A new study suggests that mummification in prehistory was more common in Europe than thought, dating back to 8,000 years ago. The researchers found evidence of desiccation and hyperflexion in skeletal remains from the Sado Valley in Portugal.
A study at Merapi Volcano, Indonesia, found that a horseshoe-shaped fracture zone is causing summit dome instabilities. Weakened rocks from the hidden fracture zone are likely the main cause of ongoing instabilities.
Researchers analyzed fossilized fish bones from the Tanis locality to reconstruct the latest Cretaceous seasonality. The study reveals that the catastrophic extinction occurred during northern-hemisphere spring and affected sensitive life stages of organisms, including dinosaurs.
Researchers uncovered bone remains of a first-generation African individual from Senegambia, buried in a Portuguese shell midden 350 years ago. The genetic signature and dietary analysis indicate that he was forcibly translocated to Portugal via the Trans-Atlantic Slave Trade.
A recent study found that exposure to complex mixtures of endocrine disrupting chemicals during pregnancy can impact children's brain development and language acquisition. The research, conducted in collaboration with multiple institutions, used a novel approach linking human population studies with experimental cell and animal models.
Researchers at Uppsala University discovered that the ancestors of Legionella bacteria infected eukaryotic cells around 2 billion years ago. This finding challenges the chicken-or-egg debate about which came first, phagocytosis or mitochondria evolution.
Researchers at Uppsala University have designed a molecule that inhibits the replication of coronaviruses, including the new variant, with great potential for developing an antiviral drug. The molecule has been shown to be effective against both old and new variants, offering hope for treatment options.
Researchers at Uppsala University studied the genomic effects of inbreeding on Scandinavian wolves, finding that 10-25% of original genetic variation was lost after five generations. The study revealed a surprisingly large number of genetic variants disappeared, highlighting the risks of inbreeding in endangered species.
A new study by Uppsala University researchers discovered that CRISPR-Cas9 can generate unexpected, heritable DNA mutations in zebrafish, highlighting the need for careful validation before using the method for medical purposes.
A new study published in PLOS ONE found that all individual COVID-19 patients with low oxygen saturation levels may need lower oxygen flows than previously believed. The study's results suggest that oxygen requirements for severely ill patients are significantly lower than the World Health Organization's estimated 10 l/min.
Researchers at Uppsala University found that DNA-binding proteins often bind to similar sequences before finding their target, contradicting previous assumptions about gene regulation. This discovery explains how these proteins can rapidly adapt to changing environments without getting stuck on specific sequences.
A new study found that curtailed sleep increases the release of troponin after exercise, a biomarker linked to cardiovascular disease. While regular exercise counters adverse effects of sleep loss on metabolism, curtailed sleep may increase the risk of heart injury during strenuous exercise.
Researchers from Uppsala University found that ocean productivity declined rapidly 4.6 million years ago in tropical regions, likely caused by reduced East Asian monsoon intensity and decreased riverine nutrient supply, coinciding with changes in the Earth's orbit.
Research in Sweden, Bhutan, and Turkey finds that low maternal mental health affects children's attentiveness, social understanding, and decision-making skills. Small community support and social networks can mitigate this impact.
A recent study identified several protein biomarkers that protect against the development of inflammatory diseases such as psoriasis and osteoarthritis. The researchers used Mendelian Randomization to determine whether high levels of these proteins are associated with a lower risk of disease.
Genetic variants at 67 genomic regions were found to contribute to increased risk of age-related hearing loss. Visualized proteins reveal molecular components critical for sound conversion and transmission.
Research at Uppsala University found a correlation between specific genes and prognosis in Chinese patients with cardia cancer. Focal amplification of the ERBB2 gene was linked to better prognosis, while EGFR amplification had worse outcomes.
A study published in Translational Psychiatry found that patients with high expectations of SSRI treatment showed a four times higher improvement rate compared to those with low expectations. The effect was attributed to the influence of dopamine on the brain's reward pathways.
A study published in Current Biology found that a mutation affecting the expression of a key carotenoid pigment gene is responsible for the yellow color of some Darwin's finch nestlings. The genetic basis for this variation was poorly understood, but researchers were able to identify the underlying mechanism using modern genetic tools.
A new study analyzing over 3,000 shark teeth reveals the importance of diet in shaping modern shark communities. The research suggests that dietary specialisation among top predatory sharks may increase their risk of extinction.
Researchers found that T-cell tests are prone to false-positive responses due to cross-reactive reactions with other infections. The study suggests that these tests should not be used for individual diagnosis, but may still have a role in research and studies.
Researchers at Uppsala University have designed new antibodies that bind to both large and small aggregates of the amyloid-beta protein, potentially providing a more effective treatment for Alzheimer's disease. The new antibody format is stronger in binding to clumps and can also target smaller aggregates.
Researchers at Uppsala University found that allergic stimulation activates mast cell precursor cells, which can produce cytokine IL-13 contributing to asthma development. This challenges the idea that only mature immune cells are involved in immune reactions.
Researchers at Uppsala University developed a new method to track individual cancer cells and their offspring over time. The study found that brain tumour cells are hierarchically organised, but with some degree of flexibility, and that drug treatment influences cell organisation. This breakthrough may lead to the development of target...
A team of Uppsala researchers has discovered the solution to finding a matching DNA template in the cell's busy interior, solving a 50-year-old puzzle. They use a CRISPR-based technique and microscopy to image the homologous recombination process, revealing that the search is reduced from three to two dimensions.
A new study from Uppsala University found that genetic tests are more accurate than traditional blood tests in determining the risk of cardiovascular diseases. The study analyzed data from 500,000 subjects and discovered a significant link between blood group genetics and coagulation proteins.
Researchers analyzed oral bacteria of wild brown bears to track history of human antibiotic use and find significant decrease in antibiotic resistance after national policies were implemented. The study highlights the effectiveness of governmental policies in mitigating a major health threat on a national level.
Researchers have created a new mouse model that facilitates study of bladder cancer progression and immune-system activation. The model allows for investigation of gender differences in bladder cancer development and response to immunotherapy, with potential implications for improving treatment strategies.
Researchers at Uppsala University discovered lymph node-like structures in brain cancer patients where immune cells can be activated. Immunotherapy enhanced these structure formation in a mouse model, suggesting new ways to regulate the anti-tumour response.
A new beetle species, Triamyxa coprolithica, has been found in 230-million-year-old fossil feces attributed to a dinosaur ancestor. The beetles were preserved in the coprolite fragment, providing a detailed description of the new genus and insights into early insect evolution.
A new study from Uppsala University reveals that males play a crucial role in maintaining genetic health by eliminating harmful mutations. The research found that selective pressure on males leads to the purging of deleterious mutations, resulting in healthier genes and increased reproductive capacity.
Researchers from Uppsala University and others found new clues about Indonesia's explosive volcanoes by analyzing lava minerals. The study enhances our understanding of how volcanism in the Indonesian archipelago works, helping predict volcanic eruptions.
A major Swedish forest fire in 2014 led to a significant loss of carbon and nutrients in the affected areas. Water quality in watercourses quickly returned to normal, while forested areas continued to lose carbon for many years after the fire.
Researchers sequenced the entire genome from Peştera Muierii 1, a woman who lived in Romania 35,000 years ago. The study found high genetic diversity, suggesting that the greatest loss of genetic diversity occurred during the last Ice Age, rather than during the out of Africa migration.
Research at Uppsala University discovered an epigenetic mechanism linking bisphenol F (BPF) exposure during fetal development to lower IQ levels in children. The study found that higher BPF levels were associated with increased DNA methylation in the GRIN2B gene, which plays a key role in neurological development.
A study by Uppsala University found that bullying is a greater risk factor than overweight for developing depressive symptoms in both girls and boys. However, boys' mental health is more affected if they suffer from obesity, with a five-fold higher risk of having depressive symptoms in 2015 compared to normal-weight boys.
A new study found a 36% decrease in prostate cancer diagnoses in Sweden during the first pandemic wave, with most pronounced declines among men aged 75 and over. The number of patients receiving curative treatment remained unaffected, suggesting that healthcare prioritized cancer care during the pandemic.
Scientists at Uppsala University resurrected 3.3 billion-year-old bacterial proteins to study their properties and evolutionary history. The researchers found that these ancient proteins had broader specificities than modern counterparts and could function with various types of ribosomes.
A Uppsala University study found that genetic variants contribute more to educational attainment in socioeconomically deprived regions. The study of over 350,000 UK Biobank participants suggests an interaction between genes and environment, with socioeconomic deprivation modifying genetic effects.
Researchers at Uppsala University have discovered that macrophages, a common immune cell, play a crucial role in re-establishing blood flow in damaged tissue. This finding could lead to the development of new treatments for cardiovascular diseases by increasing local concentrations of signal substances in damaged muscles.
Researchers at Uppsala University discovered that the surface layer of the intestinal mucosa can contract in response to bacterial attack, preventing damage and promoting healing. This finding offers a potential solution to treating bacterial gut infections, which affect hundreds of millions worldwide.
Researchers from Uppsala University discovered a new species of bumblebee, Bombus incognitus, through genetic analysis of Rocky Mountains samples. The study reveals potential for speciation in arctic and alpine environments due to climate change.
Researchers discover that serotonin release from mast cells contributes to airway hyperresponsiveness in asthma, revealing a new mechanism for this common respiratory disease. The study uses a mouse model of asthma to demonstrate how mast cells react to methacholine, leading to increased airway constriction.
A new study by Uppsala University found that unmarried patients and those with low educational attainment are less likely to be treated with a stem-cell transplantation for mantle cell lymphoma. The study suggests that this may result in poorer survival rates.
The summit aims to discuss how individual behaviour and organisational norms can be changed to slow down the development of antimicrobial resistance. Key findings include the need for strong political leadership and communication strategies to address misconceptions about antimicrobial resistance.
Researchers developed a digital self-test to improve students' ability to assess news items, images and videos critically. The tool, part of the News Evaluator project, was tested with over 200 students and showed positive results.
A new model links bacterial metabolism and growth to mechanisms of antibiotic resistance, enabling predictions of mutation types and levels. The study suggests a previously unobserved connection between nutrient uptake and resistance development, which can inform strategies for slowing resistance emergence.
Scientists at Uppsala University have created the first 3D map of the hearing nerve, tracing fine nerve threads and vibrating auditory organ to understand how frequencies are distributed. This new knowledge can lead to more effective cochlea implant treatments for the hearing-impaired.
A study published in Stroke found that propranolol can shrink and stabilize vascular lesions in the brain, potentially treating cerebral cavernous malformations. Researchers administered propranolol to mice with hereditary CCMs, which resulted in fewer and smaller lesions.
Researchers found that the innate immune system overreacts in patients with severe COVID-19, leading to blood clots and oxygen saturation issues. The study suggests that this overreaction may be driven by extensive tissue damage, and may be treatable with existing drugs for hereditary angioedema.