Researchers at the UArizona Arthritis Center will study 10,000 participants to identify determinants of rapid knee deterioration and predict patient outcomes. The goal is to improve treatment evaluation and understand the progression of debilitating knee osteoarthritis.
The Arizona Area Health Education Centers Program will receive $7.2 million in state and federal funding to grow the health professions workforce in rural and urban medically underserved communities. The program aims to increase access to primary and preventive care, addressing health disparities in Arizona.
Researchers developed a predictive test to assess asthma risk in babies, allowing for preventive treatments and potentially bypassing disease development. The test identifies a network controlled by the IRF1 gene that drives an exaggerated inflammatory response in children who develop asthma.
A study led by researchers at the University of Arizona Health Sciences has uncovered a possible path for improving T cell therapies. The study found that the CD4 molecule plays a more active role in regulating T cell receptor signaling, allowing for even more powerful versions of T cell therapy.
Occupational exposure to firefighting has been linked to increased cancer risk, including mesothelioma and bladder cancer. The new classification aims to reduce firefighter exposures and prevent cancer through interventions and research collaborations.
The University of Arizona's AZ HEROES study will continue to evaluate COVID-19 vaccine effectiveness and immunity among frontline workers, families, and children. The study has already provided important data on vaccine effectiveness for teenagers and children, informing science-based vaccine guidance and public health decisions.
Researchers propose a new paradigm for analyzing genetic mutations that may lead to cancer after finding varying levels of heterochromatin, a key player in genomic stability. The study reveals that heterochromatin is dynamic and not stable, increasing the rate of mutation.
Researchers at the University of Arizona Health Sciences have identified a genetic variation that may indicate increased susceptibility to stomach cancer. The study focused on the molecular pathways controlling immune cell response to H. pylori infection, specifically toll-like receptor 9.
Researchers at the University of Arizona Mel and Enid Zuckerman College of Public Health will measure soil and dust ingestion levels in US children to protect them from harmful chemicals. The study, funded by the EPA, aims to establish new data benchmarks for child health guidelines.
The study examines how estrogen regulates the brain's bioenergetic system, which affects glucose transport and metabolism. Researchers aim to understand changes in this system during menopause and its potential link to age-associated neurodegenerative diseases like Alzheimer's disease.
A new study reveals that Medicaid expansion under the Affordable Care Act has led to a significant decrease in diabetic foot amputations among racial and ethnic minority adults. The study found that this expansion has resulted in better healthcare outcomes for these underserved populations, reducing rates of diabetes-related major ampu...
Researchers discovered that aging lymph nodes near the skin deteriorate faster than those deeper in the body, compromising the immune response. This can lead to weakened immunity against skin infections, vaccinations, and even skin cancers.
A large-scale study identified 287 genomic regions associated with schizophrenia, pinpointing 120 genes that contribute to the disorder. The research suggests abnormal neuron function in these cells may explain the diverse symptoms of schizophrenia.
Researchers have identified key metabolic drivers of late-onset Alzheimer's disease, providing insights for personalized medicine. The study found that the APOEe4 genotype influences metabolic changes, overriding sex-specific differences in males and females.
A clinical trial is underway to test the safety and efficacy of PhytoSERM, a dietary supplement that promotes estrogenic action in the brain without affecting reproductive tissue. The study aims to reduce menopausal symptoms and lower the risk of Alzheimer's disease in post- and perimenopausal women.
Researchers identified changes in DNA methylation after multiple fire exposures, linking occupational hazards to adverse health outcomes. The discovery offers a potential mechanistic link between firefighting exposures and diseases like cancer.
A new study aims to slow muscle degeneration in ALS patients by targeting the renin-angiotensin system. Researchers have found that an investigational drug, CAP-1902, reduces inflammation and oxidative stress in models of Duchenne muscular dystrophy.
Researchers found three risk factors linked to adult spirometric restriction: maternal nutritional problems during pregnancy, low birth weight, and below normal childhood weight. Infants with poor nutrition have a higher risk of developing lung restriction and comorbidities as adults.
The UArizona Health Sciences Center is developing a Center of Excellence for Addiction Studies to advance addiction research and develop therapies for the opioid epidemic. The center will facilitate national collaborations, employ cutting-edge genetic techniques, and provide advanced methods for measuring neurotransmitters.
A new study will focus on the biological mechanisms causing cataracts, potentially leading to new treatments. The research team, led by Nicholas Delamere, PhD, will investigate the role of protein ion channels TRPV1 and TRPV4 in age-related lens cell changes.
Researchers aim to determine if knee structure changes predict clinical outcomes in people with osteoarthritis. The study will examine 76,000 X-rays and clinical data from diverse cohorts to establish healthy knee structure ranges.
Researchers at University of Arizona Health Sciences discovered a potential treatment to reduce post-stroke dementia risk by targeting the immune response to dead brain tissue. Cyclodextrin, an FDA-approved ingredient, was found to reduce inflammation and accumulate less cholesterol in the brain.
Researchers found that sleep deprivation can significantly increase serotonin 2A receptors in the brain within hours, which may influence schizophrenia symptoms. This discovery suggests environmental stressors could alter the balance of brain receptors controlled by antipsychotic drugs.
Researchers found that bacterial lysate OM-85 blocks SARS-CoV-2 infection by decreasing the virus's ability to attach to lung cells. The study suggests a new way to prevent or reduce COVID-19 infection.
Researchers discovered that infections improve the production and function of naïve T cells, the body's first line of defense against disease. This mechanism involves interleukin 7 and MHC molecules, which signal naïve T cells to stay alive and receive optimal metabolic signals.
Researchers at UArizona Health Sciences will lead a statewide effort to study the long-term effects of COVID-19, with a focus on identifying risks and developing approaches for treatment and prevention. The study aims to understand the basis of prolonged symptoms and improve recovery outcomes.
Researchers developed a compound that regulates a biological channel linked to pain, reducing the sensation of pain in rodents. The compound, dubbed 194, successfully targets sodium ion channels and promotes pain relief by activating the body's endogenous opioid system.
A UArizona Health Sciences study found that American Indian and Alaska Native women with early-stage breast cancer had a higher percentage of mastectomy and a lower percentage of lumpectomy compared to white women. The study suggests that geographic and socioeconomic factors may contribute to these disparities.
A new vaccine has shown significant protection against Valley fever in dogs, offering hope for a potential human vaccine. The study found that two doses provided high levels of protection against the fungal disease.
A study analyzing COVID-19 test results from over 1,700 essential workers in Arizona found that first responders had a twice-highest incidence of infection compared to frontline healthcare personnel. Researchers urge increased vaccine promotion and tailored mitigation strategies for these vital professionals.
Researchers are developing a standardized training program to address physician bias and improve equity in advanced heart failure treatments. The program, called SOCIAL HF, aims to reduce barriers to equitable treatment through evidence-based bias training and objective criteria.
Researchers found that cancer patients on chemotherapy had a lower immune response to the first two doses of the Pfizer-BioNTech COVID-19 vaccine. However, a third dose significantly boosted their immune response, reaching levels similar to those of healthy adults after two doses.
Researchers at UArizona Health Sciences have discovered a mechanism that tumors use to keep blood vessels growing, driving cancer growth and invasion. Targeting this mechanism with drugs could lead to more effective cancer treatments by overcoming drug resistance.
Research by University of Arizona Health Sciences identifies chronic arsenic exposure as a risk factor for developing insulin resistance and glucose intolerance. The study found that prolonged activation of NRF2 protein leads to shifts in metabolic pathways, increasing glucose production in the liver.
Researchers at the University of Arizona Health Sciences are investigating the biological complexities of Alzheimer's disease in women during midlife aging. The study aims to reveal transformations in the brain that lead to greater risk of Alzheimer's, with a focus on the menopausal transition.
Researchers developed a nanotherapeutic platform that combines camptothecin with immune checkpoint inhibitors to increase effectiveness against aggressive tumors. The approach showed promising results in eliminating difficult-to-treat late-stage metastatic colorectal cancer and melanoma tumors.
A new clinical trial will test a simple breathing exercise for adults with obstructive sleep apnea and hypertension. The study aims to reduce blood pressure and improve cardiovascular health through inspiratory muscle training.
Long COVID, or post-acute sequelae of COVID-19, affects approximately 67% of individuals with mild to moderate COVID-19 infections. The study found that non-hospitalized individuals are just as likely to experience long-term symptoms as hospitalized ones.
The AZ HEROES study, led by the University of Arizona Health Sciences, has received a $15 million award from the CDC to continue its research on COVID-19 vaccine effectiveness. The study will expand to include children aged 4 months to 17 years and focus on underserved populations.
Researchers found that Veillonellaceae family members contribute to disease by altering inflammation and metabolism in the cervicovaginal region. The study also identified three specific bacteria species - V. atypica, V. montpellierensis, and M. micronuciformis - that increase inflammation and promote cell death.
Researchers found that cannabis terpenes mimic the effects of cannabinoids, providing pain relief without increasing negative side effects. The study suggests terpenes may be used to boost the efficacy of THC and reduce psychoactive effects, leading to a potential dose-reduction strategy for pain management.
A new University of Arizona Health Sciences study found that women on hormone therapy were significantly less likely to develop neurodegenerative diseases, including Alzheimer's. The study suggests a precision medicine approach to preventing these diseases by using individualized hormone therapies.
The UArizona Center for Rural Health will continue its mission to improve health and wellness in rural Arizona with a $4.4 million grant from HRSA. The program aims to address significant health disparities affecting Native American and Latinx populations.
A University of Arizona study suggests that Objective Structured Clinical Examinations (OSCEs) can effectively assess clinical skills in community pharmacies, providing a valuable learning experience for pharmacy students. The OSCE design was found to accurately reflect the time constraints faced by pharmacists in real-world settings.
Researchers found that vaccinated individuals have a lower viral load, shorter infection time and milder symptoms than unvaccinated people. The study also showed a significant reduction in the risk of having COVID-19 with an accompanying fever.
Researchers at University of Arizona Health Sciences found that cancer cells become more aggressive when exposed to tissue stiffening, leading to changes that persist over time. The 'mechanical conditioning' score can quantify these cellular changes and predict patients at high risk for bone metastasis.
Advanced-stage kidney cancer is more common among Hispanic Americans and Native Americans than non-Hispanic whites in Arizona. The study found that Arizona's Hispanic Americans have a two times higher risk of advanced-stage kidney cancer, while Native Americans face a 30% increased risk.
The Binational Early Asthma and Microbiome Study (BEAMS) examines how the 'hygiene hypothesis' affects children's risk of asthma in Mexico and the US. The study explores the role of microbiomes, family health history, and environmental exposures in developing asthma.
A new mobile assessment tool will be developed to accurately track participants' saturated fat and added sugar consumption, addressing limitations in traditional research methods. The app aims to provide researchers with high-quality data for better recommendations on improving health and wellness.
A new approach has led to the discovery of a small molecule that may help regulate cholesterol levels in the brain, making it a potential therapeutic target for Alzheimer's disease. Increasing the activity of ABCA1 is expected to positively influence insulin signaling and reduce inflammation in the brain.