Scientists at OIST successfully engineered a protein to bind a methylating agent instead of its natural coenzyme. The study uses insertions and deletions to modify the protein's structure, offering insights into coenzyme-protein interactions and potential applications in artificial enzyme design.
A new study published in PNAS found that female and male Japanese termites can flip sex roles to form stable same-sex pairs. The researchers discovered that this 'sex role flexibility' allows same-sex pairings to evolve, enabling termites to survive and thrive.
Researchers from OIST have sequenced the genome of pearl oysters, finding key differences between chromosome pairs that could impact immunity and pearl production. The study aims to identify resilient strains for aquaculture, addressing declining pearl production in Japan.
The Global Bioconvergence Center of Innovation aims to bridge academia, government, and industry by promoting interdisciplinary synergies in life sciences, biomedical research, marine sciences, AI, and complex systems. The center will accelerate the development of practical solutions for a 'One World, One Health' society.
A recent study from Japan reveals that color patterns on fish influence their aggressive behavior and determine the color patterns of cohabitating fish. The study found that anemonefish with white bars on an orange or red background exhibit aggressive behavior towards other fish with similar color patterns.
A new study by OIST researchers has developed a model that determines variations in the speed of DNA copying proteins in bacterial genomes. The model shows that certain sections of DNA are copied faster than others, and this variation is linked to an increased error rate, which could have implications for mutation rates.
Researchers at OIST Graduate University have experimentally shown the concept of a neutral network, vital for increasing diversity, by designing and testing over 120,000 RNA variants. They found a large number of accessible pathways between two variants, challenging previous theoretical predictions.
Researchers have developed a new error correction technique called MBE-CQEC, which uses continuous measurement to detect and correct quantum errors. This approach is potentially powerful for quantum computers, but still requires experimental validation and has limitations as the number of qubits increases.
A study by OIST researchers found that a well-known gene called Tob plays an important role in reducing depression, fear, and anxiety. The presence of the Tob gene helps with stress-resilience, while its removal leads to increased symptoms.
Scientists modeled how different coronavirus shapes affect rotational diffusivity, impacting transmission and infective success. The study found that more elongated shapes result in slower rotation rates, potentially improving attachment to cells.
A study by OIST Graduate University's Marine Biophysics Unit found that mangroves in the Ryukyu Islands have limited connectivity, making it crucial to protect isolated forests. The research used genetics and oceanography to track propagule dispersal, revealing rare genetic exchanges between islands.
Scientists at OIST Graduate University discovered the neural circuitry that enables juvenile zebra finches to learn songs through social interaction with a tutor. The locus coeruleus-caudomedial nidopallium circuit plays a crucial role in attention and arousal, guiding the bird's focus on the tutor's song.
A mutated zebrafish eye provides a glimpse into the role of banp in preventing cell death and regulating the cell cycle. The study found that banp promotes the expression of 31 genes involved in DNA repair, tumor suppression, and cell duplication.
A new study reveals key clues about the form of the most ancestral nervous system and how it first evolved. Researchers found that neurons, possibly the most complicated cell type ever to evolve, share similar structures with comb jellies and other ancient animal lineages.
A high-resolution map of ant biodiversity has been created, revealing areas with high diversity and potential for new species discovery. The study's findings highlight the importance of protecting critical regions with high ant diversity.
Researchers at Okinawa Institute of Science and Technology Graduate University found that garden eels retreat into their burrows to feed in strong currents, reducing drag on their body by 57%. Their feeding rate peaks at around 0.2 m/s, wider than free-swimming reef fish.
Scientists from OIST and colleagues reveal that Kamptozoa and Bryozoa belong together, contrary to previous studies. Using high-quality sequencing technology, they found the two phyla split from mollusks and worms earlier than thought, forming a distinct group.
A recent study published in eLife has revealed that high levels of soluble tau protein impair signaling between neurons, leading to cognitive decline. The research suggests that targeting the binding site of dynamin, a protein that binds to microtubules, may rescue synaptic transmission and prevent memory impairment.
Researchers from OIST developed a PCR test that detects nine sex-determining genes in Okinawa mozuku germlings, enabling the identification of male and female haploid and diploid stages. This allows for crossbreeding to create heat-tolerant strains, improving yields and addressing issues with detachment and contamination.
Researchers have designed an iron catalyst to facilitate the olefin metathesis reaction, a widely applicable catalytic reaction for carbon-carbon double bond formation. The iron-based catalyst shows promise in reducing costs and environmental impact compared to traditional ruthenium-based catalysts.
Researchers mapped out the natural history of drywood termites, revealing oceanic voyages that accelerated their evolution and confirmed recent dispersals via humans. The study also challenged the common assumption of primitive lifestyles, highlighting the diversity and complexity of termite social behavior.
Researchers have assembled a comprehensive genome of the false clownfish, providing insights into its ecological behavior, evolutionary history and adaptability. The genome comparison with its orange-clownfish cousin reveals unique genes related to neurobiology, affecting their behavior and ecology.
Scientists have discovered that squid can camouflage to match a substrate, avoiding predators in the process. The study, published in Scientific Reports, sheds light on the behavior of this third type of cephalopod and could inform conservation initiatives.
The study reveals the structure of D13 and its role in assembling into a protein scaffold, which is critical for virus replication. The researchers discovered two ways the proteins interact to form a spherical honeycomb lattice, with a small helix structure playing a key role in assembly.
The Bank of Okinawa has awarded ¥1 million grants to two startups, Genome Miner and Menopause and Beyond, participating in the OIST Innovation Square Startup Accelerator Program. The grants aim to support their entrepreneurial journey and contribute to the development of the local economy.
Researchers develop an eco-friendly organic catalyst system that improves the production of organic molecules from pyruvate, a key biomolecule in metabolic pathways. The catalyst promotes reactions where pyruvate donates electrons to produce molecules like amino acids.
Researchers at OIST Graduate University identified the strip1 gene as essential for keeping retinal ganglion cells alive. The gene suppresses Jun-mediated apoptosis, promoting correct neural circuit formation in the retina. This finding opens promising new avenues for treating diseases like glaucoma.
Researchers from OIST found that Escherichia coli bacteria form lanes of genetically similar individuals when constrained to a channel, aligning parallel to the barriers. The study, published in PNAS, used microfluidic platforms and simulations to observe population dynamics over several generations.
Researchers have imaged and measured the two parts of a unique particle called moiré exciton, extending their lifespan. They found that excitons are localized in tiny pockets of around 1.8 nanometers, forming in places where energy is minimal.
Scientists have simulated the growth of ultra-thin polycrystalline diamond films with promising results. The two-dimensional simulations revealed interesting geometric structures and shed light on how to create robust materials. The research has implications for biomedical science, quantum devices, and other applications.
Researchers at OIST used advanced imaging to record signaling within single astrocytes, revealing ultra-fast signals on par with neurons and patterns of activity corresponding to different behaviors. The findings suggest that astrocytes may store memories as 'fingerprints' in specific areas, called hotspot maps.
Scientists have discovered that the genomes of marine invertebrates have been surprisingly stable across deep time. The study found that chromosomes are remarkably similar among sponges, jellyfish, scallops, and even humans, with some genes traveling together for almost a billion years.
Researchers used microscopic strands of DNA to guide the assembly of gel blocks that self-assembled in around 10-15 minutes. The process was highly specific and easily programmable, allowing the blocks to interact with each other in different ways by changing the sequence of DNA.
Scientists develop blue LEDs based on metal halide perovskite with asymmetrical bridges to hold layers together, creating a more stable structure. This breakthrough solves the halide segregation problem and brings perovskite LEDs closer to commercialization.
Two new species of goby fish, Rhinogobius estrellae and Rhinogobius tandikan, have been discovered in Palawan, Philippines. The discovery expands the genus Rhinogobius' known range further south than previously seen.
A recent study has found that snake venoms and mammalian salivary proteins share a common origin, suggesting that the foundation for venom to evolve exists in both snakes and mammals. This discovery reveals that the line between venomous and non-venomous mammals is blurrier than previously thought.
Scientists from OIST and University of Cambridge discovered distinct types of defects in state-of-the-art perovskite thin films, which may hinder solar cell efficiency. The most detrimental defects were grain boundaries and polytypes, while lead iodide defects had a benign impact on performance.
Microglia, the brain's immune cells, migrate to the retina using blood vessels as pathways and require neurogenesis for colonization. The study provides insights into microglial migration and its implications for neurodegenerative diseases.
Researchers have developed a powerful new tool that can determine the diversity of hard corals on a reef by analyzing DNA in seawater samples. This method is faster, easier, and less expensive than traditional visual identification, allowing for more accurate coral reef conservation and restoration.
Researchers from OIST and Kyushu University have developed a method to generate a glow-in-the-dark light using organic materials. The new method produces emissions that last for over one hour at room temperature, improving performance by tenfold compared to previous work.
Researchers at OIST Graduate University developed a new 3D scaffold design using 2-photon lithography that guides regenerating neurons in the right direction. The scaffolds promote directional growth of neurons, bridging gaps and repairing connections after spinal injuries.
Researchers at Okinawa Institute of Science and Technology (OIST) have developed a system to study cellular reactions in a way that more closely reflects how molecules behave in a living cell. By mixing a polymer with protein, they created membraneless droplets that can mimic the molecular properties of how molecules move in the cell.
Researchers used reinforcement learning to control a small particle moving in a double-well system, achieving accurate control despite noisy measurements. The method shows promise for future applications in quantum technologies and AI.
Mangroves have evolved a remarkable resistance to stress in harsh ocean environments. Researchers decoded the genome of Bruguiera gymnorhiza and found that it regulates genes to cope with stress, using adaptive epigenetic changes to survive.
A recent study from the Okinawa Institute of Science and Technology Graduate University identified a crucial protein linked to increased appetite and obesity in mice. The researchers found that mice lacking this protein, XRN1, exhibited leptin resistance, leading to insatiable hunger and weight gain.
Three new species of freshwater goby fish have been identified in Japan and the Philippines, with distinct color patterns indicating separate lineages. The researchers believe that different color patterns play a crucial role in maintaining these separate lineages during courtship and mate selection.
A new experimental method tracks the motion of fibers instead of particles to reveal previously hidden information about turbulent flows. The researchers developed an innovative solution using rigid fibers, which allowed them to measure the speed and direction of flow at two points a fixed distance apart.
Researchers identified 99 saliva metabolites related to energy synthesis, digestion, growth, and cell health, with 21 metabolites differing between young and elderly individuals. Age-linked salivary metabolites reflect biological aging, including a 1.96-fold increase in ATP production in the elderly.
Researchers at OIST and Tokyo University of Marine Science and Technology have developed a genetic resource for the kuruma shrimp, a species prone to white spot disease. The genome sequence has identified genes related to disease resistance, which could be used to establish a disease-resistant line of shrimp.
A new study published in PNAS has identified 33 metabolic compounds associated with dementia, which could aid in diagnosis and treatment. The researchers found that levels of these metabolites differed significantly between patients with dementia and healthy elderly individuals.