A new approach to epigenomic profiling has been developed that can analyze DNA-protein interactions using very small numbers of cells, ranging from 100 to 1,000. This technique, called Chromatin Integration Labeling sequencing (ChIL-seq), allows for the detection of histone modifications and DNA-binding factors with high precision.
Researchers at Tokyo Institute of Technology discover CLIP-170's critical role in T cell activation by relocating the microtubule-organizing center (MTOC) to the cell surface. This process is essential for immune response initiation and could lead to improved cancer immunotherapy.
Researchers at Tokyo Institute of Technology have developed a CO2 reduction method based on commonly occurring elements, yielding 57% overall quantum yield. The system uses a copper complex and manganese-based catalyst, offering a cost-effective solution for carbon capture.
Researchers from Tokyo Institute of Technology found that sodium chloride can assist in making RNA building blocks. This process could have occurred on early Earth, bringing us closer to understanding how life began.
Researchers at Tokyo Institute of Technology propose a new technology for direct utilization of CO2 in exhaust gases from heavy industries. The study demonstrates the ability of a rhenium-based catalyst to reduce low-concentration CO2 with high selectivity, offering a more viable and environmentally friendly solution.
Scientists at Tokyo Institute of Technology found that crystallinity at the electrode-electrolyte interface reduces resistance, resulting in high-performance batteries. The research aims to improve Li-ion batteries for modern electronic devices and electric vehicles.
Scientists at Tokyo Institute of Technology have created subnano-sized metallic particles that can perform 50 times higher catalytic activity than well-known Au-Pd bimetallic nanocatalysts. These particles are cost-effective and environmentally friendly, making them a promising solution for reducing pollution.
Scientists have developed a method to construct protein nanotubes from engineered protein crystals, which could accelerate the development of artificial enzymes, nano-sized carriers and delivery systems. The new method, reported in Chemical Science, uses protein crystals as a scaffold for proteins to self-assemble into desired structures.
A study published in Complementary Therapies in Medicine found that face massage rollers increased facial skin blood flow by up to 25% after just five minutes. Long-term use also improved the vasodilatory response, suggesting a potential mechanism behind its benefits.
A breakthrough study has identified a key protein that controls starch content in algae, allowing for increased production of biofuels and sustainable materials. The discovery could accelerate the development of environmentally friendly products and contribute to achieving Sustainable Development Goals.
Researchers develop silicone polymer chain that can self-assemble into a 3D periodic structure using triptycene molecules. The team's findings are promising and may provide a powerful tool for organizing polymers and reinforcing their structural and physical properties.
Researchers at Tokyo Institute of Technology discovered the role of Atg2 in tethering pre-autophagosomal membranes to the endoplasmic reticulum. The study found that Atg2's N- and C-terminal regions have membrane-binding capabilities, allowing it to initiate autophagosome formation and expand membranes. Understanding this mechanism is ...
A newly identified gene, ancV1R, is found to be conserved across fish and mammals, suggesting an ancient origin for pheromone sensing. The discovery opens new avenues of research into the evolution and function of pheromone signaling in vertebrates.
Researchers at Tokyo Institute of Technology have developed a method to synthesize multimetallic clusters with precise control of size and composition, opening up new possibilities for advanced functional materials. The team successfully formed clusters composed of up to six metal elements, including platinum.
Researchers have designed a novel photoluminescent material that emits blue light when excited and is stable under ambient conditions. The material, Cs3Cu2I5, has potential applications in optical and electronic devices, including white luminescent films and blue LEDs.
Researchers at Tokyo Institute of Technology have demonstrated that special tetrahedron nanostructures composed of certain metals can exhibit a higher degree of symmetry than spherical atoms. This new type of symmetry may lead to unprecedented electrical and magnetic properties, enabling the creation of novel electronic materials.
Researchers at Tokyo Institute of Technology developed a fluorescent protein sensor that can provide real-time information on dynamic changes in oxygen levels. The ANA sensor shows very high sensitivity in tracking changes in oxygen content.
Researchers designed a novel molecular wire with a polyyne backbone and a ruthenium-based unit, achieving higher conductance than previous organic molecular wires. The origin of high conductance lies in orbital splitting, which induces changes in the electron orbitals to facilitate electron transfer between metal electrodes and the wir...
Researchers at Tokyo Institute of Technology have identified an enzyme, GPAT1, as a promising target for increasing biofuel production from red algae. The study found that TAG productivity could be increased by more than 56 times in a strain overexpressing GPAT1 without negative effects on algal growth.
Researchers have identified a protein complex that helps plants 'switch off' photosynthesis at night and 'switch on' when light is available again. This complex, involving thioredoxin-like2 (TrxL2)/2-Cys peroxiredoxin (2CP), allows plants to conserve energy and restore photosynthetic activity when necessary.
Researchers have created all-solid-state batteries with extremely low interface resistance, enabling fast charging and discharging. The batteries showed excellent electrochemical properties, exceeding those of traditional Li-ion batteries.
Researchers developed a new technique to decode human motor intention from EEG using subliminal sensory stimulation. This method achieved nearly 90% single-trial decoding accuracy across tested subjects, within 96 ms of the stimulation, with zero user training and no additional cognitive load.
Researchers created a scalable method to produce pure NCAs in less time and space, overcoming limitations of existing Fuchs-Farthing method. The new technique enables on-demand synthesis of NCAs for life-saving drugs and drug carriers.
Scientists have developed BiSb alloys with a colossal spin Hall effect and high electrical conductivity, making them suitable for ultra-low-power SOT-MRAM devices. The breakthrough could accelerate the development of non-volatile memories for IoT applications.
A new mouse model has been developed to study bone metastasis, allowing researchers to inject a large number of cancer cells without causing death. The model enables the detection of bone metastasis in the hind limbs with high efficiency and provides insights into cancer cell dormancy and reactivation.
IGZO TFTs have a high electron mobility of 10 times that of hydrogenated amorphous silicon, allowing for high-resolution energy-efficient displays. These displays are used in smartphones, tablets, and large OLED televisions, which were previously thought to be impossible.
Researchers at Tokyo Institute of Technology have developed a ruthenium-based perovskite catalyst that exhibits high performance even at low temperatures and is recyclable. The new catalyst overcomes classic limitations, including the need for additives and high reaction temperatures.
Researchers have developed copper nitride semiconductors that can replace toxic materials in photovoltaic cells, offering a brighter future for solar energy. The unique nitriding technique and fluorine doping enable efficient p-type and n-type conduction, promising scalable and low-cost manufacturing routes.
A new ruthenium-based catalyst has been developed, featuring highly active flat surfaces that significantly improve its performance compared to traditional metal-supported catalysts. The catalyst's high turnover frequency and reusability make it a promising solution for the large-scale production of valuable chemicals.
Researchers create flexible terahertz imagers based on semiconducting carbon nanotube materials that can be fine-tuned to maximize detector performance. The findings expand the scope of terahertz applications, enabling wearable technologies and large-area photonic devices.
Scientists estimate that planets around almost every star in the galaxy may harbor life, prompting new research to identify biosignatures. Researchers propose solutions to detect gases and light signatures produced by life on exoplanets.
Researchers at Tokyo Institute of Technology successfully formulated and experimentally verified a unified theory for controlling coherent optical phonons in diamond. The theory explains the generation and detection of coherent optical photons based on a model involving two states of electrons and the quantum harmonic oscillator.
Scientists developed an AI program to categorize volcanic ash particle shapes, helping provide information on eruptions and aid hazard mitigation. The program achieved a success rate of 92% in classifying basal shapes with probability ratios.
A new photocatalyst composed of an organic semiconductor material and an iron complex selectively reduces CO2 to CO under visible light, converting the major factor of global warming into a valuable carbon resource. The efficiency of this process is comparable to that of precious metal or rare metal complexes.
Research by Tokyo Institute of Technology team found alpha-hydroxy acid polymers can form easily under conditions prevalent on early Earth, aiding in living system formation. The study suggests these polymers may have provided the toolkit for life's origin.
Scientists at Tokyo Institute of Technology designed a tiny, fast, reliable, and accurate 28-GHz transceiver for stable high-speed 5G communications. The new transceiver employs a local oscillator (LO) phase shifting approach, achieving an improvement in beam steering resolution of an order of magnitude compared to previous designs.
Researchers at Tokyo Institute of Technology identified USP8 as a key enzyme controlling large collagen carrier formation. The enzyme inhibits collagen secretion when active, promoting its transport instead.
Researchers have gained insights into stress granules, clumps of RNAs and proteins that form when cells are stressed, linking them to neurodegenerative diseases. The study reveals the critical role of two enzymes, USP5 and USP13, in disassembling stress granules, which could lead to innovative treatments.
Scientists at Tokyo Institute of Technology have developed a new photocatalytic material using fluorine, which exhibits an unusually small band gap and can efficiently absorb visible light. The material shows promise for improving solar energy conversion efficiency.
Researchers at Tokyo Institute of Technology developed a 4.5-nm-long molecule that forms coherent resonant electron-tunneling devices, exhibiting thermal stability similar to traditional materials. The discovery paves the way for future molecular-scale electronic research and addresses limitations in conventional electronics.
Scientists discover that excess La cations lead to highly anisotropic atomic displacement and high oxygen mobility in apatite-type materials with Si vacancies. This novel concept of 'high oxide-ion conductivity by overbonding' may be useful for designing better ion conductors.
Researchers at Tokyo Institute of Technology have created a micrometer-wide thermometer that can measure small and rapid temperature changes in real time. The device is sensitive to heat generated by optical and electron beams, enabling its use in various fields such as photo-thermal cancer treatment and advanced research on crystals.
A research team developed a method for constructing an aggregated model of a power network that can efficiently analyze and control generator groups. The symmetry of the network in graph theory is the fundamental principle for realizing the synchronization of generator groups. This achievement aims to develop analysis and control metho...
A recent study suggests that early Mars was modestly warm and prone to rain, with only small patches of ice. The research challenges the long-held idea of an icy climate on Mars.
Researchers discovered that fish regenerate skin without scarring by controlling the proliferation of stem cells in the basal layer. This mechanism may be applicable to other vertebrates, including humans, for treating various skin diseases and regenerative medicine research.
Researchers used synthetic-aperture radar data from four satellites to analyze the Lake Urmia Causeway in Iran, finding accelerated deformation due to soil consolidation and human activity. They also developed a predictive model for future deformation, highlighting the potential of space-based monitoring for critical structures.
Slow slip events (SSEs) release seismic stress at a lower rate than large earthquakes, potentially triggering megathrust earthquake events. The study analyzed waveform data from beneath Kanto, Japan, and found that seismic activity varied in response to SSEs, through episodic cycles.
A team of researchers at Tokyo Institute of Technology has discovered a novel method for creating heat dissipation materials using non-toxic filamentous viruses. The material, which can be easily prepared at room temperature, exhibits high thermal conductivity comparable to inorganic glass.
Researchers at Tokyo Institute of Technology have developed a model that parallels the kinetic theory of molecules, providing a solid foundation for understanding price fluctuations in stable financial markets. The study also aims to examine unstable markets vulnerable to external shocks.
Researchers have developed a method to produce high-quality monocrystalline silicon thin films with reduced crystal defects, grown at a rate 10 times higher than before. This technology could drastically reduce manufacturing costs while maintaining power generation efficiency.