern Indian Ocean. The discovery, a 'whale necropolis,' reveals insights into deep-sea life, evolution, and dispersal.
Scientists have isolated a key gene from maize's wild ancestor, teosinte, which enhances seed protein content. The study reveals the molecular mechanism behind the decline in maize protein content during domestication and provides a powerful genetic tool for breeding high-protein maize varieties.
Researchers discovered that supergiant deep-sea isopods have a dual survival strategy to cope with nutrient-poor conditions: an enlarged stomach for storing food and extremely low basal metabolic rate. This allows them to thrive in extreme environments.
Scientists have developed a genome engineering platform that enables simultaneous gene knockout, base substitution, insertion, deletion, duplication, and inversion in a single framework. The TRIM platform integrates multiple desirable traits by combining gene knockout with prime editing-based sequence modification.
A new study reveals that IS110 elements use two RNA-guided pathways to insert donor DNA into target sites, challenging the classical 'cut-out-paste-in' model. The researchers identified a figure-eight DNA intermediate in one pathway and a direct-transfer pathway without forming a conventional intermediate.
Small reservoirs worldwide are losing storage capacity at a rate of 7.3% per decade, affecting billions of people. The study identifies 16 global sedimentation hotspots and estimates that over half of global reservoirs may experience functional degradation by 2060.
Researchers from six Asian countries have launched a coordinated effort to create an artificial single-celled biological system. The 10-year roadmap aims to develop stable phospholipid vesicles with minimal genomes, endogenous synthesis of key metabolites, and true self-replication.
Researchers studied Chang'e-5 lunar regolith, identifying nanoscale evolution of surface materials through impact-induced silicate phase separation and formation of metallic iron. The findings provide new insights into spectral evolution of the Moon and processes responsible for forming lunar impact glass.
A study found that a mean annual precipitation threshold of 700 mm shifts dominant controls on ecosystem nitrogen retention. In dry ecosystems, higher precipitation leads to greater plant diversity and reduced nitrogen loss.
A study published in Science reports the discovery of a protist-dominated hard-substrate fauna across seven hadal regions in Oceania, highlighting an overlooked yet highly active carbon hotspot. The fauna comprises 32 species, including new monothalamous foraminiferal and bryozoan families.
Researchers have developed a new passivation strategy to improve the efficiency and operational stability of perovskite/silicon tandem solar cells. The method uses polystyrene nanospheres as a template to deposit an insulating layer, suppressing electrical leakage and achieving high power conversion efficiencies.
Researchers developed an AI-driven framework, HELIX, to predict RNA splicing and isoform usage with high accuracy. The framework integrates genomic sequence features with tissue-specific RBP expression profiles and outperforms existing methods in predicting splicing strength and isoform usage.
A study published in Science Advances found that climate warming is causing widespread and sustained oxygen loss in global rivers. Tropical rivers are particularly affected, with 78.8% of studied rivers experiencing deoxygenation.
A new study reveals that slower winds increase the ability of global grasslands to absorb more carbon while minimizing water loss. This shift could provide a critical advantage for these biomes under climate change.
Scientists have discovered two genetic mutations in H. erectus fossils, revealing links to modern humans and Denisovans. The findings provide insights into the evolutionary history of H. erectus and its potential connections to present-day human populations.
Researchers found that convective storms exert a stronger influence on biomass carbon turnover time in Amazonian forests than drought stress-related indicators. The study projects a decline of up to 15% in biomass carbon turnover time by the end of this century under high-emissions scenarios.
Researchers have identified RBPMS as a key player in driving Acute Myeloid Leukemia (AML) progression. The study proposes a novel therapy targeting the FOXO1 protein, which is enhanced by RBPMS, to selectively eliminate leukemia stem cells and improve treatment outcomes.
Researchers identify a 'vertical conveyor' mechanism that transports moisture from the mid-latitudes to the Asian Water Towers through a process of nocturnal decoupling. This process integrates up to 30% of westerlies-advected moisture into the local cycle without precipitation, sustaining near-surface moisture accumulation.
Researchers challenged thermodynamic-based framework for catalyst design and proposed new principle focusing on declining efficiency of solid-phase electron transport. They designed homonuclear cobalt-cobalt dual-atom catalyst DA-CoCo, significantly enhancing charge transport in solid intermediates, validating the new design principle.
Researchers found that mid-Holocene soil cooling reduced thermally suitable zones for millet cultivation, contributing to a southward displacement of farming. Soil temperatures recovered after around 6,000 years ago, facilitating millet expansion and late Neolithic development.
The DAMPE collaboration has directly observed charge-dependent spectral softening of five primary cosmic-ray nuclei, confirming the Peters cycle model. This observation suggests a nearby cosmic-ray accelerator with a charge-dependent energy limit, providing new insights into cosmic-ray physics.
Researchers developed an additive design strategy to control crystallization in all-perovskite tandem solar cells, achieving a certified power conversion efficiency of 30.3%. The strategy promotes homogeneous nucleation and uniform crystal growth, improving film uniformity and reducing defects.
The LHAASO collaboration has detected ultra-high-energy (UHE) gamma rays from a gamma-ray binary system, LS I +61° 303. The discovery suggests that high-energy protons are accelerated and collide with the dense surrounding stellar wind, producing these UHE gamma rays. This finding provides critical evidence for gamma-ray binaries as po...
A new study led by Prof. YAN Xiaoyuan finds that most nitrogen gas emissions from rice paddies originate from soil organic nitrogen, rather than applied fertilizers. The researchers propose a novel mechanism to explain this phenomenon, suggesting that fertilizer activates soil nitrogen pools, indirectly driving larger nitrogen losses.
The LHAASO discovery reveals an astonishingly efficient particle accelerator powered by PSR J1849-0001, exceeding theoretical limits and challenging current theories of particle acceleration. The system's gamma-ray luminosity is several times higher than that of the Crab Nebula.
A recent study by Chinese researchers has quantified lake carbon dioxide emissions in China, finding a significant increase of 24% over the past two decades. The study highlights the importance of high-resolution monitoring to refine lake carbon budgets and inform effective climate mitigation policies.
The discovery of seven millimeter-sized phosphatized fossils from the early Fortunian Kuanchuanpu Formation provides evidence of annelid body fossils from Cambrian Orsten-type fossil localities. The findings suggest that early annelids were polychaetes, supporting the hypothesis that polychaete morphologies were primitive among annelids.
Researchers cloned novel BB resistance gene Xa48 in indica rice variety Shuangkezao, revealing molecular mechanism of BB resistance. The study provides foundation for breeding high-yielding disease-resistant rice varieties and improving crop disease resistance.
A high-precision Human Immune Aging Clock (HIAC) has been developed to quantify immunosenescence and identify actionable intervention targets. The study identified RUNX1 as a functional 'brake' on T-cell senescence, and found that individuals with decelerated immune aging displayed a more youthful immune profile.
Researchers have cloned a key gene that determines whether wild rice grows as a perennial. The discovery reveals changes in the expression pattern of this gene underlie the transition of rice from perennial to annual during domestication.
The study completes the nicotine biosynthesis pathway and reveals a five-component dynamic metabolon that carries out chemical reactions to produce nicotine. This discovery establishes a new synthetic biology paradigm for scalable production of high-value natural products with defined stereochemistry.
A research team from the Chinese Academy of Sciences has developed a comprehensive model simulating the present-day dynamics of western North America's lithosphere and convecting mantle. The study reveals that magma beneath supervolcanoes originates in the shallow asthenosphere, challenging traditional hypotheses about magma generation.
A research team identified distinct subregions within the default mode network (DMN) that act as senders and receivers of information, enabling flexible shifts between perception and memory-driven thought. The study reveals that the DMN is not functionally uniform but composed of subregions with distinct connectivity biases.
A new study identifies phengite as a key carrier of halogens into the deep mantle, resolving a long-standing contradiction between shallow and deep halogen enrichment. Phengite transports fluorine and chlorine to depths of about 330 km, shedding light on diamond formation and Earth's chemical evolution.
A research team has discovered how mechanosensitive ion channels trigger the selective breakdown of damaged ER fragments via calcium signaling. This process involves the coordinated action of ER-phagy receptor FAM134B and lipidated LC3, and has implications for understanding diseases associated with ER dysfunction.
A study using Arabidopsis revealed that germline segregation occurs earlier than previously thought, with some cells segregating during inflorescence meristem formation. This finding supports Weismann's germ plasm theory and provides insight into how plants balance developmental plasticity with safeguarding genetic integrity.
Early land vertebrates exhibited distinct patterns of body size evolution, with amniote-lineage land vertebrates experiencing a relaxation of constraints, enabling them to expand their maximum body size limit. Lissamphibian precursors showed stronger constraints on body size evolution and relied on cutaneous CO2 excretion.
Researchers developed a method to predict how metal strain influences adsorption energies and reaction barriers, enabling the design of strain-engineered catalysts with desired properties. They found that electronegativity is closely correlated with the energetic response to lattice strain.
A comprehensive phylogeny of China's vascular plants reveals a hidden global biodiversity hotspot in Central China. The region supports over 14,000 vascular plant species and at least 2,024 endemic plant species, meeting the criteria for global biodiversity hotspot designation.
Researchers found that clearing intestinal commensal bacteria improves delivery efficiency of various carriers, including polymeric nanoparticles and viral vectors. This study offers a new approach to enhance therapeutic effects in tumor chemotherapy and gene therapy.
Researchers developed an innovative colloidal chemistry strategy to enhance the performance of all-perovskite tandem solar cells, achieving a power conversion efficiency of 29.76%. The unified carboxylate-based modulator system regulates nucleation dynamics, suppressing phase segregation and promoting uniform crystal growth.
A team of Chinese researchers found that façade-integrated photovoltaics can generate substantial electricity while reducing cooling demand, thereby reducing carbon emissions and improving urban climate adaptation. FIPV adoption could lead to meaningful economic and climate gains worldwide.
A new study reveals that the honey bee waggle dance is a dynamic, two-way interaction shaped by its audience, contradicting the traditional view of unidirectional information flow. Researchers manipulated the number of potential observers to test how dancers adjust their behavior based on the availability of appropriately aged bees.
Researchers discovered that N6-methyladenosine (m6A) epigenetic modifications in mosquito-borne flaviviruses enhance viral propagation in vertebrates, increasing transmission from animals to mosquitoes. The study found a host-dependent regulatory mechanism involving the stem-loop I structure and the protein G3BP1.
A team of scientists has identified a novel octameric resistosome formed by an activated wheat CC G10 -NLR immune receptor. The study reveals that the resistosome induces Ca 2+ influx and immune responses through a unique channel architecture, providing new insights into plant immunity.